Clinical trials: Cardiovascular Disorders
Peripheral Arterial Disease
Effects of Canola Oil on Blood Vessel Function in Peripheral Arterial Disease
The fatty acid composition of canola oil will have beneficial acute and chronic effects on vascular function in individuals with peripheral arterial disease.
- Trial name
- NCT01250275
- Testing
- traditional canola oil, high oleic canola oil, soybean oil
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
COVID-19 Infection
ESICM UNITE COVID-19 Project (UNITE-COVID)
COVID-19 is arguably the biggest challenge critical care medicine has been confronted with since its conception. Critical care services around the world are flooded by patients presenting with severe respiratory failure who…
- Trial name
- UNITE-COVID (NCT04836065)
- Where
- Belgium
- Volunteers
- 4,995 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Hypertension, Overweight
The Effects of Aronia Juice Polyphenols on Cardiovascular Disease Risk
The existing scientific evidence from both in vitro and clinical trials supports the notion that polyphenols can modulate platelet function.
- Trial name
- AMARCord (NCT02800967)
- Testing
- Pure Aronia juice, Aronia juice-based beverage
- Where
- Serbia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Adolescent Behavior, Lifestyle Modification
A Family-centred Approach Enhancing Cardiovascular Health in Ugandan Adolescents and Their Families
The FaCe-D Study, with funding from the Canadian Institute for Health Research (CIHR) through Global Alliance for Chronic Diseases (GACD) aims to adapt and implement an evidence-based family centred approach (FCA) to prevent…
- Conditions
- Adolescent Behavior, Lifestyle Modification, Cardiovascular Disease Other
- Trial name
- FaCe-D (NCT07265453)
- Testing
- The immediate (treatment) arm, will receive the FaCe-D intervention comprising of 'HOME VISITS, DIET, PHYSICAL ACTIVITY AND HEALTH MESSAGING, Control Arm - standard of care
- Where
- 2 sites in Uganda
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- MRC/UVRI and LSHTM Uganda Research Unit
Diabetic Foot Ulcer
Clinical Outcomes After Treatment With RestrataTM Wound Matrix in Diabetic Foot Ulcers (DFU)
The primary objective of this study is to determine the outcomes of patients who receive a certain type of skin substitute called RestrataTM Wound Matrix (Restrata™).
- Trial name
- NCT03312595
- Testing
- Restrata TM Wound Matrix
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Acera Surgical, Inc.
Healthy, Peripheral Vascular Disease
The Effect of Heat on Blood and Oxygen Flow Readings Part 2
This is the second part of a research study in order to determine if using a specialized pulse oximetry probe with external heat pack will help obtain oxygen saturation (SaO2) and heart rate (HR) during monitoring for patients…
- Conditions
- Healthy, Peripheral Vascular Disease, Vasoconstriction
- Trial name
- NCT01992939
- Testing
- Specialized pulse oximetry probe with external heat pack, Standard of Care Pulse Oximetry Probe
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- VA Pittsburgh Healthcare System
Traumatic Brain Injury, Subarachnoid Hemorrhage
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic…
- Trial name
- NCT06103201
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Malaria, Pregnancy Malaria
Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania
Sulfadoxine-pyrimethamine (SP) is currently recommended by the World Health Organization for use as intermittent preventive treatment against malaria in pregnancy (IPTp) in areas of moderate to high malaria transmission.
- Conditions
- Malaria, Pregnancy Malaria, Cardiotoxicity, Cardiac Safety
- Trial name
- NCT02909712
- Testing
- sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine (DHA-PQP)
- Where
- Tanzania
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Stroke
Upper Limb Movement Quality Following Stroke
The aim of this study is to monitor the daily upper limb movement of persons with stroke, and to relate these quantities to measures of recovery and impairment.
- Trial name
- NCT06497881
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Adi Negev-Nahalat Eran
Cardiovascular Disease
Hispanic Community Health Study / Study of Latinos
The Hispanic Community Health Study / Study of Latinos (HCHS/SOL) is a multi-center epidemiologic study in Hispanic/Latino populations to determine the role of acculturation in the prevalence and development of disease, and to…
- Trial name
- HCHS/SOL (NCT02060344)
- Where
- United States
- Volunteers
- 16,400 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke, Sympathetic Disorder
Contrast Bath and Sympathetic Skin Response
This study evaluates the effects of contrast bath on sympathetic skin response in stroke patients with complex regional pain syndrome .
- Trial name
- NCT04198532
- Testing
- Contrast bath
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Aneurysmal Subarachnoid Hemorrhage
Human Albumin for Clinical Outcome in Aneurysmal Subarachnoid Hemorrhages
Aneurysmal subarachnoid hemorrhage (aSAH) is a dreadful acute neurological condition with overwhelmingly high rate of associated morbidities and mortality.
- Trial name
- HASH (NCT06548477)
- Testing
- Human albumin
- Where
- Qatar
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Cardiovascular Analysis of PEM
The purpose of this study is to examine cardiopulmonary function in Chronic Fatigue Syndrome (CFS) patients and determine how it relates to the common symptom of Post-exertional malaise (PEM).
- Trial name
- NCT04740736
- Testing
- Saline Infusion
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes Mellitus
Assessment of Tissue Oxygenation Using Multispectral Imaging
In Canada, the age-standardized prevalence of diabetes is on the rise (increasing from 3.3% in 1998/99 to 5.6% in 2008/2009 Public Health Agency of Canada (July 2011)) and is almost 1 in 10 globally.
- Trial name
- NCT03516864
- Testing
- MIMOSA Imager, Kent Camera
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hypertension, Pure Autonomic Failure
Nitric Oxide and the Autonomic Nervous System
The amount of blood flowing to the different parts of the body is regulated by the autonomic (automatic) nerves and by local factors produced by the blood vessels.
- Trial name
- NCT00178919
- Testing
- L-NMMA, Trimethaphan
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Heart Failure
Assessment of Safety, Tolerability, Immunogenicity, and Pharmacokinetics of AZD3427
This first-time-in-human (FTIH) study will be conducted to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of single doses of AZD3427 in healthy volunteers and multiple doses of…
- Trial name
- NCT04630067
- Testing
- AZD3427
- Where
- 10 sites in United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
COPD, Pulmonary Hypertension
Haemodynamic Effects of Apelin Agonists and Antagonists in Man in COPD With Raised Pulmonary Artery Pressures
The investigators are interested in studying how Pulmonary Hypertension occurs. A substance called 'apelin', that naturally occurs in the body has been shown to have an important role in heart disease.
- Trial name
- NCT02129309
- Testing
- Forearm plethysmography, Haemodynamic studies
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Blood Platelet Disorders, Cardiac Surgery
Observational Study of Platelet Dysfunction Assessed by Thromboelastography in Cardiovascular Surgery (DISPLATEG)
Perioperative bleeding requiring blood transfusion is common during cardiovascular surgery, especially in procedures requiring cardiopulmonary bypass. Adenosine diphosphate (ADP) plays a fundamental role in platelet function.
- Conditions
- Blood Platelet Disorders, Cardiac Surgery, Postoperative Bleeding
- Trial name
- DISPLATEG (NCT06961175)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic
Association of Insulin Resistance and FGF21 on Cardiac Function in Pediatric Dilated Cardiomyopathy
This study will investigate whether there is an association between insulin resistance and cardiac function in children with dilated or hypertrophic cardiomyopathy.
- Conditions
- Cardiomyopathy, Dilated, Cardiomyopathy, Hypertrophic, Insulin Resistance
- Trial name
- NCT04222101
- Testing
- Oral glucose tolerance test
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Le Bonheur Children's Hospital
Atrial Fibrillation (AF)
Identification of the Metabolic Signature of Atrial Fibrillation for Personalized Prevention
Atrial fibrillation (AF) is a major public health problem. The efficacy of the existing techniques is limited in the more aggressive forms.
- Trial name
- IMAGE-AF (NCT06735001)
- Testing
- FA ablation, Lab test
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
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