Clinical trials: Cardiovascular Effects
Hyperlipidemia
Effect Of Capros Supplementation On Cardiovascular Disease Risk Factors In Humans
The hypothesis of this study is that the natural supplement Capros will decrease LDL levels, platelet aggregation, and serum concentrations of high sensitivity C-reactive protein in humans at risk for cardiovascular disease.
- Trial name
- Capros (NCT01858376)
- Testing
- Capros dietary supplement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chandan K Sen
Cardiovascular Diseases
Haemodynamic Effects of GLP-1 and Glucagon in Healthy Male Volunteers
The study seeks to explore the cardiovascular effects of co-agonism at two peptide receptors, GLP-1 and glucagon. Glucagon, exenatide and 0.9% saline will be intravenously infused, both in isolation, and combination into healthy…
- Trial name
- COCOA (NCT03835013)
- Testing
- Saline 0.9%, Glucagon (25ng/kg/min), Glucagon (50ng/kg/min)
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Healthy
Effect of Sex on Orthostatic Intolerance and Cardiovascular Response During Lunar Descent and Ascent
The purpose of Lunar OI (Orthostatic Intolerance) is to determine if there are differences between males and females in tolerance to and cardiovascular responses during different angles of head-up tilt simulating gravity levels…
- Trial name
- Lunar OI (NCT06467825)
- Testing
- Potassium Supplement, Furosemide 20 MG, Compression Garment
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Healthy Volunteers
An Investigational Study to Assess the Effect of BMS-986177 on Aspirin in Healthy Participants
The purpose of this study is to investigate the effect of taking multiple doses of BMS-986177 when aspirin is taken once-daily. Eligible participants will receive twice-daily doses of BMS-986177 or placebo, with a once-daily dose…
- Trial name
- NCT03341390
- Testing
- Aspirin, BMS-986177
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Cardiopulmonary Disease
Effects of Secondhand Smoke on Flight Attendant Health
This is a study on a population of flight attendants who were exposed to occupational secondhand tobacco smoke (SHS). This research will examine associations between flight attendant SHS exposure and development of respiratory…
- Trial name
- FAMRI (NCT01639235)
- Where
- United States
- Volunteers
- 592 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Type 2 Diabetes, Cardiovascular Diseases
Pistachios Blood Sugar Control, Heart and Gut Health
A two-period randomized crossover study will be conducted to evaluate the effect of nighttime pistachio consumption (i.e., after dinner and before sleep) on fasting blood sugar levels, longer-term blood sugar control, and risk…
- Trial name
- NCT04056208
- Testing
- Pistachio, Usual care
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Penn State University
Atrial Fibrillation Paroxysmal
The Effect of a Case-finding App on the Detection Rate of Atrial Fibrillation in Primary Care Patients
Atrial fibrillation is a cardiac arrhythmia commonly encountered in a primary care setting. Current screening is limited to pulse palpation and ECG confirmation when an irregular pulse is found.
- Trial name
- NCT04545723
- Testing
- FibriCheck
- Volunteers
- healthy volunteers welcome
- Sponsor
- KU Leuven
Hypercholesterolemia
Effects of Various Higher Fat and Lower Fat Snacks on Cardiovascular Risk Factors in Men and Women.
The purpose of this study is to determine whether snacks differing in fat amount and type result in changes in cardiovascular disease risk factors in men and women who have mildly elevated cholesterol levels.
- Trial name
- NCT00349765
- Testing
- higher fat, high polyunsaturated fat diet, higher fat, high saturated and trans fat diet, lower fat diet
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Long QT Syndrome
Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults
This study will evaluate the effect of oral GS-6615 on QTc interval in healthy adults with dofetilide-induced QTc prolongation.
- Trial name
- NCT02365532
- Testing
- GS-6615, Dofetilide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Cardiovascular Disease
Growth Hormone's Effect on Endothelial Progenitor Cells
To assess the effect of short-term low-dose growth hormone therapy on the mobilization of endothelial progenitor cells from the bone marrow within a group of healthy adults.
- Trial name
- NCT00397592
- Testing
- Growth Hormone
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Hypercholesterolemia, Hypertension
Effects of Rosiglitazone on Blood Vessels in Patients With High Blood Pressure and High Cholesterol
Cells in the lining of blood vessels produce various substances that cause the vessels to dilate (relax) and constrict (tighten), thereby regulating blood flow.
- Trial name
- NCT00006071
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Insulin Resistance
Effects of Obesity and Intensity of Exercise on Ghrelin Levels
This study is investigating the effect of different intensities of exercise on levels of the hormone, ghrelin. In addition, we will be examining the relationship between any exercise induced changes in ghrelin and insulin…
- Conditions
- Obesity, Insulin Resistance, Cardiovascular Risk Factor
- Trial name
- NCT04581980
- Testing
- Exercise
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Physical Activity Levels, Cardiovascular Fitness
Effects of Virtual Reality Exercise on Promoting Physical Activity and Health Among College Students
The purpose of this research is to examine the effectiveness of a 4-week immersive-virtual reality (VR) exercise bike intervention on college students' physiological outcomes (physical activity levels, cardiovascular fitness, and…
- Conditions
- Physical Activity Levels, Cardiovascular Fitness, Body Composition, Situational Motivation
- Trial name
- NCT06902727
- Testing
- VR-based exercise bike, Usual routine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Cardiovascular Disease
Effect of Peer-mentor Mediated Interventions on Cardiovascular Risk Factors at Worksites
The investigators propose conducting a pilot study to identify 6 worksites (2 India, 2 Sri Lanka, 2 Bangladesh) explore barriers to optimum cardiovascular disease(CVD) care at these worksites, quantify risk factor level in…
- Trial name
- PROGRESS (NCT02388542)
- Testing
- Educational Intervention
- Where
- 6 sites in Bangladesh, India and 1 more
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- St. John's Research Institute
Periodontal Diseases
Effect of Non-chirurgical Periodontal Treatment on the Immune System From a Gender Perspective
The goal of this observational study is to evaluate non-surgical periodontal treatment in women and men with periodontitis with and without obesity.
- Trial name
- NCT06261723
- Testing
- non-chirurgical periodontal treatment
- Where
- 2 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Elevated Blood Pressure, Hypertension
The Effects of Pumpkin Seed Oil Supplementation on Cardiovascular Function in Postmenopausal Women.
Postmenopausal women have a higher prevalence of cardiovascular (CV) disease than age-match men. Growing evidence from rat studies have demonstrated CV-protective effects of pumpkin seed oil (PSO).
- Trial name
- NCT03716960
- Testing
- Pumpkin Seed Oil
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Marymount University
Hypertension, Prehypertension
Effects and Safety of Menthol on Blood Pressure and Metabolic Parameters in Prehypertensive and Mild Hypertensive Patients
Prehypertension and mild hypertension are associated with an increased risk of atherosclerosis and coronary artery disease, and often complicated with the metabolic disorder of glucose and lipid.
- Trial name
- ESMAB (NCT01408446)
- Testing
- Menthol
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Zhiming Zhu
Prehypertension, Hypertension
Health Effects of a Nordic Diet Rich in Plant-based Foods and Fish
The purpose of this study is to investigate the effects of a Nordic diet rich in plant-based foods and fish on indicators of cardiovascular disease risk at two different levels of salt intake.
- Trial name
- NCT01412346
- Testing
- Effects of a Nordic diet rich in plant-based foods and fish
- Where
- Finland
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Vascular Stiffness, Inflammation
Anthocyanin-rich Blackcurrant and Vascular Function
Regular consumption of fruits and vegetables may improve human health and reduce the risk of chronic diseases, such as heart disease, certain cancers and type 2 diabetes, but the active components and the underlying mechanisms…
- Trial name
- NCT02459756
- Testing
- Beverage: Spray dried blackcurrant powder dissolved in water
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Reading
Electricity; Effects, Heart Arrhythmia
Transcutaneous Electrical Stimulation & Sinoatrial Node Function
Transcutaneous electrical stimulation (TES) is used in clinical practice to diagnose or treat a diverse range of medical conditions for over a century.
- Trial name
- TENS&HR (NCT05966922)
- Testing
- Transcutaneous Electrical Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital