Clinical trials: Cardiopulmonary Diseases
Thromboses, Deep Vein, Tranexamic Acid Adverse Reaction
Dose Effect of Tranexamic Acid on the Incidence of Deep Venous Thrombus in Cardiac Surgery
In recent years, the lysine analogs tranexamic acid (TXA) has gained wide use in cardiac surgery as a blood-sparing agent. However, the safety of the drug and its impact on overall outcomes of cardiac surgery remains debated.
- Trial name
- NCT03838328
- Testing
- Tranexamic Acid
- Where
- China
- Volunteers
- 360 people
- Sponsor
- SHI Jia
Cardiopulmonary Resuscitation
Pulse Control Using USG and Manual Palpation Methods in Cardiopulmonary Resuscitation
The final approach adopted in Advanced Cardiac Life Support (ACLS) guidelines as defined by the American Heart Association (AHA) and the European Resuscitation Council (ERC) is to minimize the time between chest compressions in…
- Trial name
- NCT05557032
- Testing
- cardiopulmonary resuscitation
- Where
- Turkey (Türkiye)
- Volunteers
- 536 people
- Sponsor
- Izmir Katip Celebi University
Cardiovascular Disease
FEIBA and Use of Blood Products in Cardiac Surgery
The purpose of this pilot study is to evaluate the feasibility of the prophylactic administration of Factor VIII Inhibitor Bypass Activity (FEIBA) at termination of cardiopulmonary bypass (CPB) period.
- Trial name
- FEIBA (NCT02577614)
- Testing
- FEIBA, Normal Saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Oregon Health and Science University
Heart Failure, Cardiopulmonary Exercise Test
Aerobic Training and Cardiopulmonary Responses In Heart Failure
The goal of this observational study is to learn about the short-term effects of aerobic exercise in heart failure patients who were given exercise prescription with cardiopulmonary exercise stres test acocording to aerobic…
- Conditions
- Heart Failure, Cardiopulmonary Exercise Test, Aerobic Capacity, Aerobic Exercise
- Trial name
- NCT07128784
- Testing
- Aerobic exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Ankara City Hospital Bilkent
Congenital Heart Disease (CHD), Hypoxic Encephalopathy
Early Detection of Brain Injury After Congenital Heart Surgery in Infants
Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury.
- Trial name
- NCT07424976
- Testing
- Observational study: blood analisys, EEG, MRI
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Pulmonary Disease, Cardiac Disease
World Trade Center (WTC) CHEST
This project will evaluate the effects of World Trade Center (WTC) exposure in WTC responders 10-13 years following the events of 9/11.
- Conditions
- Pulmonary Disease, Cardiac Disease, Cardiopulmonary Disease, Obstructive Sleep Apnea
- Trial name
- NCT01466218
- Where
- United States
- Volunteers
- 1,012 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Atrial Fibrillation
Exercise Training to Atrial Fibrillation
To test the impacts of different exercise training programs to the cardiopulmonary function, muscle metabolism, and body mass composition
- Trial name
- ExAF (NCT04508478)
- Testing
- Aerobic training, Resistance training, Control physical exercise
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- National Taiwan University Hospital
Thoracic Surgery, Cardiopulmonary Bypass
Cerebral Autoregulation Monitoring During Cardiac Surgery
Neurological complications from cardiac surgery are an important source of operative mortality, prolonged hospitalization, health care expenditure, and impaired quality of life.
- Trial name
- NCT00981474
- Testing
- blood pressure maintenance based on cerebral blood flow autoregulation measurement, Control group
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Northwestern University
Adults With Cardiopulmonary Disease at Risk of Prolonged Weaning From Mechanical Ventilation
Neurally Adjusted Ventilatory Assist in Adults at Risk of Delayed Weaning From Mechanical Ventilation
Many patients admitted to intensive care have heart or lung problems. Patients with these conditions often require longer durations of support from breathing machines.
- Trial name
- RESTUS (NCT01826890)
- Testing
- NAVA Technology
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- King's College Hospital NHS Trust
Cardiac Arrest (CA)
Incidence of Colon Ischemia in Patients After Cardiopulmonary Resuscitation (CPR)
Bedside colonoscopy 24-36 hours after successful CPR
- Trial name
- NCT07359313
- Testing
- colonoscopy
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital Freiburg
Cardiovascular Diseases
Continuous Hemofiltration During Cardiopulmonary Bypass and Its Effect on Lactatemia
This study aims to analyze the impact of using polysulfone membranes on continuous ultrafiltration with volume replacement in patients undergoing cardiac surgery.
- Trial name
- CPB-LACTATE (NCT03412968)
- Testing
- Polysulfone Filter, Procedure/ Surgery: without Polysulfone Filter
- Where
- Spain
- Volunteers
- 76 people
- Sponsor
- University of Cadiz
Rural Health, Pulmonary Disease
Risk Underlying Rural Areas Longitudinal Cohort Study (RURAL) Heart and Lung Study
The University of Texas Health Science Center at San Antonio (UTHSCSA) will serve as the site for the RURAL Study Coordinating Center, led by PI Vasan Ramachandran, MD.
- Conditions
- Rural Health, Pulmonary Disease, Heart Diseases
- Trial name
- RURAL (NCT05006729)
- Where
- United States
- Volunteers
- 4,600 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Ischemic Heart Disease
Randomized Clinical Trial Comparing Coronary Bypass Grafting With or Without Cardiopulmonary Bypass
Coronary artery bypass grafting (CABG) is a well established treatment modality for patients with coronary artery disease. For 30 years now CABG operations have been performed with the help of the heart lung machine…
- Trial name
- NCT00216957
- Testing
- Coronary bypass surgery without cardiopulmonary bypass
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Maritime Heart Centre
Malignant Solid Tumour, Hematologic Malignancies
Assessing Physical Fitness in Cancer Patients With Cardiopulmonary Exercise Testing and Wearable Data Generation
The primary objective of this study is to assess the feasibility of a multi-institutional study that collects cardiopulmonary exercise testing and 6 minute walk distance performance testing prior to a cycle of chemotherapy (or…
- Conditions
- Malignant Solid Tumour, Hematologic Malignancies, Planned Hematopoietic Cell Transplantation
- Trial name
- NCT02786628
- Testing
- Physical performance testing and patient-generated health data
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Obstructive Sleep Apnea of Adult
Obstructive Sleep Apnea and Bronchoscopy
The prevalence of sleep-disordered breathing in Republic of Korea is 27% and 16% in men and women aged 40-69 years. Up to 93% of women and 82% of men with obstructive sleep apnea (OSA) remain undiagnosed.
- Trial name
- NCT03325153
- Where
- South Korea
- Volunteers
- 546 people
- Sponsor
- Seoul National University Hospital
Ischemia-Reperfusion Injury
Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Open Heart Surgery With Cardiopulmonary Bypass
About 200000 cardiac operations are performed in China every year. Cardiopulmonary bypass is the basic strategy of open-heart surgery, which may lead to myocardial ischemia-reperfusion injury and low cardiac output syndrome.
- Trial name
- NCT05598177
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Affiliated Hospital of Nantong University
Congenital Cardiovascular Defects, Low Cardiac Output Syndrome
Levosimendan in Congenital Cardiac Surgery
Many pediatric patients undergoing cardiac surgery under cardiopulmonary bypass for repair of complex congenital malformations, require inotropic support for low cardiac output syndrome.
- Trial name
- NCT00695929
- Testing
- Levosimendan, Milrinone
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Spinal Cord Injuries
Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury
Over the past ten years, the Cardiovascular Research Laboratory at Spaulding has refined a unique form of exercise for those with spinal cord injuries (SCI).
- Trial name
- NCT04458324
- Testing
- Buspirone Hydrochloride, Noninvasive Ventilation (NIV), Functional Electrical Stimulation Row Training (FESRT)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Spaulding Rehabilitation Hospital
Professional Burnout, Professional Stress
Impact of a Curriculum About Professionalism on Stress Response During a Critical Situation
The purpose of this study is to evaluate the impact of a curriculum about professionalism on stress response during a critical situation in anesthesiology residents.
- Conditions
- Professional Burnout, Professional Stress, Anesthesia, Medical Education
- Trial name
- NCT04192097
- Testing
- Professionalism curriculum
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Grenoble Alps
Congenital Heart Disease, Acute Kidney Injury
Nitric Oxide During CPB to Reduce AKI in Neonates
This is a prospective, randomized, double-blind, placebo-controlled pilot study to investigate whether supplemental Nitric Oxide (NO) gas delivered during cardiac surgery with cardiopulmonary bypass (CPB) reduces the incidence…
- Trial name
- NCT03946462
- Testing
- NO gas delivered during cardiac surgery
- Where
- United States
- Sponsor
- Fabio Savorgnan
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