Clinical trials: Cardiovascular Disorders
Hypertension
A Cluster-Randomized Trial of a Hypertension Risk Model-Based Precision Intervention in High-Risk Adults in Shunyi District
This community cluster-randomized controlled trial aims to evaluate the effectiveness of a hypertension risk model-based precision intervention among adults at high risk of developing hypertension in Shunyi District, Beijing…
- Trial name
- NCT07804420
- Testing
- Hypertension Risk Model-Based Precision Intervention, Standard Health Education
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University
Heart Failure, Aortic Stenosis
The Role of Cardiac Mechanics, Biomarkers and Frailty in Aortic Stenosis
The role of cardiac mechanics, circulating biomarkers and frailty in predicting outcomes in patients with aortic stenosis after aortic valve replacement (SCRABLES -The 2-Parts Study) Part I: Observational study to characterize…
- Trial name
- SCRABLES (NCT02856620)
- Testing
- Observational only
- Where
- Canada
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Christine Henri
Hypertension
Intermittent Hypoxia-hyperoxia Conditioning as a New Therapeutic Intervention to Reduce Hypertension (HyperIHHC)
The primary objective of this project is to examine the efficiency of intermittent hypoxia-hyperoxia conditioning (IHHC) protocol to improve vascular health and reduce blood pressure in hypertensive patients (stage 1).
- Trial name
- HyperIHHC (NCT05603676)
- Testing
- Intermittent hypoxia-hyperoxia conditioning
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gregoire Millet
Hemorrhoids
The Relationship Between Hemorrhoids and Smartphone Use in the Lavatory
The objective of this study is to examine the relationship between hemorrhoids, a common complaint, and the use of smartphones, also a common feature of modern life, in the lavatory.
- Trial name
- NCT03444389
- Where
- Turkey (Türkiye)
- Volunteers
- 1,798 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Erectile Dysfunction, Coronary Artery Disease
Erectile and Ejaculatory Function Following Coronary Revascularization
This observational, cross-sectional study aims to compare erectile and ejaculatory function between men with a history of coronary revascularization and men without known coronary artery disease.
- Conditions
- Erectile Dysfunction, Coronary Artery Disease, Ejaculation Disorders
- Trial name
- NCT07878260
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Muscular Atrophy
Resistive/Cardiovascular Training Study
This is a training study in healthy volunteers to characterize gains in lower-body resistive strength and cardiovascular capacity with exercise on a Combined Countermeasure Device (CCD) we have developed for the National Space…
- Trial name
- CCD (NCT00835601)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cardiovascular Disease
Healthy Fatty Acids in Transition
Diacylglycerol (DAG) is a molecule that consists of two fatty acid chains bound by ester links to a glycerol molecule, in the form of 1,2 and 1,3 structural isomers.
- Trial name
- FAT (NCT00937963)
- Testing
- Palm DAG Oil
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Penn State University
Depressive Symptoms, Aging
Twelve Weeks of Resistance Training is Equally As Effective At Improving Cardiovascular Risk Factors in Older Women with and Without Depression: a Non-randomized Cross-over Trial
Background: the purporse was to evaluate and compare the effects of 12 weeks of resistance training (RT) on cardiovascular disease (CVD) risk factors in older women with and without depressive disorders Methods: We included 79…
- Conditions
- Depressive Symptoms, Aging, Resistance Training, Cardiovascular Risk Factor
- Trial name
- NCT06591325
- Testing
- exercise, Control
- Where
- Brazil
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Aortic Aneurysm
Patient Tailored Contrast Volume for Preoperative CT Angiography of the Aorta
An in-house calculator was developed to calculate the appropriate contrast dose, rather than standardly administering a 120ml dose.
- Trial name
- NCT05716568
- Testing
- Contrast dose reduction, CT-angiography
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Fabry's Disease
Analysis of the Nervous System in Patients With Fabry's Disease
Fabry's disease a genetic disorder (X-linked recessive) due to the absence of the enzyme ceramidetrihexosidase. The disease is characterized by abnormal collections of glycolipids in cells (histiocytes) within blood vessel walls…
- Trial name
- NCT00001491
- Where
- United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Fabry Disease
Lipidomics and Functional Analyses of Platelets in Fabry Disease
This study aims to evaluate whether platelets are biochemically and functionally altered in Fabry disease (FD) and therefore possibly implicated in FD manifestations such as cerebrovascular events.
- Trial name
- NCT02649660
- Where
- 2 sites in Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Spital Linth
Child, Only, Infant, Newborn, Diseases
Capnography Monitoring in Ventilated Children
End-tidal CO2 measurements in children will be assessed for their accuracy with arterial CO2 measurements.
- Conditions
- Child, Only, Infant, Newborn, Diseases, Critical Illness, ARDS, Human
- Trial name
- NCT04354220
- Testing
- capnography monitoring, arterial blood gas
- Where
- Switzerland
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Vincenzo Cannizzaro
Vascular Diseases, Myocardial Ischemia
Assessment of Oxygen Changes in the Heart With Cardio-vascular Magnetic Resonance Imaging
The ability of a new SSFP-based BOLD MRI sequence to assess myocardial oxygenation changes in response to coronary flow changes induced by adenosine and increased CO2-partial pressure will be examined in healthy volunteers and…
- Trial name
- NCT00693758
- Testing
- adenosine, modified end-tidal forcing system, arm cuff occlusion
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Cancer, Cancer Metastatic
The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors
The purpose of this prospective, interventional, single-arm pilot study is to evaluate whether virtually delivered group-based physical activity is feasible for adolescent and young adult (AYA) cancer survivors.
- Conditions
- Cancer, Cancer Metastatic, Neoplasms, Breast Cancer
- Trial name
- NCT05131815
- Testing
- Virtual group based physical activity (BurnAlong) and Social Media Discussion Board
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Diabetic Cardiomyopathies, Type2 Diabetes
Effect of High-intensity Interval Training on Cardiac Function and Regulation of Glycemic Control in Diabetic Cardiomyopathy
According to data of the International Diabetes Federation (IDF), diabetes in general affects approximately 415 million people worldwide and this number is still increasing.
- Trial name
- NCT03299790
- Testing
- high-intensity interval exercise training (HIIT), moderate-intensity exercise training (MIT)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Acute Lymphoblastic Leukemia, Post Thrombotic Syndrome
Post-thrombotic Syndrome After Deep Venous Thrombosis (DVT) in Patients Treated According to the NOPHO ALL2008 Protocol
Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood. Today more than 90% of children and 75% of adults (18-45 years) survive ALL.
- Trial name
- NCT04825548
- Testing
- No intervention
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Stroke
The Effects of Inspiratory Pressures on Diaphragmatic Contraction in People After Stroke
This is a cross-sectional study to determine the optimal inspiratory muscle training (IMT) intensity for stroke survivors. Participants will breathe through a pressure threshold inspiratory loading device with varying loads in…
- Trial name
- NCT06267768
- Testing
- Various intensities of inspiratory muscle training
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Hong Kong Metropolitan University
Cardiovascular Disease
Measurement of Distinct Biological Pools of Hydrogen Sulfide in Women With Cardiovascular Disease
Cardiovascular disease which includes coronary artery disease and peripheral artery disease remains the leading cause of death among women in the United States.
- Trial name
- NCT02180074
- Where
- United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Thromboembolism, Unspecified Adult Solid Tumor, Protocol Specific
Detecting Abnormal Blood Clotting in Patients With Metastatic Cancer Undergoing Surgery
RATIONALE: A test that detects abnormal blood clotting in patients with cancer may help doctors plan cancer surgery. PURPOSE: This laboratory study is looking at a new blood test to detect abnormal clotting in patients with…
- Trial name
- NCT00096590
- Testing
- coagulation study, immunoenzyme technique, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Prediabetes
Development of Smart Food /Nutraceutical Solutions Dedicated to Cardiometabolic Disorders in Ageing
Describe the anthropometric measurements and informations relating to body composition, blood chemistry tests, blood glucose monitoring, and dietary habits of the volunteers participating in the study before and after taking…
- Trial name
- NutriAge (NCT07817290)
- Testing
- Probiotic
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
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