Clinical trials: Cardiac and Respiratory Arrest
Cardiac Arrest, Frailty
The Impact of Frailty on Cardiopulmonary Resuscitation Adverse Outcomes in Patients Requiring Code Blue Activation
The aim of this study was to determine the independent association of frailty with cardiopulmonary resuscitation and predictive factors in patients triggering code blue response
- Conditions
- Cardiac Arrest, Frailty, Respiratory Arrest
- Trial name
- NCT06405581
- Testing
- Edmonton frailty scale calculation
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Umraniye Education and Research Hospital
Cardiac Arrest, Anoxic Encephalopathy
TELSTAR: Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation
The purpose of this study is to estimate the effect of medical treatment of electro-encephalographic status epilepticus on neurological outcome of patients with postanoxic encephalopathy after cardiac arrest.
- Conditions
- Cardiac Arrest, Anoxic Encephalopathy, Status Epilepticus
- Trial name
- TELSTAR (NCT02056236)
- Testing
- Anti-epileptic drugs, No anti-epileptic drugs
- Where
- 11 sites in Belgium, Netherlands
- Volunteers
- 172 people
- Sponsor
- University of Twente
Ventilator-associated Pneumonia, Cardiac Arrests With Shockable Rhythm
Antibiotherapy During Therapeutic Hypothermia to Prevent Infectious Complications
Mild therapeutic hypothermia is currently recommended in management of cardiac arrests with shockable rhythm. In mechanically ventilated patients who were resuscitated after out-of-hospital cardiac arrests, mild therapeutic…
- Conditions
- Ventilator-associated Pneumonia, Cardiac Arrests With Shockable Rhythm, Mild Therapeutic Hypothermia, Preventive Antibiotics
- Trial name
- ANTHARTIC (NCT02186951)
- Testing
- Amoxicillin - clavulanic acid
- Where
- 16 sites in France
- Volunteers
- 197 people
- Sponsor
- University Hospital, Limoges
Cardiac Arrest (CA)
Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?
To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest…
- Trial name
- LUCASVP (NCT06824961)
- Testing
- 5-second ventilation pause duration during mechanical CPR, 3-second ventilation pause duration during mechanical CPR
- Where
- 2 sites in Netherlands
- Volunteers
- 692 people
- Sponsor
- Amsterdam UMC, location VUmc
Sleep Apnea, Sudden Cardiac Death
European Sleep Apnea and Sudden CArdiac Death ProjEct
The objective of ESCAPE-SCD Study is assessment of the effect of sleep apnea on sudden cardiac death risk and cardiovascular outcomes in patients with ischemic cardiomyopathy.
- Conditions
- Sleep Apnea, Sudden Cardiac Death, Heart Failure, Ischemic Cardiomyopathy
- Trial name
- ESCAPE-SCD (NCT02506166)
- Testing
- Positive Airway Pressure Therapy
- Volunteers
- 900 people
- Sponsor
- University Hospital Olomouc
Shortness of Breath Episode, Tachycardia
Verification of Prediction Algorithm
Prospective observational clinical study to verify an algorithm used to predict cardiopulmonary events in patients presenting to the emergency department.
- Conditions
- Shortness of Breath Episode, Tachycardia, Bradycardia, Difficulty Breathing
- Trial name
- VPAC (NCT02863666)
- Where
- 3 sites in United States, Belgium
- Volunteers
- 673 people
- Sponsor
- Zoll Medical Corporation
Hypoxic-Ischemic Encephalopathy, Cardiac Arrest
EEG Slow Wave Activity in Hypoxic Brain Injury
BrainICU is a prospective observational study investigating the EEG slow wave activity in comatose cardiac arrest survivors under propofol anesthesia and its association with neurological outcome.
- Trial name
- BrainICU (NCT04506788)
- Where
- Finland
- Volunteers
- 25 people
- Sponsor
- University of Oulu
Hypoxia-Ischemia, Brain
Delineating Between Pathophysiologic Phenotypes of Hypoxic Ischemic Brain Injury After Cardiac Arrest
The main outcome determinant following cardiac arrest is hypoxic ischemic brain injury. Management has involved increasing the delivery of oxygen to the brain.
- Trial name
- DIFFUSION (NCT05390060)
- Testing
- Neuromonitoring
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Cardiac Arrest, Hypoxic Ischemic Brain Injury
TIBOHCA: Safety, Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) After OHCA
Following successful cardiopulmonary resuscitation (CPR) after out of hospital cardiac arrest (OHCA), 50% of patients admitted to the Intensive Care Unit (ICU) die.
- Trial name
- TIBOHCA (NCT02836340)
- Testing
- 2-Iminobiotin
- Where
- Netherlands
- Volunteers
- 21 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury
Multiomics Profiling of CSF in Cardiac Arrest Survivors
The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples.
- Conditions
- Cardiac Arrest (CA), Hypoxic-Ischemic Brain Injury, Post-Resuscitation Syndrome
- Trial name
- MOPCAS (NCT07090577)
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Chungnam National University Hospital
Cardiac and Respiratory Arrest
SST in Emergency Education
This study looks back at how the investigatorsll two different teaching methods work for training medical and nursing students in CPR (cardiopulmonary resuscitation), a life-saving emergency procedure used when someone's heart…
- Trial name
- SST (NCT07803861)
- Testing
- case-based scenario simulation teaching
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Brain Death, Anoxic Brain Injury
Rapid Reversal of CNS-Depressant Drug Effect Prior to Brain Death Determination
Current standard of care prior to determination of brain death in subjects with suspected anoxic brain injury is to exclude complicating medical conditions that may confound clinical assessment (such as severe electrolyte, acid…
- Conditions
- Brain Death, Anoxic Brain Injury, Cardiac Arrest, Sedative Intoxication
- Trial name
- NCT03743805
- Testing
- Flumazenil, Naloxone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Prisma Health-Midlands
Cardiac Arrest With Successful Resuscitation, Hypoxia, Brain
Sedation, Temperature and Pressure After Cardiac Arrest and Resuscitation
The STEPCARE-trial is a 2x2x2 randomised trial studying patients who have been resuscitated from cardiac arrest and who are comatose.
- Trial name
- STEPCARE (NCT05564754)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 56 sites in Australia, Belgium and 13 more
- Volunteers
- 3,500 people
- Sponsor
- Region Skane
Medical Condition Requiring Extracorporeal Organ Support
The University of Freiburg Medical Center Extracorporeal Organ Support Device Registry
A prospective registry collecting pseudonymized clinical and treatment data from all patients treated with extracorporeal organ support (i.e., VV ECMO, VA ECMO, ECPR, Impella, IABP, and others) on the wards of the Department of…
- Trial name
- NCT05811780
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- University Hospital Freiburg
Pulmonary Embolism, Respiratory Failure
Construction of Early Warning Model for Pulmonary Complications Risk of Surgical Patients Based on Multimodal Data Fusion
The goal of this observational study is to establish an intelligent early warning system for acute and critical complications of the respiratory system such as pulmonary embolism and respiratory failure.
- Conditions
- Pulmonary Embolism, Respiratory Failure, Infection Complication, Cardiac Arrest
- Trial name
- NCT06057688
- Where
- China
- Volunteers
- 1,770 people, healthy volunteers welcome
- Sponsor
- Renrong Gong
Cardiac Sudden Death, Hypoxia Brain
New Biomarkers of Neurological Outcome After a Sudden Cardiac Death
The aim of the project is to establish the value of circulating microparticles as a new biomarker for neurological prognosis of patients recovered from sudden cardiac death who remain comatose.
- Conditions
- Cardiac Sudden Death, Hypoxia Brain, Cell Membrane Microparticles, Biomarkers
- Trial name
- NCT03962361
- Testing
- Concentration of circulating microparticles.
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiac Arrest During and/or Resulting From A Procedure
Prehospital Laryngeal Tube vs. Bag-Valve Mask Ventilation Used by Paramedics During CPR
During CPR bag-valve mask ventilation is difficult for basically skilled rescuers. Ventilation may be inefficient or with too high pressures result in stomach inflation and aspiration.
- Trial name
- NCT01718795
- Testing
- Bag-valve mask or laryngeal tube ventilation
- Where
- Austria
- Volunteers
- 78 people
- Sponsor
- Michael Baubin, MD
Cardiac Arrest
The Rescuer Fatigue During Cardiopulmonary Resuscitation in Manikin by Using Personal Protective Equipment.
Background: High-quality cardiopulmonary resuscitation is the key to recovering patients with sudden cardiac death. However, when the environment is exposure to biologic hazard, the medical personnel need to use different…
- Trial name
- NCT04802109
- Testing
- wearing level D personal protective equipment, wearing Level C personal protective equipment with N-95, wearing Level C personal protective equipment with Powered Air-Purifying Respiratory
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- An-Nan Hospital, China Medical University
Hypoxic Encephalopathy
The Neurological Pupil Index (NPi) on Intensive Care Unit (ICU) Trial
The trial will evaluate the use of the "Neurological Pupil index" NPi, measured with the digital pupillometer (NeurOptics) compared to clinical examination for better reliability.
- Trial name
- NPI-ON-ICU (NCT01920347)
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Charite University, Berlin, Germany
Inflammation, Death, Sudden, Cardiac
The Effects of Enzymes and Flavonoids on Inflammation and Coagulation After Marathon
The aim of the present study is to investigate changes in inflammatory status and incidence of infection after extreme aerobic physical stress (participation in a marathon).
- Conditions
- Inflammation, Death, Sudden, Cardiac, Death, Heart Diseases
- Trial name
- Enzy-MagIC (NCT01916408)
- Testing
- Wobenzym plus, PL 1
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich