Clinical trials: Cardiometabolic Conditions
Elevated LDL-C and High Cholesterol
A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)
STX-1150 is an investigational therapy designed to lower LDL-C by silencing a gene called PCSK9 in the liver. STX-1150 does not edit or permanently change the gene.
- Trial name
- STX-1150-01 (NCT07428473)
- Testing
- STX-1150
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 64 people
- Sponsor
- Monash University
Obesity
Enhancing Efficacy of Mango Polyphenols in Lean and Obese
The objective of this research is to determine beneficial impact of mango phytochemicals in lean and obese individuals for cognitive function and gut health.
- Trial name
- NCT04970589
- Testing
- Mango, Probiotics
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Obesity, Abdominal, Dyslipidemias
Dietary Approaches for Cardiometabolic Health
This pilot study aims to recruit 30 adults with abdominal obesity, without major chronic disease, and test whether clinical dietary advice that is solely focused on the timing of eating (time restricted eating), has an effect on…
- Conditions
- Obesity, Abdominal, Dyslipidemias, Insulin Resistance, Blood Pressure
- Trial name
- DACH (NCT03527290)
- Testing
- Time Restricted Eating, Standard Cardiometabolic Health Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Obesity
Cardiometabolic Disease and Pulmonary Hypertension
This study will investigate if metformin can help people with obesity and high pressures inside their lung blood vessels. Metformin is approved by the U.S.
- Trial name
- NCT03349775
- Testing
- Metformin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation, Obesity and Obesity-related Medical Conditions
Metabolic Surgery for Atrial Fibrillation Elimination
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030.
- Trial name
- METSAFE (NCT07027969)
- Testing
- Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ali Aminian
PreDiabetes
Cleaner Air for Lower Cardiometabolic Risk
The purpose of this interventional sham-controlled pilot study is to study the effects of using portable air cleaners (PACs) in outpatient adults with prediabetes.
- Trial name
- NCT05994937
- Testing
- PAC with HEPA filter intact, PAC with HEPA filter removed
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Sedentary Time, Overweight and Obesity
Exercise-snacks at Work: Impact on Cardiometabolic Parameters
The main objective is to measure the effects of intense brief exercise program in the workplace of administrative staff on the cardio-metabolic health
- Conditions
- Sedentary Time, Overweight and Obesity, Work-Related Condition
- Trial name
- NCT05942144
- Testing
- Exercise-snacks program
- Where
- France
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Avignon
Diet, Healthy, Obesity
FEAST Perinatal Support Program Intervention
Latino individuals face an elevated risk of adverse health outcomes during pregnancy, impacting both the birthing parent and the baby with potential long-term chronic health conditions.
- Conditions
- Diet, Healthy, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT06715787
- Testing
- FEAST Perinatal Support Program
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Southern California
Hyperglycemia, Dyslipidemias
The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes
The goal of this clinical trial is to test the effect of 12 weeks of 1.5 cups per day of fresh mango on glucose control, insulin resistance, lipids, inflammation, oxidation and body composition in individuals with prediabetes.
- Conditions
- Hyperglycemia, Dyslipidemias, Insulin Resistance, Inflammation
- Trial name
- NCT06159543
- Testing
- Mango
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Loma Linda University
Cardiovascular Risk Factor, Heart Diseases
Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors
This research study will test the effects of Q CAN PLUS powder on serum lipids, selected inflammatory and oxidative parameters and genome-wide methylation
- Conditions
- Cardiovascular Risk Factor, Heart Diseases, Inflammation
- Trial name
- FS (NCT03429920)
- Testing
- Q CAN PLUS
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Loma Linda University
Type 2 Diabetes Mellitus (T2DM), Hypertension (HTN)
Cohort Study of Metabolic Disease and Hypertension
The goal of this observational study is to learn how type 2 diabetes and high blood pressure develop over time in adults in Mexico.
- Trial name
- NCT07577063
- Testing
- Observational Study
- Where
- Mexico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Abdominal Obesity, Cardiac Disease
Effects of Different Dietary Interventions on Abdominal Fat Components, Quadriceps Muscles and Cardiometabolic Parameters
The study aims to evaluate the impact of different dietary interventions on body composition (abdominal fat components and quadriceps muscles) and cardiometabolic parameters.
- Conditions
- Abdominal Obesity, Cardiac Disease, Metabolic Disease, Cardiometabolic Syndrome
- Trial name
- NCT06320782
- Testing
- Calorie restriction and balanced distribution of macronutrients, Calorie restriction and low-carbohydrate diet, Calorie restriction and low-fat diet
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Obesity and Overweight, Insulin Resistance
New Mechanisms of Obesity
Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition.
- Conditions
- Obesity and Overweight, Insulin Resistance, Obesity and Obesity-related Medical Conditions
- Trial name
- NMoO (NCT06768827)
- Testing
- Lactulose Oral Product
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Yale University
Cardiovascular Diseases, Lipid Disorder
SRMA of the Effect of Soy Milk vs Cow's Milk on Cardiometabolic Outcomes
Dairy consumption has shown associations with decreased incidence of cardiometabolic diseases. With the growing interest in plant-based eating, and the mounting evidence for the cardiovascular benefits of plant forward diets…
- Conditions
- Cardiovascular Diseases, Lipid Disorder, Metabolic Disease, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT05637866
- Testing
- Soy milk
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Pediatric Obesity
Impact of Comprehensive Intervention on the Cardiometabolic Risk in Children With Central Obesity (IGENOI)Obesity
Central obesity, present in the metabolic syndrome (MS), is associated with increased risk of insulin resistance (RI). The aim of the project is to evaluate the protective effect of comprehensive intervention (Mediterranean diet…
- Trial name
- IGENOI (NCT03147261)
- Testing
- Lifestyle intervention
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Overweight Adults
Effects of a Sugar-Based Synbiotic Product on Cardiometabolic and Intestinal Health (SUGAR-SYN BC3O)
This randomized, double-blind, controlled, crossover study investigates the effects of a sugar-based synbiotic product containing inulin and Bacillus coagulans BC30™ spores in healthy overweight individuals.
- Trial name
- SUGAR-SYN BC3O (NCT07806383)
- Testing
- Sugar-Based Synbiotic Product, Inulin-Containing Sugar Product
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Cardiovascular Disease (CVD), Elevated Cardiovascular Risk
Sacha Inchi-CoQ10 Supplementation and Cardiovascular Health
The goal of this clinical trial is to learn if Sacha Inchi-CoQ10 supplementation can improve cardiovascular health in adults who have an increased risk of cardiovascular disease.
- Conditions
- Cardiovascular Disease (CVD), Elevated Cardiovascular Risk, Endothelial Dysfunction
- Trial name
- Sacha-Q10 (NCT07792005)
- Testing
- Sacha-Q10 Plus
- Volunteers
- 60 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Non-Alcoholic Fatty Liver Disease
Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD
This clinical trial aims to investigate the effects of TOTUM-448, a mix of 5 plant extracts and choline, consumed at the daily regimen of two times per day, on liver fat content, cardiometabolic risk factors and gut microbiota…
- Trial name
- CARDIO-LIVER (NCT06704321)
- Testing
- TOTUM-448
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Individual Variability in (Poly)Phenol Metabolism, Cardiometabolic Health
Precision Nutrition to Improve Cardiometabolic Health With Dietary (Poly)Phenols
This chronic study aims at assessing whether the effects of a personalized, plant-based diet rich in (poly)phenols on cardiometabolic health depend on the capability to metabolize dietary (poly)phenols, creating predictive models…
- Conditions
- Individual Variability in (Poly)Phenol Metabolism, Cardiometabolic Health, Personalized Dietary Intervention, Obesity
- Trial name
- PRE-CARE-DIET (NCT06347094)
- Testing
- Personalized Dietary Plan, Oral (Poly)phenol Challenge Test (OPCT), General Dietary Advice
- Where
- 2 sites in Italy
- Volunteers
- 330 people
- Sponsor
- University of Parma
Overweight , Obesity, Class I Obesity
Dietary Guidelines for Americans-Ultra Processed Study
The purpose of this research is to test how processing food can affect how one's body responds to it.
- Trial name
- DGA-UP (NCT07252037)
- Testing
- Low-processed DGA Diet, Ultra-processed DGA Diet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center