Clinical trials: Cardiovascular Disease (CVD)
Vitreous Detachment, Diabetic Retinopathy
Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment
The purpose of this study is to assess the efficacy of intravitreous injections of Vitrase to induce posterior vitreous detachment(PVD) in subjects with moderate to severe non-proliferative diabetic retinopathy.
- Trial name
- NCT00198471
- Testing
- Vitrase
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Bausch & Lomb Incorporated
Left Main Coronary Artery Disease
Functional Diagnostic Accuracy of Ultrasonic Flow Ratio in Assessment of Left Main Coronary Artery Stenosis
This is a prospective, observational, single-center study. The main purpose of this study is to evaluate the diagnostic accuracy of offline computational ultrasonic flow ratio (UFR) in predicting functionally significant left…
- Trial name
- FUNCTION II (NCT06053944)
- Testing
- fractional flow reserve (FFR); ultrasonic flow ratio (UFR); intravascular ultrasound (IVUS)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- China National Center for Cardiovascular Diseases
Stroke
Sensory Stimulation to Enhance Hand Function Post Stroke
The objective of this pilot project is to assess the impact of the novel sensory stimulation technique the investigators have developed in enhancing outcomes of hand therapy as well as the central nervous system responsiveness in…
- Trial name
- NCT02675764
- Testing
- Vibration, therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical University of South Carolina
Stroke Syndrome, Hemiplegia
Effects of Virtual Reality Based Rehabilitation in Acute Stroke Patients in an Inpatient Rehab Setting
To evaluate the effects of virtual reality-based rehabilitation (Neofect Glove) for newly diagnosed cognitively intact adult dominant hemisphere stroke patients with paresis of their hand in supplementation with conventional…
- Trial name
- NCT03039764
- Testing
- Rapael
- Where
- United States
- Sponsor
- Montefiore Medical Center
Stroke
RIsk of Apoplexia Cerebri in CLOpidogrel Non-responders
Stroke patients are given prophylactic treatment with clopidogrel to prevent new strokes. Some of these patients (the investigators don't know precisely how many, but previous studies indicate 4-34%) are so called non-responders…
- Trial name
- RISCLON (NCT02093299)
- Testing
- Clopidogrel
- Where
- Denmark
- Volunteers
- 165 people
- Sponsor
- Zealand University Hospital
Long QT Syndrome
Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults
This study will evaluate the effect of oral GS-6615 on QTc interval in healthy adults with dofetilide-induced QTc prolongation.
- Trial name
- NCT02365532
- Testing
- GS-6615, Dofetilide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Diabetes, Hypertension
Fresh Start Experiment
The investigators are proposing an experiment to help Humana investigate when to launch programs or send messages that are designed to improve customers' engagement.
- Trial name
- NCT02411032
- Testing
- Reminder, Fresh start, Fresh start framing
- Where
- United States
- Volunteers
- 13,323 people
- Sponsor
- University of Pennsylvania
Stroke
Effect of SynPhNe Physio-neuro Platform on Hand Motor Function Rehabilitation of Acute and Subacute Stroke Patients
Stroke is a major cause of adult long term disability and the fourth leading cause of death and affects 1·8/1000 persons in Singapore.
- Trial name
- NCT05133232
- Testing
- SynPhNe physio-neuro platform
- Where
- Singapore
- Volunteers
- 51 people
- Sponsor
- National University Hospital, Singapore
Atrial Fibrillation
Safety Study on Stopping Anticoagulation Medication in Patients With a History of Atrial Fibrillation
The purpose of this study is to determine whether it is safe to stop anticoagulation medication in patients with a history of atrial fibrillation (AF) based on information from a pacemaker or implantable cardioverter…
- Trial name
- TACTIC AF (NCT01650298)
- Testing
- Drug (Direct thrombin or Factor Xa inhibitor)
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- Abbott Medical Devices
Coronary Artery Disease
xSPECT-based Myocardial Perfusion Scintigraphy: Consistency of Functional Values and Feasibility of Myocardial Uptake Quantitation in Patients With Suspected Coronary Artery Disease
This study is to evaluate the feasibility of myocardial Standardized Uptake Volume (SUV) assessment by means of X- (Single photon emission tomography) SPECT/Computed tomography (CT), to assess normal reference value under rest…
- Trial name
- xSPECT MPI (NCT04583787)
- Testing
- 99mTc-sestamibi myocardial perfusion SPECT, 82Rb-Chloride myocardial perfusion PET with CCTA
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- University Hospital, Basel, Switzerland
Diabetes, Depression
e-Pharmacovigilance II - Surveillance for Safety and Effectiveness - Calling for Earlier Detection of Adverse Reactions
Specific Aim 1: To develop a patient-reported, EHR-integrated system to actively monitor the safety and effectiveness of treatment for patients taking FDA-approved medications for one of four common chronic conditions (diabetes…
- Conditions
- Diabetes, Depression, Insomnia, Hypertension
- Trial name
- CEDAR (NCT02087293)
- Testing
- Intervention arm - automated call and phone-based pharmacist counseling
- Where
- United States
- Volunteers
- 38,400 people
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Diseases
Effects of the Mediterranean Diet on Cardiovascular Risk Profile in Men and Women (ALIMED)-Part 2
The purpose of this study is to document differences between men and women (referred here as gender differences) in diet adherence and in changes in specific dietary intakes and energy density in response to a 12-week nutritional…
- Trial name
- NCT01852721
- Testing
- Experimental: Men and Mediterranean diet, Experimental: Women and Mediterranean diet
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- Laval University
Hypomagnesemia, Coagulopathy
Association Between Hypomagnesemia and Coagulopathy in Sepsis
This study aimed to investigate the association between hypomagnesemia and coagulopathy in patients with sepsis, with a focus on evaluating whether low serum magnesium levels are independently linked to the development of…
- Conditions
- Hypomagnesemia, Coagulopathy, Sepsis
- Trial name
- NCT07576621
- Testing
- Serum magnesium concentration
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Cardiovascular Diseases
Evaluation of Energy Drinks on Electrocardiographic, Vascular and Hematologic Parameters in Healthy Volunteers
This study will determine the cardiovascular effects of energy drink consumption in healthy individuals through electrocardiogram (ECG), central blood pressure assessment, and ROTEM® analysis.
- Trial name
- NCT03021616
- Testing
- energy drink, Moxifloxacin 400mg
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Stroke, Blood Pressure
Community Stroke Self-management Program
This pilot project aims develop a need-based community stroke self-management program that would improve the stroke self-management self-efficacy and competencies among African American stroke survivors living in rural Alabama.
- Trial name
- NCT06251128
- Testing
- Stroke Self management Program
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama, Tuscaloosa
Multiple Myeloma
Effects of Daratumumab Monotherapy on Bone Parameters in Patients With Relapsed and /or Refractory Multiple Myeloma
The purpose of this study is to evaluate the effects of daratumumab monotherapy on bone disease in patients with relapsed/refractory MM who have received at least 2 prior lines of therapy, including lenalidomide and a PI.
- Trial name
- REBUILD (NCT03475628)
- Testing
- Daratumumab
- Where
- Greece
- Volunteers
- 57 people
- Sponsor
- Hellenic Society of Hematology
Coronary Artery Disease
MCG Algorithm Optimization Study in Patients With Coronary Artery Stenosis
This prospective, multicenter study aims to optimize the Magnetocardiography (MCG) algorithm for detecting myocardial ischemia in patients with coronary artery stenosis.
- Trial name
- NCT07888465
- Volunteers
- 165 people
- Sponsor
- AMCG
Heart Failure
SUSTAIN-IT: Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support?
The purpose of this study is to compare health-related quality of life (HRQOL) outcomes in older (60-80 years) advanced heart failure (HF) patients who undergo heart transplantation (HT) or mechanical circulatory support (MCS) as…
- Trial name
- SUSTAIN-IT (NCT02568930)
- Where
- 13 sites in United States
- Volunteers
- 694 people
- Sponsor
- Northwestern University
Atrial Fibrillation
Atrial Fibrillation Recurrence After Cryoballoon Ablation
The purpose of the study is to evaluate the mechanisms of recurrent atrial fibrillation after cryoballoon ablation using the Arctic Front Ablation System.
- Trial name
- NCT01772030
- Testing
- Use of the Achieve catheter followed by ICE-guided mapping catheter
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
Heart Failure With Reduced Ejection Fraction
Dashboard Activated Services and Tele-Health for Heart Failure
The Dashboard Activated Services and tele-Health for Heart Failure (DASH-HF) study is a pragmatic randomized controlled trial of a quality improvement (QI) intervention of a prospective panel management intervention to optimize…
- Trial name
- DASH-HF (NCT05001165)
- Testing
- Proactive Panel Management Clinics for HFrEF
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- VA Greater Los Angeles Healthcare System
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