Clinical trials: Cardiovascular Outcome, open to volunteers
Aortic Stenosis
Impact of Beta-blocker on Outcome Among Patients Undergoing Transcatheter Aortic Valve Replacement (B-TAVR)
This is a multi-centric, open-label, randomized trial to evaluate the safety and efficacy of temporary discontinuation of beta-blocker treatment in patients undergoing transcatheter aortic valve replacement.
- Trial name
- NCT06472934
- Testing
- Transcatheter aortic valve replacement in the absence of B-blocker treatment, Transcatheter aortic valve replacement
- Where
- 11 sites in Austria, Germany and 1 more
- Volunteers
- 498 people
- Sponsor
- University Hospital, Basel, Switzerland
Stroke, Acute, Cerebrovascular Disorders
Therapy Evaluation in Patients With Minor Stroke and Large Vessel Occlusion
This multicenter registry study, which record the therapy strategy and follows up these acute ischemic stroke (AIS) patients with low NIHSS and large vessel occlusion (LVO), is intended to provide the important data for therapy…
- Conditions
- Stroke, Acute, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- TEMPOS (NCT06633809)
- Testing
- Immediate endovascular therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sir Run Run Shaw Hospital
Stroke, Ischemic, Thrombectomy
Prognostic Value of Isolated and Combined Score Aspects in Acute Ischemic Stroke
This study, called TARGET-ASPECT, looks at patients who had a type of stroke called acute ischemic stroke and were treated with clot-busting medicine and a procedure to remove the clot.
- Conditions
- Stroke, Ischemic, Thrombectomy, Thrombolytic Therapy, Brain Ischemia
- Trial name
- NCT07069452
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Centre Hospitalier de Gonesse
Sepsis - to Reduce Mortality in the Intensive Care Unit, Trauma Coagulopathy
ROTEM in Sepsis Trauma Outcome in Intensive Care
This prospective observational study aims to investigate the ability of advanced ROTEM analysis using Principal Component Analysis (PCA) to detect early signs of disseminated intravascular coagulation (DIC) and trauma-induced…
- Trial name
- ROSTIC (NCT06891599)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Region Stockholm
Intracerebral Hemorrhage
Chinese Multicenter Cohort Study of Intracerebral Hemorrhage
Spontaneous intracerebral hemorrhage is a severe form of stroke associated with high mortality and long-term disability. The Chinese Multicenter Cohort Study of Intracerebral Hemorrhage (CASA) is a prospective observational…
- Trial name
- CMCS-ICH (NCT07833410)
- Where
- China
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Xiangya Hospital of Central South University
Heart Failure, Diastolic Heart Failure
Heart Failure and Postoperative Outcome in Surgery - a National Registry Study
The study is an exploratory study that aims to explore the incidence of heart failure in a national surgical cohort, and to compare postoperative mortality and morbidity in patients with and without heart failure.
- Conditions
- Heart Failure, Diastolic Heart Failure, Systolic Heart Failure
- Trial name
- NCT07634822
- Where
- 2 sites in Sweden
- Volunteers
- 2,200,000 people
- Sponsor
- Umeå University
Coronary Artery Disease, Stroke
Effects of Left Atrial Appendage Resection and Marshall Ligament Amputation on Clinical Outcome in Patients Undergoing Off-pump Coronary Artery Bypass
Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative…
- Conditions
- Coronary Artery Disease, Stroke, Atrial Fibrillation
- Trial name
- NCT04220047
- Testing
- Left Atrial Appendage Resection and Marshall Ligament Amputation
- Where
- China
- Volunteers
- 400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiogenic Shock
Genomic Determinants of Outcome in Cardiogenic Shock
The aim of this project is to understand the heterogeneity of both the immune consequences and treatment responses in CS. We will explore this heterogeneity through identification of transcriptomic sub-phenotypes and their…
- Trial name
- Goldilocs (NCT05728359)
- Testing
- Observational study
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Barts & The London NHS Trust
Aneurysms, Arteriovenous Malformations
Neurosurgical Outcome Network
The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared.
- Conditions
- Aneurysms, Arteriovenous Malformations, Cavernomas, Skull Base Tumors
- Trial name
- NEON (NCT06724029)
- Where
- 27 sites in Italy
- Volunteers
- 4,500 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Aortic Stenosis
Avr Thrombosis OutcoMe Study
This study aims to utilise novel biomarkers assessing thrombosis and thrombolysis (through a blood test), to identify patients undergoing either surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation…
- Trial name
- ATOM (NCT04234841)
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 750 people
- Sponsor
- East and North Hertfordshire NHS Trust
Lymphoma, Hodgkin Lymphoma
Early Assessment of Lymphoma Treatment Response Using Phased Variant Analysis With Next-Generation Sequencing
Lymphoma is a prevalent lymphoid malignancy globally and in Taiwan. Large B-cell lymphoma (LBCL) is the most common subtype of aggressive B-cell lymphoma.
- Conditions
- Lymphoma, Hodgkin Lymphoma, T-cell Lymphoma, Waldenstrom Macroglobulinaemia
- Trial name
- NCT06550427
- Testing
- ctDNA analyzed by phased variant
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Chronic Cardiovascular Disease, Acute Cardiovascular Disease
Chronic and Acute Cardiovascular Diseases in Elderly Intensive Care Patients
Very old patients are a rapidly growing and vulnerable population in acute cardiovascular care but remain underrepresented in clinical trials.
- Conditions
- Chronic Cardiovascular Disease, Acute Cardiovascular Disease, Frailty
- Trial name
- NCT07385482
- Where
- Germany
- Volunteers
- 4,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Ischemic Stroke, Acute, Rehabilitation Outcome
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study
The study evaluates the effect and safety of Cerebrolysin administered during early rehabilitation in patients with moderate neurological impairment after acute ischemic stroke, conducted at the Department of Vascular Neurology…
- Conditions
- Ischemic Stroke, Acute, Rehabilitation Outcome, Cerebrolysin
- Trial name
- NCT07043686
- Testing
- Cerebrolysin treatment, Standard treatment (including neurorehabilitation) of acute ischemic stroke
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Patients With Heart Failure Undergoing Cardiac Surgery
Telemedically Assisted Optimization for Heart Failure Patients Before Cardiac Surgery to Improve Perioperative Outcome
Patients with heart failure undergoing cardiac surgery face a significantly increased perioperative risk, yet no standardized strategy exists to mitigate this risk effectively.
- Trial name
- PREPARE-HF (NCT07391683)
- Testing
- PREPARE-HF disease management program, which includes:
- Where
- Austria
- Volunteers
- 162 people
- Sponsor
- Medical University Innsbruck
Ischemic Stroke, Oral Anticoagulation
Advancing Knowledge in Ischemic Stroke Patients on Oral Anticoagulants
The Advancing knowledge in ischemic Stroke PatiEnts on oRal Anticoagulants (ASPERA) study aims to investigate characteristics of ischemic stroke cases occurring in patients on oral anticoagulation for atrial fibrillation (AF) or…
- Conditions
- Ischemic Stroke, Oral Anticoagulation, Atrial Fibrillation (AF), Outcome Assessment
- Trial name
- ASPERA (NCT06823466)
- Where
- 47 sites in Croatia, Denmark and 13 more
- Volunteers
- 200 people
- Sponsor
- University of L'Aquila
Internal Carotid Artery Dolichoarteriopathy, Carotid Artery Tortuosity
Clinical Significance of Internal Carotid Artery Dolichoarteriopathy
This observational study aims to investigate the clinical significance of internal carotid artery dolichoarteriopathy, including tortuosity, kinking, and coiling, and to identify factors associated with cerebral dysfunction and…
- Trial name
- DALISTA (NCT07882875)
- Where
- Russia
- Volunteers
- 560 people
- Sponsor
- Kuban State Medical University
Ischaemic Stroke, Cognitive Impairment, Mild
Cognitive Care Bundle for Ischaemic Stroke : A Pilot Randomised Controlled Trial
The goal of this clinical trial is to learn if a set of treatments, called a "cognitive care bundle," can help preserve cognitive ability in people who have had a stroke.
- Trial name
- COGIS (NCT07610291)
- Testing
- Cognitive care bundle, Standard Medical Care (SMC)
- Where
- Malaysia
- Volunteers
- 50 people
- Sponsor
- National University of Malaysia
Peripheral Artery Disease
Campania Registry On Peripheral Artery Disease
The CAmpania REgistry on Peripheral Artery Disease (CARE-PAD) is a single-center observational study which has the purpose to collect clinical, laboratory, instrumental, procedural and follow-up data and to evaluate the outcome…
- Trial name
- CARE-PAD (NCT04903912)
- Testing
- Vascular ultrasound or other imaging methods according to current guidelines, Laboratory tests, Medical treatment according to current guidelines
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Federico II University
Intracranial Hemorrhage, Spontaneous
Prediction of Functional Recovery in Patients With Intracerebral Hemorrhage
Currently, we lack sufficiently reliable tools to accurately predict, in the first few hours, the vital prognosis, functional status, and quality of life of patients with intracerebral hemorrhage (ICH).
- Trial name
- PRO-ICH (NCT07728734)
- Testing
- CLINICAL SCORE TO PREDICT FUNCTIONAL OUTCOME, Variables necessary for calculating the score under study (PRO-ICH) will be collected, as well as baseline and 60-120 minutes after baseline of serum blood samples
- Where
- Spain
- Volunteers
- 1,688 people
- Sponsor
- Germans Trias i Pujol Hospital
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille