Clinical trials: Cardiac Resynchronization
Congenital Heart Disease
Cardiac Resynchronization Therapy in Congenital Heart Diseases With Systemic Right Ventricle
This study aims to analyze outcomes of patients with systemic right ventricle (SRV) implanted with Cardiac Resynchronization Therapy (CRT) systems and to compare the impact of CRT in SRV patients with other congenital heart…
- Trial name
- NCT04842851
- Testing
- cardiac resynchronization therapy
- Volunteers
- 85 people
- Sponsor
- Paris Cardiovascular Research Center (Inserm U970)
Heart Failure
Care-HF CArdiac Resynchronization in Heart Failure
The CARE-HF trial evaluates the effects of Cardiac Resynchronization (CR) therapy on the mortality and morbidity of patients with heart failure due to left ventricular systolic dysfunction already receiving diuretics and optimal…
- Trial name
- NCT00170300
- Testing
- Implantable Cardiac Resynchronisation (pacing) device
- Volunteers
- 813 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Corelab Remotely Echocardiographic Imaging Acquisition in Cardiac Resynchronization Therapy Candidates
Purpose of the observational study is to assess the capability of a satellite tele-echocardiography (STE) system to acquire and transmit echocardiographic images and clips to an echocardiographic core laboratory (ECL) in a real…
- Trial name
- CORELAB-CRT (NCT02235766)
- Testing
- Echocardiographic assessment
- Where
- 4 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Kell s.r.l.
Heart Failure, Left Bundle-Branch Block
Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients
Heart failure (HF) is the most common nosology encountered in clinical practice. Its incidence and prevalence increase exponentially with increasing age and it is associated with increased mortality, more frequent hospitalization…
- Conditions
- Heart Failure, Left Bundle-Branch Block, Ischemic Cardiomyopathy, Non-ischemic Dilated Cardiomyopathy
- Trial name
- RECOVER-HF (NCT05769036)
- Testing
- Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Biventricular Pacing, Implantation of Cardioverter-defibrillator with a Resynchronization Function Using Left Bundle Branch Pacing
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Indication for Cardiac Resynchronization Therapy (CRT)
Evia/Entovis HF-T Master Study
The Evia HF-T and the Entovis HF-T are triple-chamber pacemakers for cardiac resynchronisation therapy (CRT-P). The objective of this study is to prove the safety and efficacy of these pacemakers.
- Trial name
- NCT01545739
- Testing
- Evia/Entovis HF-T pacemaker for CRT therapy
- Where
- Hungary
- Volunteers
- 122 people
- Sponsor
- Biotronik SE & Co. KG
Dilated Cardiomyopathy, Pediatric
Resynchronization Therapy in Young Patients With and Without CHD
Pacemakers can be attached to one or more than one of the heart chambers. After watching pacemakers work over time, doctors have found that the pacemakers that stimulate only one chamber of the heart sometimes lead to problems…
- Trial name
- NCT00208806
- Testing
- congestive heart failure patients
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Congestive Heart Failure
Effect of Bi-ventricular Pacing on Autonomous Nervous System
Patients with congestive heart failure are often associated with delayed intraventricular depolarization which causing dyssynchrony and an inefficient pattern of left ventricular contraction.
- Trial name
- NCT00190138
- Testing
- Bi-ventricular pacing
- Sponsor
- Far Eastern Memorial Hospital
The Patient Meets ACC/AHA/ESC Guidelines for Implantable Cardioverter Defibrillator (ICD) or Cardiac Resynchronization Therapy (CRT-D) Device
Clinical Evaluation Of Remote Monitoring With Direct Alerts To Reduce Time From Event To Clinical Decision
St. Jude Medical developed the Merlin.net™ Patient Care Network (Merlin.net™ PCN) to augment or replace routine scheduled in-clinic visits.
- Trial name
- REACT (NCT01090349)
- Testing
- Implantation of an ICD/CRT-D device, Merlin.NET PCN
- Where
- 2 sites in Germany, United Kingdom
- Volunteers
- 220 people
- Sponsor
- Abbott Medical Devices
Cardiac Resynchronisation Therapy
Acute Assessment of a Micro Multipolar Lead for Enhanced Cardiac Resynchronisation Therapy
Pilot study to evaluate the performance of a lead below 2 French with specific distal shape to deliver efficient LV pacing
- Trial name
- AXONE-Acute (NCT03750058)
- Testing
- Implant test procedure
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Rouen
Hypertrophic Cardiomyopathy With Obstruction
Triple Chamber Pacing in Hypertrophic Obstructive Cardiomyopathy (HOCM) Patients - TRICHAMPION STUDY
This investigation is a prospective, randomized, single-blinded and multicenter design. The purpose of this study is to evaluate the benefit of atrial-synchronous biventricular (BiV) pacing in severely symptomatic hypertrophic…
- Trial name
- TRICHAMPION (NCT01614717)
- Testing
- CRT-P Implant
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Abbott Medical Devices
Heart Failure, Left Bundle-Branch Block
LV Only MPP With SyncAV
The objective of this clinical investigation is to evaluate the clinical benefits of left ventricle (LV) only pacing combined with automatic adjustment of AV timing (SyncAV) in patients receiving cardiac resynchronization therapy…
- Trial name
- NCT03567096
- Testing
- BiV pacing with MPP and SyncAV, LV only pacing with MPP and SyncAV
- Where
- 6 sites in Canada, France and 2 more
- Volunteers
- 101 people
- Sponsor
- Abbott Medical Devices
Heart Failure
MultiPoint Pacing™ Post Market Study
This is a prospective, multicenter, non-randomized registry/observational study. The study will enroll up to 2,000 patients with successful St.
- Trial name
- MPP-PMS (NCT02832622)
- Testing
- MPP, BiV/MPP
- Where
- 128 sites in United States, Argentina and 2 more
- Volunteers
- 2,169 people
- Sponsor
- Abbott Medical Devices
Adult Congenital Heart Disease
Real-World Data on the Effects of Cardiac Resynchronization Therapy in Adult Patients With Congenital Heart Disease
This study aims to evaluate the real-world effects of cardiac resynchronization therapy (CRT) in adult patients with congenital heart disease (ACHD).
- Trial name
- RECORD-CHD (NCT06969924)
- Testing
- Cardiac resynchronization therapy
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center
Heart Failure
Acute Impact of Cardiac Resynchronization on Vascular Function (RVA-CRT)
Evaluation of the effect of short term activation/deactivation of biventricular pacing (BivP) of the CRT (during routine CRT interrogation) on vascular function as assessed via retinal vessel analysis (RVA), in patients treated…
- Trial name
- RVA-CRT (NCT04379401)
- Testing
- Cardiac Resynchronization Therapy (ON vs. OFF)
- Where
- Switzerland
- Volunteers
- 35 people
- Sponsor
- Andreas Flammer
Cardiac Resynchronization Therapy
Revisit the Value of Imaging in Best Using CArdiac Resynchronization Therapy
Many studies have shown the benefits of cardiac resynchronization therapy (CRT) with biventricular pacing in patients with heart failure with left ventricular dysfunction.
- Trial name
- RICART (NCT02528032)
- Testing
- Echographic evaluation of heart function
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Heart Failure, Ventricular Dyssynchrony
Trip HF Study: Triple Resynchronization in Paced Heeart Failure Patients
The purpose of this study is to evaluate the feasibility of permanent biventricular pacing using three ventricular leads, and its efficacy in terms of inter and intra-ventricular resynchronization, in patients with congestive…
- Trial name
- NCT00187265
- Testing
- Cardiac Resynchronization Therapy
- Where
- France
- Sponsor
- Abbott Medical Devices
Heart Failure, CRT and/or ICD
Evaluation of Electrical and Hemodynamic Effects of Different Pacing Strategies in CRT Candidates
Heart failure patients with delayed electrical activation of the heart often benefit from cardiac resynchronization therapy (CRT). However, traditional CRT using biventricular pacing is not effective in all patients.
- Trial name
- NCT07032064
- Testing
- Sequential ventricular pacing at five sites
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai Zhongshan Hospital
Heart Failure, Left Bundle-Branch Block
Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure
The purpose of this study is to evaluate the efficacy and safety of conduction system pacing versus biventricular pacing in patients with chronic heart failure with reduced ejection fraction and left bundle branch block.
- Conditions
- Heart Failure, Left Bundle-Branch Block, Cardiac Resynchronization, Conduction System Pacing
- Trial name
- PhysioSync-HF (NCT05572736)
- Testing
- Conduction system pacing, Biventricular pacing
- Where
- 14 sites in Brazil
- Volunteers
- 179 people
- Sponsor
- Hospital Moinhos de Vento
Systolic Heart Failure
Pilot Study Using Echocardiography to Evaluate Patients With Heart Failure and Dyssynchrony Who Have a CRT-D Device
Out of all the patients that receive a CRT-D ( a dual chamber pacemaker with defibrillator ) for cardiac resynchronization therapy there is approximately one-third that do not respond.
- Trial name
- NCT01127334
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Heart Failure - NYHA II - IV
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
This study will compare two different methods to pace the heart to treat heart failure including: 1. The current standard method of implanting a pacing lead in a vein on the surface of the left lower chamber of the heart (left…
- Trial name
- SYNCHRONICITY (NCT07069738)
- Testing
- CRT-D with a Quadripolar LV lead, CRT-D with INGEVITY+ pace/sense lead
- Where
- 43 sites in United States
- Volunteers
- 850 people
- Sponsor
- Boston Scientific Corporation