Clinical trials: Cardiac Flow
Respiration; Artificial, Positive-Pressure Respiration
Flow Controlled Ventilation in Cardiac Surgery
This trial investigates effects of individualized (by compliance guided pressure settings) flow-controlled ventilation compared to best clinical practice pressure controlled ventilation in cardiac surgery requiring…
- Trial name
- NCT04306757
- Testing
- Evone, Primus
- Where
- Austria
- Volunteers
- 54 people
- Sponsor
- Medical University Innsbruck
Coronary Disease
Assessment of Coronary Pressure Using the Combined Guidewire and Catheter Wirecath
In summary, the purpose of the study is to evaluate whether the Wirecath device can be used as a standard pressure wire in a safe and efficient way.
- Trial name
- NCT04776577
- Testing
- Wirecath@ and Abbott PressureWire® (20 patients), Wirecath® (20 patients), Coronary flow reserve
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Vastra Gotaland Region
Borderline Coronary Stenoses Assessment, Fractional Flow Reserve, Plaque Composition
INTegrated Assessment of intERmediate Coronary Stenoses by Fractional Flow rEserve (FFR) and Near-infraREd Spectroscopy (NIRS)
Revascularization of borderline coronary stenoses (40-70%) is usually driven by fractional flow reserve (FFR) which expresses the physiological significance of a lesion and tells the operator whether PCI may reduce the rate of…
- Trial name
- INTERFERE (NCT02985112)
- Testing
- FFR and IVUS-NIRS
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- S.M. Misericordia Hospital
Coronary Artery Disease
PrOgnostic imPlicaTIons of 2-diMensIonal Patterns for Residual Disease After Stenting CharacteriZEd by Quantitative Flow Ratio Pullback Curve Analysis
The purpose of this study is to investigate the prognostic values of 2-dimensional residual disease patterns determined by quantitative flow ratio (QFR) pullbacks after stent implantation.
- Trial name
- CHART-OPTIMIZE (NCT05125107)
- Testing
- Quantitative Flow Ratio derived PPG and dQFR/ds
- Volunteers
- 1,607 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Heart Disease
Myocardial Blood Flow by 15O Water PET
Coronary heart disease is a very common condition caused by narrowings in the blood vessel supplying the heart. the investigators are studying new tests to diagnose heart disease.
- Trial name
- NCT01805193
- Testing
- Computed tomography myocardial perfusion imaging, Oxygen 15 labelled water positron emission tomography
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Edinburgh
Heart Failure.
The Increase Study. Effect of Incremental Versus Fixed Pump on Peak Oxygen Consumption in Heart Failure Patients Supported With a Continuous Flow Left Venticular Assist Device
The purpose of the study is to examine the relationship between working capacity (peak oxygen consumption) and pump speed of continuous flow left ventricular assist devices (CF-LVADs)in heart failure patients.
- Trial name
- NCT01698398
- Testing
- Incremental pump speed of CF-LVAD.
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Arterial Disease (CAD), Acute Coronary Syndromes (ACS)
Non-Invasive Follow-Up of Patients With Coronary Artery Disease Treated With Drug-Coated Balloon PCI Using CT-Derived Fractional Flow Reserve
This study investigates changes in coronary artery anatomy and physiology after treatment with a paclitaxel drug-coated balloon (DCB) during percutaneous coronary intervention (PCI).
- Conditions
- Coronary Arterial Disease (CAD), Acute Coronary Syndromes (ACS), Stable Coronary Artery Disease Undergoing PCI
- Trial name
- RECORD-CT-FFR (NCT07811960)
- Volunteers
- 150 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Reduced Ejection Fraction (HFrEF)
Flow Regulation by Opening the SepTum in Patients With Heart Failure; a Prospective, Randomized, Sham-controlled, Double-blind, Global Multicenter Study
The purpose of this clinical study is to assess the safety and effectiveness of the Atrial Flow Regulator in the treatment of subjects, 18 years of age or older, who have symptomatic heart failure with preserved ejection fraction…
- Trial name
- FROST-HF (NCT05136820)
- Testing
- Atrial Flow Regulator
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Occlutech International AB
Heart Failure, Systolic, Mechanical Circulatory Support
Cardiac Output in Heart Failure Patients With Mechanical Pumps
This study will be looking at how cardiovascular hemodynamics, including cardiac output and flow through a left ventricular assist device (LVADs), change in response to alterations in preload, afterload, and contractility, and…
- Conditions
- Heart Failure, Systolic, Mechanical Circulatory Support, Cardiovascular Hemodynamics
- Trial name
- NCT05195931
- Testing
- preload challenge, afterload challenge, contractility assessment
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Colorado, Denver
Cardiology, Radiology
The Evaluation of the Roles of New Cardiac Imaging in Patients With Chest Pain
This is a prospective, observational study designed to evaluate the role of dynamic computed tomographic perfusion (CTP) and Computed Tomography-Derived Fractional Flow Reserve (CT-FFR) in patients presenting with chest…
- Conditions
- Cardiology, Radiology, Stenoses
- Trial name
- NCT03800862
- Testing
- CT-FFR and CTP
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Lancaster General Hospital
Coronary Artery Disease
PrOgnostic Implications of PRe-stent Pullback Pressure GradIent and Post-stent Quantitative Flow Ratio in Patients UnderGoing Percutaneous Coronary INtervention
The purpose of this study is to investigate the prognostic implication of pre-percutaneous coronary intervention (PCI) focal or diffuse disease patterns combined with post-PCI quantitative flow ratio (QFR).
- Trial name
- CHART-ORIGIN (NCT05104580)
- Testing
- Quantitative Flow Ratio derived PPG
- Volunteers
- 1,395 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Ischemia, Myocardial, Ischemic Heart Disease
Coronary Flow Reserve (CFR) in Cardiovascular Risk Stratification
CFR has been studied for few years using 82 Rubidium PET (positron emission tomography) /CT. CFR has shown to be correlated with cardiovascular events occurring in the 10 following years.
- Trial name
- CFR-OR (NCT03586492)
- Testing
- CZT SPECT acquisition
- Where
- 2 sites in France
- Volunteers
- 137 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Expiratory Flow Limitation, Recent Myocardial Infarction
Effects of Interval Physical Training on Expiratory Flow Limitation in Recent Myocardial Infarction
Introduction: Expiratory flow limitation (EFL) and ventilatory inefficiency during dynamic exercise have been identified in patients with recent myocardial infarction (RMI) with preserved ventricular and pulmonary function.
- Trial name
- NCT03121911
- Testing
- Interval Training (IT), Inspiratory Muscle Training (IMT)
- Where
- Brazil
- Sponsor
- Federal University of Uberlandia
Hypoxemic Acute Respiratory Failure
High Flow Nasal Oxygen Therapy for Hypoxemy After Cardiac Surgery
The main objective of this study is to evaluate the gas exchange (ventilation-perfusion ratio) with the system Optiflow® compared to facial mask among patients having an acute respiratory failure after cardiac surgery.
- Trial name
- Optiflow (NCT01617252)
- Testing
- Optiflow / Facial mask
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Nantes University Hospital
Myocardial Ischemia, Coronary Disease
Ammonia N-13 Myocardial Blood Flow Absolute Quantification by PET in Patients With Known or Suspected CAD (Ammonia MAP)
This study is being conducted to provide access to and collect test data for an established nuclear medicine diagnostic imaging test called Positron Emission Tomography (PET), using a specific radioactive drug called Ammonia N-13…
- Conditions
- Myocardial Ischemia, Coronary Disease, Coronary Artery Disease, Heart Diseases
- Trial name
- NCT04343209
- Testing
- Myocardial Perfusion Imaging Study, AMMONIA N-13 37.5 mCi in 1 mL INTRAVENOUS INJECTION [Ammonia N 13]
- Where
- 5 sites in United States
- Volunteers
- 170 people
- Sponsor
- Ionetix Corporation
Calcific Aortic Valve Disease, Aortic Valve Stenosis
Serum and Cellular Biomarkers for Aortic Valve Stenosis
AthenaValve aims to develop and initial validate a novel serum diagnostic kit, for the assessment of severity and prognosis of progression of aortic valve stenosis (AS, a devastating disease without early diagnosis and medical…
- Conditions
- Calcific Aortic Valve Disease, Aortic Valve Stenosis, Aortic Valve, Calcification of
- Trial name
- AthenaValve (NCT04312139)
- Testing
- Echocardiography, Computerized Tomography Aortic Valve Calcium Score, Untargeted LC/MS and LC-MS/MS
- Where
- 2 sites in Greece
- Volunteers
- 280 people
- Sponsor
- National and Kapodistrian University of Athens
Coronary Artery Disease
Palmar Arch Insufficiency as a Risk Factor for Radial Artery Occlusion After Transradial Catheterization
Transradial access (TRA) is commonly used in different medical fields due to the superficial position of the radial artery and related advantages.
- Trial name
- PAIRAO (NCT03993834)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Amyloidosis Cardiac, Aortic Stenosis, Severe
Analysis of Calcium Score of Severe Aortic Stenosis in Patients With and Without Cardiac Amyloidosis (CAUSATIVE Study)
The concomitant presence of cardiac amyloidosis (CA) in patients with aortic stenosis (AS) may challenge the estimation of stenosis degree.
- Trial name
- CAUSATIVE (NCT06066632)
- Where
- Italy
- Volunteers
- 480 people
- Sponsor
- University Hospital of Ferrara
Anesthesia, General, Hypotension
Haemodynamic Effects of Four Sevoflurane Wash-In Strategies After Tracheal Intubation
The goal of this clinical trial is to compare how four different ways of starting sevoflurane anaesthesia (the "wash-in" phase) affect the heart and circulation during the first 10 minutes after endotracheal intubation in adults…
- Trial name
- WASH-PRAM (NCT07894393)
- Testing
- End-tidal-controlled sevoflurane wash-in, Low-flow high-concentration wash-in (0.5 L/min, 8% sevoflurane), Low-flow wash-in (1 L/min, 4% sevoflurane)
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Ataturk University
Aortic Valve Stenosis
Multicenter Prospective Study of Low-Flow Low-Gradient Aortic Stenosis (TOPAS Study)
Low-flow, low-gradient (LF-LG) aortic stenosis (AS) may occur with depressed (i.e. Classical LF; CLF) or preserved (i.e. Paradoxical LF; PLF) LV ejection fraction (LVEF) and both situations are amongst the most challenging…
- Trial name
- NCT01835028
- Testing
- Echocardiography, Computed tomography, Magnetic resonance imaging
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 320 people
- Sponsor
- Laval University
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