Clinical trials: Cardiac Resynchronization
Congenital Disorders
Resynchronization of Left Ventricular Contraction After Reimplantation of Anomalous Left Coronary Artery
Spontaneous resynchronization of dyskinetic segments of the left ventricle occurs after coronary bypass surgery in adults and has been shown in some children.
- Trial name
- NCT00268112
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Children's Healthcare of Atlanta
Sudden Cardiac Death, Heart Failure
Next Generation INCEPTA Implantable Cardioverter Defibrillator (ICD) and Cardiac Resynchronization Therapy (CRT-D) Field Following Study
This study has 2 purposes: The first purpose of the study is to test a new family of Boston Scientific Implantable Cardioverter Defibrillators ("ICDs") and cardiac resynchronization therapy ICDs ("CRT-Ds") and show how well these…
- Trial name
- NOTICE-HF (NCT01227785)
- Testing
- INCEPTA ICD or CRT-D
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Guidant Corporation
Atrial Fibrillation, Heart Failure
RAFT - Pace &Ablate
Atrial fibrillation (AF) is an irregular heartbeat that can cause symptoms of skipped beats, shortness of breath, stroke, or in some cases fluid in the lungs or legs.
- Conditions
- Atrial Fibrillation, Heart Failure, Pacemaker, Arrhythmia Atrial
- Trial name
- RAFT-P&A RCT (NCT06299514)
- Testing
- Pace and Ablate, Medication
- Where
- 12 sites in Canada
- Volunteers
- 600 people
- Sponsor
- Habib Khan
Congestive Heart Failure
BOAT: Beta Blocker Uptitration With OptiVol After Cardiac Resynchronization Therapy (CRT)
Many heart failure patients are unable to reach target beta blocker doses. This study will address whether cardiac resynchronization therapy (CRT) will enable uptitration of beta-blockers to target doses and whether it will…
- Trial name
- NCT00433043
- Testing
- Beta blocker (carvedilol or metoprolol succinate), CRT (cardiac resynchronization therapy)
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Heart Failure
Atrio-Ventricular (AV) Delay Optimization Using Echocardiography Versus the SonR Signal
The purpose of this study is to evaluate an external device (SonR sensor) that is capable of detecting sounds created by the heart (SonR signal).
- Trial name
- SonR Pilot (NCT01287234)
- Testing
- Echocardiogram/SonR
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Piedmont Healthcare
Systolic Heart Failure
Pilot Study Using Echocardiography to Evaluate Patients With Heart Failure and Dyssynchrony Who Have a CRT-D Device
Out of all the patients that receive a CRT-D ( a dual chamber pacemaker with defibrillator ) for cardiac resynchronization therapy there is approximately one-third that do not respond.
- Trial name
- NCT01127334
- Where
- United States
- Sponsor
- University of Mississippi Medical Center
Heart Failure, Left Bundle Branch Block
High Septal Pacing for Cardiac Resynchronization Therapy
The purpose of this acute study is to perform a preliminary investigation of high septal right ventricular pacing in the vicinity of the His bundle region as an alternate or adjunctive means for cardiac resynchronization in…
- Conditions
- Heart Failure, Left Bundle Branch Block, Heart Disease
- Trial name
- HISTORY (NCT01325480)
- Testing
- Cardiac Pacing
- Where
- Hong Kong
- Volunteers
- 15 people
- Sponsor
- Boston Scientific Corporation
Congestive Heart Failure
An-Art Study: Atrioventricular (AV) Node Ablation in Cardiac Resynchronisation Therapy
Cardiac resynchronisation therapy (CRT) is a highly effective treatment option for patients with symptomatic heart failure and electrical intraventricular dyssynchrony, who are unresponsive to medical therapy.
- Trial name
- NCT00260546
- Testing
- AV-node ablation
- Sponsor
- University Hospital, Basel, Switzerland
Congenital Heart Disease, Systemic Right Ventricle
Cardiac Resynchronization Therapy in Adult Congenital Heart Disease With Systemic Right Ventricle: RIGHT-CRT
The main objective of RIGHT-CRT is to assess the impact/efficacy of CRT on functional capacity in ACHD patients with SRV.
- Conditions
- Congenital Heart Disease, Systemic Right Ventricle, Congenitally Corrected Transposition of the Great Arteries, Transposition of Great Vessels
- Trial name
- RIGHT-CRT (NCT05524324)
- Testing
- CRT ON (biventricular pacing) / CRT OFF (inactive or univentricular pacing), CRT OFF (inactive or univentricular pacing) / CRT ON (biventricular pacing)
- Where
- 13 sites in France
- Volunteers
- 26 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Left Bundle-Branch Block, Heart Failure
The Left Bundle Cardiac Resynchronization Therapy Trial
Cardiac resynchronization therapy (CRT) via biventricular (BiV) pacing significantly reduces morbidity and mortality in patients with left bundle branch block (LBBB), impaired LV function and heart failure in spite of optimal…
- Conditions
- Left Bundle-Branch Block, Heart Failure, Impaired Left Ventricular Function
- Trial name
- NCT05434962
- Testing
- Cardiac resynchronization therapy
- Where
- 10 sites in Spain
- Volunteers
- 176 people
- Sponsor
- Óscar Cano Pérez
Heart Failure, Cardiac Arrhythmia
Evaluation of the BIOTRONIK AutoAdapt Algorithm for Continuous Automatic Adaptive Cardiac Resynchronization
BIO|Adapt study is designed to provide evidence for the clinical benefit of the CRT AutoAdapt feature. This feature provides continuous adaptation of AV delay and biventricular pacing modality.
- Conditions
- Heart Failure, Cardiac Arrhythmia, Left Ventricular Dysfunction
- Trial name
- BIO|Adapt (NCT04774523)
- Testing
- Echo-based assessment of the acute hemodynamic effect of the CRT AutoAdapt feature., Echocardiography AV optimization, Echocardiography
- Where
- Spain
- Volunteers
- 198 people
- Sponsor
- Biotronik SE & Co. KG
Heart Failure
Attain StarFix™ Model 4195 Left Ventricular Lead
People who have abnormal heart beats, or whose heart does not beat on its own, may need an electronic device called a pacemaker or a defibrillator.
- Trial name
- NCT00269230
- Testing
- Pacing Lead
- Where
- 25 sites in United States, Canada and 1 more
- Volunteers
- 441 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Failure
Optimization of Cardiac Resynchronization Therapy by Non-Invasive Imaging of Cardiac Electrophysiology
The principal aim is to analyze total left and right ventricular activation time in different CRT device programming algorithms (SyncAV) measured by non-invasive electrophysiology
- Trial name
- NICE CRT (NCT04662970)
- Testing
- Device programming
- Where
- Austria
- Volunteers
- 25 people
- Sponsor
- Medical University Innsbruck
Heart Failure
Triple-site Biventricular Stimulation in the Optimization of CRT
Cardiac resynchronization is a recommended therapy for patients with advanced heart failure, under optimized medical treatment with reduced left ventricular ejection fraction and prolonged QRS, nevertheless, still 30% of the…
- Trial name
- TRIUMPH-CRT (NCT02350842)
- Testing
- triple-site biventricular pacing with peri-operative echo guidance, standard biventricular pacing
- Where
- 14 sites in France, Germany and 4 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- MicroPort CRM
Heart Failure (HF)
Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients
The primary objective of this study is to demonstrate that in patients with recuperated/normalized left ventricular function, defined as an ejection fraction (EF) ≥ 50%, after implantation of cardiac resynchronization therapy…
- Trial name
- STOP-CRT (NCT02200822)
- Testing
- beta blockers, RAAS blockers
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Hasselt University
Intrathoracic Blood Volume in Heart Failure Patients
Intrathoracic Bloodvolume Measurement by Contrast Enhanced Ultrasound: Validation of the Technique and Evaluation as a Measurement of Response to Cardiac Resynchronization Therapy: a Pilot Study
Summary Rationale: Cardiac resynchronisation therapy (CRT) with biventricular pacemakers and implantable cardiac defibrillators (ICD) has proven to be a valuable therapy in selected patients with systolic heart failure…
- Trial name
- NCT01735838
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Heart Failure
Clinical Prospective ranDomized Trial to Evaluate the Non-inferiority of Left Bundle Branch Area Pacing Vs Cardiac ResynchronIzatioN Therapy With ECG guIded AV Optimization
Cardiac resynchronization therapy is the gold standard therapy for patients with advanced HF left ventricle dysfunction and large QRS.
- Trial name
- DA VINCI (NCT07107048)
- Testing
- Pacemaker and defibrillator
- Where
- Italy
- Volunteers
- 194 people
- Sponsor
- Leonardo Calò, MD
Congestive Heart Failure, Cardiac Resynchronization Therapy
Quartet™ Bad Oeynhausen Trial
Primary objective of this study is to evaluate whether the use of a quadripolar left ventricular (LV) electrode compared to a standard bipolar LV electrode leads to lower non-responder rates in patients undergoing cardiac…
- Trial name
- QUOTA (NCT01850264)
- Testing
- Application of quadripolar / bipolar LV electrodes
- Where
- Germany
- Volunteers
- 81 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Heart Failure
Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy Post Approval Registry
MADIT-CRT PAR is an FDA mandated follow-up registry for patients that participated in the MADIT-CRT IDE study examining long-term mortality. (MADIT-CRT IDE: NCT00180271)
- Trial name
- MADIT-CRT PAR (NCT01294449)
- Testing
- MADIT-CRT ICD, MADIT-CRT CRT-D
- Where
- United States
- Volunteers
- 394 people
- Sponsor
- Boston Scientific Corporation
Heart Failure
Choosing the Right Pacing Mode in Heart Failure - The CHOICE Trial
The aim of the study is to see if biventricular pacemakers offer any advantage over conventional pacemakers in patients with heart failure who require pacemakers.
- Trial name
- CHOICE (NCT00875732)
- Testing
- Bi Ventricular Pacing, Right Ventricular Pacing
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Dundee