Clinical trials: Cardiac Transplant Disorder
Cardiovascular Diseases, End Stage Renal Disease
Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates
The Canadian Australasian Randomized Trial of Screening Kidney Transplant Candidates for Coronary Artery Disease (CARSK) will test the hypothesis that eliminating the regular use of non-invasive screening tests for CAD AFTER…
- Conditions
- Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication
- Trial name
- CARSK (NCT03674307)
- Testing
- No screening, Regular Screening
- Where
- 22 sites in United States, Canada and 2 more
- Volunteers
- 3,306 people
- Sponsor
- University of British Columbia
Left Ventricular Dysfunction, Acute Myocardial Infarction
UC-MSC Transplantation for Left Ventricular Dysfunction After AMI
A pilot study to evaluate the safety and feasibility of umbilical cord mesenchymal stem cells in the treatment of acute myocardial infarction by catheter transplantation
- Trial name
- NCT03902067
- Testing
- UC-MSC, Control Group
- Where
- China
- Sponsor
- Shanghai Life Science & Technology
Heart Disease
German Off Pump Coronary Artery Bypass in Elderly Study
Comparison of two operative techniques (on-pump vs off-pump)of coronary revascularisation of the best treatment concept for patients older or 75 years old.
- Trial name
- GOPCABE (NCT00719667)
- Testing
- coronary artery bypass grafting
- Where
- 2 sites in Germany
- Volunteers
- 2,000 people
- Sponsor
- German Off Pump Coronary Artery Bypass in Elderly Study Group
Heart Failure, Liver Fibrosis
Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
Magnetic resonance elastography is a novel non-invasive MRI technique to obtain stiffness of soft tissues such as liver, heart, kidneys, etc.
- Conditions
- Heart Failure, Liver Fibrosis, Cardiac Transplant Rejection, Aortic Aneurysms
- Trial name
- MRE (NCT01757730)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Arunark Kolipaka
Lung Transplant
Study of Cyclosporine Inhalation Solution (CIS) in Improving Bronchiolitis Obliterans Syndrome-Free Survival Following Lung Transplantation
A Phase III, multi-center, randomized, controlled study designed to demonstrate the efficacy and safety of Cyclosporine Inhalation Solution (CIS)in improving survival and preventing bronchiolitis obliterans syndrome (BOS) when…
- Trial name
- CIS001 (NCT00755781)
- Testing
- Cyclosporine Inhalation Solution (CIS)
- Where
- 19 sites in United States, Canada
- Volunteers
- 284 people
- Sponsor
- APT Pharmaceuticals, Inc.
Coronary Artery Disease
Tai Chi Exercises on Physical Activity and Pulmonary Function in CABG
To improve the cardiopulmonary endurance in Coronary artery bypass grafting (CABG) patients. Internationally in cardiac hospital facility of cardiac rehabilitation is available to improve the patient's physical activity and…
- Trial name
- NCT03857282
- Testing
- Aerobic Exercises, Tai Chi Exercises
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Coronary Artery Bypass Grafting
Randomized Endo-Vein Graft Prospective
Coronary artery bypass grafting (CABG) is the most common major surgical procedure in the United States with over 300,000 cases performed each year.
- Trial name
- REGROUP (NCT01850082)
- Testing
- Vein Harvesting Procedures
- Where
- 16 sites in United States
- Volunteers
- 1,150 people
- Sponsor
- VA Office of Research and Development
Coronary Artery Disease, General Anesthetic Drug Allergy
Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery
Xenon is a gaseous anaesthetic agent registered in several European countries. It has been administered safely during cardiac surgery in pilot studies.
- Conditions
- Coronary Artery Disease, General Anesthetic Drug Allergy, Coronary Artery Bypass Graft Surgery
- Trial name
- NCT01294163
- Testing
- Xenon, Sevoflurane, Propofol
- Where
- 17 sites in France, Germany and 2 more
- Volunteers
- 509 people
- Sponsor
- Air Liquide Santé International
Coronary Artery Occlusive Disease
The Effect of 6% Hydroxyethyl Starch 130/0.4 on Blood Loss and Coagulation in Patients Medicated With Antiplatelet Agents Prior to Off-Pump Coronary Bypass Graft Surgery
HES 130/0.4 significantly solution will not affect on coagulation and blood loss in patients medicated with antiplatelet agents prior to off-pump coronary bypass surgery (OPCAB).
- Trial name
- NCT01051206
- Testing
- 6% hydroxyethyl Stach 130/0.4
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Yonsei University
Coronary Artery Disease
Resting Full-cycle Flow Ratio (RFR) Versus Angiography to Guide Revascularization Strategy in Patients Undergoing Coronary Artery By-pass Grafting (CABG)
Different trials have shown that fractional flow reserve (FFR) could successfully guide revascularization in patients undergoing percutaneous coronary intervention (PCI).
- Trial name
- RFR-CABG (NCT04375306)
- Testing
- RFR guided CABG, Angio guided CABG
- Where
- 4 sites in Belgium, Poland and 1 more
- Volunteers
- 500 people
- Sponsor
- Diagram B.V.
Coronary Artery Disease, Chronic Kidney Disease
Effects of Surgical, Percutaneous or Medical Treatments for Coronary Artery Disease on Renal Function: Long-Term Outcome. Cardiorenal-trial.
Background: Coronary artery disease (CAD) is treated with coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or optimized medical therapy (OMT).
- Trial name
- NCT07195747
- Testing
- Creatinine
- Where
- Brazil
- Volunteers
- 1,700 people
- Sponsor
- Instituto do Coracao
Coronary Artery Disease
Effect of an Educational Intervention on Cardiac Patients' Participation Rate in Cardiac Rehabilitation Programs
The main aim of the study is to determine the effectiveness of an educational intervention designed to increase attendance of coronary artery bypass grafting (CABG) patients at Cardiac Rehabilitation Programs (CRPs) on actual CRP…
- Trial name
- MECRIS (NCT00356863)
- Testing
- Increasing awareness to cardiac rehabilitation programs
- Where
- Israel
- Volunteers
- 1,024 people
- Sponsor
- Sheba Medical Center
Major Adverse Cardiovascular Events, Saphenous Vein Graft Disease
Virtual Histology Intravascular Ultrasound to Evaluate Prognostic Risks of Saphenous Vein Graft Disease Before Percutaneous Coronary Intervention.
The study is a prospective cohort study conducted in Tianjin Chest Hospital, China. Patients with saphenous vein graft disease after coronary artery bypass graft, and planning for receiving percutaneous coronary intervention…
- Conditions
- Major Adverse Cardiovascular Events, Saphenous Vein Graft Disease, Virtual Histology Intravascular Ultrasound, Percutaneous Coronary Intervention
- Trial name
- NCT03175952
- Testing
- virtual histology intravascular ultrasound
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Tianjin Chest Hospital
Acute Renal Injury, Preventive Measures
Prevention and Early Detection and Intervention of Post-Coronary Artery Bypass Grafting Surgery (CABG) Acute Kidney Injury (AKI)
Nephrology participation in care of patients undergoing CABG could reduce AKI through correction of modifiable risk factors and early detection and intervention of post-op AKI.
- Trial name
- NCT02838667
- Testing
- Standard of Care plus Nephrology Care
- Where
- United States
- Volunteers
- 2,300 people
- Sponsor
- Mayo Clinic
Heart Failure
Coronary Artery Disease in Hearts Donated for Transplantation
In spite of recent initiatives, in particular, the introduction into clinical practice of donation after circulatory death (DCD), there is a persistent mismatch between the demand for donor hearts for transplantation and their…
- Trial name
- NCT06528834
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Coronary Heart Disease
Levosimendan Pretreatment for Weaning Patients From Cardio-Pulmonary Bypass
The study evaluates the efficacy of intravenous levosimendan treatment started during a coronary artery bypass operation to wean patients from a heart lung machine.
- Trial name
- NCT00130871
- Testing
- levosimendan
- Where
- 2 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Orion Corporation, Orion Pharma
CABG
Effects of E-care Protocol in Patients With Coronary Artery Bypass Graft
Coronary artery disease (CAD) is a heart disease caused by the buildup of plaque inside the coronary arteries that restricts blood flow to the heart which leads to heart attack.
- Trial name
- CABG (NCT07574411)
- Testing
- IMT Threshold device
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Pain, Procedural, Pain, Postoperative
The Effect of Vibration and Cold on Pain and Anxiety Associated With Chest Tube Removal Following CABG
Removal of chest tubes after coronary artery bypass graft (CABG) surgery can cause severe pain and anxiety, which may negatively affect the recovery process.
- Conditions
- Pain, Procedural, Pain, Postoperative, Coronary Artery Bypass Surgery, Chest Tubes
- Trial name
- CABG (NCT06217263)
- Testing
- Vibration device, Vibration device&Cold application pack
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Istanbul University - Cerrahpasa
Saphenectomy, No Touch
Morbidity of Conventional and No-touch Saphenectomy in Coronary Artery Bypass Grafting.
A clinical research project will be carried out that will consist of a non-inferiority study. The objective is to compare the morbidity of two different surgical techniques for the extraction of the internal saphenous vein…
- Conditions
- Saphenectomy, No Touch, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- TNT (NCT06496321)
- Testing
- Conventional Saphenous vein harvest, No touch Saphenous vein harvest
- Where
- Uruguay
- Volunteers
- 52 people
- Sponsor
- Instituto Nacional de Cirugia Cardiaca, Uruguay
Heart Transplantation
Exchange of Azathioprine by Mycophenolatmofetile and Cyclosporine A Dose Reduction After Heart Transplantation
The purpose of this study is to improve or save renal function by optimizing the immunosuppressive regimen by reducing the Cyclosporine A dose and the exchange of Azathioprine by Mycophenolatmofetile, which is an effective…
- Trial name
- NCT00359814
- Testing
- Mycophenolatmofetile, Cyclosporin A
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Hannover Medical School