Clinical trials: Cardiac Failure
Heart Failure
Utility of Thenar Near Infrared Spectroscopy (NIRS) in Pediatric Patients With Heart Failure
This is a single-center, non-randomized study.The study staff will use the InSpectraTM tissue oxygen saturation (StO2) monitor manufactured by Hutchinson Technology to measure baseline StO2 levels after applying the noninvasive…
- Trial name
- NCT02368041
- Testing
- InSpectraTM StO2 monitor
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
COVID-19, Long COVID
Using Data From a Multisensor Rapid Health Assessment Device to Predict Decompensation in Long COVID (AIDI)
We are conducting a research study at the VA hospital in Bedford, MA to learn more about how a multisensor rapid health assessment device, MouthLab, can help predict or anticipate future health complications in patients with…
- Trial name
- AIDI (NCT05713266)
- Testing
- MouthLabTM
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Edith Nourse Rogers Memorial Veterans Hospital
Heart Failure, Hypertension, Pulmonary
Dietary Nitrate for Heart Failure
The purpose of this study is to determine if nitrates in a food, in this case - beetroot juice (BRJ) - is efficacious in improving exercise tolerance and/or peak power in patients with heart failure.
- Trial name
- NCT01682356
- Testing
- Beetroot juice
- Where
- 2 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Healthy, Heart Failure
Evaluating the Safety, Pharmacokinetics and Haemodynamic Effect of a Slow Release Oral Formulation of Milrinone
To determine the pharmacokinetic profile of a new (extended release) formulation of milrinone and to demonstrate evidence of hemodynamic effect Primary: Pharmacokinetic profile - to demonstrate stable plasma levels Secondary (HF…
- Trial name
- NCT01849094
- Testing
- Milrinone 6mg, milrinone 10mg ER, milrinone 14mg
- Where
- 2 sites in Australia
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- The Alfred
Myocardial Ischemia, Exercise
Exercise-induced Changes in Cardiac Function & Morphology
Until now it has been assumed that regular endurance training has a positive influence on cardiac function and that the positive effect increases with increasing intensity.
- Conditions
- Myocardial Ischemia, Exercise, Myocardial Contraction, Myocardial Stunning
- Trial name
- NCT01179802
- Testing
- Strenuous Endurance exercise
- Where
- Switzerland
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Neurodegenerative Diseases
Ccf mtDNA as a Neurodegenerative Biomarker
There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice.
- Trial name
- NCT03938909
- Testing
- cif mtDNA biomarker
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Heart Failure, Congestive
Skeletal Muscle Dysfunction in Heart Failure
Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.
- Trial name
- NCT00156234
- Testing
- One-knee extension ergometer
- Where
- 2 sites in Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Heart Failure
Water Immersion in Chronic Stable Heart Failure
This study aims to investigate the effects of water immersion and exercise on heart function and blood flow in patients with chronic stable heart failure.
- Trial name
- IMMERSE-HF (NCT02949544)
- Testing
- water immersion
- Where
- United Kingdom
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Heart Failure, Dilated Cardiomyopathy
Brain Function and Perfusion in Patients With Heart Failure
The investigators will evaluate the determinants of cerebral impairment in patients with non-ischemic heart failure compared to controls, and its relation to cognitive function.
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Perfusion, Cognitive Impairment
- Trial name
- BRAIN-HF (NCT01756014)
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Heart Failure, Congenital Heart Defects
Right Ventricular Failure in Congenital Heart Defects
Usually, "heart failure" refers to myocardial insufficiency of the left ventricle. However, in patients with congenital heart defects, often predominantly the right ventricle is affected.
- Trial name
- NCT00266201
- Where
- 9 sites in Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Competence Network for Congenital Heart Defects
Cardiovascular Diseases, Heart Failure, Congestive
Evaluating the Relationship Between Fatty Acids and Heart Disease
Cardiovascular disease (CVD) affects millions of people in the United States; each year, more people die from CVD than from any other disease.
- Conditions
- Cardiovascular Diseases, Heart Failure, Congestive, Atrial Fibrillation, Cerebrovascular Accident
- Trial name
- NCT00404872
- Where
- 4 sites in United States
- Volunteers
- 4,766 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Myocardial Infarction, Ischemia
Smartphone Twelve-Lead ECG Utility In ST-Elevation Myocardial Infarction II
AliveCor (www.alivecor.com) has developed several electrocardiogram (ECG) devices that interface with iOS and Android smartphones and tablets via various Kardia apps.
- Conditions
- Myocardial Infarction, Ischemia, Myocardial Ischemia, Heart Diseases
- Trial name
- STLEUISII (NCT06271577)
- Testing
- AliveCor 12-lead ECG
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- AliveCor
Heart Failure With Left Ventricular Ejection Fraction Greater Than or Equal to 40 Per Cent, Healthy Volunteers
A Study to Compare How Much of the Study Treatment Finerenone Gets Into the Blood When the Same Amount is Taken in One and in Two Tablets of Different Strengths in Healthy Male Participants
In this bioequivalence study, healthy male participants took the study treatment finerenone in the form of one and two tablets of different strengths by mouth.
- Trial name
- NCT07116512
- Testing
- Finerenone (BAY94-8862): intervention A, Finerenone (BAY94-8862): intervention B
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bayer
Education, Nursing
Health Coaching to Empowering Hospitalised Chronic Heart Failure Patients
Aims: To evaluate the preliminary efficacy of Health Coaching in empowering hospitalised chronic heart failure patients. Methods: pre-post quasi-experimental pilot study was carried out with 59 patients, allocated into the…
- Trial name
- NCT05716685
- Testing
- Health coaching
- Where
- Spain
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Heart Failure, Systolic
Telesonography for Visually Estimating Ejection Fraction
Background: Given that an experienced physician is not always available 24 hours a day, immediately and always available echocardiography is usually impossible in the emergency department (ED) and intensive care unit (ICU).
- Trial name
- NCT02960685
- Testing
- Echocardiography
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hanyang University
Heart Failure, Heart Failure With Preserved Ejection Fraction
Randomized Controlled Pilot Trial of DASH Feeding in Older Low Socioeconomic Adults Without Heart Failure
This is a study of the DASH diet (Dietary Approaches to Stop Hypertension) in the exploration of effective strategies for Heart failure (HF) with preserved ejection fraction (HFPEF) prevention.
- Trial name
- DASHF (NCT04113291)
- Testing
- DASH Diet, Usual diet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Exposure to Pollution, Heart Failure
Effects of Air Pollution Exposure Reduction by Filter Mask on Heart Failure
Exposure to air pollution is associated with increase in cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function and heart rate variability on healthy volunteers.
- Trial name
- NCT01960920
- Testing
- Filtered diesel exhaust, Unfiltered diesel exhaust, Clean air
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
COPD, Asthma
Cardiorespiratory Diagnostic Study
This study uses a new breathing device called 'N-Tidal C' handset which measures breathing patterns. Investigators have found that people with cardiac and respiratory illnesses breathe out a gas, called carbon dioxide (CO2), in a…
- Conditions
- COPD, Asthma, Lung Cancer, Anemia
- Trial name
- CARES (NCT04939558)
- Testing
- N-Tidal C handset
- Where
- United Kingdom
- Volunteers
- 744 people, healthy volunteers welcome
- Sponsor
- TidalSense
Coronary Heart Disease (CHD), Heart Failure
a Foundational Model for Cardiovascular Disease Diagnosis and Prediction
The goal of this observational study is to develop and evaluate the efficacy of a foundational model that integrates multimodal medical data to improve the diagnosis and prediction of cardiovascular diseases in patients aged 18…
- Conditions
- Coronary Heart Disease (CHD), Heart Failure, Arrhythmias, Valvular Heart Disease
- Trial name
- NCT06591923
- Testing
- No Interventions
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Ventricular Fibrillation, Ventricular Tachycardia
Implantable Cardioverter Defibrillator (ICD) Support Groups and Veterans
In this study, we will compare the quality of life in veterans having ICD who attend the ICD support groups to those who do not.
- Conditions
- Ventricular Fibrillation, Ventricular Tachycardia, Sudden Cardiac Death
- Trial name
- NCT00846417
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Emory University