Clinical trials: Cardiovascular Adaption
Hypoxia, Sleep Apnea
Intermittent Hypoxia 2: Cardiovascular and Metabolism
The purpose of this study is to compare cardiovascular physiological adaptation to intermittent hypoxia (IH) of nonobese healthy subjects. The exposure will be two periods of two weeks (IH versus exposure "placebo hypoxia").
- Conditions
- Hypoxia, Sleep Apnea, Obstructive Sleep Apnea
- Trial name
- IH2 (NCT02058823)
- Testing
- Valsartan, Amlodipine
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Exercise, Heat Strain
Effect of Exercise and Heat Stress on Acute Cardiometabolic Adaptations in Healthy Young Adults
Life in space is completely void of physical and environmental stress. It is well known that living things need regular physical stress (e.g. exercise) to remain strong, functional and healthy.
- Conditions
- Exercise, Heat Strain, Control Condition
- Trial name
- NCT06872762
- Testing
- Exercise, Heat strain
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Healthy, Stroke
Error-augmented Walking on Gait Performance and Brain Activities in Stroke
This three-year study is proposed to document the effect and further implementation of error-augmented walking on gait performance and brain activities in individuals with stroke.
- Trial name
- NCT04455334
- Testing
- Error-augmented treadmill training, active control group, Error-augmented concept combined physical therapy group
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pregnancy Related, Pregnant Women
Physical Exercise Cardiovascular Adaptation Monitoring in Pregnancy (PE-CAMP Study)
The main theme of this study focuses on providing evidence of the impact of antenatal physical activity on maternal/foetal cardiovascular changes during pregnancy and maternal cardiovascular adaptations during the early…
- Conditions
- Pregnancy Related, Pregnant Women, Maternal-Fetal Relations
- Trial name
- PE-CAMP (NCT03748888)
- Testing
- Exercise group
- Where
- United Kingdom
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Swansea University
Diabetes Mellitus, Type 2, Obesity
Culturally-Adapted Diet for Puerto Rican Adults
This pilot project will determine whether a diet culturally-adapted to Puerto Ricans can effectively decrease cardiometabolic risk for diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Hypertension, Dyslipidemias
- Trial name
- NCT03975556
- Testing
- Culturally tailored food and diet advice, Standard healthy eating advice
- Where
- Puerto Rico
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Stroke, Spinocerebellar Ataxia
Laryngeal Adaptation for Speech and Swallowing
This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6.
- Conditions
- Stroke, Spinocerebellar Ataxia, Cerebral Stroke, Dysphagia
- Trial name
- NCT03770377
- Testing
- Intermittent Perturbation to Continuous Perturbation, Continuous Perturbation to Intermittent Perturbation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Exercise
Importance of Blood Volume and Its Interaction With Cardiovascular Adaptations
The present project aims to investigate the interaction between training-induced blood volume expansion (plasma- and red blood cell volume responses), central as well as peripheral cardio-vascular adaptations.
- Trial name
- NCT05191979
- Testing
- Exercise regiment (aerobic exercise on bike)
- Where
- 2 sites in Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Stroke
Validation and Standardisation of a Pool of Simplified Evaluation Aimed to the Diagnoses of Aphasic Disorders and Adapted to the Patients Suffering an Acute Phase of Stroke
Every year in France, from 100 000 to 145 000 people are affected by a stroke. 75% patients survived with aftereffects, in particular aphasic disorders.
- Trial name
- BESTA-AVC (NCT02548481)
- Testing
- BESTA scale
- Where
- France
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Hypertension, Menopause
8 Weeks of L-CIT Supplementation and LIRET on Vascular Function in Hypertensive Postmenopausal Women
The overall objective of this project is to bring forth evidence that L-Citrulline (L-CIT) supplementation and low intensity resistance exercise training (LIRET) alone and combined will improve vascular function and muscle…
- Trial name
- NCT05227781
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Hypertension
Health Impacts of a Climate Change Adaptation Strategy to Address Drinking-water Salinity in Coastal Bangladesh
Background (brief): 1. Burden: Excessive salinity is common in groundwater aquifers across south-western coastal Bangladesh. Higher adult mean systolic and diastolic blood pressure and increased risk of gestational hypertension…
- Trial name
- NCT02746003
- Testing
- Managed Aquifer Recharge water
- Where
- Bangladesh
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Cardiovascular System
Vascular Adaptations to Single-Sprint Training
The long-term objective of this research line is to identify and implement an effective and feasible intervention capable of preventing and/or reducing the burden of cardiometabolic and obesity-related diseases that affect…
- Trial name
- VASST (NCT05727332)
- Testing
- Single-Sprint Training
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Mississippi, Oxford
Postmenopausal, Hypertension
Cardiovascular Adaptations to Resistance Exercise: Effect of Set Configuration on Postmenopausal Women
The main purpose of this project is to analyze the effect of set configuration of resistance exercise on cardiovascular responses and adaptations of postmenopausal women.
- Trial name
- CARE (NCT05544357)
- Testing
- Short set configuration resistance training, Long set configuration resistance training
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Spatial Neglect, Stroke
Transcranial Stimulation (tDCS) and Prism Adaptation in Spatial Neglect Rehabilitation
The present study aims to compare the relative therapeutic efficacy of prism adaptation therapy combined with real versus sham tDCS.
- Conditions
- Spatial Neglect, Stroke, Cerebrovascular Disorders, Cerebral Infarction
- Trial name
- NCT02080286
- Testing
- Prism Adaptation, Anodal tDCS
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Postexercise Hypotension
Histamine as a Molecular Transducer of Adaptation to Exercise
This study is investigating the role of histamine in generating adaptation to exercise
- Trial name
- NCT05206227
- Testing
- Aerobic Exercise, alpha-FMH, Resistance and Aerobic Exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Motor Learning and Physiological Adaptation
Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity
The aim of the study presented here is to assess the effects of exoskeleton training on performance in a real hypergravity situation.
- Trial name
- EGOS (NCT07278245)
- Testing
- Training with an exoskeleton
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Heart Diseases
Cross Cultural Adaptation of International Physical Activity Questionaire Short Form in Urdu Version
The IPAQ-SF scale is widely used in our clinical settings. The translated version of IPAQ-SF scale in Urdu will help the clinician in collecting data thus, easy to understand for the patient and making it more desirable in our…
- Trial name
- NCT04973865
- Testing
- Validation & reliability
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Transcranial Direct Current Stimulation, Ankle
Investigating the Effects of Transcranial Direct Current Stimulation to Different Brain Regions on Ankle Tracking Motor Learning, Motor Adaptation, and Brain Connectivity in Healthy Middle-aged and Older Adults and Patients With Subcortical Stroke
Ankle control is essential to safe over-ground navigation for humans. Middle- aged and older adults and patients with stroke whose ankle control is poor often lose their balance or fall.
- Conditions
- Transcranial Direct Current Stimulation, Ankle, Motor Learning, Adaptation
- Trial name
- tDCS (NCT06556043)
- Testing
- cM1 transcranial direct current stimulation, cPPC transcranial direct current stimulation, iCBM transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Postmenopausal, Hypertension
Cardiometabolic Adaptations to Concurrent Training: Effect of Effort Configuration on Postmenopausal Women
The main objectives of this project are to assess the effects of a 20-week concurrent training program on neuromuscular adaptations, body composition, cardiometabolic health, quality of life, mood state, physical self-perception…
- Trial name
- CARE+E (NCT07377383)
- Testing
- Concurrent Training Program
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Stroke, Frailty
Pilot of Cognitive Stimulation Therapy for Pre-frail Stroke Survivors
Frailty is described as a type of vulnerability where one can struggle to recover fully from things that can put stress on one\'s body, e.g., cold weather or bronchitis.
- Conditions
- Stroke, Frailty, Carers
- Trial name
- NCT06733103
- Testing
- Stroke Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Cardiovascular Fitness
SAQ Training Versus Small-Sided Games for Cardiovascular Adaptations in Youth Football Players
This randomized controlled trial aimed to compare the effects of Speed, Agility, and Quickness (SAQ) training and Small-Sided Games (SSGs) on cardiovascular adaptations in youth football players.
- Trial name
- SAQ-SSG (NCT07633210)
- Testing
- SAQ Training, Small-Sided Games Training
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Benha University