Clinical trials: Cardiac Resynchronization
Congestive Heart Failure
Echocardiography and Peak Endocardial Acceleration (PEA) Measurements in Cardiac Resynchronization Therapy (CRT)
This study used an external endocardial acceleration sensor (sonR sensor), placed on the patient's chest, to time the closure of aortic and mitral valves, and compared its performance with echocardiography.
- Trial name
- NCT01066078
- Testing
- Echocardiography and SonR recording
- Where
- 4 sites in France
- Volunteers
- 216 people
- Sponsor
- LivaNova
Heart Failure
Quadripolar Pacing Post Approval Study
The purpose of this post-approval study is to evaluate the acute and chronic performance of a Quadripolar CRT-D device system in a patient population indicated for cardiac resynchronization therapy (CRT).
- Trial name
- Quad PAS (NCT01555619)
- Testing
- CRT-D System
- Where
- 71 sites in United States
- Volunteers
- 1,971 people
- Sponsor
- Abbott Medical Devices
Heart Failure
Clinical Evaluation of Mediguide System in Cardiac Resynchronization Therapy (CRT) Implants
The purpose of this study is to evaluate the safety and performance of the MediGuide™ system during CRT implants.
- Trial name
- NCT01519739
- Testing
- MediGuide™
- Volunteers
- 15 people
- Sponsor
- Abbott Medical Devices
Congestive Heart Failure
Cardiac Resynchronization Therapy, Dyspnea and Exercise Tolerance in Patients With Congestive Heart Failure (CHF)
A new therapy for patients with advanced heart failure (HF) involves the implantation of a specialized pacemaker device (Cardiac Resynchronization Therapy, CRT) that attempts to restore the synchronized contraction of the…
- Trial name
- NCT00700700
- Testing
- Active Cardiac Resynchronization Therapy (CRT)
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Queen's University
Heart Failure
Markers and Response to Cardiac Resynchronization Therapy
The purpose of this study is to investigate: the relation of a set of (bio)markers and response to Cardiac Resynchronization Therapy (CRT); the interrelationship as well as the potential predictive power of these (bio)markers on…
- Trial name
- MARC (NCT01519908)
- Testing
- CRT-D (Medtronic)
- Where
- 6 sites in Netherlands
- Volunteers
- 240 people
- Sponsor
- University Medical Center Groningen
Heart Failure, Systolic
Multi-lead ECG to Effectively Optimize Resynchronization Devices: New CRT Recipients
Cardiac resynchronization therapy (CRT), or atrial-synchronized biventricular (BiV) pacing, is an FDA-approved device therapy option for heart failure (HF) patients with reduced left ventricular ejection fraction and electrical…
- Trial name
- METEOR-CRT (NCT04083690)
- Testing
- Reprogramming of CRT Device Settings to Optimal Electrical Synchrony
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Allina Health System
Sick Sinus Syndrome, Atrioventricular Block, Second and Third Degree
Evaluating the Safety and Effectiveness of 5G Cloud Follow-up for Cardiovascular Implantable Electronic Devices
Objective: This clinical study employs a prospective, paired, self-controlled, non-inferiority, multicenter research design to assess the safety and efficacy of utilizing 5G cloud follow-up for CIED in parameters monitoring and…
- Conditions
- Sick Sinus Syndrome, Atrioventricular Block, Second and Third Degree, Heart Failure
- Trial name
- CIED-CARE (NCT06652750)
- Testing
- Routine Management, 5G Cloud Follow-up
- Where
- 2 sites in China
- Volunteers
- 688 people
- Sponsor
- The Third People's Hospital of Chengdu
Pacemaker DDD, His Bundle Pacing
Pacing to Maintain Physiologic Ventricular Activation
Right ventricular pacing causes ventricular dyssynchrony and may be associated with impaired outcome. In the last decade, several approaches for more physiological pacing became available and were implemented in the latest…
- Conditions
- Pacemaker DDD, His Bundle Pacing, LBB Area Pacing, Pacing-Induced Cardiomyopathy
- Trial name
- Pace-Conduct (NCT04416958)
- Testing
- cardiac implantable electronic device (CIED) implantation
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Klinikum-Fuerth
Congestive Heart Failure
Cardiac Resynchronization and Iodine Meta-Iodobenzylguanidine (MIBG) Imaging
Subjects were recruited if their healthcare provider decided that they needed treatment with a special Internal Cardiac Defibrillator (ICD) called a biventricular ICD.
- Trial name
- NCT01522378
- Testing
- 123 iodine metaiodobenzylguanidine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Permanent Atrial Fibrillation
Atrioventricular Junction Ablation and Biventricular Pacing for Atrial Fibrillation and Heart Failure
There is evidence of superiority of AV junction ablation strategy over pharmacological therapy only for symptoms of atrial fibrillation, but not for heart failure, hospitalization, morbidity and mortality.
- Trial name
- APAF-CRT (NCT02137187)
- Testing
- AV junction ablation, CRT, Optimized drug therapy
- Where
- Italy
- Volunteers
- 1,830 people
- Sponsor
- Centro Prevenzione Malattie Cardiovascolari N. e V. Corbella
Heart Failure
Dual-Site LV Pacing in CRT Non Responders: Multicenter Randomized Trial
Cardiac resynchronization therapy (CRT) is an effective treatment of heart failure (HF) refractory to optimal medical management, in presence of a depressed left ventricular (LV) ejection fraction and a wide QRS complex.
- Trial name
- V3 (NCT01059175)
- Testing
- Additional Endocardial or Epicardial LV Lead, CRT-P or CRT-D
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Atrio-Ventricular (AV) Delay Optimization Using Echocardiography Versus the SonR Signal
The purpose of this study is to evaluate an external device (SonR sensor) that is capable of detecting sounds created by the heart (SonR signal).
- Trial name
- SonR Pilot (NCT01287234)
- Testing
- Echocardiogram/SonR
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Piedmont Healthcare
Left Bundle Branch Block, Left Bundle Branch Area Pacing
UHF ECG in LBBB and Response to CRT Prediction
The main objective of the project is to demonstrate that in patients with heart failure and QRS complex of nonRBBB morphology lasting over 130 ms, UHF-ECG can differentiate patients with trueLBBB from IVCD better than existing…
- Conditions
- Left Bundle Branch Block, Left Bundle Branch Area Pacing, Biventricular Pacing, Intraventricular Conduction Delay
- Trial name
- UHF BLOCK (NCT07057544)
- Testing
- LBBAP CRT device implantation, BVP-CRT
- Where
- Czechia
- Volunteers
- 200 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Heart Failure, Systolic
ECG Belt vs. Echocardiographic Optimization of CRT
Cardiac resynchronization therapy (CRT) has been a valuable intervention for patients with systolic heart failure for over 15 years.
- Trial name
- NCT03305692
- Testing
- Optimization of CRT Device
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Alan J. Bank, MD
Heart Failure
One Day Implantation Program for Heart Failure Patients Implanted With CRT-P
This study has been implemented to evaluate cardiac resynchronization therapy pacemaker (CRT-P) implantations on a same-day basis
- Trial name
- OEDIPE-CRT-P (NCT05142293)
- Testing
- Ambulatory procedure
- Where
- 19 sites in France
- Volunteers
- 354 people
- Sponsor
- Biotronik SE & Co. KG
Sudden Cardiac Death
'Effect of CRT on Defibrillation Threshold Estimates' Study
The purpose of this prospective study is to evaluate the effect of cardiac resynchronization therapy (CRT) on the defibrillation threshold (DFT) estimates in cardiac resynchronization therapy defibrillators (CRT-D) patients.
- Trial name
- NCT00626093
- Testing
- Cardiac Resynchronization Therapy - Defibrillator (CRT-D)
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- Abbott Medical Devices
Heart Failure
Optimal Left Ventricular Lead Positioning During Cardiac Resynchronisation Therapy; Comparison of Two Methods of Targeting
Cardiac Resynchronisation Therapy (CRT) is a well-known treatment for patients with heart failure. It is a special pacemaker that consists of three pacing wires, which are implanted in the right upper and bottom chambers of the…
- Trial name
- NCT03769272
- Testing
- Measurement of electrical delay during LV lead placement
- Volunteers
- 40 people
- Sponsor
- Peter J Pugh
Heart Failure, Ventricular Arrythmias
Safety and Efficacy of Automatic Testing Feature in New ICDs and CRT-Ds
This study is a prospective, non-randomized, multi-center clinical trial that will assess the safety and effectiveness of investigational models of the Promote™ RF CRT-D and Current™ RF ICD devices.
- Trial name
- NCT00746356
- Testing
- Testing of the autocapture features of the device
- Where
- 5 sites in United States
- Volunteers
- 128 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Cardiomyopathy
InSync Model 8040 (InSync) and InSync III Model 8042 (InSync III) Registry
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Trial name
- NCT00273182
- Testing
- InSync Model 8040, InSync III Model 8042
- Where
- 82 sites in United States
- Volunteers
- 1,999 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Quartet Lead and Resynchronization Therapy Options III (QUARTO_III)
The purpose of the study is to assess prospectively at 6 months the percentage of responder patients implanted with a Cardiac Resynchronization Therapy (CRT-D) device and a Quartet Left Ventricular (LV) quadripolar lead and with…
- Trial name
- QUARTO_III (NCT02476201)
- Testing
- MPP ON
- Where
- Spain
- Volunteers
- 105 people
- Sponsor
- Abbott Medical Devices