Clinical trials: Cardiovascular Biomarkers
Giant Cell Arteritis
Giant Cell Arteritis and PET Scan (GAPS) Study
Giant cell arteritis (GCA) is a medium to large vessel vasculitis with a predilection for the superficial cranial and intrathoracic arteries.
- Trial name
- NCT02771483
- Where
- Australia
- Volunteers
- 64 people
- Sponsor
- Royal North Shore Hospital
Diabetic Retinopathy (DR), Diabetic Macular Edema (DME)
Biomarkers in Diabetic Retinopathy Treated With Faricimab vs Biosimilar Ranibizumab
The goal of this clinical trial is to see if treatment with faricimab or biosimilar ranibizumab leads to different early imaging changes in adults with diabetic retinopathy requiring anti-VEGF treatment and to identify OCT and…
- Trial name
- NCT07520045
- Testing
- Faricimab, Biosimilar ranibizumab
- Where
- Croatia
- Volunteers
- 100 people
- Sponsor
- Osijek University Hospital
Carotid Artery Diseases
Biomarkers and Unstable Carotid Plaque
This prospective study investigated associations between circulating miRNAs and symptomatic and asymptomatic ICAS, carotid plaque morphology and future cardiovascular events.
- Trial name
- NCT06887894
- Testing
- Carotid endarterectomy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Myocardial Infarction
Inflammatory Response in Myocardial Infarction Evaluated by MRI and Biomarkers
An intense inflammatory reaction is triggered by the ischemic injury during myocardial infarction. The inflammatory processes involved are complex and haven't been explored in detail in human patients.
- Trial name
- RIFIFI (NCT02823886)
- Testing
- MRI at D7, Blood samples
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Women and Men Over 18 Years Old, AF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AF
Predictive Properties of Myocardial Fibrosis Biomarkers on the Outcome of Atrial Fibrillation Ablation
Atrial fibrillation (AF) is the most common cardiac arrhythmia. As an independent predictor of cardiovascular mortality, particularly for stroke, its management is a real public health issue.
- Conditions
- Women and Men Over 18 Years Old, AF Ablation (ECS recommendation2020&ACS2014) Either for Paroxysmal AF Unresponsive to Anti-arrhythmic Treatment Either for Persisting Symptomatic AF, Able to Give His Non Opposition to Participate to the Study
- Trial name
- PROFIB-AF (NCT05179902)
- Where
- France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Clermont-Ferrand
Preload-responsiveness
Is Mitral Velocity Time-integral a Marker of Preload-responsiveness in Patients With Acute Circulatory Failure?
The aim of this is to assess the reliability of the variability of the mitral velocity time-integral with passive leg raising to predict the fluid responsiveness in patients with acute circulatory failure in intensive care.
- Trial name
- NCT05538637
- Testing
- Echocardiography
- Where
- Morocco
- Volunteers
- 50 people
- Sponsor
- Avicenna Military Hospital
Stroke
Biomarkers Based EArly Diagnosis of STroke Subtype Cohort（Bio-EAST）
Intracerebral hemorrhage carries high rates of mortality and disability, imposes a significant societal burden. Based on findings from our previous multicenter randomized controlled clinical trial (INTERACT4), we revealed that…
- Trial name
- Bio-EAST (NCT07003477)
- Testing
- Detection of peripheral blood biomarkers
- Where
- China
- Volunteers
- 527 people
- Sponsor
- Shanghai East Hospital
Myocardial Diseases
Improved Detection of Myocardial Fibrosis: a Cardiovascular Magnetic Resonance Imaging Study
Myocardial fibrosis, or scarring, is a common endpoint in many cardiomyopathies and is associated with adverse outcomes, and precise tools to measure myocardial fibrosis are needed.
- Trial name
- NCT06697509
- Where
- Norway
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Akershus
Central Post-stroke Pain, Stroke
Motor Cortex Stimulation for Post-Stroke Thalamic Pain
The goal of this clinical trial is to investigate the mechanisms and predictive factors of motor cortex stimulation (MCS) for treating post-stroke thalamic pain, a challenging central neuropathic pain condition.
- Conditions
- Central Post-stroke Pain, Stroke, Electric Stimulation Therapy, Multimodal Imaging
- Trial name
- NCT07758829
- Testing
- Motor Cortex Stimulation (MCS) System
- Volunteers
- 200 people
- Sponsor
- Aerospace Center Hospital
Cardiotoxicity, Breast Cancer
Identification of Novel Inflammation-related Biomarkers for Early Detection of Anthracycline-induced Cardiotoxicity in Breast Cancer Patients
This study aims to identify possible set of inflammatory biomarkers before, during and after anthracycline-based chemotherapy in breast cancer patients to identify (sub)clinical chemotherapy-related cardiac dysfunctionCRCD to…
- Conditions
- Cardiotoxicity, Breast Cancer, Heart Failure
- Trial name
- NCT05298072
- Volunteers
- 180 people
- Sponsor
- University Hospital, Essen
Sepsis, Septic Shock
Cardiovascular Phenotypes in Sepsis
This prospective observational study will investigate cardiovascular phenotypes in adults with sepsis and hemodynamic instability.
- Conditions
- Sepsis, Septic Shock, Cardiovascular Dysfunction, Microcirculatory Dysfunction
- Trial name
- CaPS (NCT07442032)
- Volunteers
- 400 people
- Sponsor
- Karolinska Institutet
Atherosclerosis, Coronary Artery Disease
Imaging and Biomarkers of Atherosclerosis in Patients With Stable or Unstable Coronary Artery Disease
In this study, multimodal imaging of atherosclerosis and dosage of new circulating biomarkers will be used to compare patients with stable or unstable coronary artery disease
- Conditions
- Atherosclerosis, Coronary Artery Disease, Acute Coronary Syndrome
- Trial name
- BIOCORE-2 (NCT01186666)
- Testing
- Coronary intervention using IVUS-VH & FDG PET-MDCT
- Where
- France
- Volunteers
- 85 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cancer, Breast Cancer
Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors
This Phase 1/2 study evaluates the safety, feasibility, and preliminary anti-tumor activity of allogeneic donor-derived CAR-NK cells in participants with advanced solid tumors.
- Conditions
- Cancer, Breast Cancer, Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (Locally Advanced or Metastatic)
- Trial name
- SELECT-CAR-NK (NCT07410494)
- Testing
- EB-SELECT Single-Target CAR-NK Cells, Dual-Target Antigen-Selected CAR-NK
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Essen Biotech
Sleep Apnea Syndrome, Heart Failure
PRevalence, Persistence and prOgnostic ValuE of Sleep Apnea Syndrome in Acute Heart Failure
The prevalence of sleep-disordered breathing is common in patients with stable chronic heart failure (up to 83%). Basically, the SAS is divided into two categories: central SAS (CSAS) and obstructive SAS (OSAS).
- Trial name
- PROVE-SAS-AHF (NCT02317848)
- Testing
- polygraphy and ECG
- Where
- 4 sites in France
- Volunteers
- 54 people
- Sponsor
- French Cardiology Society
Cardiovascular Risk Factor
Evaluation and Comparison of Two Biomarkers (VOP and SCC) for the Prognosis of the Occurrence of Clinical Cardiovascular Events
The aim of our study is to assess the Cardiovascular risk and the quality of the arteries by comparing the Coronary Calcium Score SCC measured with a CT scann and the Pulse Wave Velocity PWV measured with pOpmeter for the…
- Trial name
- VOP-SCC (NCT04300738)
- Testing
- CCS wit CT Scann measurement
- Where
- France
- Volunteers
- 220 people
- Sponsor
- Clinique Bizet
Long QT Syndrome, Sleep Apnea
Long QT Syndrome and Sleep Apnea
Obstructive sleep apnea (OSA) has been associated with cardiac repolarization abnormalities and implicated in sudden cardiac death.
- Trial name
- NCT03678311
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- The Cleveland Clinic
Heart Failure
Effect of Genetic Polymorphism on the Clinical Outcome of Patients With Heart Failure
Heart failure (HF) is one the most common cause of hospitalization and represents the end stage of a variety of heart conditions; it is associated with significant morbidity and mortality.The pathophysiology of HF is centered on…
- Trial name
- SNPs (NCT03122834)
- Where
- Egypt
- Volunteers
- 246 people
- Sponsor
- Ain Shams University
Rheumatoid Arthritis, Cardiovascular Diseases
NSAIDs vs. Coxibs in the Presence of Aspirin
The objectives of this single site, randomized, crossover study is to evaluate the pharmacodynamic interactions between aspirin, NSAIDs and Coxibs with respect to platelet function, biomarkers of inflammation and endothelial…
- Trial name
- NCT03699293
- Testing
- celecoxib 200mg capsule, naproxen sodium 550mg tablet, Aspirin 81mg tablet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Platelet and Thrombosis Research, LLC
Pre-Eclampsia
Preeclamptic Patients and Pentraxin 3 & Lipoprotein-associated Phospholipase A2
In particular, pentraxine 3 (PTX3) molecule was assumed to have a prognostic value in acute myocardial infarction.In patients affected by acute myocardial infarction, early plasma elevation of PTX3 appears to predict a worse…
- Trial name
- NCT04239352
- Testing
- Pentraxin 3 ; new biomarker, Lipoprotein-associated phospholipase A2 ; new biomarker
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Prostate Cancer
Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy
GAIN PC CONTROL is a study investigating Glucagon-Like Peptide-1 Receptor Agonists in men with prostate cancer who are being treated with androgen deprivation therapy.
- Trial name
- GAINPCCONTROL (NCT06908694)
- Testing
- Semaglutide Pen Injector
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Hamilton Health Sciences Corporation
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