Clinical trials: Cardiac Complications
Bleeding Disorder, Ischemic Stroke
XIENCE 28 USA Study
The XIENCE 28 USA Study is prospective, single arm, multi-center, open label, non-randomized trial to evaluate safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of bleeding (HBR)…
- Conditions
- Bleeding Disorder, Ischemic Stroke, Hemorrhagic Stroke, Hematological Diseases
- Trial name
- NCT03815175
- Testing
- XIENCE, DAPT (aspirin and/or P2Y12 receptor inhibitor)
- Where
- 111 sites in United States, Austria and 13 more
- Volunteers
- 1,605 people
- Sponsor
- Abbott Medical Devices
Hemorrhage, Blood Loss, Surgical
Desmopressin in Cardiac Surgery
Patients undergoing cardiac surgery could develop excessive perioperative bleeding requiring transfusions of blood products. Desmopressin (DDAVP), already used for patients with von Willebrand syndrome, could reduce bleeding and…
- Conditions
- Hemorrhage, Blood Loss, Surgical, Postoperative Hemorrhage
- Trial name
- NCT00337766
- Testing
- Desmopressin (DDAVP)
- Where
- 4 sites in Italy
- Sponsor
- Università Vita-Salute San Raffaele
Healthy, Cancer
Archival of Human Biological Samples in CU-Med Biobank
CU-Med Biobank collaborates with different researchers for collecting and distributing human biospecimens and clinical data for assisting scientific research.
- Conditions
- Healthy, Cancer, Heart Diseases, Neurological Diseases or Conditions
- Trial name
- NCT04706481
- Testing
- Specimen Collection
- Where
- Hong Kong
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Heart Failure Acute, Heart Failure; With Decompensation
Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart Failure
This is a prospective, single-center, open-label and randomized trial for evaluation of the effect of a 5-day administration of high doses of spironolactone (≥100mg daily) on diuresis, natriuresis, weight loss and levels of…
- Trial name
- DANAUS-AHF (NCT04618601)
- Testing
- Spironolactone
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Laikο General Hospital, Athens
Acute Kidney Injury
Acute Kidney Injury After Cardiac Surgery Based on KDIGO Criteria
The aim of this study was to apply the acute kidney injury criteria based on KDIGO classification in a population of patients undergoing cardiac surgery [coronary artery bypass grafting (CABG) or cardiac valve surgery (CVS)] and…
- Trial name
- NCT00777465
- Where
- Brazil
- Volunteers
- 2,804 people
- Sponsor
- Hospital de Base
Postoperative Pain, Renal Insufficiency
Pain Management After Cardiac Surgery - Opioids or NSAID
The aim of this randomized controlled study is to shed light on the analgesic properties and side-effect profile of an opiod-based regimen as opposed to an Ibuprofene based regimen.
- Conditions
- Postoperative Pain, Renal Insufficiency, Myocardial Infarction
- Trial name
- NCT02479165
- Testing
- Ibuprofene, Oxycodone
- Volunteers
- 182 people
- Sponsor
- Aalborg University Hospital
Infant, Premature, Ductus Arteriosus, Patent
Plasma B-Type Natriuretic Peptide Concentrations in Preterm Infants < 28 Weeks
The aim of the study was to evaluate BNP in preterm infants < 28 weeks on the second day of life, when it is still unknown, if a patent ductus arteriosus is hemodynamic significant or not.
- Conditions
- Infant, Premature, Ductus Arteriosus, Patent, Natriuretic Peptide Brain
- Trial name
- NCT00528736
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Charite University, Berlin, Germany
Postoperative Cardiovascular Complications
Preoperative BNP as Biomarker of Postoperative Cardiovascular Complications
BNP is a hormone that predicts preoperatively the occurrence of postoperative cardiovascular complications. In practice, the problem is that the practitioner don't know the most opportune moment for the preoperative sample or…
- Trial name
- BNP (NCT02570607)
- Testing
- BNP dosage
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Heart Valve Diseases, Surgery--Complications
Machine Learning-Based Risk Profile Classification of Patients Undergoing Elective Heart Valve Surgery
Machine learning methods potentially provide a highly accurate and detailed assessment of expected individual patient risk before elective cardiac surgery.
- Trial name
- NCT03724123
- Volunteers
- 2,229 people
- Sponsor
- Kepler University Hospital
Heart Failure, Cardiomyopathies
Towards Understanding the Phenotype of Cardiovascular Disease in CKD - TRUE-Type-CKD Study
Premature cardiovascular disease (CVD) is the leading cause of death in patients with kidney disease (CKD). Excessive cardiac mortality is thought to be secondary to non-atherosclerotic processes, with left ventricular (LV)…
- Conditions
- Heart Failure, Cardiomyopathies, Chronic Kidney Diseases, Hypertrophy, Left Ventricular
- Trial name
- TRUE-TypeCKD (NCT03749551)
- Testing
- cardiac magnetic resonance (CMR) post haemodialysis
- Where
- Germany
- Volunteers
- 276 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cardiac Valve Disease, Coronary Artery Disease
Telehealth Interventions for Cardiac Surgery
The goal of this clinical trial is to compare telehealth monitoring at home against usual care in patients undergoing planned heart surgery. The main questions it aims to answer are: 1.
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Surgical Complication
- Trial name
- TICS (NCT05621954)
- Testing
- Telehealth Monitoring
- Where
- United Kingdom
- Volunteers
- 318 people
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Respiratory, Postoperative Pain
The Effect of Pranayama on Pain and Respiration After Coronary Bypass Surgery
After CABG surgery, patients tend to breathe superficially because they experience pain while breathing. By restricting deep inspiration and cough; There is a decrease in lung tidal volume, vital capacity, and functional residual…
- Conditions
- Respiratory, Postoperative Pain, Nursing
- Trial name
- NCT06485531
- Testing
- Pranamaya, Pursed Lips Breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Autoimmune Diseases, Cardiovascular Disorders
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
This multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions.
- Conditions
- Autoimmune Diseases, Cardiovascular Disorders, Diabetes Complications, Integumentary Disease
- Trial name
- NCT04684602
- Testing
- PrimePro™/ PrimeMSK™
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Thomas Advanced Medical LLC
Postoperative Pain
Thoracic Paravertebral Block Versus IV Fentanyl Infusion
High-quality analgesia during and following cardiac surgery is infrequently obtained, Sternotomy and thoracotomy is associated with significant pain that resulte in hypoventilation, atelectasis, and hypoxemia,Pain management is…
- Trial name
- NCT03903367
- Testing
- Fentanyl Citrate
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Beni-Suef University
Heart Failure, Chronic Kidney Disease
PD-HF: A Trial of Peritoneal Dialysis in Patients With Severe Heart Failure and Chronic Kidney Disease
This trial is to establish whether ultrafiltration by peritoneal dialysis is a clinically effective treatment for patients with severe heart failure and moderate chronic kidney disease, thus improving quality of life and symptoms.
- Trial name
- PD-HF (NCT02708407)
- Testing
- Peritoneal Dialysis
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Nottingham
Echocardiography, Mechanical Circulatory Support
The Usefulness of Myocardial Work IndeX in ExtraCorporeal Membrane Oxygenation Patients
Investigation of the potential prognostic role of non-invasive myocardial work in patients receiving veno-arterial extracorporeal membrane oxygenation therapy.
- Conditions
- Echocardiography, Mechanical Circulatory Support, Myocardial Failure, Cardiogenic Shock
- Trial name
- MIX-ECMO (NCT05838937)
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Nephropathy
A Prospective, Randomized TrialComparing Oral N-Acetylcysteine and Intravenous Sodium Bicarbonate
The purpose of this study is to compare the efficacy of oral N-acetylcysteine and intravenous sodium bicarbonate for the prevention of Contrast-Induced Nephropathy (CIN) after cardiac catheterization.
- Trial name
- PROTECt (NCT00579995)
- Testing
- Oral N-Acetylcysteine, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
CABG, Physiological Parameter
The Effect of Virtual Reality and Eye Mask During Dressing After CABG Surgery
This study aims to evaluate the effects of virtual reality (VR) and eye mask (EM) applications on pain, anxiety, and physiological parameters during dressing after Coronary Artery Bypass Graft (CABG) surgery.
- Conditions
- CABG, Physiological Parameter, Postoperative Pain, Postoperative Anxiety
- Trial name
- CABG (NCT07039812)
- Testing
- Virtual Reality Headset, Eye Mask
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul University - Cerrahpasa
Congestive Heart Failure, Renal Insufficiency
Risk Factors of the Revisit of the Adult Heart Failure Patients in Emergency Department Siriraj Hospital
To identify the risk factors of the revisit of the adult HF patients in emergency department.
- Trial name
- NCT01373775
- Testing
- Patient charts reviewing
- Where
- Thailand
- Volunteers
- 533 people
- Sponsor
- Mahidol University
Blood Platelet Disorders, Cardiac Surgery
Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)
Perioperative bleeding requiring blood transfusion is common during cardiovascular surgery, especially in procedures requiring cardiopulmonary bypass. Adenosine diphosphate (ADP) plays a fundamental role in platelet function.
- Conditions
- Blood Platelet Disorders, Cardiac Surgery, Postoperative Bleeding
- Trial name
- DISPLATEG (NCT06961175)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
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