Clinical trials: Cardiac Infection
Chagas Disease, Heart Diseases
Genetic Architecture of Heart Disease in Rural Brazil
To examine the genetics of human susceptibility to Chagas' disease, a leading cause of heart disease throughout Latin America.
- Conditions
- Chagas Disease, Heart Diseases, Arrhythmia, Heart Failure, Congestive
- Trial name
- NCT00023556
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Tuberculous Pericarditis, HIV Status
High vs. Standard Dose Rifampicin for Effusive Tuberculous Pericarditis
The investigators hypothesise that high dose RIF (RIF35) will increase pericardial fluid RIF exposure and so enhance mycobacterial clearance, compared to standard of care dosing (RIF10).
- Trial name
- IMPI-3 (NCT04521803)
- Testing
- high dose Rifampicin (RIF)
- Where
- 2 sites in South Africa
- Volunteers
- 52 people
- Sponsor
- University of Cape Town
Staphylococcus Aureus, Bacteremia
Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia
To study whether fluoroquinolone (trovafloxacin or levofloxacin), added to standard treatment, could reduce the high mortality and complication rates in Staphylococcus aureus bacteremia.
- Conditions
- Staphylococcus Aureus, Bacteremia, Endocarditis, Sepsis
- Trial name
- FINLEVO (NCT00548002)
- Testing
- trovafloxacin and levofloxacin
- Where
- Finland
- Volunteers
- 430 people
- Sponsor
- University of Helsinki
SARS-CoV-2 Infection, COVID-19 Recurrent
Efficacy of a Physical and Respiratory Rehabilitation Program for Patients With Persistent COVID-19 (SARS-CoV-2).
The pandemic caused by SARS-CoV-2 infection has resulted, in addition to the well-known acute symptoms, in the emergence of a plethora of persistent, diffuse and heterogeneous symptoms such as fatigue, shortness of breath and…
- Conditions
- SARS-CoV-2 Infection, COVID-19 Recurrent, Cognitive Dysfunction, Fatigue
- Trial name
- COPERIA-REHAB (NCT05629884)
- Testing
- COPERIA-REHAB
- Where
- 4 sites in Spain
- Volunteers
- 56 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Surgical Wound Infection
Efficacy of Diluted Betadine vs Antibiotic Installation Before Surgical Wound Closure in Prevention of Post Cardiac Surgery Wound Infection
1. Infection control and health-care-associated infections and Safety of medical service providers 2. Evidence based management of common medical and surgical problems
- Trial name
- NCT05276687
- Testing
- Betadine, Vancomycin
- Volunteers
- 80 people
- Sponsor
- Assiut University
Sepsis, Septic Shock
Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients
NUROPI is a single-centre, prospective, non-interventional study in the Intensive Care Unit (ICU) of Erasme Hospital (Hôpital Universitaire de Bruxelles, Brussels, Belgium).
- Conditions
- Sepsis, Septic Shock, Cardiac Arrest (CA), Pancreatitis
- Trial name
- NuROPI (NCT07184593)
- Testing
- Plasma H3.1 nucleosome measurement
- Volunteers
- 1,000 people
- Sponsor
- Erasme University Hospital
COVID, SARS-CoV-2
European/Euro-ELSO Survey on Adult and Neonatal/ Pediatric COVID-19 Patients in ECMO
In the last 10 years, severe acute respiratory infection (SARI) was responsible of multiple outbreaks putting a strain on the public health worldwide.
- Conditions
- COVID, SARS-CoV-2, ARDS, Human, Refractory Hypoxemia
- Trial name
- EuroECMO-COVID (NCT04366921)
- Where
- 97 sites in Austria, Belgium and 17 more
- Volunteers
- 150 people
- Sponsor
- Maastricht University Medical Center
Hypoxic-Ischemic Encephalopathy, Sepsis
Continous Renal Replacement Therapy With the CARPEDIEM® in a French National Cohort of 25 Neonates and Small Infants
Historically, CKRT and hemodialysis were performed in small infants and newborns with devices developed for adults with high rates of complications and mortality.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Sepsis, Kidney Diseases, Metabolic Disease
- Trial name
- NCT05495607
- Testing
- CARPEDIEN
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Sepsis, Hypotension
Non-Invasive Cardiac Output Monitor (NICOM) for Goal-directed Fluid Resuscitation for Inpatients With Hypotension and/or Septic Shock
The Non-Invasive Cardiac Output Monitor (NICOM) is a non-invasive monitor capable of measuring cardiac output (CO) and cardiac index (CI), and stroke volume (SV) and stroke volume index (SVI) based on heart rate.
- Conditions
- Sepsis, Hypotension, Septic Shock
- Trial name
- NCT05630716
- Testing
- NICOM
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- University of Minnesota
Toxoplasmosis, Rhd
Measuring the Prevalence of Toxoplasmosis and Its Socio-economic Consequences
The investigators propose a fast and inexpensive procedure to determine the prevalence of the Toxoplasmosis infection (Toxoplasma Gondii) in the general population, using response times in a cognitive task instead of costly…
- Trial name
- EconToxo (NCT05860998)
- Testing
- Presence of Toxoplasma gondii IgG Antibodies
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Parkinson Disease (PD), Chronic Heart Failure (CHF)
An Innovative Disease-net Management Model for Non-communicable Diseases (SIDERA^B)
The SIDERA^B telerehabilitation system is enabled by a multi-domain, multi-device platform providing at home multi-component rehabilitation, targeting cardiovascular (Chronic Heart Failure, CHF), pulmonary (Chronic Obstructive…
- Conditions
- Parkinson Disease (PD), Chronic Heart Failure (CHF), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SIDERA^B (NCT04041193)
- Testing
- SIDERA^B, Usual Care Program
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Chagas Disease, Chagas Cardiomyopathy
Cardiac Rehabilitation in Chagas Heart Failure
Due to the lack of information in the literature about the role of cardiac rehabilitation on Chagas heart failure, the aim of the present study was to evaluate the effects of a cardiac exercise program on functional capacity…
- Trial name
- NCT02516293
- Testing
- Exercise, nutritional and pharmaceutical counseling
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Evandro Chagas National Institute of Infectious Disease
Covid19, Myocardial Infarction
Outcomes of Patients Who Survived Treatment on an Intensive Care Unit for COVID-19 in England and Wales
This retrospective cohort study aims to characterise outcomes for patients treated on an intensive care unit (ICU) with COVID-19 in England and Wales, one year after discharge from hospital.
- Conditions
- Covid19, Myocardial Infarction, Stroke, Critical Illness
- Trial name
- OPTIC-19 (NCT04838106)
- Testing
- Not applicable as observational study
- Where
- United Kingdom
- Volunteers
- 319,600 people
- Sponsor
- University of Oxford
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Cardiac Surgery, Bone Wax, NU-KNIT, Median Sternotomy, Deep Sternal Wound Infection, Surgical Site Infection
Surgicel NU-KNIT Vs Bone Wax on Median Sternotomy
Bone wax is traditionally used as part of surgical procedures to prevent bleeding from exposed spongy bone. It is an effective hemostatic device which creates a physical barrier.
- Trial name
- NBCS (NCT06869772)
- Testing
- Closure of sternotomy
- Where
- Qatar
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
COVID-19 Pandemic, Intensive Care Unit Syndrome
Post-ICU Follow-up Study in Covid-19 Patients
A follow up study of adult patients who have been treated in the ICU at Mölndal hospital due to Covid19 in the period of 2020 to 2022.
- Conditions
- COVID-19 Pandemic, Intensive Care Unit Syndrome, Delirium
- Trial name
- NCT05299346
- Testing
- Follow up
- Where
- Sweden
- Volunteers
- 793 people
- Sponsor
- Sahlgrenska University Hospital
Coronary Artery Disease, Congestive Heart Failure
Prognostic Indicators as Provided by the EPIC ClearView
The objective of this study is to determine whether the finger tip images captured by the EPIC ClearView device, when analyzed via the ClearView software, produce a Response Scale that characterizes trends consistent with known…
- Conditions
- Coronary Artery Disease, Congestive Heart Failure, Valvular Heart Disease, Atrial Fibrillation
- Trial name
- GBMC (NCT01476995)
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Epic Research & Diagnostics, Inc.
COVID-19, Cardiomyopathies
The Heart Hive COVID-19 Study
All patients with heart disease should have the opportunity to participate in research into their condition, to advance knowledge and treatment.
- Trial name
- NCT04468256
- Testing
- COVID-19 experience surveys
- Where
- United Kingdom
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Surgical Incision, Surgical Site Infection
Comparison of the Classical Median Sternotomy Skin Incision with the Paramedian Flap Skin Incision
The goal of this observational study is to determine the effects of a flap-shaped paramedian skin incision on protection from mediastinal infections, wound healing, and scar formation in open heart surgery performed through the…
- Conditions
- Surgical Incision, Surgical Site Infection, Keloid Scar Following Surgery
- Trial name
- NCT06725472
- Testing
- Open Heart Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ataturk University
Pre-Eclampsia, Atherosclerosis
The CoPenHagen PREeClampsia and cardIOvascUlar diSease Study
Women with a history of preeclampsia (PE) have increased risk of hypertension and cardiovascular disease (CVD) later in life. Thus, PE is acknowledged as an independent risk factor for CVD, which is the number one cause of death…
- Conditions
- Pre-Eclampsia, Atherosclerosis, Cardiovascular Diseases, Heart Disease in Women
- Trial name
- CPH-PRECIOUS (NCT03949829)
- Testing
- Cardiovascular CT
- Where
- 3 sites in Denmark
- Volunteers
- 921 people
- Sponsor
- Klaus Fuglsang Kofoed
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