Clinical trials: Cardiac Complications
Cohort Studies
The Impact of Preoperative Depression on Postoperative Delirium in Elderly Chinese Patients: A Retrospective Multicenter Observational Study
This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the impact of preoperative depression on the incidence of postoperative delirium among elderly Chinese patients…
- Trial name
- NCT07744282
- Volunteers
- 8,000 people
- Sponsor
- Chinese PLA General Hospital
Congenital Heart Disease in Children, Neurologic Complication
Erector Spinae Plane Block in Congenital Heart Disease Patients
Pediatric cardiac patients undergoing surgical anesthesia are at an increased risk of poor neurologic outcome (20-50%). Unattenuated anesthetic exposure and pain contributes to physiologic perturbations that may increase…
- Trial name
- NCT04158024
- Testing
- Erector Spinae Plane Block
- Volunteers
- 150 people
- Sponsor
- Stanford University
White Spot Lesions, Orthodontic Appliance Complication
Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment
Dental cavities are among the most frequent diseases that affect teeth, particularly in patients who are treated with braces due to the difficulty in maintaining good oral hygiene in the presence of the mouth appliances.
- Conditions
- White Spot Lesions, Orthodontic Appliance Complication, Caries Arrested, Smooth Surface Caries
- Trial name
- NCT05733676
- Testing
- Resin infiltration, Casein Phosphopeptide (CPP) - Amorphous Calcium Phosphate (ACP) - Fluoride
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Cardiogenic Shock, Peripartum Cardiomyopathy
"Treatment Use of ECMO In Pregnancy or Peripartum Patient."
The goal of this study is to describe the use of ECMO (Extracorporeal Membrane Oxygenation) in the pregnant or peripartum patient.
- Conditions
- Cardiogenic Shock, Peripartum Cardiomyopathy, Complication, Pregnancy
- Trial name
- NCT04144660
- Testing
- Extracorporeal Membrane Oxygenation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sarah Thordsen
Surgical Site Infection (SSI), Mediastinitis
Use of Platelet-Rich Plasma to Reduce Sternal Wound Complications After CABG With Median Sternotomy
The goal of this clinical trial is to learn whether applying autologous platelet-rich plasma (PRP) to the sternal wound during heart surgery improves wound healing and reduces complications after surgery.
- Conditions
- Surgical Site Infection (SSI), Mediastinitis, Delayed Wound Healing
- Trial name
- NCT07352020
- Testing
- Autologous Platelet-Rich Plasma (PRP) Application, Standard Sternal Wound Closure
- Where
- Pakistan
- Volunteers
- 98 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
Protection of the Heart With Doxycycline During Coronary Artery Bypass Grafting
The purpose of this study is to determine whether doxycycline (Periostat) at a sub-antimicrobial dose will decrease reperfusion injury after coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB).
- Conditions
- Coronary Artery Bypass Grafting, Cardiopulmonary Bypass, Reperfusion Injury
- Trial name
- NCT00246740
- Testing
- Periostat
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- University of Alberta
Cardiac Surgery, Acute Kidney Injury
Acute Normovolemic Hemodilution in Complex Cardiac Surgery
Postoperative bleeding in cardiac surgery is a frequent complication, and cardiac surgery utilizes 15-20% of the national blood supply. Packed red blood cells (pRBCs) are associated with worse short and long term outcomes.
- Conditions
- Cardiac Surgery, Acute Kidney Injury, Congenital Heart Disease, Aortic Surgery
- Trial name
- ANH (NCT05049590)
- Testing
- Acute normovolemic hemodilution (ANH)
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of California, Los Angeles
Acute Kidney Injury (Nontraumatic)
Biomarkers of Acute Kidney Injury in Cardiac Surgery
Acute kidney injury (AKI) is the most common complication in patients after cardiac surgery. An usual estimation of risk for AKI is estimation of serum creatinine, which is unreliable indicator of AKI risk.
- Trial name
- AKIrisk (NCT03830450)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nikola Bradic, MD
Postoperative Cognitive Dysfunction
Cognitive Dysfunction Following Cardiac Surgery
Postoperative cognitive dysfunction (POCD) is the most common complication after cardiac surgery. This prospective study was conducted to investigate the mechanisms of development of POCD following cardiac surgery taking into…
- Trial name
- CDCS (NCT02767713)
- Testing
- Dexamethasone
- Volunteers
- 171 people
- Sponsor
- Clinical Hospital Center, Split
Postoperative Delirium, Cardiac Surgery
Effect of RIPC on the Prevention of POD in Patients Undergoing Cardiac Surgery
Postoperative delirium (POD) is one of the most frequent neurological complications in elderly patients and is closely associated with longer ICU stay and hospitalization, deterioration of long-term neurocognitive function, and…
- Trial name
- NCT05434455
- Testing
- RIPC induced with 3 cycles of 5 minutes of ischaemia and 5 minutes of reperfusion
- Volunteers
- 216 people
- Sponsor
- Shanghai Zhongshan Hospital
Pregnancy Complication, Aortic Dissection
PregnAncy-Related Aortic DISsEction in China
A multicenter observational study on pregnancy-related aortic dissection
- Conditions
- Pregnancy Complication, Aortic Dissection, Marfan Syndrome, Loeys-Dietz Syndrome
- Trial name
- PARADISE (NCT07672210)
- Testing
- Intervention strategies including medication or surgery
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- DeltaHealth Hospital · Shanghai
Cardiac Surgery, Cardiopulmonary Bypass
Predictive and Prognostic Value of Cellular Dysoxia Markers After Cardiac Surgery With Extracorporeal Circulation
The study consist of evaluation in cardiac surgery with cardiopulmonary bypass (CPB) setting the ability of PCO2 derived variables (ΔPCO2, ΔPCO2/C(a-v)O2 ratio), compared to lactate and ScVO2 to predict major postoperative…
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Microcirculation, Tissue Oxygenation
- Trial name
- NCT03107572
- Where
- France
- Volunteers
- 330 people
- Sponsor
- University Hospital, Lille
Type 2 Diabetes Mellitus, Chronic Kidney Disease
Extended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome
Among adult individuals with type 2 diabetes mellitus and at risk for heart failure with impaired relaxation of the heart mildly reduced kidney filtration function (Type 4 cardiorenal syndrome) this trial will evaluate the…
- Conditions
- Type 2 Diabetes Mellitus, Chronic Kidney Disease, Left Ventricular Diastolic Dysfunction
- Trial name
- NCT02251431
- Testing
- BYDUREON
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Baylor Research Institute
Postoperative Pulmonary Complications
Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients
Controversies remain concerning the best intraoperative mechanical ventilation regimen for major cardiac surgery. While the use of intra operative low tidal volumes is now standard practice, the optimal level of positive…
- Trial name
- VACARM (NCT04408495)
- Testing
- Intervention group_MRA, Control group
- Where
- 10 sites in France
- Volunteers
- 441 people
- Sponsor
- Rennes University Hospital
Postoperative Delirium
Acetaminophen-Mannitol Injection and Postoperative Delirium
The aim of this multicenter randomized controlled study is to evaluate the effect of an intravenous acetaminophen-mannitol opioid-sparing analgesic strategy on the cumulative incidence of POD, compared with an intravenous…
- Trial name
- PAPOD-ES (NCT07235995)
- Testing
- Acetaminophen group, Sufentanil group
- Where
- China
- Volunteers
- 1,092 people
- Sponsor
- Xiangya Hospital of Central South University
Pain, Postoperative, Heart Valve Diseases
Erector Spinae Plane Block for Minimal Invasive Cardiac Surgery (Heart-Port).
Minimally invasive cardiac surgery is performed through a right thoracotomy, the pain management of this surgery is of great importance.
- Trial name
- ESP (NCT04011501)
- Testing
- Continuous Erector spinae block
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona
Postoperative Pain, Cardiac Surgery
The Effect of Acupressure Application on Respiratory Performance and Pain Levels in Adult Patients Undergoing Cardiac Surgery
The purpose of this randomized controlled trial is to evaluate the effect of acupressure on respiratory performance and pain levels in adult patients who have undergone open-heart surgery.
- Conditions
- Postoperative Pain, Cardiac Surgery, Postoperative Complications
- Trial name
- NCT07771751
- Testing
- Acupressure, Incentive spirometry
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Fenerbahce University
Bispectral Index, Transcutaneous Carbon Dioxide
Compare the Side Effects and Difference Awake Level of Three TCI Propofol Formula in TVOR Patients
This study is to find the fewer side effects formula of anesthesia for TVOR patients, to compare the BIS level during emergence and to find the correlation between BIS and transcutaneous carbon dioxide concentration.
- Conditions
- Bispectral Index, Transcutaneous Carbon Dioxide, PONV, Blood Pressure
- Trial name
- NCT00760253
- Where
- Taiwan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Bypass Complications, Disorder of Blood Gas
Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.
- Trial name
- NCT01698853
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Preeclampsia, Pulmonary Edema
Point-of-care Ultrasound Abnormalities in Early Onset Preeclampsia
The study is planned to describe the prevalence and severity of cardiac, lung and optic-nerve sheath diameter (ONSD) ultrasound abnormalities in women with early onset preeclampsia with severe features.
- Conditions
- Preeclampsia, Pulmonary Edema, Cardiac Function
- Trial name
- NCT05662995
- Testing
- Lung ultrasound
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- University of Cape Town
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