Clinical trials: Cardiovascular Biomarkers
Chronic Kidney Disease
Evaluation of Serum Klotho as a Predictor of Progression of Cardiovascular Calcification in Chronic Kidney Disease
This prospective observational study aims to investigate the relationship between CVC and serum Klotho for renal function correction in patients with different CKD stages
- Trial name
- NCT03996746
- Testing
- No intervention
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Stroke, Acute
Biological Dating of Cerebral Ischemia With GST-π/PRDX1 to Detect Patients With Stroke of Unknown Onset Within the Therapeutic Window of Thrombolysis
The FLAG1 study will assess the diagnostic performance of biomarkers Glutathion S-Transferase-π (GST-π) and Peroxyredoxin 1 (PRDX1) to identify cerebral infarction of less than 4,5 hours in a population of patients with…
- Trial name
- FLAG1 (NCT03364296)
- Testing
- Blood Samples
- Where
- 5 sites in France
- Volunteers
- 935 people
- Sponsor
- Central Hospital, Nancy, France
STEMI - ST Elevation Myocardial Infarction
Multicenter Cohort of STEMI Patients
Ischemic heart disease is the leading cause of mortality with 7.2 million of death in industrialized countries (WHO data). Myocardial infarction corresponding to acute occlusion of a coronary artery is the most brutal form and…
- Trial name
- HIBISCUS-STEMI (NCT03070496)
- Testing
- Blood sampling, ECG, MRI
- Where
- 3 sites in France
- Volunteers
- 281 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer Female, Heart Failure
Prevention of Cardiac Dysfunction During Breast Cancer Therapy
Breast cancer is the most common cancer among women. The modern post-surgery treatment with chemotherapy, immunotherapy, radiation and hormone therapy has improved the overall 5-years survival drastically.
- Trial name
- PRADAII (NCT03760588)
- Testing
- Sacubitril/valsartan
- Where
- 4 sites in Norway
- Volunteers
- 138 people
- Sponsor
- Torbjorn Omland
Pulmonary Embolism
Exploratory Metabolomics Study of Exhaled Breath in Pulmonary Embolism
Pulmonary embolism is a frequent and recurrent pathology, especially in the elderly. It is often preventable, with high mortality and morbidity, making it a major public health issue.
- Trial name
- MetabolAir (NCT04001179)
- Testing
- Pulmonary embolism diagnosis by nuclear medicine imaging
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Strasbourg, France
Circulatory Failure
NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy
1 in 1000 babies are born suffering from a lack of oxygen. This is known as hypoxic ischemic encephalopathy (HIE). Infants with this condition can suffer multiple organ problems.
- Trial name
- NCT02051894
- Testing
- Dobutamine
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Stroke, Cognitive Decline
Biomarkers Related to PSCI: An fNIRS Study
This is an fNIRS study performed to identify biomarkers related to post-stroke cognitive impairment.
- Trial name
- NCT06703307
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dingqun Bai
Atrial Fibrillation
Assess Safety, Efficacy and Usability of Application for Atrial Fibrillation Vocal Marker
Voice Assist Arrhythmia Monitoring (VAAM) is an application running on smartphones and/or landline phones that performs vocal tests for the monitoring of abnormalities in the heart rhythm.
- Trial name
- NCT04613544
- Testing
- Voice Assist Arrhythmia Monitoring (VAAM)
- Where
- 2 sites in Israel
- Volunteers
- 400 people
- Sponsor
- Cardiokol Ltd
Spatial Neglect, Stroke
A Biomarker for Personalized Care in Post-Stroke Spatial Neglect
More than 30,000 Veterans are hospitalized for stroke each year, and in the critical first months of recovery, at least half are disabled by abnormal 3-D spatial function (spatial neglect).
- Trial name
- NCT05256563
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Arteriosclerosis, Atherosclerosis
Early Detection of Arteriosclerosis
Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or…
- Conditions
- Arteriosclerosis, Atherosclerosis, Myocardial Infarction, Stroke
- Trial name
- NCT00863967
- Volunteers
- 269 people
- Sponsor
- Kantonsspital Baselland Bruderholz
Aortic Stenosis
Prediction of Long-term Outcome in Aortic Stenosis After Valve Intervention
Patients with severe aortic stenosis accepted for transcatheter intervention or open surgery are included before the intervention, and then followed up with clinical visits during the first year after intervention.
- Trial name
- NCT05629104
- Testing
- There is no intervention since it is an observational study patients are treated according to clinical praxis
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Uppsala University
Stroke, Stroke, Acute
PRecisiOn Medicine In StrokE: Evolution of Plasma Brain-Derived Tau in Acute Stroke
The investigators recently identified Brain-derived tau (BD-tau) as a sensitive blood-based biomarker for brain injury in acute ischemic stroke: in patients with acute ischemic stroke, plasma BD-tau was associated with…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic, Cerebrovascular Disorders
- Trial name
- PROMISE-BD-100 (NCT06121336)
- Testing
- Plasma levels of BD-tau
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Frail Elderly Syndrome, Coronary Heart Disease
Frailty Syndrome in Daily Practice of Interventional Cardiology Ward
The impact of frailty on immediate and long term outcomes of invasive treatment of coronary artery disease is not fully characterized.
- Conditions
- Frail Elderly Syndrome, Coronary Heart Disease, Acute Coronary Syndrome, Coronary Artery Bypass Grafting
- Trial name
- FRAPICA (NCT03209414)
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Silesia
Atrial Fibrillation
Hybrid Atrial Fibrillation Ablation Registry
Recently a combined approach of surgeon ablation in combination with endocardial ablation (hybrid ablation) has been introduced.
- Trial name
- NCT02516033
- Volunteers
- 250 people
- Sponsor
- University Medical Center Groningen
Alzheimer's Disease, Cerebrovascular Disease
Co-LEsions in Alzheimer Disease and Related Disorders
One of the crucial challenges for the future of Alzheimer's disease (AD) therapeutic approaches in elderly is to target the main pathological process responsible for disability and dependency.
- Conditions
- Alzheimer's Disease, Cerebrovascular Disease, Lewy Body Disease
- Trial name
- CLEM (NCT02052947)
- Testing
- SPECT-DaTscan
- Where
- France
- Volunteers
- 214 people
- Sponsor
- Hospices Civils de Lyon
Aortic Valve Stenosis, Hypertrophy, Left Ventricular
Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS
Aortic stenosis is the most common valvular disease in the Western world. It is caused by progressive narrowing of the aortic valve leading to increased strain on the heart muscle which has to work increasingly hard to pump blood…
- Trial name
- EVoLVeD (NCT03094143)
- Testing
- Aortic valve intervention
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Edinburgh
Heart Diseases, Heart; Functional Disturbance
The Protein Disrupted in Schizophrenia 1 (DISC1) as a Novel Biomarker for Cardiac Disease
To study the association between DISC1 RNA expression levels and cardiac function in patients with schizophrenia.
- Conditions
- Heart Diseases, Heart; Functional Disturbance, Schizophrenia
- Trial name
- NCT06304233
- Testing
- Echocardiography, Cardiac Magnetic Resonance Imaging, Electrocardiography
- Where
- 2 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Norwegian University of Science and Technology
Coronary Artery Disease
Coronary Artery Disease: a Case- Control Study
Atherosclerosis is a chronic inflammatory condition, which is associated by the involvement of several pathological events, and alteration in the serum levels of pro- and anti-inflammatory, and lipid markers.
- Trial name
- NCT03075566
- Testing
- Healthy subjects, Patients
- Where
- Tunisia
- Volunteers
- 517 people, healthy volunteers welcome
- Sponsor
- Nadia Bouzidi, PhD
Atrial Fibrillation, Coronary Artery Disease
Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients
The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures.
- Conditions
- Atrial Fibrillation, Coronary Artery Disease, Aortic Valve Stenosis, Aortic Valve Disease
- Trial name
- CAREBANK (NCT03444259)
- Testing
- Cardiac surgery
- Where
- Finland
- Volunteers
- 1,001 people
- Sponsor
- University of Turku
Cerebral Small Vessel Diseases, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Retina is a Marker for Cerebrovascular Heath
Cerebral small vessel disease (SVD), present in 80-94% of adults over age 65 years, increases the risk of stroke by 2-fold, and dementia by 2.3-fold. There is currently no treatment to slow SVD progression.
- Conditions
- Cerebral Small Vessel Diseases, Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy, Cerebral Microbleeding, Sporadic White Matter Disease
- Trial name
- NCT04753970
- Testing
- Cilostazol
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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