Clinical trials: Cardiac Thrombus
Coronary Artery Disease, Acute Coronary Syndrome
Platelet Acetyl Coenzyme A Carboxylase Phosphorylation in Coronary Artery Disease
In human purified platelets, only thrombin, and not the other platelet agonists, leads to a transient activation of the protein kinase activated by AMP (AMPK) and to phosphorylation of its "bona fide" substrate, ACC on its Ser79.
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Coronary Thrombosis
- Trial name
- ACCTHEROMA (NCT03034148)
- Testing
- Platelet Acetyl Coenzyme A Carboxylase analysis in CAD
- Where
- Belgium
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Foramen Ovale, Patent
Risk of Ischaemic Stroke After Pulmonary Embolism in Patients With and Without Patent Foramen Ovale
stroke's risk is increased in patients with pulmonary embolism and PFO compared to patients without PFO. Does this increased risk persist years after pulmonary embolism ?
- Trial name
- EPIC-FOPCohort (NCT04987008)
- Where
- 3 sites in France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Brest
Pulmonary Embolism, Venous Thromboembolism
Implementing Prescriber-Pharmacist Collaborative Care for Evidence-based Anticoagulant Use
The researchers hypothesize that existing-prescription notifications directed to pharmacists are more likely to lead to a prescription change than existing-prescription notifications directed to prescribers.
- Conditions
- Pulmonary Embolism, Venous Thromboembolism, Atrial Fibrillation
- Trial name
- NCT05351749
- Testing
- New-prescription Alert, New-prescription Alert with referral option, Existing-prescription notification to prescriber
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- University of Michigan
Ischemic Heart Disease, Stenotic Coronary Lesion
RESOLUTE China Registry:
To document the safety and overall clinical performance of the Resolute Zotarolimus-Eluting Coronary Stent System in a real-world patient population requiring stent implantation.
- Conditions
- Ischemic Heart Disease, Stenotic Coronary Lesion, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- R-C Registry (NCT01243749)
- Where
- 6 sites in China
- Volunteers
- 1,800 people
- Sponsor
- Medtronic Vascular
Congenital Heart Defects, Atrial Fibrillation
NOACs for Atrial Tachyarrhythmias in Congenital Heart Disease
Rationale: Adult patients with congenital heart disease (CHD) with atrial tachyarrhythmias need to be anticoagulated. It is not known whether non-vitamin K antagonist oral anticoagulants (NOAC) in this patient group are efficient…
- Conditions
- Congenital Heart Defects, Atrial Fibrillation, Ectopic Atrial Tachycardia
- Trial name
- NOTE (NCT02928133)
- Where
- Netherlands
- Volunteers
- 300 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Atrial Fibrillation
REgistry on Real-Life EXperience With Left Atrial Appendage Occlusion
The objective of this observational non-randomized multicenter study is to compile real-world clinical characteristics and outcomes data for patients treated with LAA (left atrial appendage) closure systems in a daily clinical…
- Trial name
- RELEXAO (NCT03279406)
- Testing
- Percutaneous Left Atrial Appendage Occlusion
- Volunteers
- 400 people
- Sponsor
- University Hospital, Tours
On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications, DVT - Deep Vein Thrombosis
This Research Proposal Focuses on Evaluating the Effectiveness of a Nursing Care Protocol in Preventing Deep Vein Thrombosis (DVT) in Patients Undergoing On-pump Cardiac Surgery. The Study Will Include an Intervention Group That Receives the Nursing Protocol and a Control Group That Receives Routine
The primary focus of this research proposal is to examine the efficacy of a nursing care protocol in preventing the occurrence of deep vein thrombosis (DVT) in patients undergoing on-pump cardiac surgery.
- Conditions
- On-pump Cardiac Surgery - Prevention - Intervention - Experimental Group - Control Group - Incidence - Complications, DVT - Deep Vein Thrombosis, DVT Prophylaxis, DVT Prevention
- Trial name
- DVT (NCT07347652)
- Testing
- IPC devices facilitate venous return by simulating the physiological effects of muscle contraction, reducing venous stasis.
- Where
- Cyprus
- Volunteers
- 67 people
- Sponsor
- Near East University, Turkey
Stroke, Ischemic, Device Related Thrombosis
APPEND-CT Registry
The APPEND-CT registry is an investigator-driven multicenter retrospective observational database intended to compile cardiac CT follow-up data after Watchman FLX device implantation and function as a platform for answering…
- Conditions
- Stroke, Ischemic, Device Related Thrombosis, Atrial Fibrillation
- Trial name
- APPEND-CT (NCT06213285)
- Testing
- Watchman FLX left atrial appendage occlusion
- Where
- 2 sites in United States, Denmark
- Volunteers
- 2,000 people
- Sponsor
- Aarhus University Hospital
Coronary Artery Disease, Peripheral Arterial Disease
NEtwork to Control ATherothrombosis (NEAT Registry)
NEAT is an observational cohort (Prospective registry of real world data) of patients with coronary and peripheral artery disease in an outopatient setting.
- Conditions
- Coronary Artery Disease, Peripheral Arterial Disease, Atherothrombosis
- Trial name
- NEAT (NCT04677725)
- Where
- Brazil
- Volunteers
- 2,000 people
- Sponsor
- Hospital do Coracao
Acute Coronary Syndrome, Myocardial Infarction
What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI?
The optimal antithrombotic management in patients with coronary artery disease (CAD) and concomitant atrial fibrillation (AF) is unknown.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Atrial Fibrillation, Atrial Flutter
- Trial name
- WOEST-3 (NCT04436978)
- Testing
- 30-day DAPT, Guideline-directed therapy
- Where
- 20 sites in Belgium, Netherlands
- Volunteers
- 2,000 people
- Sponsor
- St. Antonius Hospital
Saphenous Vein Graft Disease, Myocardial Ischemia
The RETRIEVE Study: Use of the FiberNet® Embolic Protection System in Saphenous Vein Grafts
This is a multicenter, prospective study designed to demonstrate the performance and safety of the FiberNet Embolic Protection System when used as an adjunctive device during saphenous vein graft (SVG) intervention.
- Conditions
- Saphenous Vein Graft Disease, Myocardial Ischemia, Embolism
- Trial name
- RETRIEVE (NCT00453518)
- Testing
- FiberNet EPS used during SVG intervention.
- Where
- 6 sites in United States
- Volunteers
- 29 people
- Sponsor
- Lumen Biomedical
Stable Angina
COBRA SHIELD OCT Study
Phase one of this study is a prospective, randomized (2:1), pilot study that will evaluate COBRA PzF vascular healing patterns and thrombus formation with Optical Coherence Tomography (OCT) at 3 months after stent implantation in…
- Trial name
- NCT02224235
- Testing
- Aspirin, Resolute Integrity DES, COBRA PzF
- Where
- 2 sites in Finland
- Volunteers
- 8 people
- Sponsor
- CeloNova BioSciences, Inc.
Arterial Occlusive Diseases, Myocardial Ischemia
RESOLUTE Japan - The Clinical Evaluation of the MDT-4107 Drug-Eluting Coronary Stent
The objective of the study is to verify the safety and efficacy of the MDT-4107 Drug-Eluting Coronary Stent for the treatment of de novo lesions in native coronary arteries.
- Conditions
- Arterial Occlusive Diseases, Myocardial Ischemia, Cardiovascular Diseases, Coronary Artery Disease
- Trial name
- RJ (NCT00927940)
- Testing
- MDT-4107 Drug Eluting Stent
- Where
- 14 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Medtronic Vascular
Dyspnea, Peripheral Edema
NT-proBNP and New Biomarkers in Patients With Dyspnea and/or Peripheral Edema
The objectives of this study are to: Evaluate the sensitivity and specificity of NT-proBNP (N-terminal prohormone brain natriuretic peptide) and new biomarker measurements for the diagnosis of heart failure in patients with acute…
- Trial name
- MANPRO (NCT00143793)
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Universitätsmedizin Mannheim
Atrial Fibrillation, Thrombus Due to Heart Valve Prosthesis
Validation of International Warfarin Pharmacogenetics Consortium (IWPC) Algorithm in Elderly Patients With Comorbidity
The purpose of this study is to validate the International Warfarin Pharmacogenetics Consortium (IWPC) algorithm in a prospective cohort of elderly people (65 years or older) with heart valves and/or nonvalvular atrial…
- Trial name
- VIALE (NCT02069132)
- Testing
- Warfarin
- Where
- 3 sites in Italy
- Volunteers
- 376 people
- Sponsor
- University of Campania Luigi Vanvitelli
Cardiovascular Diseases, Arterial Thrombosis
Immune Checkpoint Inhibitor Associated Cardiovascular Adverse Events in Patients With Cancer
Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment and are now approved for various types of cancer. The most common side effects of ICI are immune-related adverse events which can affect any organ or system…
- Conditions
- Cardiovascular Diseases, Arterial Thrombosis, Myocardial Infarction, Stroke
- Trial name
- ITHACA (NCT06519292)
- Testing
- Coronary computed tomography angiography (CCTA) at baseline, Coronary computed tomography angiography (CCTA) after 1 year
- Where
- Netherlands
- Volunteers
- 214 people
- Sponsor
- Hanneke W. M. van Laarhoven
Ischemic Heart Disease, Coronary Stenosis
RESOLUTE Asia: Evaluation of the Endeavor Resolute Zotarolimus-Eluting Stent System in a Patient Population With Long Lesion(s) and/or Dual Vessels in Asia
The purpose of this study is to document the safety and overall clinical performance of the Endeavor Resolute Zotarolimus-Eluting Coronary Stent System in a patient population with long lesion(s) and/or dual vessels requiring…
- Conditions
- Ischemic Heart Disease, Coronary Stenosis, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- R-A (NCT01132456)
- Testing
- Drug eluting stent treatment
- Where
- India
- Volunteers
- 312 people
- Sponsor
- Medtronic Vascular
Upper Gastrointestinal Bleeding
Non-warfarin Oral AntiCoagulant Resumption After Gastrointestinal Bleeding in Atrial Fibrillation Patients
Current clinical society guidelines and statements are non-specific and relatively open-ended regarding the optimal timing to restart non-warfarin oral anticoagulant (NOAC) after gastrointestinal bleeding (GIB) in patients with…
- Trial name
- NOAC-GAP (NCT03785080)
- Testing
- restart NOAC very early, restart NOAC early
- Where
- 3 sites in Australia, Hong Kong and 1 more
- Volunteers
- 552 people
- Sponsor
- Chinese University of Hong Kong
ST Elevation Myocardial Infarction
Minimal Invasive Procedure for Myocardial Infarction
In the setting of primary Percutaneous Coronary Intervention (PCI), the investigators hypothesize that a 24-48 hour delay strategy of stenting after successful thrombus aspiration and establishment of Thrombolysis In Myocardial…
- Trial name
- MIMI (NCT01360242)
- Testing
- MIMI procedure (two-step strategy), Immediate Stenting (one-step strategy)
- Where
- 24 sites in France
- Volunteers
- 160 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Postoperative Myocardial Injury
Direct Evaluation of Postoperative Myocardial Injury Using Coronary Computed Tomography Angiography After Non-Cardiac Surgery
This is a prospective study in patients who undergo routine postoperative troponin assessment after major (semi-)elective noncardiac surgery.
- Trial name
- NCT02682966
- Testing
- Coronary Computed Tomography Angiography
- Volunteers
- 354 people
- Sponsor
- UMC Utrecht