Clinical trials: Cardiac Surgery-associated Acute Kidney Injury
Acute Kidney Injury, Critical Illness
Predicting Adverse Kidney Events of Cardiac Surgery-Associated Acute Kidney Injury Using Novel Biomarkers
The aim of this study was to identify and validate novel biomarkers for predict acute kidney injury (AKI) subphenotype, major adverse kidney events and other poor outcomes.
- Conditions
- Acute Kidney Injury, Critical Illness, Kidney Failure
- Trial name
- NCT06351813
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Shanghai Zhongshan Hospital
Infective Endocarditis, Infection Related to Ventricular Assist Device
Retrospective Analysis of Nephrotoxicity During Daptomycin Versus Vancomycin Treatments in High Risk Patients
Acute kidney injury (AKI) is a frequent complication that occurs in 15 to 25% of patients after vascular surgery, and up to 40% of patients after cardiac surgery.
- Conditions
- Infective Endocarditis, Infection Related to Ventricular Assist Device, Infection Related to Vascular Prothesis, Surgical Site Infection
- Trial name
- DVN (NCT03961503)
- Testing
- Daptomycin (DAP) treatment, Vancomycin (VAN) treatment
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
Cardiac Surgery Associated Acute Kidney Injury
Serum and Urine Metabolome Studies in Patients With Acute Kidney Injury After Cardiac Surgery
The goal of this observational study is to learn about serum and urine metabolome in patients after cardiac surgery.
- Trial name
- NCT06245720
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Acute Kidney Injury, Heart Valve Diseases
Correlation of Brain and Thenar Muscle Oximetry During Cardiac Surgery With Parameters of Acute Kidney Injury
Identification of risk factors of acute kidney injury (AKI). It is hypothesized that there might be a correlation between brain oximetry, tissue saturation of thenar muscle and marker of AKI in blood - neutrophil…
- Trial name
- NCT02979275
- Testing
- Open heart surgery on cardiopulmonary bypass.
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Kidney Failure, Acute
Evaluation of Neutrophil Gelatinase-associated Lipocalin (NGAL) in Early and Evolving Acute Kidney Injury
Some patients who undergo cardiovascular surgery requiring cardiopulmonary bypass will develop a kidney injury following their surgery.
- Trial name
- EVOLVE (NCT00445809)
- Where
- 11 sites in United States, Canada
- Volunteers
- 355 people
- Sponsor
- Abbott RDx Cardiometabolic
Acute Kidney Injury
Deferoxamine for the Prevention of Cardiac Surgery-Associated Acute Kidney Injury
Multiple lines of evidence support a central role of iron in causing acute kidney injury (AKI), including the finding that prophylactic administration of iron chelators attenuates AKI in animal models.
- Trial name
- DEFEAT-AKI (NCT04633889)
- Testing
- Deferoxamine, Normal saline
- Where
- 3 sites in United States
- Volunteers
- 320 people
- Sponsor
- Brigham and Women's Hospital
Acute Kidney Injury After Adult Cardiac Surgery, Gastrointestinal Microbiome
Development and Validation of a Risk Prediction Model for Cardiac Surgery-associated Acute Kidney Injury Based on the Gut-Kidney Axis, Incorporating Gut Microbiota and Their Metabolites
This is a single-center prospective observational cohort study enrolling adult patients scheduled for cardiac surgery. Multi-timepoint clinical indicators, stool samples for gut microbiota and metabolomics profiling and artery…
- Conditions
- Acute Kidney Injury After Adult Cardiac Surgery, Gastrointestinal Microbiome, Metabolome, Risk Assessment
- Trial name
- NCT07738796
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Peking Union Medical College Hospital
Acute Kidney Injury, Cardiac Surgical Procedures
Terbinafine for CSA-AKI Prevention
Primary Objective: To evaluate the efficacy and safety of perioperative oral terbinafine in reducing the incidence of cardiac surgery-associated acute kidney injury (CSA-AKI).Secondary Objectives:To assess the effects of…
- Trial name
- NCT07738328
- Testing
- Terbinafine
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Guangdong Provincial People's Hospital
Acute Kidney Injury, Renal Insufficiency
Timing of Coronary Angiography, Cardiac Surgery, and Adverse Renal and Cardiac Events (MARCE)
1. To examine two main predictor variables independently and then jointly in stratified and multivariate analyses for the outcomes of CSA-AKI, MARCE, need for RRT, and inpatient mortality, and the composite, as well as the…
- Trial name
- MARCE (NCT02332070)
- Testing
- cardiac surgery
- Where
- United States
- Volunteers
- 965 people
- Sponsor
- Baylor Research Institute
Acute Kidney Injury, Cardiac Disease
The Prevention of Erythropoietin on Cardiac Surgery-associated Acute Kidney Injury
To testify the prevention of Erythropoietin on cardiac surgery associated-acute kidney injury, and trying to provide evidence for protecting the renal function and improving the prognosis for patients after cardiac surgery.
- Conditions
- Acute Kidney Injury, Cardiac Disease, Surgery
- Trial name
- NCT03007537
- Testing
- Erythropoietin, 0.9% sodium chloride, cardiac surgery
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Acute Kidney Injury
A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)
The purpose of this study is to determine whether THR-184 when administered around the time of cardiac surgery that requires cardiopulmonary bypass can prevent or ameliorate the development of acute kidney injury.
- Trial name
- NCT01830920
- Testing
- THR-184
- Where
- 41 sites in United States, Canada
- Volunteers
- 452 people
- Sponsor
- Thrasos Innovation, Inc.
Acute Kidney Injury
Influence of Albumin on Acute Renal Dysfunction Associated With Cardiac Surgery Under Extracorporeal Circulation
Acute renal dysfunction associated with cardiac surgery (DRA-ACC) in our hospital population affects 39% of patients, being an important cause of morbidity and mortality, increasing the need for dialysis and assuming a…
- Trial name
- NCT03373318
- Testing
- Human albumin, Plasmalyte
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Acute Renal Failure, Acute Kidney Injury
Early Diagnosis of Postoperative Acute Renal Failure-using Biomarker to Predict Outcome of Cardiac Surgery Associated Acute Kidney Injury
The purpose of this study is to determine soluble HJV could be an early diagnosis urinary biomarker of ischemia/reperfusion injury in post CPB-patients.
- Trial name
- NSARF (NCT01503710)
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cardiac Surgery
Neutrophil Gelatinase-associated Lipocalin as a New Biomarker to Detect Acute Kidney Injury in Postoperative Cardiac Surgery
Observational study aimed to test the ability of Neutrophil Gelatinase-associated Lipocalin (NGAL) concentration in blood and urine to predict and diagnose early acute renal failure (ARF) in patients after cardiac surgery…
- Trial name
- NCT01594788
- Where
- Spain
- Volunteers
- 340 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Acute Kidney Injury, Cardiac Surgery Associated - Acute Kidney Injury
Perioperative Role Of Vascular Endothelial Growth Factor In Cardiac Surgery-associated Acute Kidney Injury
The goal of this prospective observational study is to find out whether the protein vascular endothelial growth factor (VEGF) measured in blood and urine can predict which patients will develop acute kidney injury (AKI) after…
- Trial name
- PROVE-AKI (NCT07803328)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Universität Münster
Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury
Increased Adsorption Membranes During Cardiopulmonary Bypass
Our project intends to reduce cardiac surgery associated - acute kidney injury (CSA-AKI) in non emergent patients with the use of an increased adsorption membrane (oXiris®) connected to the cardiopulmonary bypass (CPB) circuit…
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery Associated - Acute Kidney Injury, Systemic Inflammatory Response Syndrome, Acute Kidney Injury
- Trial name
- NCT02518087
- Testing
- oXiris®
- Where
- 3 sites in Spain
- Volunteers
- 340 people
- Sponsor
- Hospital Universitari de Bellvitge
AKI - Acute Kidney Injury, Cardiac Surgical Procedures
rhBNP for Prevention of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI)
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common and serious perioperative complication, independently associated with prolonged hospitalization, increased mortality, and progression to chronic kidney disease.
- Conditions
- AKI - Acute Kidney Injury, Cardiac Surgical Procedures, Cardiopulmonary Bypass
- Trial name
- PROTECT-CS (NCT07617675)
- Testing
- Recombinant Human Brain Natriuretic Peptide (rhBNP)
- Where
- China
- Volunteers
- 694 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Kidney Injury
Application of CLCVP Technique in Early Intervention of CSA-AKI
The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: 1.
- Trial name
- NCT05855954
- Testing
- controlled low central venous pressure technique (CLCVP)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Acute Kidney Injury
NAD Supplementation to Reduce the Incidence of Cardiac Surgery Associated Acute Kidney Injury
The purpose of this single-center, randomized, double-blinded placebo-controlled pilot trial is to demonstrate feasibility and help design a larger trial to assess the effectiveness of nicotinamide (NAM) supplementation in…
- Trial name
- NCT07739290
- Testing
- Nicotinamide (NAM)
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Stellate Ganglion Block
SGB Reduces the Incidence and Severity of CSA-AKI
The incidence of acute kidney injury after cardiopulmonary bypass cardiac surgery is high, which increases postoperative mortality and is not conducive to the prognosis of patients.
- Trial name
- NCT05652179
- Testing
- Stellate ganglion block
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Yangzhou University