Clinical trials: Cardiac Flow
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Left Main Coronary Artery Disease
Functional Diagnostic Accuracy of Ultrasonic Flow Ratio in Assessment of Left Main Coronary Artery Stenosis
This is a prospective, observational, single-center study. The main purpose of this study is to evaluate the diagnostic accuracy of offline computational ultrasonic flow ratio (UFR) in predicting functionally significant left…
- Trial name
- FUNCTION II (NCT06053944)
- Testing
- fractional flow reserve (FFR); ultrasonic flow ratio (UFR); intravascular ultrasound (IVUS)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndrome
ObseRvation After Acute Coronary Syndrome for deveLopment of trEatment Options
The aim of the study is developing an individualized risk model for the unfavorable outcomes of coronary artery disease and complications from ongoing therapy, according to clinical, instrumental, biochemical and genetic…
- Trial name
- ORACLE (NCT04068909)
- Volunteers
- 1,655 people
- Sponsor
- Central State Medical Academy
Acute Myocardial Infarction, Unstable Angina
Exploring the Mechanism of Plaque Rupture in Acute Coronary Syndrome Using Coronary CT Angiography and Computational Fluid Dynamics II (EMERALD II) Study
The EMERALD II study is a multinational, multicenter, and retrospective study. ACS patients who underwent CCTA from 1 months to 3 years prior to the event will be retrospectively identified.
- Trial name
- EMERALD II (NCT03591328)
- Testing
- Coronary CT angiography
- Where
- South Korea
- Volunteers
- 429 people
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
Pressure-wire Guided PTCA: Drug Eluting Stent Versus Drug Eluting Balloon (WinDEB Study)
The aim of the study is to show the safety and efficacy of the SeQuent® Please (Drug Eluting Balloon or DEB) vs. commonly used Drug Eluting Stents in the treatment of small vessel disease and side branches by pressure wire guided…
- Trial name
- NCT01399463
- Testing
- Angioplasty performed via Paclitaxel Eluting Balloon catheter, Angioplasty via DES
- Sponsor
- Medical University of Vienna
Diabetes Mellitus, Coronary Artery Disease
Coronary Physiology and Its Relationship to Anatomy in Patients With Diabetes Mellitus
Comprehensive assessment of coronary physiology (fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microcirculatory resistance (IMR)) in patients with diabetes mellitus and coronary artery disease (CAD).
- Trial name
- NCT02745821
- Testing
- Pressure Wire Certus, St. Jude Medical, USA
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Congestion, Heart Failure
Portal Vein Flow Variability to Quantify Right-Sided Hemodynamic Congestion (PORTAL)
This study evaluates the accuracy of a comprehensive venous Doppler echography including the portal vein pulsatility index (PVPI) to quantify invasively measured right-sided venous pressures.
- Conditions
- Congestion, Heart Failure, Right Heart Catheterisation, Central Venous Pressure
- Trial name
- PORTAL (NCT05411263)
- Testing
- Comprehensive transthoracic echocardiography, Doppler echography & Kino-cardiograph (Kino)
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Vrije Universiteit Brussel
Ischemic Heart Disease, Atherosclerosis
Imaging and Physiologic Evaluation of Coronary Artery Disease
To evaluate the long-term clinical outcomes and prognostic factors in patients with coronary artery disease (CAD) undergoing invasive coronary angiography (ICA), intravascular imaging, or invasive physiologic assessment.
- Trial name
- NCT05124249
- Testing
- Intravascular imaging (IVUS or OCT) or Invasive physiologic assessment, PCI
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Chonnam National University Hospital
Peripheral Arterial Disease
Effect of Beetroot Juice on Coronary Blood Flow and Walking Performance in PAD
In this study the investigators will test the hypothesis that short-term consumption of inorganic nitrate (supplied in concentrated beetroot juice) enhances coronary blood flow responses, large artery hemodynamics, and leg…
- Trial name
- HeartBeet (NCT02553733)
- Testing
- Beetroot juice
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- David N. Proctor, PhD
Hypertension
Does Ultraviolet Irradiation Reduce Platelet Reactivity and Improve Coronary Microvascular Function in Man?
Endothelium derived nitric oxide (NO) regulates vascular tone and blood pressure in man. NO also inhibits platelet aggregation and mediates a variety of beneficial anti-inflammatory and repair mechanisms.
- Trial name
- NCT01785511
- Testing
- UVA Radiation
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Aortic Valve Stenosis, Aortic Valve Insufficiency
Pilot Trial: Comparison of Flow Patterns
The purpose of this study is to determine why sutureless aortic bioprostheses apparently offer better haemodynamic properties compared to sewed-in aortic bioprostheses in patients who underwent aortic valve replacement.
- Trial name
- NCT02288871
- Testing
- Cardiac CT-scan
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Vienna
Orthotopic Heart Transplant
Coronary Artery Vasculopathy in Pediatric Heart Transplant Patients
Heart transplantation is a life-sustaining therapy that allows patients with either congenital or acquired heart disease and severe cardiac dysfunction to survive. Over time, however, the transplanted heart can develop problems.
- Trial name
- CFR-OHT (NCT03231371)
- Testing
- Adenosine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Bryan Goldstein
Cancer, Chemotherapeutic Toxicity
Serial PET MPI in Patients Undergoing Cancer Treatment
This study aims to evaluate the effects of cardiotoxic cancer therapies on myocardial blood flow (MBF) and perfusion in a prospective sample of VA patients.
- Conditions
- Cancer, Chemotherapeutic Toxicity, Coronary Artery Disease, Coronary Microvascular Disease
- Trial name
- NCT05913999
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Coronary Artery Disease, Myocardial Ischaemia
The FAVOR III China Study
The overall purpose of the FAVOR III China trial is to investigate if a strategy of quantitative flow ratio (QFR)-guided percutaneous coronary intervention (PCI) yields superior clinical outcome and cost-effectiveness compared to…
- Conditions
- Coronary Artery Disease, Myocardial Ischaemia, Coronary Circulation, Coronary Stenosis
- Trial name
- FAVORIII (NCT03656848)
- Testing
- QFR, Angiography
- Where
- China
- Volunteers
- 3,847 people
- Sponsor
- China National Center for Cardiovascular Diseases
to Assess the Corresponding PEEP Values in NIV With CPAP Under Different Airflow Rates During HFOT in Heart Failure Patients
Using Electrical Impedance Tomography to Investigate the Relationship Between Airflow Rate During High-flow Oxygen Therapy and Pressure in Patients With Heart Failure Compared to Non-invasive Ventilation
Non-invasive ventilation (NIV) has been widely used in heart failure patients with supporting evidence. However, the drawbacks and contraindications associated with NIV limit its applicability in certain patients.
- Trial name
- NCT06107907
- Testing
- Non-invasive ventilation (NIV) or high-flow oxygen therapy (HFOT) using electrical impedance tomography (EIT)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease, Coronary Stenosis
The Flash FFR Ⅱ Study
The overall purpose of Flash FFR Ⅱ is to investigate whether coronary angiography-derived fractional flow reserve (caFFR), compared with fractional flow reserve (FFR) measured by a pressure wire, has non-inferior clinical effect…
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Myocardial Ischaemia, Coronary Circulation
- Trial name
- NCT04575207
- Testing
- caFFR, FFR
- Where
- 13 sites in China
- Volunteers
- 2,132 people
- Sponsor
- Peking University First Hospital
Healthy, Lactate Blood Increase
The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and Brain
The aim of the proposed study is to investigate the effect of increased plasma lactate concentrations on the heart and brain's metabolism of other energy sources, primarily glucose in the brain and glucose and FFA in the heart.
- Trial name
- NCT06665763
- Testing
- Sodium Lactate Solution
- Where
- 2 sites in Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Aortic Valve Stenosis
Low Flow Low Gradient Aortic Stenosis Relevance of the (re)Search for a Contractile Reserve
Investigators sought to demonstrate that the increase in the stroke volume during a dobutamine stress echocardiography might impact the prognosis of a patient addressed for a low flow low gradient suspected severe aortic valve…
- Trial name
- LOWAS (NCT02727504)
- Testing
- Electrocardiogram, 2D and 3D echocardiography, Dobutamine stress echocardiography
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Rennes University Hospital
Coronary Artery Disease
The Internal Thoracic Artery Skeletonization Study: A Paired, Within-Patient Comparison
The purpose of this study is to determine whether skeletonization of the internal thoracic artery leads to improved flow, increased length, improved sternal perfusion, and decreased pain and dysesthesia in patients undergoing…
- Trial name
- NCT00265499
- Testing
- Skeletonization of the internal thoracic artery
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Ottawa
Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques
Effectiveness of Interventional Therapy for Non-Flow-Limiting Vulnerable Plaques
The aim of this clinical trial is to explore the optimal preventative treatment strategy for non-flow-limiting vulnerable plaques.
- Conditions
- Coronary Arterial Disease (CAD), Vulnerable Coronary Plaques, Thin-cap fIbroatheroma, Acute Coronary Syndromes (ACS)
- Trial name
- NCT06855537
- Testing
- PCI strategy, OMT strategy
- Where
- China
- Volunteers
- 2,190 people
- Sponsor
- Beijing Anzhen Hospital
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