Clinical trials: Cardiac Resynchronization
Heart Failure, Left Ventricular Dysfunction
Resynchronization for Ambulatory Heart Failure Trial - LV Endocardial
This trial will compare two strategies for patients with Heart Failure, Left Ventricular systolic dysfunction, and intermediate QRS durations. The control group is conventional CRT. The experimental group is LVendo CRT
- Trial name
- RAFT-LVendo (NCT02757976)
- Testing
- Conventional CRT, LV endocardial CRT
- Where
- 11 sites in Canada
- Volunteers
- 8 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Post Market Surveillance Study Following Clinical Routine
Optimizing Pacing Therapy by Using Multi-Programmable Pulse Generators for Cardiac Resynchronization Pacing (CRT-P)
The objective of this Post Market Clinical Follow-up (PMCF) is to collect data on the performance of the Ingenio 2 CRT-P devices and to document that device-related events, device malfunctions or device deficiencies (DDs) do not…
- Trial name
- Rally CRT-P (NCT02488239)
- Testing
- CRT-P indicated patients
- Where
- 8 sites in Finland, Germany
- Volunteers
- 64 people
- Sponsor
- Boston Scientific Corporation
Heart Failure, Atrial Fibrillation
Atrial Fibrillation Associated With Heart Failure Treated by BIOTRONIK's CRT-DX System
The purpose of the BIO-AffectDX Study is to prospectively evaluate improvement from baseline in heart failure subjects with atrial fibrillation (AF) implanted with a two-lead CRT-DX system, with emphasis on a comparison of…
- Conditions
- Heart Failure, Atrial Fibrillation, Cardiac Resynchronization Therapy
- Trial name
- BIO-AffectDX (NCT04870281)
- Testing
- CRT-DX
- Where
- 23 sites in United States
- Volunteers
- 13 people
- Sponsor
- Biotronik, Inc.
Cardiac Resynchronization Therapy, Chronic Heart Failure
Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment
The objective of this prospective, multicenter controlled study is to assess the feasibility of a patient-tailored implantation by creating a cloud-based pre-procedural multimodality CRT-roadmap by integration of 3D images from…
- Conditions
- Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block
- Trial name
- CRT-DRIVE (NCT05327062)
- Testing
- CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment
- Where
- 13 sites in United States, Austria and 5 more
- Volunteers
- 150 people
- Sponsor
- XSpline S.p.A.
Congenital Heart Defects
Cardiac Resynchronization Therapy in Congenital Heart Defects
The objective of this multicentre prospective therapeutic study is to evaluate the effects of CRT on the right and left ventricular function of patients with CHD in the medium and long term.
- Trial name
- CARE-CHD (NCT00450684)
- Testing
- Implantation and testing of CRT
- Where
- 16 sites in Austria, Germany
- Volunteers
- 55 people
- Sponsor
- Competence Network for Congenital Heart Defects
Heart Failure
Evaluation of Resynchronization Therapy for Heart Failure
Heart failure is a major health problem in Canada. Recent advances in medical and device therapy have helped to reduce the morbidity and mortality of patients with this problem.
- Trial name
- EARTH (NCT00900549)
- Testing
- CRT on, CRT off
- Where
- 11 sites in Canada
- Volunteers
- 120 people
- Sponsor
- Montreal Heart Institute
Cardiac Resynchronization Therapy
cArdiac Non Invasive MApping in resynchronizaTION
Non-invasive mapping using the Cardio Insight system is performed in heart failure patients requiring biventricular pacing to optimize therapy, and understand mechanisms underlying pacing-induced cardiomyopathy and ventricular…
- Trial name
- ANIMATION (NCT04347109)
- Testing
- Non invasive epicardial mapping
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Tours
Heart Failure
Clinical Prospective ranDomized Trial to Evaluate the Non-inferiority of Left Bundle Branch Area Pacing Vs Cardiac ResynchronIzatioN Therapy With ECG guIded AV Optimization
Cardiac resynchronization therapy is the gold standard therapy for patients with advanced HF left ventricle dysfunction and large QRS.
- Trial name
- DA VINCI (NCT07107048)
- Testing
- Pacemaker and defibrillator
- Where
- Italy
- Volunteers
- 194 people
- Sponsor
- Leonardo Calò, MD
Chronic Heart Failure
Image Fusion of SPECT MPI and Fluoroscopy Venography to Guide LV Lead Placement for Improved CRT Response (GUIDE-CRT II)
CRT response will be significantly better using image fusion of SPECT MPI and fluoroscopy venogram to guide LV lead placement at the latest activation segment without scar than standard-of-care implantation.
- Trial name
- GUIDE-CRT (NCT03125720)
- Testing
- Image fusion of SPECT MPI and fluoroscopy venography
- Where
- 14 sites in China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Heart Failure
Image Supported Lead Placement in CRT
Cardiac resynchronization therapy (CRT) is an established pacemaker therapy for patients with symptomatic chronic heart failure, but is hampered by a non-response rate of 30-40%.
- Trial name
- ADVISE (NCT05053568)
- Testing
- CARTBox
- Where
- 7 sites in Netherlands
- Volunteers
- 130 people
- Sponsor
- UMC Utrecht
Congestive Heart Failure
His Bundle Pacing Versus Coronary Sinus Pacing for Cardiac Resynchronization Therapy
The goal of this study is to compare the effectiveness of pacing from a physiologic His bundle (HB) lead position versus with the standard coronary sinus (CS) lead position in subjects with heart failure undergoing cardiac…
- Trial name
- His-SYNC (NCT02700425)
- Testing
- CRT Pacemaker
- Where
- 8 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Chicago
Heart Failure
Effectiveness and Reliability of VectSelect™ Feature for Avoidance of Phrenic Nerve Stimulation in Cardiac Resynchronisation Therapy (CRT) Patients
It's the aim of this study to analyse efficacy and reliability of VectSelect Feature for avoidance of phrenic nerve stimulation in cardiac resynchronisation therapy (CRT) patients.
- Trial name
- Efface (NCT01244308)
- Where
- 10 sites in Germany
- Volunteers
- 132 people
- Sponsor
- Abbott Medical Devices
Heart Failure
Heart Failure Study of Multi-site Pacing Effects on Ventriculoarterial Coupling
To perform a comparative study of multi-site left ventricular pacing and cardiac resynchronization therapy effects on ventriculoarterial coupling and energy efficiency of the failing heart
- Trial name
- HUMVEE (NCT03189368)
- Testing
- Activation of multi-site pacing capability on CRT devices
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- National and Kapodistrian University of Athens
Heart Failure
Cardiac Resynchronisation Therapy In Patients With Heart Failure: Mechanistic Insights From Cardiac MRI And Electroanatomical Mapping
Cardiac Resynchronisation Therapy (CRT) is a specialist pacemaker procedure that aims to improve the efficiency of the heartbeat.
- Trial name
- NCT04322877
- Testing
- Temporary pacing Study, Thoracic CT, Acute hemodynamic study
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Atrial Fibrillation, Ventricular Tachycardia
An Assessment of Dual Site Left Ventricular Endocardial Pacing
We are investigating ways to help patients with heart failure, which is caused by damaged hearts which function less well, and cause symptoms of breathlessness, fatigue, lack of energy and swelling.
- Conditions
- Atrial Fibrillation, Ventricular Tachycardia, Heart Failure
- Trial name
- DOUBLE-CRT (NCT02211456)
- Testing
- Atrial Fibrillation/flutter (AF) or Ventricular Tachycardia (VT) ablation with multi-site pacing protocol
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Oxford University Hospitals NHS Trust
Atrial Fibrillation, Atrial Flutter
Combined Use of BIOTRONIK Home Monitoring and Predefined Anticoagulation to Reduce Stroke Risk
The IMPACT Study will investigate the potential clinical benefit of the combined use of BIOTRONIK Home Monitoring (HM) technology and a predefined anticoagulation plan compared to conventional device evaluation and…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Stroke, Embolism, Systemic Arterial
- Trial name
- IMPACT (NCT00559988)
- Testing
- Home Monitoring Guided OAC, Physician-Directed OAC
- Where
- 80 sites in United States, Australia and 4 more
- Volunteers
- 2,718 people
- Sponsor
- Biotronik, Inc.
Heart Failure
Electrical Activation Mapping Guided Tailor Made Approach for Cardiac Resynchronization Therapy
Background Cardiac Resynchronization Therapy (CRT) is proven to improve survival and heart function of patient with certain electrical conduction abnormality and heart failure.
- Trial name
- NCT03356652
- Testing
- Noninvasive electrical dyssynchrony study
- Where
- Hong Kong
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Heart Failure
CardioInsight 2 - Non-responder
Background Cardiac Resynchronization Therapy (CRT) is proven to improve survival and heart function of patient with certain electrical conduction abnormality and heart failure.
- Trial name
- CardioInsight2 (NCT05555992)
- Testing
- Electrical Activation Mapping Guided Cardiac resynchronization therapy
- Where
- Hong Kong
- Volunteers
- 18 people
- Sponsor
- Chinese University of Hong Kong
Heart Failure
Multisite Pacing With a Quadripolar Lead
The purpose of this study is to evaluate the effects of multisite left ventricular (LV) biventricular (BiV) pacing on LV hemodynamics in CRT patients.
- Trial name
- NCT00964938
- Testing
- Quadripolar LV lead (pacing configurations)
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Abbott Medical Devices
Heart Failure
Sensor Optimization of Cardiac Resynchronization Therapy Response
The Sensor Optimization of Cardiac Resynchronization Therapy (CRT) Response (SOCR) Study is a multicenter, prospective, non-randomized acute feasibility study that is being conducted to determine if subcutaneous heart sounds…
- Trial name
- SOCR (NCT01832493)
- Testing
- Cardiac Resynchronization Therapy
- Where
- 9 sites in United States, Canada and 2 more
- Volunteers
- 50 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure