Clinical trials: Cardiovascular Dysfunction
Autonomic Dysfunction
Cardiac Autonomic Modulation in Older Hypertensive Individuals Submitted to Different Types of Physical Training
Sixty-one sedentary older hypertensive individuals were randomized to four groups: continuous aerobic training (CA), interval aerobic training (IA), resistance training (R), and control (C) group.
- Trial name
- NCT05135247
- Testing
- Exercise
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Stroke, Hemiparesis
Telerehabilitation Through Serious Games in Virtual Reality in a Stroke Population (AutoRReVi)
After a stroke, individuals present with motor and/or cognitive impairments. These impairments limit activity, restrict participation and affect quality of life.
- Conditions
- Stroke, Hemiparesis, Cognitive Impairment, Healthy Subjects
- Trial name
- AutoRReVi (NCT04694833)
- Testing
- Motor and cognitive virtual reality-based assessments, Motor and cognitive virtual reality-based serious games
- Where
- Belgium
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Stroke Sequelae, Cognitive Impairment
Remote Bimanual Virtual Rehabilitation Post CVD
The aim of the study is to develop the BrightBrainer G (grasp), a game-based upper-extremity motor and cognitive rehabilitation system using custom virtual reality simulations.
- Conditions
- Stroke Sequelae, Cognitive Impairment, Depression
- Trial name
- NCT04713384
- Testing
- Integrative tele-rehalitation of chronic stroke survivors using custom therapeutic games
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Grigore Burdea
Hypertension, Elderly
Predictive Values of Blood Pressure and Arterial Stiffness in Institutionalized Very Aged Population
Introduction: High blood pressure especially systolic hypertension is a common condition in the elderly and is considered as a major determinant not only of cardiovascular (CV) morbidity and mortality, but also of several other…
- Conditions
- Hypertension, Elderly, Cardiovascular Mortality, Cognitive Impairment
- Trial name
- PARTAGE (NCT00901355)
- Where
- 6 sites in France, Italy
- Volunteers
- 1,130 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Cardiovascular Diseases, Hypertension
The Impact of KETO5 XOGenius Beverage on Markers of Physiological and Neurocognitive Health
The primary objectives of this application are to 1) investigate the effect of increased daily consumption of the Keto5 XOGenius beverage on outcomes associated with elevated risk for various neurocognitive and pathophysiological…
- Conditions
- Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet
- Trial name
- NCT06318390
- Testing
- XO Genius
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Hypertension, Autonomic Dysfunction
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical…
- Conditions
- Hypertension, Autonomic Dysfunction, Orthostatic Hypotension
- Trial name
- NCT07482462
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Transposition of Great Arteries
Cardiovascular Magnetic Resonance in Adults With SysTemic Right Ventricle (STAR)
The main aim of the study is to explore HFs in SRV, comparing their magnitude and direction with that of subpulmonary RV and systemic LV.
- Trial name
- STAR (NCT05690854)
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Diabetes Mellitus, Type 1, Hypertension
Correlation of Flicker Induced and Flow Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers.
A couple of studies have shown that illuminating the eye with diffuse flickering light is accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and retinal blood flow.
- Conditions
- Diabetes Mellitus, Type 1, Hypertension, Hypercholesterolemia, Regional Blood Flow
- Trial name
- NCT00432029
- Testing
- Forearm blood flow measurement, Flow mediated dilation (FMD), Zeiss Retinal Vessel Analyzer (RVA), Stimulation with Flicker-light
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Moyamoya Disease
Study on the Mechanism of Cognitive Impairment in Patients with Moyamoya Disease
The purpose of this study is to comprehensively evaluate the risk factors for cognitive decline in patients with moyamoya disease, identify imaging target areas associated with cognitive damage in the brain, and explore the…
- Trial name
- NCT06832839
- Testing
- Revascularization
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Cognitive Decline, Dementia
MIND Diet Intervention and Cognitive Decline
Phase III randomized controlled trial designed to test the effects of a 3-year intervention of the MIND diet (Mediterranean-DASH Intervention for Neurodegenerative Delay) on cognitive decline and brain neurodegeneration among 600…
- Conditions
- Cognitive Decline, Dementia, Alzheimer Disease, Vascular Dementia
- Trial name
- MIND (NCT02817074)
- Testing
- MIND Diet, Mild Weight Loss
- Where
- 2 sites in United States
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Aging, Mild Cognitive Impairment
A Study of Characterizing Cognitive Decline and Functional Cardiac Senescence in Healthy Korean Volunteers
Although aging process appears to be generally characterized, investigators have been paid much attention to the specific target molecules, which leads to discover the clinical markers of the senescence.
- Conditions
- Aging, Mild Cognitive Impairment, Angina Pectoris
- Trial name
- NCT01590706
- Where
- South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Oriental Medicine
Intraabdominal Hypertension, Multi-Organ Disorder
Correlation Between Intra-abdominal Pressure, Biomarkers of Bacterial Translocation and Intestinal Wall Damage
Main scientific hypotheses of the project: 1. The level of intestinal microflora translocation markers and biomarkers of intestinal wall damage the in the blood serum correlates with the level of intra-abdominal pressure…
- Conditions
- Intraabdominal Hypertension, Multi-Organ Disorder, Translocation Syndrome
- Trial name
- NCT06221293
- Testing
- immunoenzyme analysis
- Where
- 5 sites in Kazakhstan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Karaganda Medical University
Insulin Resistance, Obesity
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With Obesity
A combination of generally regarded as safe (GRAS) compounds named GLY-LOW, which included: alpha lipoic acid, pyridoxamine, nicotinamide, piperine and thiamine, were examined in pre-clinical experiments.
- Conditions
- Insulin Resistance, Obesity, Cardiovascular Diseases, Cognitive Impairment
- Trial name
- NCT06242535
- Testing
- GLY-LOW
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Hoskinson Health and Wellness Clinic
Cardiomyopathy
Characterization of Sympathetic Nerve Activity in Stress Cardiomyopathy
Stress (Takotsubo) cardiomyopathy (SC) is a peculiar form of acute, reversible myocardial dysfunction predominantly affecting the apical and mid left ventricular segments.
- Trial name
- NCT01048125
- Testing
- Sympathetic Nerve Activity, Mental Stress Test (Color Word Test), The Modified Oxford Technique for Baroreflex Sensitivity
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
MINOCA, STEMI
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
The aim of this study is to evaluate microvascular dysfunction through OCTA in MINOCA patients. In order to better understand the condition, OCTA will also be performed in two matched patient groups: healthy controls and ACS…
- Conditions
- MINOCA, STEMI, Normal
- Trial name
- REVEAL (NCT07055152)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Cardiac Arrest, Cognitive Function
Brain Function After Cardiac Arrest (Measured With FMRI and Cognitive Tests)
The aim of this longitudinal study is to determine whether brain function is affected after a cardiac arrest. The primary question is whether cognitive function is affected after cardiac arrest and whether it changes over time…
- Trial name
- BRAINnHEART (NCT03579498)
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Uppsala University
COVID-19, Endothelial Dysfunction
The Glycocalyx in COVID-19 Patients. A Pilot Study
The damage of the endothelial glycocalyx is based on microvascular endothelial dysfunction and typical for critical clinical conditions like sepsis, trauma, bleeding, shock, as well as ARDS.
- Conditions
- COVID-19, Endothelial Dysfunction, Coagulation Disorder
- Trial name
- Glycovid-19 (NCT05137249)
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dementia, Dementia, Vascular
Feasibility of the SmartPrompt for Improving Everyday Function in Dementia
Difficulty completing everyday tasks is a primary reason for the high cost of care, loss of caregiver paid hours, and general caregiver burden associated with dementia.
- Conditions
- Dementia, Dementia, Vascular, Dementia Alzheimers, Dementia, Mixed
- Trial name
- SmartPrompt (NCT04313582)
- Testing
- SmartPrompt smartphone application
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Temple University
Cardiometabolic Health, Pregnancy Related
Cardiometabolic Health in First Time Pregnancy
Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth…
- Conditions
- Cardiometabolic Health, Pregnancy Related, Diabetes, Placental; Syndrome, Dysfunction
- Trial name
- POPPY (NCT05856318)
- Where
- 7 sites in United Kingdom
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust