Clinical trials: Cardiac Complications
Anesthesia, Surgery With General Anesthesia
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery
Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient…
- Conditions
- Anesthesia, Surgery With General Anesthesia, Noncardiac Surgery, Hypotension During Surgery
- Trial name
- VEGA-2 (NCT06802224)
- Testing
- Norepinephrine, Phenylephrine
- Where
- 10 sites in United States, Canada
- Volunteers
- 18,000 people
- Sponsor
- University of California, San Francisco
Growth Hormone Deficiency, Turner's Syndrome
Evaluation of the Adherence and the Patient Acceptability of Zomacton® Treatment With the Zomajet® Vision X Device
The study is performed to collect long-term data on the treatment adherence and patient's acceptability when Zomacton®10 mg is administered with the Zomajet® Vision X device in patients with a growth hormone deficiency or…
- Trial name
- ZOMAXEPT (NCT02018172)
- Testing
- somatropin
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Ferring Pharmaceuticals
Radiocontrast-Induced Nephropathy, Chronic Kidney Disease
Efficacy of N-Acetylcysteine in Prevention of Post-Catheterization Contrast-Induced Nephropathy in Diabetic Patients With Chronic Kidney Disease
Contrast-induced nephropathy (CIN) is the third most common cause of hospital acquired acute kidney injury, accounting for 10% of all cases. The pathophysiology of CIN is unclear. Possible mechanisms involve 1.
- Conditions
- Radiocontrast-Induced Nephropathy, Chronic Kidney Disease, Diabetes Mellitus
- Trial name
- NCT00808795
- Testing
- N-acetylcysteine
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences
Infective Endocarditis
Effect of Dexmedetomidine on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
Acute kidney injury is major complication after open heart surgery. The cause of acute kidney injury following open heart surgery is related to activation of sympathetic nervous system, decrease of renal blood flow…
- Trial name
- NCT02698930
- Testing
- dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Yonsei University
Thyroid Diseases, Heart Diseases
Interest of the SPECT-CT Scan SUVspect in the New Generation of Gamma-cameras With Semiconductor
Since 2017, a revolution began in the departments of nuclear medicine, with the routine use of gamma-cameras with semiconductor.
- Conditions
- Thyroid Diseases, Heart Diseases, Bone Diseases, Brain Diseases
- Trial name
- GAMMA-CAM (NCT03414021)
- Testing
- SPECT-CT Scan
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Lille Catholic University
Ventricular Tachycardia (VT), Premature Ventricular Complexes
Severe Complications During Ventricular Tachycardia or Premature Ventricular Complex Ablation
The investigators aim to characterize patients presenting with a severe ventricular tachycardia (VT) and premature ventricular complex (PVC)-ablation-related complication including patient characteristics, procedural details and…
- Trial name
- NCT07777744
- Where
- 25 sites in United States, Austria and 14 more
- Volunteers
- 15,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Delirium
Automated Pupillometry in Patients Underwent Cardiac Surgery to Predict Postoperative Delirium
The rate of postoperative delirium in patients who underwent cardiac surgery is very high. Different predictors and/or scores were studied for the prediction of Post Operative Delirium (POD)after heart surgery, but none of them…
- Trial name
- NCT06255132
- Testing
- Automated pupillometer NPi-200
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Premature Birth
Assessment of Autonomic Regulation During the Listening of Mother Heart Beat in Newborns
Prematurity birth lead to an early breaking link with the in utero environment. A special attention is brought in the neonatal intensive care units to reduce noise and lighting surrounding aiming to protect the newborn.
- Trial name
- Cardio_Sound (NCT04821011)
- Testing
- electronic stethoscope, acoustic listening of mother's heartbeats, Recording of the newborn's heart rate
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Consecutive Incident Adult Patients Undergoing Elective Cardiac Surgery
The Diagnostic Role of Cystein-rich Protein 61 (Cyr61) in Acute Kidney Injury: Correlation With the Harmonic Analysis of Arterial Pressure Pulse Waves.
Acute kidney injury (AKI) is a common heterogeneous disease that complicates several medical and surgical conditions. Recent studies have demonstrated that the occurrence of AKI significantly increase the risk of adverse…
- Trial name
- NCT01876134
- Volunteers
- 150 people
- Sponsor
- National Taiwan University Hospital
Diabetes Mellitus, Renal Impairment
Development of a Biomarker Panel for the Earlier Prediction of Acute Kidney Injury in Patients With Diabetes
Patients living with diabetes mellitus have double the risk of kidney failure compared to patients without diabetes following use of dye in many x-rays and procedures to diagnose and treat narrowing of the arteries (blood…
- Trial name
- BIOMARKERS (NCT00948116)
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Barts & The London NHS Trust
Chronic Disease, Neoplasm Metastasis
Facilitating Communication Study
This study is a randomized clinical trial of an intervention to improve outcomes for patients and their family by using ICU nurse facilitators to support, model, and teach communication strategies that enable patients and their…
- Conditions
- Chronic Disease, Neoplasm Metastasis, Lung Neoplasm, Pulmonary Disease, Chronic Obstructive
- Trial name
- FCS2 (NCT03721952)
- Testing
- Facilitator-Based Intervention
- Where
- 3 sites in United States
- Volunteers
- 977 people
- Sponsor
- University of Washington
Turner Syndrome
A Study to Evaluate Subjects With Turner Syndrome Treated With Growth Hormone
This study is a multicenter, open-label, observational, postmarketing surveillance study of Genentech growth hormone (GH) products in the treatment of girls with Turner syndrome in the United States and Canada.
- Trial name
- NCT00097552
- Volunteers
- 1,696 people
- Sponsor
- Genentech, Inc.
Saphenectomy, No Touch
Morbidity of Conventional and No-touch Saphenectomy in Coronary Artery Bypass Grafting.
A clinical research project will be carried out that will consist of a non-inferiority study. The objective is to compare the morbidity of two different surgical techniques for the extraction of the internal saphenous vein…
- Conditions
- Saphenectomy, No Touch, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- TNT (NCT06496321)
- Testing
- Conventional Saphenous vein harvest, No touch Saphenous vein harvest
- Where
- Uruguay
- Volunteers
- 52 people
- Sponsor
- Instituto Nacional de Cirugia Cardiaca, Uruguay
General Surgery
The GUARDIAN Pilot Trial
The treatments will be: 1) norepinephrine or phenylephrine infusion to maintain intraoperative MAP ≥85 mmHg, delayed resumption of chronic antihypertensive medications, and a target ward MAP ≥80 mmHg (tight pressure management)…
- Trial name
- GUARDIAN (NCT04789733)
- Testing
- Tight pressure management, Routine pressure management
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Cleveland Clinic
Congestive Heart Failure, Renal Impairment
Effects of MK7418 on Diuresis and Renal Function in Congestive Heart Failure Patients
A study to determine the most appropriate dose of MK7418 in heart failure patients presenting with symptoms of volume overload requiring increased diuretic doses.
- Trial name
- NCT00652782
- Testing
- rolofyline
- Volunteers
- 160 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Atrial Fibrillation, Atrial Flutter
Strategies for the Management of Atrial Fibrillation in patiEnts Receiving Dialysis 2 (SAFE-D2)
People receiving dialysis are more likely to develop atrial fibrillation (AF), an irregular heartbeat that increases the risk of stroke.
- Conditions
- Atrial Fibrillation, Atrial Flutter, End Stage Kidney Disease (ESRD), Dialysis Patients
- Trial name
- SAFE-D2 (NCT07779746)
- Testing
- Eliquis, No oral anticoagulation
- Volunteers
- 848 people
- Sponsor
- Unity Health Toronto
Cardiac Anaesthesia
Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity.
- Trial name
- NCT06581289
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Cardiovascular Complication, Pulmonary Embolism
MACE and PE in Elective Primary TKA & THA
This study ought to identify the occurence of the major adverse cardiovascular events (MACE) and the pumonary emoblism (PE) in patients undergoing elective primary THA \& TKA
- Conditions
- Cardiovascular Complication, Pulmonary Embolism, Stroke, Transient Ischemic Attack
- Trial name
- NCT05116280
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Thessaly
Hypertension, Pregnancy-Induced
Hemodynamic Assessment of Healthy and Hypertensive Pregnant Women by Non-Invasive Bio-Reactance
The purpose of this study is to determine whether a noninvasive method of measuring certain aspects of blood circulation (e.g., blood pressure, cardiac output) is an accurate and reliable method to detect changes in pregnant…
- Trial name
- NCT00949260
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Kidney Disease, Chronic
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)
This study is open to adults with chronic kidney disease at risk of progression. People with and without type 2 diabetes can take part in this study.
- Trial name
- NCT06531824
- Testing
- BI 690517, Empagliflozin
- Where
- 562 sites in United States, Argentina and 18 more
- Volunteers
- 8,371 people
- Sponsor
- Boehringer Ingelheim
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