Clinical trials: Cardiovascular Complication
Infant, Premature, Anemia
Liberal Versus Restrictive Transfusion Guidelines for Preterm Infants
The purpose of this study was to determine whether restrictive guidelines for red blood cell (RBC) transfusions for preterm infants can reduce the number of transfusions without adverse consequences.
- Conditions
- Infant, Premature, Anemia, Intracranial Hemorrhages, Leukomalacia, Periventricular
- Trial name
- NCT00369005
- Testing
- Red blood cell transfusion guidelines
- Volunteers
- 100 people
- Sponsor
- University of Iowa
Diabetic Macular Edema, Diabetic Retinopathy
A Phase 2 Study of Intravitreal AVD-104 in Diabetic Macular Edema
A Phase 2 study to determine the safety and preliminary efficacy of intravitreal injections of AVD-104, a novel glyco-mimetic nanoparticle, in reducing macular edema associated with diabetic retinopathy.
- Trial name
- NCT06181227
- Testing
- AVD-104
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Aviceda Therapeutics, Inc.
Leg Ulcer, Venous Leg Ulcer
Time to Heal (Wound, Healing, Dialogue, Nutrition)
The objective of this study is to examine the feasibility, acceptability, fidelity, and outcome of a nurse-led nutritional intervention for patients with leg ulcers in a outpatient clinics.
- Conditions
- Leg Ulcer, Venous Leg Ulcer, Arterial Leg Ulcer, Foot Ulcer, Diabetic
- Trial name
- SNAK (NCT06255288)
- Testing
- SNAK intervention
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Hvidovre University Hospital
Retinopathy of Prematurity, Pain
The Effect of Eyemasks on Neonatal Stress Following Dilated Retinal Examination
Although screening exams for retinopathy of prematurity (ROP) prevent blindness they are physiologically stressful for infants. The investigators postulate that photosensitivity during mydriasis contributes to post-examination…
- Conditions
- Retinopathy of Prematurity, Pain, Premature Infant, Retinal Disease
- Trial name
- MASK-ROP (NCT03824782)
- Testing
- Phototherapy Mask
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Kidney Failure, Chronic
Arteriovenous Fistula Tissue Bank for Pre- and Post-Fistula Placement Specimens
This project will bank sera, DNA and vascular specimens from patients undergoing arteriovenous fistula creation and revision.
- Trial name
- NCT00836862
- Testing
- Biologic specimens
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Nebraska
Chronic Renal Failure, Arterial Stiffness
Arterial Stiffness, Wave Reflections and Renal Failure
1. Cardiovascular risk is high in patients with renal failure. 2. Cross-sectional studies have indicated a relationship between arterial stiffness and renal function.
- Conditions
- Chronic Renal Failure, Arterial Stiffness, Arterial Wave Reflections
- Trial name
- NCT00354588
- Where
- Austria
- Volunteers
- 115 people
- Sponsor
- Klinikum Wels-Grieskirchen
Negative-Pressure Wound Therapy, Diabetic Foot
Comparison Between Negative Pressure Wound Therapy and Conventional Wound Dressings Before and After Split-Thickness Skin Grafting in Diabetic Foot Wounds
The aim of this thesis is to compare the efficacy of Vacuum assisted closure device versus conventional dressing before and after split thickness skin grafting in diabetic foot wounds.
- Trial name
- NCT05716503
- Testing
- Negative Pressure Wound Therapy (NPWT), Ordinary dressings with antibiotic ointment and gauze
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Delirium, Ischemic Stroke
CTSN Embolic Protection Trial
This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.
- Conditions
- Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease
- Trial name
- EMPRO (NCT06027788)
- Testing
- CardioGard Embolic Protection Cannula, Standard Aortic Cannula
- Where
- 24 sites in United States, Canada
- Volunteers
- 842 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Breast Cancer, Leukemia
Doxorubicin Hydrochloride Liposome and Bortezomib in Treating Patients With Refractory Hematologic Cancer or Malignant Solid Tumor or Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as doxorubicin hydrochloride liposome, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Breast Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00237627
- Testing
- PS-341, Doxil, Velcade
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Peripheral Arterial Disease, Critical Limb-Threatening Ischemia
Peripheral Extreme Revascularization in "No-option" Patiens With Chronic Limb Threatening Ischemia
The objective of the study is to evaluate early safety and effectiveness of the percutaneous deep foot venous arterialization performed in clinical practice, in an unselected population of patients with "no-option" CLTI.
- Conditions
- Peripheral Arterial Disease, Critical Limb-Threatening Ischemia, Diabetic Foot
- Trial name
- PiPER (NCT06277362)
- Where
- 9 sites in Italy
- Volunteers
- 50 people
- Sponsor
- EndoCore Lab s.r.l.
Chronic Stable Angina, Vascular Dementia
The Effect of Danzhu Fuyuan Granule as Adjunctive Therapy for Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy: A Bayesian Basket Trial
This study is designed as a bayesian basket trial , which aims to evaluate the efficacy of Danzhu Fuyuan Granule in patients with Chronic Stable Angina, Vascular Dementia and Idiopathic Membranous Nephropathy
- Conditions
- Chronic Stable Angina, Vascular Dementia, Idiopathic Membranous Nephropathy
- Trial name
- NCT04498962
- Testing
- Danzhu Fuyuan Granule
- Where
- 7 sites in China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Jingqing Hu
Phlebitis, Catheter Complications
Peripheral IV Dressing and Phlebitis in Patients From Amazon
Pragmatic, randomized, single-blinded, controlled clinical trial of the effect of dressing and stabilization of peripheral intravenous catheters on the occurrence of phlebitis in adult patients attended at a hospital from the…
- Trial name
- IVDRESAMAZON (NCT04569474)
- Testing
- Transparent dressing
- Where
- 2 sites in Brazil
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Macular Edema, Diabetic
A Phase 2, Multi-Center Study To Compare The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist With Ranibizumab In Adults With Diabetic Macular Edema
The study hypothesis under test is that administration of the CCR2/5 antagonist has the potential to be as effective as the current treatment options for subjects with diabetic macular edema.
- Trial name
- NCT01994291
- Testing
- Ranibizumab, PF-04634817
- Where
- 63 sites in United States, Bulgaria and 7 more
- Volunteers
- 199 people
- Sponsor
- Pfizer
Diabetic Foot - Telemedical Monitoring, Diabetic
Virtual Reality-Based 'Health at My Feet' Program for Individuals With Type 2 Diabetes
This randomized controlled experimental study aims to develop and evaluate the effectiveness of a Virtual Reality-Based "Health to My Foot" program designed for individuals with Type II Diabetes Mellitus.
- Conditions
- Diabetic Foot - Telemedical Monitoring, Diabetic, Foot Care, Virtual Reality
- Trial name
- NCT07473050
- Testing
- "Health for My Feet" virtual reality program.
- Volunteers
- 70 people
- Sponsor
- Ege University
Vascular Diseases, Stent Complication
Eluvia DES for the Patients with Femoropopliteal Artery Lesions.
This study is a multicenter, prospective, observational study, aiming to enroll 400 patients with peripheral arterial disease in the femoral-popliteal segment implanted with Eluvia stent. Each patient was followed up for 2 years.
- Trial name
- NCT05522218
- Testing
- Eluvia drug eluting stent
- Where
- China
- Volunteers
- 400 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Arrhythmias, Cardiac, Breast Cancer
LEARN: Learning Environment for Artificial Intelligence in Radiotherapy New Technology
This study will develop a whole-of-body markerless tracking method for measuring the motion of the tumour and surrounding organs during radiation therapy to enable real-time image guidance.
- Conditions
- Arrhythmias, Cardiac, Breast Cancer, Prostatic Cancer, Brain Cancer
- Trial name
- LEARN (NCT05184790)
- Where
- 4 sites in Australia
- Volunteers
- 300 people
- Sponsor
- University of Sydney
Vascular Complications, Vascular Stiffness
Cardiovascular Effects of Chronic Snus Use
The current study proposes to investigate the effects of chronic snus use on the blood vessels. Several cardiovascular endpoints are measured using various methods in healthy daily snus users as well as in healthy matched…
- Conditions
- Vascular Complications, Vascular Stiffness, Tobacco Dependence
- Trial name
- CHROS (NCT02564289)
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Umeå University
Diabetic Foot, Leg Ulcer
Obtaining and Storing Standard of Care Wound Biopsies for Immediate or Future Wound-Related Scientific Study
The objective of this study protocol is to use wound biopsies that have been obtained during standard of care management for further scientific evaluation after standard evaluation by a pathologist.
- Conditions
- Diabetic Foot, Leg Ulcer, Decubitus Ulcer
- Trial name
- NCT00759889
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Southwest Regional Wound Care Center
Chronic Kidney Disease; End-Stage Renal Disease; Hemodialysis; Pain; Anxiety
Deep Breathing Relaxation and Lemongrass Aromatherapy on Pain
This randomized controlled trial aims to evaluate the effect of deep breathing relaxation combined with lemongrass aromatherapy on pain during arteriovenous fistula needle insertion and anxiety in hemodialysis patients.
- Trial name
- NCT07825974
- Testing
- Deep Breathing Relaxation, Lemongrass Aromatherapy
- Where
- Iraq
- Volunteers
- 190 people
- Sponsor
- University of Baghdad
Diabetes, Retinopathy
Telemedicine Retinal Screening Utilizing a Mobile Medical Unit
Objective: To test the accuracy of a referral system for diabetic eye disease conducted by a trained screener using a digital camera, a mobile medical unit and a centralized image-storing software in underserved, ethnically…
- Trial name
- NCT01412905
- Where
- United States
- Volunteers
- 1,229 people
- Sponsor
- Scripps Whittier Diabetes Institute