Clinical trials: Cardiac-Related Conditions
Lymphoma, Non-Hodgkin, Lymphoma, Hodgkin
Early Detection of Patients at Risk of Developing Anthracycline Cardiotoxicity With TEP/CT -FDG
Management of patients with lymphoma is based on the administration of a chemotherapy containing anthracyclines (ATC), and allows cure rates of 65% to 80% at 5 years.
- Trial name
- DETECT (NCT04892667)
- Testing
- Intervention
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Pain, Postoperative, Sternotomy Pain
Early Screening of Chronic Post-sternotomy Pain Using the DN4-i Questionnaire
Chronic post-sternotomy pain (CPSP) is a common complication after cardiac surgery, with a reported prevalence between 30% and 50%.
- Trial name
- DEPDN4i (NCT07603271)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institute Arnault Tzanck, France
Doxorubicin Induced Cardiomyopathy
Role of Statin Therapy in Prevention of Anthracycline-Induced Cardiotoxicity
This study aims at evaluating the role of Atorvastatin in prevention of Anthracycline induced cardiotoxicity
- Trial name
- NCT05792293
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Breast Cancer
Generation of Heart Muscle Cells From Blood or Skin Cells of Breast Cancer Patients
The purpose of this study is to investigate whether cells from a biopsy taken from the patient skin can be transformed into cardiomyocytes the changes in cardiomyocyte (heart muscle cells) when grown in a special culture medium…
- Trial name
- NCT02772367
- Testing
- skin punch biopsy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Atrial Fibrillation
Relationship Between Autonomic Central Nervous System Activation and Atrial Fibrillation Using Functional MRI (fMRI)
The fMRI study is a prospective study with the objective of evaluating the effects of the autonomic central nervous system on the regulation of heart rate in patients with atrial fibrillation (AF).
- Trial name
- fMRI (NCT02524028)
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Utah
Breast Cancer Stage 2 and 3
Evaluation of Possible Safety and Efficacy of Fenofibrate in the Prophylaxis of Doxorubicin Induced Cardiotoxicity in Breast Cancer Patients
This study aims at evaluating the possible safety and efficacy of fenofibrate in attenuating doxorubicin related cardiac toxicity in breast cancer patients.
- Trial name
- NCT06155331
- Testing
- Fenofibrate, Doxorubicin, Cyclophosphamide
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Myocardial Infarction, Heart Failure
Effect of Exercise Training on Left Ventricular Function in Patients Post Myocardial Infarction
Patients who have suffered a heart attack are at risk of developing worsening heart function and heart failure. Exercise training has a beneficial effect on heart function and prevents heart failure.
- Conditions
- Myocardial Infarction, Heart Failure, Coronary Artery Disease
- Trial name
- EXIT-V (NCT02048696)
- Testing
- Secondary prevention and cardiac rehabilitation clinic
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Montreal Heart Institute
Cardiotoxicity, Heart Failure
ML Score Prediction of Cardiotoxicity in Cancer Patients Receiving Anthracycline Chemotherapy or HER2-Targeted Therapies
Cancer treatments have improved substantially over the past decades, but some effective therapies such as anthracyclines and HER2-targeted agents are associated with severe cardiovascular adverse effects, including heart failure.
- Conditions
- Cardiotoxicity, Heart Failure, Neoplasms, Breast Neoplasms
- Trial name
- ML-CardioTox (NCT07191730)
- Where
- France
- Volunteers
- 600 people
- Sponsor
- University Hospital, Caen
Cardiotoxicity, Cardiomyopathies
The Cardio-Oncology Breast Cancer Study
The main objective of this randomized controlled trial is to test the association between standard cardiac risk factors, biomarkers and parameters of echocardiography, electrocardiography, and cardiac magnetic resonance imaging…
- Conditions
- Cardiotoxicity, Cardiomyopathies, Breast Cancer
- Trial name
- COBC (NCT02571894)
- Testing
- Subclinical cardiotoxicity surveillance and treatment
- Where
- Sweden
- Volunteers
- 320 people
- Sponsor
- Karolinska University Hospital
Atrial Fibrillation, Quality of Life
Evaluation of the Added Value of an Internet-based Educational Program for Patients With Atrial Fibrillation.
This study is prospective, open and randomized concerning the value of an Internet-based educational program for patients with atrial fibrillation compared to "care as usual".
- Conditions
- Atrial Fibrillation, Quality of Life, Signs and Symptoms, Health Economy
- Trial name
- AMADEUS (NCT03763500)
- Testing
- Internet-based education
- Where
- 3 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Ulla Walfridsson
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Breast Cancer
Efficacity of Deep Inspiration Breath Hold and Intensity-modulated Radiotherapy in Preventing PErfusion Defect for Left Sided Breast Cancer (EDIPE)
Breast irradiation is known to cause radiation-induced heart disease (RIHD) many years later after radiotherapy. Recent studies suggest that RIHD could be an earlier complication and that subclinical cardiac injury can be…
- Trial name
- EDIPE (NCT05454553)
- Testing
- myocardial perfusion SPECT
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Institut de cancérologie Strasbourg Europe
Thoracic Cancer, Left Sided Breast Cancer
Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity
Patients enrolled in the study will receive standard of care adjuvant or definitive breast, chest wall or thoracic radiation therapy.Cardiac mitochondrial dysfunction is a hallmark of radiation-induced cardiac injury.
- Trial name
- NCT04044872
- Testing
- [1-13C]pyruvate along with MRI imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Texas Southwestern Medical Center
Atrial Fibrillation
Relationship Between Fibroblast Growth Factor 23 and Recurrence of Atrial Fibrillation After Catheter Ablation
To investigate whether fibroblast growth factor 23 can be used to predict recurrence after catheter ablation for atrial fibrillation and to provide an objective basis for the clinical selection of the optimal patients for…
- Trial name
- REBECCA (NCT02958839)
- Testing
- Catheter ablation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Healthy Subjects, Pulmonary-Related Conditions
High Image Matrix CT Reconstruction
Background: Computed Tomography (CT) scans make detailed pictures of the body in seconds. CT scans make pictures by passing x-rays through a person. CT scans are common.
- Conditions
- Healthy Subjects, Pulmonary-Related Conditions, Cardiac-Related Conditions
- Trial name
- NCT02610465
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation
Atrial Fibrillation in Relationship to Plasma Biomarkers
The general objective of this study is to: A. To identify novel plasmatic biomarkers associated with prevalent/incident atrial fibrillation in patients with high risk for AF and stroke. B.
- Trial name
- AFISBIO II (NCT04710745)
- Testing
- Peripheral blood samples for routine analysis including NT-proBNP and plasmatic biomarkers., Echocardiography, ECG Holter monitor
- Where
- 6 sites in Slovakia
- Volunteers
- 300 people
- Sponsor
- Premedix Academy
Posttraumatic Stress Disorder, Myocardial Infarction
EMDR Treatment in PTSD Following Cardiac Events
Cardiac events can often result in debilitating and persistent psychological symptoms. A key question involves whether optimal treatment of cardiac-induced posttraumatic stress disorder (PTSD) reduces PTSD symptoms and thereby…
- Conditions
- Posttraumatic Stress Disorder, Myocardial Infarction, Eye Movement Desensitization and Reprocessing
- Trial name
- EMDR_PTSD_MI (NCT04672551)
- Testing
- EMDR Treatment
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Cardiac Toxicity, Lymphoma
Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells.
- Trial name
- NCT00002827
- Testing
- bleomycin sulfate, filgrastim, dexrazoxane hydrochloride
- Where
- 39 sites in United States, Australia and 1 more
- Volunteers
- 294 people
- Sponsor
- Children's Oncology Group
Adherence, Medication, Chronic Disease
Efficacy of CareAide® App in Improving Adherence in Adults With Chronic Diseases
The goal of this clinical trial is to study the impact of a medication adherence app, CareAide, in adult population diagnosed with chronic diseases in Malaysian population. The main question[s] it aims to answer are: 1.
- Conditions
- Adherence, Medication, Chronic Disease, Quality of Life, Economic Burden
- Trial name
- CAREAide (NCT06068309)
- Testing
- CareAide App Usage
- Where
- 3 sites in Malaysia
- Volunteers
- 900 people
- Sponsor
- University of Malaya
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health in Colima, Mexico
Ambient air temperatures in Mexico have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06834893)
- Testing
- Cool roof
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker