Clinical trials: Cardiac Valve Surgery
Cardiac Disease, Surgery
The Quality of Recovery-15 Survey After Cardiac Surgery
Patient reported outcomes are becoming increasingly recognized as an important metric to determine efficacy of interventions following recovery after cardiac surgery.
- Conditions
- Cardiac Disease, Surgery, Surgery-Complications, Cardiac Valve Disease
- Trial name
- NCT05602298
- Testing
- Quality of Recovery 15 survey
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- University of British Columbia
Prehabilitation, Cardiac Surgery
Feasibility of Physical Prehabilitation for High-Risk Patients Undergoing Cardiac Surgery Via Sternotomy
Rationale Cardiac surgery via median sternotomy carries an elevated risk of postoperative complications and delayed functional recovery.
- Conditions
- Prehabilitation, Cardiac Surgery, Risk Assesment, Aortic Valve
- Trial name
- PREPA-STER (NCT07893184)
- Testing
- Physical Prehabilitation Intervention
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Atrial Fibrillation, Venous Thromboembolism
Reinitiation of Anticoagulation After Temporary Withdrawal of Vitamin K Antagonist
It is not known how to best restart warfarin after temporary withdrawal. Participants will be randomized to two groups. Group 1 will restart warfarin at their usual maintenance dose, group 2 will restart warfarin at double their…
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Heart Valve Disease, Surgery
- Trial name
- DOSIDO (NCT01348074)
- Testing
- Double dose
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- McMaster University
Heart Disease, Coronary Artery Disease
Bleeding Prediction in Patients Following Cardiac Surgery Using Whole Blood Aggregometry and Thromboelastometry
Use of whole blood impedance aggregometry and rotational thromboelastometry can reveal useful data about platelet function and viscoelastic properties of blood clot in patients undergoing cardiac surgery.
- Conditions
- Heart Disease, Coronary Artery Disease, Aortic Valve Disease, Mitral Valve Disease
- Trial name
- NCT01281397
- Where
- Croatia
- Volunteers
- 148 people
- Sponsor
- University of Zagreb
Tricuspid Regurgitation
Long-term Outcomes of Isolated Tricuspid Valve Surgery According to Preoperative Clinical and Functional Staging
Tricuspid regurgitation (TR) was identified as an independent prognostic factor associated with excess mortality and morbidity, independent of left ventricular (LV) function and pulmonary hypertension.
- Trial name
- NCT05721417
- Testing
- Tricuspid valve surgery
- Where
- Italy
- Volunteers
- 172 people
- Sponsor
- Michele De Bonis
Heart Valve Diseases
Cardiopulmonary Rehabilitation In Heart Valve Surgery
The aim of this study was to investigate the effects of postoperative early mobilization and Bottle-P.E.P. application on respiratory parameters and functional capacity in patients undergoing heart valve surgery.
- Trial name
- NCT06493123
- Testing
- Conventional Cardiopulmonary Rehabilitation, Bottle P.E.P. (Pozitive Expiratory Pressure), Early Mobilization
- Where
- Turkey (Türkiye)
- Sponsor
- Istanbul Saglik Bilimleri University
Mitral Regurgitation
TEER for Severe DMR of Low to Intermediate Surgery Risk
To investigate the efficacy and safety of transcatheter mitral valve edge-to-edge repair (TEER) for severe degenerative mitral regurgitation (DMR) patients of low to intermediate surgery risk.
- Trial name
- NCT06162780
- Testing
- ultrasonic cardiography (UCG), TEER
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Heart Valve Diseases
Interdisciplinary Perioperative Care in Minimally-invasive Heart Valve Surgery
Valvular heart diseases are among the most common cardiac pathologies in adult patients in Germany. Currently, the process of care before, during and after heart valve surgery does not follow a standardized and interdisciplinary…
- Trial name
- INCREASE (NCT04977362)
- Testing
- Enhanced Recovery After Surgery, Treatment as Usual
- Where
- 2 sites in Germany
- Volunteers
- 201 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Heart Valve Diseases, Surgery--Complications
Machine Learning-Based Risk Profile Classification of Patients Undergoing Elective Heart Valve Surgery
Machine learning methods potentially provide a highly accurate and detailed assessment of expected individual patient risk before elective cardiac surgery.
- Trial name
- NCT03724123
- Volunteers
- 2,229 people
- Sponsor
- Kepler University Hospital
Aortic Stenosis, Severe
The CardioFit Trial: Exercise Training Before Aortic Valve Surgery
The CardioFit Trial: The feasibility, safety and tolerability of an exercise training programme in patients with severe aortic stenosis prior to aortic valve replacement surgery: A feasibility trial To investigate if a Structured…
- Trial name
- CardioFit (NCT06818110)
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Coronary Artery Bypass Graft Redo, Heart Valve Diseases
SONOlysis in Risk REduction of Symptomatic and Silent Brain infarCtions dUring Cardiac surgEry
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MHz diagnostic probe on the reduction of risk of brain infarctions due to the activation of…
- Trial name
- SONORESCUE (NCT01591018)
- Testing
- sonolysis, cardiac surgery
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- University Hospital Ostrava
Aortic Valve Stenosis
Nitinol Circular Blade
The Nitinol Circular Blade (NCB) is indicated for use in patients with symptomatic aortic stenosis requiring aortic valve replacement, who are going to be operated by conventional sternotomy with native valve resection and…
- Trial name
- NCB (NCT03881527)
- Testing
- Aortic valve replacement using a nitinol blade, aortic valve replacement
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Mitral Regurgitation, Mitral Valve Insufficiency
Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery
The goal of this project is to study whether local anesthetic via the erector spinae plane (ESP) block may be beneficial in minimally invasive mitral valve surgery (MIMVS).
- Conditions
- Mitral Regurgitation, Mitral Valve Insufficiency, Mitral Valve Prolapse
- Trial name
- NCT04770961
- Testing
- Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco
Infective Endocarditis, Valvular Heart Disease
Inflammatory Mediator Profiles During Heart Valve Replacement Surgery
The study aims at the comparative examination of pre-, intra- and post-operative release profiles of inflammatory and vasoactive mediators in patients undergoing heart valve surgery under cardiopulmonary bypass (CPB) due to…
- Trial name
- Remove-Pilot (NCT02727413)
- Testing
- Blood sample collection, Assessment of signs of organ dysfunction
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Jena University Hospital
Atrial Fibrillation New Onset, Hemorrhage
Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation
The aim of this study is to evaluate the prophylactic effects of Ranolazine on new onset atrial fibrillation in post-operative coronary artery bypass graft and valve surgery patient population at Staten Island University hospital.
- Conditions
- Atrial Fibrillation New Onset, Hemorrhage, Prolonged QTc Interval, Ventricular Tachycardia
- Trial name
- NCT01590979
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Northwell Health
Aortic Valve Disease, Valve Disease, Heart
Del Nido Versus HTK Cardioplegia in Adult Aortic Valve Replacement
The goal of this clinical trial is to compare del Nido and Bretschneider-HTK (HTK) cardioplegia solutions in patients undergoing elective aortic valve replacement.
- Conditions
- Aortic Valve Disease, Valve Disease, Heart, Cardiac Ischemia
- Trial name
- NCT06235424
- Testing
- Del Nido Cardioplegia Solution, HTK solution
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Gdansk
Heart Valve Diseases, Left Ventricle Remodeling
Effect of Losartan on the Neurohumoral Axis and Ventricular Remodeling of Patients With Severe Aortic Regurgitation Undergoing Valve Surgery.
Why Is This Study Important? The heart has valves that help control blood flow. Aortic regurgitation (AR) is a condition where one of these valves (the aortic valve) doesn't close properly, causing blood to leak back into the…
- Conditions
- Heart Valve Diseases, Left Ventricle Remodeling, Aortic Regurgitation Disease, Heart Failure Congestive
- Trial name
- ARBNP (NCT07099859)
- Testing
- Losartan 50 mg
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Vitor Emer Egypto Rosa
Ischemic Heart Disease, Valvular Heart Disease
Study on Optimal Temperature During Cardiopulmonary Bypass (THERMIC-4)
In order to perform heart surgery, a machine called cardiopulmonary bypass (CPB), or more commonly known as a heart-lung machine, is used to maintain the circulation of oxygenated blood needed by the rest of the body and its…
- Conditions
- Ischemic Heart Disease, Valvular Heart Disease, Cardiovascular Diseases, Surgery-Complications
- Trial name
- THERMIC-4 (NCT05996120)
- Testing
- Hypothermic Cardiopulmonary Bypass, Normothermic Cardiopulmonary Bypass
- Where
- 11 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Leicester
Atrial Fibrillation
HEart Surgery In Atrial Fibrillation and Supraventicular Tachycardia
Atrial fibrillation is the most common cardiac arrhythmia, the incidence of which increases drastically with age. As more and more elderly patients undergo heart surgery, the proportion of patients in this population will…
- Trial name
- HEIST (NCT04860882)
- Volunteers
- 10,000 people
- Sponsor
- Nicolaus Copernicus University
Mitral Valve or Aortic Valve Replacement
A Retrospective Study to Collect the Data From the Patients Who Had the Perimount Heart Valve Replacement Surgery in China During 2001 to 2007
The objective of the study is to obtain the clinical data from patients who had the Perimount Heat Valve (Type:6900P and 2900) Replacement Surgery in Guangdong General Hospital during 2001-2007 in order to evaluate the performace…
- Trial name
- NCT02381678
- Testing
- Perimount 2900/6900 Heart Valve
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Edwards (Shanghai) Lifesciences Medical Supplies Co., Ltd.