Clinical trials: Cardiac Infection
Heart Transplant Infection Prevention
Safety and Efficacy of Measles, Mumps, Rubella Vaccination in Pediatric Heart Transplantation Patients
The study is an interventional, non-randomized assessment of safety and efficacy of live Measles, Mumps and Rubella (MMR) vaccine in subjects aged 12-months to 17 years who have undergone heart transplantation.
- Trial name
- NCT07195032
- Testing
- Commercial measles, mumps, and rubella (MMR) vaccine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Mercy Hospital Kansas City
Stroke (CVA) or TIA, Diabetes
Risk Factors, Costs, and Impacts of ED Boarding
The goal of this observational study is to learn about the risk factors, costs, and operational impacts of emergency department boarding (patients admitted to the hospital but remaining in the emergency department awaiting…
- Conditions
- Stroke (CVA) or TIA, Diabetes, Asthma (Diagnosis), COPD (Chronic Obstructive Pulmonary Disease)
- Trial name
- NCT07532564
- Where
- United States
- Volunteers
- 30,486 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Long COVID Syndrome
Does Taurine Supplementation Improve Vascular Function and Orthostatic Responses in Long COVID?
Millions have developed Long COVID (LC), and recent findings show an association between taurine deficiency (an amino acid) and symptoms in LC.
- Trial name
- NCT07312409
- Testing
- Taurine supplementation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- York University
Chagas Cardiomyopathy
Cell Therapy in Chagas Cardiomyopathy
The purpose of this study is to determine effect of cell therapy in patients with severe dilated cardiomyopathy
- Trial name
- NCT00349271
- Testing
- Stem cell, Filgrastime (G-CSF), Standart therapy
- Where
- Brazil
- Volunteers
- 182 people
- Sponsor
- Ministry of Health, Brazil
Coronary Artery Disease
Robot Assisted Percutaneous Cardiovascular Intervention as a Strategy to Reduce or Risk of Intra-Procedure Contamination by COVID-19 and Other Respiratory Viruses
Percutaneous cardiovascular intervention procedures (e.g. coronary angioplasty, peripheral artery angioplasty) must be performed in person, requiring the physical presence of one or more medical, nursing and technical…
- Trial name
- NCT04379453
- Testing
- Robot Assisted Percutaneous Cardiovascular Intervention
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Hospital Israelita Albert Einstein
Nosocomial Infection, Respiratory Tract Infection
Prevention of Nosocomial Infection by Decontamination of the Naso- and Oropharynx With Chlorhexidine (NONI Trial)
Does chlorhexidine gluonate, a simple broad-spectrum antimicrobial agent with virtually no adverse-effects lower the incidence of NI after cardiac surgery, especially with respect to LTI and SSI?
- Conditions
- Nosocomial Infection, Respiratory Tract Infection, Surgical Site Infection
- Trial name
- NCT00272675
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Septic Shock and Use of Vasopressin
Effect of Adding Vasopressin on Cardiac Output, Blood Pressure, Diuresis, and Tissue Perfusion Indices in Patients With Septic Shock
In patients with septic shock, vasopressin is increasingly used in combination with norepinephrine, but its timing of initiation remains heterogeneous and its clinical hemodynamic effects are still insufficiently characterized.
- Trial name
- VASO-PHENO (NCT07697144)
- Where
- 8 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Bloodstream Infections, Central Nervous System Infections
INfectious DIsease REgistry BIObank
Prospective observational study designed to describe the clinical, laboratory, imaging, microbiological characteristics and treatment of specific infectious diseases, with the addition of a dedicated biobank.
- Conditions
- Bloodstream Infections, Central Nervous System Infections, Bone and Joint Infections, Endovascular Infections
- Trial name
- INDI-REBIO (NCT06418048)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- IRCCS San Raffaele
Surgical Site Infections
Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting
The hypothesis is that application of Mupirocin to the nose before and after coronary artery bypass grafting surgery will reduce the incidence of surgical site infections.
- Trial name
- MIR-CABG (NCT01949935)
- Testing
- Mupirocin
- Where
- Canada
- Volunteers
- 974 people
- Sponsor
- Horizon Health Network
HIV, Cardiovascular Disease
Healing Hearts and Mending Minds in Older Adults Living With HIV
The purpose of this study is to see if exercise is helpful for improving memory, concentration thinking abilities, physical function, and quality of life for adults aged 50 to 89 years living with HIV and who have two or more…
- Conditions
- HIV, Cardiovascular Disease, AIDS
- Trial name
- FitBrain (NCT02711878)
- Testing
- Let's Move Program, Let's Flex Program, Group Motivational Interviewing
- Where
- 3 sites in United States
- Volunteers
- 115 people
- Sponsor
- Emory University
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Covid19
Dual MRI for Cardiopulmonary COVID-19 Long Haulers
The next phase of the COVID-19 pandemic is likely to see a surge in an associated chronic cardiopulmonary disease that will challenge health systems.
- Trial name
- NCT04828135
- Testing
- Hyperpolarized 129Xenon gas
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Bastiaan Driehuys
Coronary Heart Disease, Heart Failure
Cardiovascular Diseases in HIV-infected Patients HIV-HEART Study: 7.5 Years Follow-up
Since the introduction of antiretroviral therapy life expectancy of HIV-infected persons is rising. Different cohorts are observing an increased risk for cardiovascular diseases in this aging HIV-infected population.
- Conditions
- Coronary Heart Disease, Heart Failure, HIV, AIDS
- Trial name
- NCT01667068
- Testing
- Comprehensive non invasive cardiovascular examination
- Where
- 6 sites in Germany
- Volunteers
- 1,481 people
- Sponsor
- University Hospital, Essen
Covid19, Comorbidities and Coexisting Conditions
Analysis of Health Status of Сomorbid Adult COVID-19 Patients Hospitalised in Second Wave of SARS-CoV-2 Infection
Comparison of COVID-19 disease course in hospitalized patients infected by SARS-CoV-2 in first and second waves of the novel coronavirus infection
- Conditions
- Covid19, Comorbidities and Coexisting Conditions, Risk Factor, Cardiovascular, Death
- Trial name
- ACTIV-2 (NCT04709120)
- Where
- Russia
- Volunteers
- 2,968 people
- Sponsor
- Eurasian Association of Therapists
Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis
Medicine-induced Cardiac Hemodialysis on COVID-19
The clinical trial studies the human pathogen of SARS-CoV-2, with a specificity in the circulating Spike 2 protein in the human system.
- Conditions
- Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis, Vaccines, Myocarditis Allergic
- Trial name
- NCT05711810
- Testing
- Nifedipine 30 MG, Kangzhu BPCB0A-3A, Low Mobility
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Yang I. Pachankis
Rheumatic Heart Disease
RhEumatiC Heart diseAse Genetics
Rheumatic fever (RF) is an autoimmune disease that is mediated by the cellular and humoral immune response that follows an untreated pharyngeal Streptococcus pyogenes infection.
- Trial name
- RECHARGE (NCT02118818)
- Testing
- Next generation sequencing
- Where
- Rwanda
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Endocarditis, Sepsis
Cytokine REmoval in CRitically Ill PAtients Requiring Surgical Therapy for Infective Endocarditis (RECReATE)
Infectious endocarditis (IE) and other severe infections are well-known to induce significant changes in the immune response including immune functionality in a considerable number of affected patients.
- Conditions
- Endocarditis, Sepsis, Septic Shock
- Trial name
- RECREATE (NCT03892174)
- Testing
- Treatment protocol with adsorption
- Where
- Switzerland
- Volunteers
- 54 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sepsis
Study of Treatment's Echocardiographic Mechanisms
This ancillary study determines whether the Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) [ClinicalTrials.gov Identifier: NCT03434028] treatment arms (restrictive fluids strategy vs.
- Trial name
- NCT03913403
- Testing
- ECHO, Blood Draw
- Where
- 7 sites in United States
- Volunteers
- 210 people
- Sponsor
- Intermountain Health Care, Inc.
Intracardiac Thrombus, Intracardiac Mass
AngioVac Aspiration Therapy Registry
As a structured, multinational retrospective registry the AVATAR Registry addresses the following scientific aspects through systematic data collection, centralized quality control, and robust statistical analysis in patients…
- Conditions
- Intracardiac Thrombus, Intracardiac Mass, Intravascular Thrombosis, Vegetation; Heart
- Trial name
- AVATaR (NCT07769320)
- Testing
- Retrospective analysis of assigned treatment
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Charite University, Berlin, Germany
Critically Ill, Acute Kidney Injury
Renal Resistive Index and Cardiac Output Changes During Resuscitation Predict the Occurrence of Acute Kidney Injury in Septic Shock Patients
Record the renal resistive index and hemodynamic parameters ( record the cardiac output and stroke volume if the patient's next to kin agree to undertake a PiCCO monitoring ) before and after resuscitation for severe sepsis or…
- Conditions
- Critically Ill, Acute Kidney Injury, Septic Shock
- Trial name
- CORRI (NCT01862588)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Zhongda Hospital
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