Clinical trials: Cardiac Flow
Hypertension, Cardiovascular Risk Factors
Rosuvastatin Effect on Serial Echocardiographic Measurement of Coronary Flow Velocity Reserve
In ASCOT study, lipid lowering with a statin provided additional beneficial effects in hypertensive patients with average levels of serum total cholesterol.
- Trial name
- RESERVE (NCT01490398)
- Testing
- Rosuvastatin
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Asan Medical Center
Stroke
Safety Study of External Counterpulsation as a Treatment for Acute Ischemic Stroke
The purpose of this study is to determine if external counterpulsation (ECP) is feasible to perform, tolerable, and safe as a treatment for patients with acute ischemic stroke (i.e., a blockage of one of the arteries supplying a…
- Trial name
- CUFFS (NCT00983749)
- Testing
- Full-pressure ECP
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Diego
Coronary Artery Disease
Role of On-site CT-derived FFR in the Management of Suspect CAD Patients
The primary of this registry is to evaluate whether the availability of CTA/CT-FFR procedure could effectively optimize the flow of clinical practice of stable chest pain versus conventional clinical pathway in decision making…
- Trial name
- TARGET (NCT03901326)
- Testing
- CT-FFR assessment
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Disease
Comparison of UFR With QFR in Stable Coronary Artery Disease
Quantitative flow reserve (QFR), derived from coronary angiography, has shown high accuracy in detecting significant lesions. Ultrasonic flow ratio (UFR), a new development from IVUS, integrates physiological estimation with…
- Trial name
- NCT06322355
- Testing
- Coronary angiography, Fractional Flow Reserve measurement, Intravascular ultrasound
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Shanghai Zhongshan Hospital
Microvascular Coronary Artery Disease, Coronary Artery Disease
The MASTER-PACT Study
The goal of this clinical trial is to compare non-invasive myocardial perfusion reserve (MRR) to invasively measured MRR in patients suspected for coronary artery disease (CAD).
- Trial name
- MASTER-PACT (NCT06069401)
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Aortic Stenosis
OpSens PRIME CLASS
In this study it is aimed to determine the diagnostic value of physiological measurements in the presence of aortic stenosis, and whether these are more accurate than angiographic assessment.
- Trial name
- NCT05070130
- Testing
- dPR and FFR
- Where
- 5 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Opsens, Inc.
Heart Failure
Biological Markers Predicting Exercise Capacity in CF-LVAD Patients.
Establishing the association between biological markers and exercise capacity in continuous-flow left ventricular assist device patients.
- Trial name
- NCT02303236
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiovascular Diseases, Vasodilation
The Nitrite and Coronary Flow Study
This study is a pharmacodynamic proof of concept study investigating the physiological effects of systemic infusion of nitrite on coronary blood flow using MRI.
- Conditions
- Cardiovascular Diseases, Vasodilation, Hypoxia
- Trial name
- NCT04354051
- Testing
- Sodium Nitrite
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema
Ultrasound Evaluation of Cardiac Function During Spontaneous Breathing Trials
The goal of this clinical trial is to evaluate the evolution of a cardiac ultrasound index (E/E') during 3 spontaneous breathing trials in Intensive Care Unit (ICU) adults (over 18 years) patients at risk for weaning failure.
- Conditions
- Weaning Invasive Mechanical Ventilation, Weaning-induced Pulmonary Edema, Weaning Failure of Mechanical Ventilation, Spontaneous Breathing Test
- Trial name
- ATARI (NCT06923267)
- Testing
- No Pressure Support No Positive End Expiratory Pressure Spontaneous Breathing Trial, Pressure Support Spontaneous Breathing trial, Humidified High Flow Spontaneous Breathing Trial
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Multi Vessel Coronary Artery Disease
Angiogram Based Fractional Flow Reserve in Patients With Multi-Vessel Disease
This is a prospective, observational, single-center, single-arm, clinical trial designed to assess the efficacy of FFRangio in measuring FFR obtained from angiography compared to Invasive FFR for diagnosing hemodynamically…
- Trial name
- NCT03455244
- Testing
- FFRangio
- Where
- Japan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CathWorks Ltd.
Angina, Stable Chest Pain
The Value of CT Fractional Flow Reserve
Coronary Computed Tomography Angiogram (CCTA) is a non-invasive imaging modality that has high sensitivity and negative predictive value for the detection of coronary artery disease (CAD).
- Trial name
- VFFRCTA (NCT03026283)
- Testing
- HeartFLow CT-FFR
- Volunteers
- 586 people
- Sponsor
- Northwell Health
Myocardial Infarction, Myocardial Ischemia
Coronary Flow and Myocardial Viability: the FloVITA Study
Evaluation of fractional flow reserve (FFR) is a key method for assessing ischemia with a view to guiding revascularization strategy following acute coronary syndrome.
- Trial name
- FloVita (NCT04818918)
- Testing
- Absolute coronary flow measurement, Microvascular resistance measurement, Cardiac MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Heart Failure.
Optimizing Continuous-flow Left Ventricular Assist Device Settings and Identification of Pump Malfunction - A Comparative Study of Echocardiography and Invasive Hemodynamics
The purpose of the trial is to identify factors which can be used as guidance when optimizing continuous-flow left ventricular assist device (CF-LVAD) settings.
- Trial name
- NCT01851889
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Disease
CRIC Combined With MFT for MFR in Patients With Incomplete Revascularization of CAD
The main objective of this study is to demonstrate whether the combination of chronic remote ischemic conditioning and mindfulness therapy can improve myocardial flow reserve in patients with incomplete revascularization of…
- Trial name
- CRMF-MFR (NCT07514624)
- Testing
- CRIC, MFT
- Volunteers
- 480 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Stable Angina, Unstable Angina
International Collaboration of Comprehensive Physiologic Assessment
The current study evaluated prognostic implication of comprehensive physiologic assessment using fractional flow reserve, coronary flow reserve (CFR) and index of microcirculatory resistance (IMR).
- Conditions
- Stable Angina, Unstable Angina, Non-ST Elevation Myocardial Infarction, ST-segment Elevation Myocardial Infarction
- Trial name
- NCT03690713
- Testing
- Fractional flow reserve, coronary flow reserve, and index of microcirculatory resistance
- Where
- 4 sites in Japan, South Korea and 1 more
- Volunteers
- 1,397 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Computed Tomography-derived Fractional Flow Reserve vs. Angiographic Quantitative Flow Ratio in Management of Patients With Coronary Artery Disease
This is a multi-center, randomized controlled trial to compare the clinical outcomes between CT-derived fractional flow reserve (CT-FFR) guided strategy and angiography-derived quantitative flow ratio (QFR) guided strategy among…
- Trial name
- CONQUER (NCT07308496)
- Testing
- CT-FFR guided strategy, QFR guided strategy
- Volunteers
- 1,402 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Angiography, Coronary Artery Disease
Assessment Of Total Coronary Circulation Time Using TIMI Frame Count Method (TCCT-TIMI)
The aim of this study is to evaluate and describe the total coronary circulation time (TCCT) by using TIMI frame count method in patients performed coronary angiography.
- Conditions
- Coronary Angiography, Coronary Artery Disease, Coronary Artery Ectasia, Slow-Flow Phenomenon
- Trial name
- TCCT-TIMI (NCT02818127)
- Testing
- coronary angiography
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 2,000 people
- Sponsor
- Vascular and Molecular Cardiology Society
Fractional Flow Reserve, Myocardial, Coronary Artery Disease
Diagnostic Agreement of iFR and QFR.
A Prospective, observational, single center diagnostic study to investigate the the diagnostic agreement between QFR and the pressure wire-based iFR in a real world setting.
- Trial name
- DETECTISCHEMIA (NCT03420131)
- Testing
- QFR and iFR
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Contilia Clinical Research Institute
Diabetes Mellitus, Microvascular Coronary Artery Disease
Study in Diabetes Mellitus Patients Without Prior Myocardial Infarction or Stroke Undergoing Elective Percutaneous Coronary Intervention.
This study is designed to test the hypothesis that ticagrelor is superior to clopidogrel, in improving coronary microvascular function, as measured by coronary flow reserve (CFR) in patients with T2DM at high risk of…
- Trial name
- AUGEAS (NCT04069234)
- Testing
- Ticagrelor, Clopidogrel
- Sponsor
- Region Skane
Coronary Artery Disease
Differential Effect of High (200μg/kg/Min) Adenosine Dose on Fractional Flow Reserve in Patients Presenting Variation of FFR ≥0.05 During the Usual Dose of Adenosine Infusion (140μg/kg/Min).
Fractional flow reserve (FFR) is an established invasive method for assessing the physiological significance of coronary artery stenosis.
- Trial name
- NCT02350439
- Testing
- Adenosine infusion at 200μg/Kg/min
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Patras
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