Clinical trials: Cardiac Flow
High-Risk Percutaneous Coronary Intervention (High-risk PCI), Left Ventricular Assist Devices
Interventional Ventricular Assist System for PCI in CHIP Patients
In patients with complex coronary artery disease (CAD), determining the optimal revascularization strategy (percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) remains a challenge.
- Trial name
- REC-CHIPMCS (NCT06373120)
- Testing
- Microaxial flow pump, VA-ECMO
- Where
- China
- Volunteers
- 262 people
- Sponsor
- Shenzhen Core Medical Technology CO.,LTD.
ANOCA - Angina With Non-obstructive Coronary Arteries, HFpEF - Heart Failure With Preserved Ejection Fraction
Peripheral Microvascular Blood Flow in ANOCA
An observational cross-sectional cohort study investigating whether peripheral endothelial function assessed using Laser speckle contrast analysis and coronary endothelial function measured with invasive coronary function testing…
- Trial name
- NCT05610410
- Testing
- Laser speckle contrast analysis
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Amsterdam UMC, location VUmc
Coronary Artery Disease
Blood Flow Reserve: Effects After Training With Heavy Inspiratory Exercises
The goal of this single-site, parallel-group, double-blind, sham-controlled randomized control trial is to examine the effect of high-intensity inspiratory muscle strength training (IMST) on coronary blood flow assessed using…
- Trial name
- BREATHE (NCT05632614)
- Testing
- High-intensity IMST, Low-intensity IMST
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Kidney Injury, Acute Renal Failure
Acute Kidney Injury After Cardiac Surgery: Novel Ultrasound Techniques for Prediction of Acute Kidney Injury
Acute Kidney Injury (AKI) is a frequent and important complication to cardiac surgery. This study will evaluate the diagnostic ability of ultrasonographic measures of blood flow in kidneys and liver in predicting AKI after…
- Conditions
- Acute Kidney Injury, Acute Renal Failure, Cardiac Surgery
- Trial name
- NCT03727204
- Testing
- On-pump cardiac surgery
- Where
- 2 sites in Denmark, South Africa
- Volunteers
- 150 people
- Sponsor
- Aarhus University Hospital
Cardiac Arrest
Effects of Laryngeal Tube Ventilation on no Flow Time During Out of Hospital Cardiac Arrest
International recommendations stress on the importance of no flow time reduction in cardiac arrest management. In fact, no flow time is an independent factor of morbidity and mortality.
- Trial name
- FLOWERS (NCT01295749)
- Testing
- laryngeal tube ventilation and continuous chest compression
- Where
- 2 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Grenoble
Ischemia, Angina
PrEssure wiRe Compared to Microcatheter-based Sensing Technology For the Evaluation of FFR Measurements
The model by which physicians measure the lack of blood flow in the vessels that supply blood to the heart muscle is called Fractional Flow Reserve (FFR).
- Trial name
- PERFORM (NCT02648230)
- Testing
- St. Jude Medical Pressure Wire, ACIST Navvus Microcatheter
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Columbia University
Coronary Stenosis
Comparison of Optical Coherence Tomography-derived Minimal Lumen Area, Invasive Fractional Flow Reserve and FFRCT
Significant left main (LM) stenosis is associated with a poor prognosis, therefore, adequate judgement of the prognostic significance of LM stenosis is essential to improve patients' prognosis.
- Trial name
- OPTICO-LM (NCT03820492)
- Testing
- OCT, FFR, CTA and FFRCT
- Where
- 13 sites in France, Germany and 2 more
- Volunteers
- 104 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Microvascular Dysfunction, Coronary Microvascular Disease
Absolute Flow for Ischemia With No Obstructive Coronary Arteries
The main objective is to prospectively validate the capacity of continuous thermodilution coronary flow reserve (CFRflow) as a predictor of the presence of angina measured by SAQ7 in patients with INOCA at 3 months.
- Conditions
- Coronary Microvascular Dysfunction, Coronary Microvascular Disease, Angina, Stable
- Trial name
- AF-INOCA (NCT05825339)
- Testing
- Coronary Flow Reserve
- Where
- 6 sites in Spain
- Volunteers
- 121 people
- Sponsor
- Spanish Society of Cardiology
Intensive Care Unit, Cardiac Surgery
Comparison of Two Methods for Assessing Cough Capacity in Intensive Care Unit After Cardiac Surgery
Weaning from mechanical ventilation represents 50% of the time spent under mechanical ventilation (1). The risk factors identified in the failure to wean from mechanical ventilation are: left heart dysfunction with LVEF < 30%.
- Trial name
- DEPT (NCT03983044)
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Noninvasive Cardiac Monitoring
Monitoring Blood Flow and Breathing Using a New Device (RFII) Compared to the Gold Standard Device in Post Operative Cardiac Patients
The purpose of this study will be to compare standard of care invasive methods to an FDA approved non-invasive device and a novel wireless non-invasive device, both manufactured by Non-Invasive Medical Technologies Inc., with the…
- Trial name
- NCT01434771
- Sponsor
- University of Florida
Peripheral Artery Disease
Evaluation of Concomitant Administration of Cilostazol and Probucol on Biomarkers, Endothelial Function and Safety
Based upon evidence of efficacy and safety of both cilostazol and probucol administration in independent randomized controlled trials in PAD and CAD, the present trial seeks to investigate the effect of concomitant administration…
- Trial name
- NCT01142284
- Testing
- Cilostazol, Probucol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Coronary Artery Disease
Influence of Intensive Lipid-lowering on FFRCT (The FLOW-PROMOTE Study)
The FLOW-PROMOTE Study is an investigator-initiated, Danish multicenter study of patients with stable chest pain investigating whether lipid lowering is associated with recovery of impaired coronary flow as assessed by CT derived…
- Trial name
- FlowPromote (NCT04737408)
- Testing
- Rosuvastatin 40mg
- Where
- 3 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Bjarne Linde Noergaard
Cardiac Output, Low, Coronary Arterial Disease
Post-Induction Low Cardiac Output Syndrome in Coronary Artery Bypass Graft Surgery
Hemodynamic change after induction of general anesthesia is usually judged from mean arterial pressure. Pressure, however, is a surrogate for flow, and the two can separate: cardiac output may fall while arterial pressure remains…
- Conditions
- Cardiac Output, Low, Coronary Arterial Disease, Anesthesia, General
- Trial name
- PiLCOs (NCT07810621)
- Testing
- routine clinical monitoring, observed only
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 103 people
- Sponsor
- Ataturk University
Aortic Valve Stenosis
Volume Challenge Added to DSE in the Diagnosis of Severe LFLGAS
The aim of this study is to test the diagnostic added value of Volume Challenge (VC) to low-dose dobutamine stress echocardiography (LDDSE) in patients with a low-flow, low-gradient aortic stenosis (LFLGAS).
- Trial name
- FLOW-AS (NCT03617406)
- Testing
- Volume Challenge
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Heart Failure
Prospective Multi-Center Randomized Study for Evaluating the EVAHEART®2 Left Ventricular Assist System
This is a prospective, multi-center, unblinded, randomized, controlled, and non-inferiority study comparing the EVA2 LVAS to the most recent magnetically levitated centrifugal LVAS (HM3 LVAS).
- Trial name
- COMPETENCE (NCT01187368)
- Testing
- EVAHEART Left Ventricular Assist System (LVAS), HeartMate 3
- Where
- 12 sites in United States
- Volunteers
- 399 people
- Sponsor
- Evaheart, Inc.
Coronary Arterial Disease (CAD), Coronary Artery Bypass
Comparison of Bidirectional Palpation Test and Transit Time Flow Measurement for LIMA-LAD Graft Patency
The most important factor determining mortality and morbidity after coronary artery bypass graft (CABG) surgery is graft patency.
- Conditions
- Coronary Arterial Disease (CAD), Coronary Artery Bypass, LIMA, Graft Patency
- Trial name
- NCT06934993
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people
- Sponsor
- Abdulgani Orhun YENİGÜN
Coronary Artery Disease
Comparative Analysis of NTG-Pd/Pa and Saline-Pd/Pa (CANS)
The goal of this observational study is to compare the value of NTG-Pd/Pa and saline-Pd/Pa in participants with intermediate stenosis of the coronary artery.
- Trial name
- NCT07195968
- Testing
- NTG-Pd/Pa measurement, Saline-Pd/Pa measurement
- Where
- 3 sites in Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease
Fractional Flow Reserve Derived From Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain
To determine whether, in a population of patients presenting to the rapid access chest pain clinic (RACPC), routine FFRct (Fractional Flow Reserve Computed Tomography) as a default test is superior in terms of resource…
- Trial name
- FORECAST (NCT03187639)
- Testing
- FFRct, Standard care
- Where
- United Kingdom
- Volunteers
- 1,400 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Coronary Artery Disease
Fluid Responsiveness Through the Corrected Carotid Flow Time, Before and After Sternotomy
Perioperative fluid management is used to maintain the perfusion of vital organs, prevent hypovolemia, inadequate tissue perfusion, and tissue edema, and cardiovascular complications caused by the infusion of large amounts of…
- Trial name
- NCT06967142
- Testing
- Correcte Carotid flow measurement by USG Doppler
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Ankara City Hospital Bilkent
Coronary Artery Stenosis
FFR and Inducible Myocardial Ischemia During Adenosine Stress Testing
This is a prospective, single center study involving 150 patients with stable coronary artery disease undergoing coronary angiography for chest pain evaluation.
- Trial name
- NCT04401657
- Testing
- Fractional flow reserve with adenosine stress testing
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Asan Medical Center
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