Clinical trials: Cardiovascular Condition
Hypertension
Early-warning Intervention for Heat and Cold in Older Hypertensive Patients: Impact on Blood Pressure and ECG
This cluster-randomized trial, conducted in Tianjin, China, aims to evaluate the effectiveness of integrating a digital health risk early warning tool for heat with self-monitoring.
- Trial name
- NCT06011213
- Testing
- Issuing health risk warning for a heat waves or cold spells, A digital heat or cold health risk early warning tool, Self-monitoring blood pressure and ECG device
- Where
- China
- Volunteers
- 342 people, healthy volunteers welcome
- Sponsor
- Tiantian Li
Hypertension, Renal Insufficiency, Chronic
Evaluation of an Electronic CKD Clinical Decision Support System (CDSS) in Clinical Care
The investigators propose a three-arm, pragmatic, cluster-randomized clinical trial based in primary care. Participating Primary Care Providers (PCPs) will be randomized to usual care or one of two intervention arms.
- Trial name
- CDSSR18 (NCT02925962)
- Testing
- Clinical Decision Support System (CDSS), Clinic Decision Sup System + Pharmacist
- Where
- United States
- Volunteers
- 542 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypothermia
Study of Heat and Intravenous Fluids for Exogenous Rewarming
The purpose of this study is to compare two novel active rewarming techniques in mildly hypothermic people. Volunteers will undergo 3 cooling trials in a circulating bath at 14 degrees celsius and will then be rewarmed with…
- Trial name
- SHIVER (NCT02339103)
- Testing
- Warmed IV fluids, Warmed perfusion pads
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Stanford University
Intubation, Cardiac Arrest
Pediatric Intubation
The aim of the study was to compare time and success rates of TruView PCD video laryngoscope and Macintosh laryngoscope for the pediatric emergency intubation with three airway scenarios in a standardized manikin model.
- Trial name
- ETICPR (NCT02289872)
- Testing
- Macintosh Laryngoscope, TruView PCD Video laryngoscope
- Where
- Poland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes
Type 1 Diabetes Autonomic and Vascular Function
The goal of this clinical trial is to investigate the autonomic and vascular function in men and women with Type 1 diabetes. The main questions it aims to answer are: 1.
- Conditions
- Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes, Diabetes, Autoimmune
- Trial name
- NCT06786546
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Turner Syndrome, Klinefelter Syndrome
X-chromosome Inactivation, Epigenetics and the Transcriptome
The human genetic material consists of 46 chromosomes of which two are sex chromosomes. The sex-chromosome from the mother is the X and from the father the Y-chromosome.
- Conditions
- Turner Syndrome, Klinefelter Syndrome, Triple X Syndrome, 47 XYY Syndrome
- Trial name
- NCT01678261
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypertension
Implementation of a Beauty Salon-Based Strategy for Blood Pressure Management Among Women
CROWN is a two-arm, cluster-randomized pilot trial testing the feasibility and preliminary efficacy of a salon-based cardiovascular intervention - training stylists as Heart Health Stylists to conduct in-salon blood pressure…
- Trial name
- CROWN (NCT07042386)
- Testing
- CROWN Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Heart Failure Risk Factors in Healthy Individuals
Cleveland Heart and Metabolic Prevention Study
The purpose of this research study is to investigate the role of chemical reactions, such as inflammation and oxidation, in the cause of cardiac dysfunction (the heart does not function properly).
- Trial name
- CHAMPS (NCT03012022)
- Where
- United States
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Fitness Trackers, Sedentary Time
Fullscale_Intervention Study: Genetic Risk Communication in Coronary Heart Disease and Wearables
Background: This study aims to determine the effects of communicating genetic risk for Coronary Heart Disease (CHD) alone or in combination with goal setting and prompts from a wearable device on objectively measured sedentary…
- Conditions
- Fitness Trackers, Sedentary Time, Genetic Predisposition to Disease, Coronary Heart Disease
- Trial name
- NCT05789966
- Testing
- Genetic Risk Estimate+Health Coaching, Genetic Risk Estimate + Fitbit Functions+Health Coaching
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Venous Thrombosis
Switching Study From Warfarin to Rivaroxaban
The study objective is to investigate the pharmacodynamics (effects of a drug product) when switching the treatment from warfarin to rivaroxaban.
- Trial name
- NCT01507051
- Testing
- Warfarin (Coumadin), Rivaroxaban (Xarelto, BAY59-7939), Vitamin K (Konakion)
- Where
- 2 sites in Germany
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Bayer
Cerebrovascular Accident
Focus of Attention in Individuals With Stroke
This two phase feasibility study looked at the feasibility of conducting a clinical trial in the outpatient and inpatient rehab setting exploring how individuals post stroke respond to different focus of attention cues.
- Trial name
- NCT04696302
- Testing
- Focus of attention
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Western Carolina University
Hypertension
The Effect of a Targeted Video Intervention on Beliefs Regarding Hypertension
Researchers have linked media messages such as television programs to multiple problematic health behaviors. The narrative style of many television programs-involving a plot, recurrent characters, entertaining situations, and…
- Trial name
- NCT01411956
- Testing
- 24-minute video episode of patient education TV sitcom "White Coats"
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Cardiac Arrest
Instruction to Compress Chest Approximately 6-7cm for Healthcare Provider in Hospital
Unlikely the other element for high quality chest compression during Cardiopulmonary resuscitation(i.e. compression rate, chest recoil, hand position), chest compression depth (CCD) is influenced by surface on which the patient…
- Trial name
- NCT01936402
- Testing
- Education of chest compression depth
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Jaehoon Oh
Cardiovascular Diseases, Coronary Disease
Lifetime Risk for Cardiovascular Disease Among Non-White Ethnic Groups
Cardiovascular disease (CVD) is one of the leading causes of death in the United States. Currently, there is little information about the lifetime risk of CVD among non-white ethnic groups.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Failure, Congestive, Atrial Fibrillation
- Trial name
- NCT00377702
- Where
- United States
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Myocarditis, Pericarditis
COVID-19 Vaccine-induced Inflammatory Heart Disease Prevalence Registry
Myocarditis and pericarditis are inflammatory diseases of the myocardium and pericardium, and can be related to different causes, including vaccines.
- Trial name
- COVID-VIHPR (NCT05046002)
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Premature Ventricular Contraction (PVC)
Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions
Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine.
- Trial name
- NCT03218137
- Testing
- Adenosine
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Brain Aneurysm
Current Treatment Modalities for Wide Necked Intracranial Aneurysms
Give an effective treatment for intracranial wide necked aneurysm and can detect the best method could be used. Improve the outcome of these patients and decease rate of recurrence and complications.
- Trial name
- NCT03852680
- Testing
- aneurysm clipping
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rare Diseases, Thoracic Aortic Aneurysm (TAA)
Fibroblasts and Thoracic Aortic Aneurysms: in Vitro Characterization in With Marfan Syndrome and Genetic Aortic Diseases
The aim of the present study is to characterise the phenotype of fibroblasts and to classify different mechanisms involved in the onset and progression of TAAD in syndromic and non-syndromic subjects in order to evaluate…
- Conditions
- Rare Diseases, Thoracic Aortic Aneurysm (TAA), Marfan Syndrome
- Trial name
- FIBRA (NCT06786754)
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Cardiovascular Diseases, Hypertension
The African-PREDICT Study
The African-PREDICT study aims to (i) generate new knowledge on the early pathophysiology accompanying hypertension development in black South Africans; and (ii) to identify early novel markers or predictors for the development…
- Conditions
- Cardiovascular Diseases, Hypertension, Health Risk Behaviors, Arterial Stiffness
- Trial name
- PREDICT (NCT03292094)
- Where
- South Africa
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- North-West University, South Africa
Healthy
Trial to Assess the Effects of Different Trans-fatty Acids on Endothelial Function in Humans
The aim of the study is to compare a diet rich in trans fatty acids (TFA) from ruminant sources with a diet rich in TFA from hydrogenated vegetable oils (PHVO) in regard to their effects on cardiovascular risk markers…
- Trial name
- NCT00933322
- Testing
- diet enriched with industrial trans fatty acids, diet enriched with ruminant trans fatty acids, diet without any trans fatty acids
- Where
- Switzerland
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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