Clinical trials: Cardiovascular Disease Risk Factors
Cardiovascular Risk Factor
Effect of a Low Calorie Diet Containing Nuts on Systemic and Vascular Inflammation
Accumulating evidence from prospective observational studies and a large clinical trial suggests that nut intake lowers the risk of cardiovascular disease (CVD).
- Trial name
- NCT04078919
- Testing
- Nut consumption, Low calorie diet
- Where
- Iran
- Volunteers
- 67 people
- Sponsor
- Shahid Beheshti University
Psoriasis, Inflammation
A Proof-of-Activity Study With Orticumab in Subjects With Psoriasis and Cardiometabolic Risk Factors
The primary purpose of this proof-of-activity, phase 2 trial is to evaluate the safety and activity of orticumab in subjects with moderate to severe psoriasis and cardiometabolic risk factors.
- Conditions
- Psoriasis, Inflammation, Coronary Artery Disease, Cardiometabolic Syndrome
- Trial name
- NCT04776629
- Testing
- Orticumab
- Where
- 13 sites in United States
- Volunteers
- 77 people
- Sponsor
- Abcentra
PTSD, Cardiovascular Disease
Lifestyle and Cardiometabolic Risk in Post-9/11 Veterans
Heart disease and diabetes are leading causes of death and disability in the US, especially among Veterans. Posttraumatic stress disorder (PTSD) is a disabling condition that also affects many Veterans.
- Conditions
- PTSD, Cardiovascular Disease, Metabolic Syndrome
- Trial name
- NCT04911153
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cardiovascular Risk Factor, Cardiovascular Diseases
VOPITB a New Devices to Determine Peripheral Arterial Stiffness: Validation Study
Our group has developed a device called "Velocidad Onda de Pulso Indice Tobillo Brazo (VOPITB)" . In this device the oscillometric method is used for easily and accurately measure the pulse wave velocity PWV in the arms and legs…
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Atherosclerosis of Artery
- Trial name
- NCT04303546
- Testing
- arterial stiffness measurements
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Hypertension in Type 2 Diabetes, Diabetes Mellitus Type 2
The SWITCH (Substitution of High With Low Ultra-processed Soy Protein Foods In a Guideline-based Diet inTervention for Cardiometabolic Health) Trial
This is a randomized, controlled, parallel study with 3 experimental arms aimed to assess the effect of a digital dietary intervention (web-based app, online behavior change curriculum) enhanced with 10 servings of vegetables and…
- Conditions
- Hypertension in Type 2 Diabetes, Diabetes Mellitus Type 2, Dyslipidemia, Hypertension
- Trial name
- SWITCH (NCT06907862)
- Testing
- Reference Treatment, Control, Active Treatment
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University of Toronto
Atrial Fibrillation, Heart Failure
A CALIBER Study: Risk Factors for Stroke, Heart Failure, and Myocardial Infarction in Atrial Fibrillation
We aim to investigate the prognosis of patients diagnosed with AF, particularly in relation to the development of subsequent stroke, heart failure, and myocardial infarction.
- Conditions
- Atrial Fibrillation, Heart Failure, Stroke, Myocardial Infarction
- Trial name
- NCT01944397
- Where
- United Kingdom
- Volunteers
- 125,000 people, healthy volunteers welcome
- Sponsor
- University College, London
Cannabis, Cardiovascular Risk Factor
Cannabis Inhalation: Effects on Cardiovascular Function During Rest and Exercise
This two-phase project seeks to examine the cardiovascular response to consumption of cannabis variants of different cannabinoid composition through different methods (smoking vs. vaporizing), at rest and during aerobic exercise.
- Trial name
- NCT04693884
- Testing
- Cannabis
- Where
- Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Jamie Burr
Aneurism
Genetic Profile In Patients With Ruptured and Unruptured Intracranial Aneurysms
The project will involve multiple units within our Institute (Neurosurgery, Cerebrovascular Diseases, Neurology IV), as well as additional neurosurgical centers across Italy, for the enrollment of patients with saccular…
- Trial name
- ANEUBIO (NCT07233915)
- Where
- Italy
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Peripheral Artery Disease
Self Selected Exercise Intensity in PAD Patients
Although the benefits of supervised walking training in patients with peripheral arterial disease (PAD) and symptoms of intermittent claudication (IC) are well established, one of the main problems found in this type of protocol…
- Trial name
- NCT04333615
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Nove de Julho
Adrenal Incidentalomas
Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas
The general objective is to evaluate the consequences of surgical removal of SCSI on hypertension and cardiovascular risk factors in order to determine on an evidence-based basis if surgical excision of SCSI is preferable to an…
- Trial name
- CHIRACIC (NCT02364089)
- Testing
- Laparoscopic surgical removal of the adrenal tumor, Standardized medical treatment of hypertension by SAHR
- Where
- 17 sites in France, Germany and 1 more
- Volunteers
- 78 people
- Sponsor
- University Hospital, Bordeaux
Hyperlipidemias, Overweight and Obesity
Pilot Study on the Effects of a Plant-Strong Diet on Cardiovascular Risk Factors
The purpose of this study is to conduct a preliminary test of the effectiveness of various educational interventions to promote adoption of a whole-food, plant-strong diet and reduce specific cardiovascular risk factors in…
- Conditions
- Hyperlipidemias, Overweight and Obesity, Diabetes
- Trial name
- NCT03330548
- Testing
- TeleMOVE!, Culinary Rx
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Phoenix VA Health Care System
Healthy
Sodium vs Potassium Education to Improve Vascular Health
The goal of this clinical trial is to determine if a self-selected high potassium diet is easier to achieve and more effective at improving vascular health than a low sodium diet in generally healthy young adults who typically…
- Trial name
- NCT07221448
- Testing
- High potassium dietary education/counseling, Low sodium dietary education/counseling
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Florida State University
Coronary Disease, Coronary Syndrome
Prognostic Accuracy of the HEART Score in Undifferentiated Chest Pain: A Multicenter Validation Study
Chest pain remains one of the most common, potentially serious presenting complaints for adults emergency department visits with approximately 7.6 million yearly visits in the united states.
- Conditions
- Coronary Disease, Coronary Syndrome, Risk Factor, Cardiovascular, Major Adverse Cardiovascular Events
- Trial name
- NCT04580017
- Where
- 3 sites in Tunisia
- Volunteers
- 4,267 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Diet Modification, Cardiovascular Risk Factor
Bioavailability and Beneficial Properties of Coffee and Cocoa Bioactive Compounds
The aim of this study will be to define the bioavailability and the beneficial properties of coffee bioactive compounds. Moreover, the contribution of cocoa-based products containing coffee to the pool of circulating metabolites…
- Conditions
- Diet Modification, Cardiovascular Risk Factor, Nutritional and Metabolic Diseases
- Trial name
- P4L (NCT03166540)
- Testing
- cup of espresso coffee, cocoa-based products containing coffee
- Where
- Italy
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Parma
Discrete Coronary Artery Stenosis, Coronary Angiography of Multiple Detectors
Implications of the Presence of Non-obstructive Atherosclerotic Plaques on Platelet and Vascular Reactivity
Approximately 50% of coronary events occur in previously asymptomatic patients. Thus, the early detection of the individuals at higher risk became an important research target within the current cardiology.
- Conditions
- Discrete Coronary Artery Stenosis, Coronary Angiography of Multiple Detectors, Platelet Aggregation, Spontaneous, Cardiovascular Risk Factor
- Trial name
- NCT03632785
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- University of Sao Paulo
Cardiovascular Diseases
Aorta Calcium Scoring
Calcium scoring of the coronary arteries is use as a predictor of coronary stenosis. The aim of this study is to measure the calcium scoring of the abdominal aorta using an helicoidal fast scan and to correlate this measurement…
- Trial name
- NCT00496717
- Testing
- Helicoidal fast scann
- Where
- 2 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Gastrointestinal Hemorrhage, Cardiovascular Diseases
Study of the Risk Factors and Outcomes After Gastrointestinal Bleeding
The purpose of this multicenter, two component observational and standardized case-control study is to evaluate risk factors of gastrointestinal (GI) bleeding with a prospective 3-month and 12-month follow-up to examine outcomes…
- Trial name
- NCT02514304
- Where
- Canada
- Volunteers
- 4,745 people
- Sponsor
- Population Health Research Institute
Diabetes Mellitus, Type 2, Cardiovascular Risk Factor
The Effect of Different States of Lipid in Food on Glycaemia, Lipaemia and Insulinaemia.
The aim of this study is to investigate if the application of lipid in various form (i.e. liquid and solid) affects glycaemia, lipaemia and insulinaemia.
- Trial name
- NCT04115592
- Testing
- Cocoa butter, Cocoa butter oleogel, Sal seed oil
- Where
- Singapore
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Food and Biotechnology Innovation
Cardiovascular Diseases
Broccoli and Vascular Health Study
The participants of this study will be men \& women ≥50 years who are deemed to have a 10-30% risk of developing CVD over the next 10 years.
- Trial name
- BASH (NCT01929564)
- Testing
- Beneforte broccoli, Parthenon Broccoli
- Where
- 2 sites in United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Tumor, Stroke
Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）
This is a randomized controlled study to explore whether perioperative blood pressure management with different strategies can reduce the incidence of delirium and postoperative cognitive impairment and serious perfusion related…
- Trial name
- PRECISION (NCT06711432)
- Testing
- Norepinephrine or phenylephrine
- Where
- China
- Volunteers
- 214 people
- Sponsor
- Zhejiang Cancer Hospital