Clinical trials: Cardiac Flow
Coronary Heart Disease
Cadmium-zinc-telluride (CZT) Imaging of Myocardial Blood Flow (MBF) (SPECT MBF)
This study is being done to compare the blood flow measurements obtained with the SPECT and PET imaging scans. Measurements such as myocardial blood flow (MBF) and myocardial flow reserve (MFR) are analyzed on PET scans.
- Trial name
- SPECTMBF (NCT02280941)
- Testing
- single photon emission computed tomography
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Mitral Regurgitation, Aortic Regurgitation
Expiratory Flow Limitation and Mechanical Ventilation During Cardiopulmonary Bypass in Cardiac Surgery
During general anesthesia a reduction of Functional Residual Capacity (FRC) was observed. The reduction of FRC could imply that respiratory system closing capacity (CC) exceeds the FRC and leads to a phenomenon called expiratory…
- Trial name
- NCT02633423
- Testing
- Use of PEEP before and after CPB, No use of PEEP before and after CPB(ZEEP), Ventilation with CPAP during CPB
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Ospedale San Raffaele
Pregnancy, Physical Activity
The Effect of Physical Activity During Pregnancy on Uterine and Fetal Parameters
This study investigates the relationship between physical activity levels and fetal health in the third trimester of pregnancy. Using the PPAQ and daily step counts, researchers will measure physical activity and examine its…
- Trial name
- TEOPADPUFP (NCT07147777)
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Acute Coronary Syndromes
Does Optical Coherence Tomography Optimise Results of Stenting
Optical Coherence Tomography (OCT) is a recent imaging modality that yields cross-sectional images with a resolution 10 times greater than that of intravascular ultrasound (IVUS).
- Trial name
- DOCTORS (NCT01743274)
- Testing
- OCT
- Where
- 8 sites in France
- Volunteers
- 240 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Coronary Microvascular Disease
Coronary MicrovAscular Diseases Intervention With Compound Danshen Dropping Pills
Objective: To investigate the effect of Compound Danshen Dripping Pills （CDDP）on improving coronary flow reserve（CFR） in patients with coronary microvascular disease (CMVD) and to evaluate their efficacy and safety.
- Trial name
- MAID (NCT07885462)
- Testing
- Compound Danshen Dripping Pills
- Where
- China
- Volunteers
- 496 people
- Sponsor
- Qilu Hospital of Shandong University
ST Segment Elevation Myocardial Infarction
Microvascular Dysfunction in Acute Myocardial Infarction (AMI) and Its Relation to Outcome
The purpose of this study is first to evaluate absolute myocardial blood flow and resistance over time in the acute and sub-acute phase of myocardial infarction and second, to correlate these parameters to preservation of left…
- Trial name
- NCT01538303
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Cardiac Surgery
High Flow Nasal Oxygen Therapy (Optiflow™) in High-risk Cardiac Surgical Patients
Background: High risk patients with lung disease who undergo cardiac surgery are at significant risk of postoperative complications leading to prolonged hospital stay.
- Trial name
- NCT02496923
- Testing
- High flow nasal oxygen therapy (Optiflow™), Standard oxygen therapy (Hudson Type face mask or nasal prongs)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Cardiovascular Diseases
Dysphagia in Cardiac Surgical Patients_
The proposed study seeks to determine the incidence of dysphagia and vocal fold mobility impairment (VFMI) in individuals undergoing cardiovascular surgical procedures.
- Trial name
- NCT04496986
- Testing
- Fiberoptic Endoscopic Evaluation of Swallowing, Simultaneous FEES and Videofluoroscopy instrumental swallowing exam, Voluntary Cough Peak Expiratory Flow (PEF) Testing
- Sponsor
- University of Florida
Sepsis, Respiratory Physiological Phenomena
Respiratory Variations for Predicting Fluid Responsiveness
Hypovolemia and acute circulatory failure affects more than 60% of patients hospitalized in intensive care or resuscitation. The volume expansion (VE) by fluid replacement therapy is the first treatment improve circulatory…
- Conditions
- Sepsis, Respiratory Physiological Phenomena, Circulatory Failure
- Trial name
- ReVaPreF (NCT03066362)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Lille
Coronary Stenosis
The Sensitivity and Specificity of CardioSimFFRct Analysis Software on Coronary Artery Stenosis
The device involved in this trail is a diagnostic software with a Prospective, Multicenter, Self Controlled design. FFRCT diagnostic performance was calculated by CardioSimFFRct Analysis software, and the diagnostic accuracy…
- Trial name
- NCT04569669
- Testing
- FFR and FFRCT
- Where
- 8 sites in China
- Volunteers
- 325 people
- Sponsor
- CCRF Inc., Beijing, China
Hypertrophic Cardiomyopathy, Obstruction
4D-flow MRI to Assess Left Ventricular Obstruction in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is a frequent cardiac pathology with an estimated prevalence of 1/500 in France. The main risk factor for sudden death in this pathology is the presence and extent of left ventricular…
- Conditions
- Hypertrophic Cardiomyopathy, Obstruction, Echocardiography
- Trial name
- CMHFLUX (NCT04439942)
- Testing
- cardiac magnetic resonance imaging (MRI)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Coronary Stenosis
Relationship Between Pressure and Flow Velocity on Coronary Physiology
Subjects are patients who are planned to do percutaneous coronary intervention for coronary stenosis in the left circumflex artery without other stenosis in the left ascending artery and the right coronary artery, or a patient…
- Trial name
- NCT02330861
- Testing
- combowire and IVUS
- Where
- Japan
- Sponsor
- Hyogo Medical University
Pulmonary Hypertension
Noninvasive Determination of Cerebral Tissue Oxygenation in Pulmonary Hypertension
To study the effect of acute pulmonary vasodilatation on cerebral tissue oxygenation (CTO) and cerebral blood flow (CBF) as indicator for cerebrovascular autoregulation in comparison to the effects of supplemental oxygen…
- Trial name
- NCT01463514
- Testing
- Right heart catheterization, Near-infrared spectroscopy
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Coronary Artery Disease, Aortic Valve Disease
Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery
Open heart surgery, including coronary artery bypass grafting (CABG) and/or aortic valve replacement (AVR) is associated with a significant risk of mortality.
- Trial name
- GLORIOUS-II (NCT05635227)
- Testing
- Dexamethasone phosphate, Isotonic sodium chloride (0.9%), Olanzapine 10 MG
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease
ABSORB PHYSIOLOGY Clinical Investigation
The target enrollment goal for the trial was to enroll 36 subjects. However due to a challenging protocol inclusion/ exclusion criteria, only one subject was enrolled since the trial was initiated in June 2011.
- Trial name
- NCT01308346
- Testing
- Bioabsorbable Vascular Solutions Everolimus Eluting Coronary Stent System (BVS EECSS), XIENCE V® Everolimus Eluting Coronary Stent System (EECSS)
- Where
- 6 sites in Australia, China and 2 more
- Volunteers
- 1 people
- Sponsor
- Abbott Medical Devices
Hypertension, Cardiovascular Risk
Effect of Pitavastatin on Coronary Flow Reserve in Hypertensive Patients
Although statins reduce cardiac events in hypertensive patients with cardiovascular risk factors, the effect of statins on coronary flow reserve (CFR) has not been examined in such patients.
- Trial name
- EPOCH (NCT02144922)
- Testing
- Pitavastatin, Control
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Asan Medical Center
Congenital Heart Disease (CHD), Univentricular Heart
Fontan Outcomes in Oligemia vs Plethora in Univentricular CHD
This prospective cohort study evaluates differences in clinical outcomes between pulmonary oligemia and pulmonary plethora in patients with cyanotic congenital heart disease and univentricular heart physiology undergoing staged…
- Trial name
- NCT07535203
- Testing
- Fontan Procedure
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Sisca Natalia Siagian
Chronic Coronary Syndrome
Computational mOdelliNg of myoCardial pERfusion to Improve ouTcome Prediction Based on cOronary Artery Stenosis and Atherosclerotic Plaque Burden Assessment by Computed Tomography
Detection of coronary stenosis is of utmost importance in identifying vulnerable patients. The combined use of coronary computed tomography angiography at rest (CCTA) and stress myocardial computed tomography perfusion…
- Trial name
- CONCERTO (NCT06337461)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Centro Cardiologico Monzino
Coronary Artery Disease, Coronary Disease
Treatment of Functionally Non-significant Vulnerable Plaques in Patients With Multivessel ST-elevation Myocardial Infarction The VULNERABLE Trial
The study aims to compare a preventive percutaneous coronary intervention (PCI) plus optimal medical treatment (OMT) strategy vs.
- Conditions
- Coronary Artery Disease, Coronary Disease, Ischemic Heart Disease
- Trial name
- VULNERABLE (NCT05599061)
- Testing
- FFR>0.80+ OCT with findings indicative of vulnerable plaque
- Where
- 49 sites in Spain
- Volunteers
- 609 people
- Sponsor
- Fundación EPIC
Coronary Artery Disease, Heart Diseases
Angiography-Derived Quantitative Functional Assessment Versus Pressure-Derived FFR and IMR: The FAIR Study
Coronary angiography-derived FFR assessment (AngioQFA) is a novel technique for physiological lesion assessment based on 3-dimensional (3D) quantitative coronary angiography (QCA) and virtual hyperemic flow derived from contrast…
- Conditions
- Coronary Artery Disease, Heart Diseases, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- NCT06039748
- Testing
- AngioQFA
- Where
- 5 sites in China
- Volunteers
- 330 people
- Sponsor
- Shenzhen Raysight Intelligent Medical Technology Co., Ltd.
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