Clinical trials: Cardiovascular Outcomes
Marfan Syndrome, Marfan Syndrome Cardiovascular Manifestations
Living With Marfans and Your Aorta: Surgical Outcomes Study
Marfan Syndrome (MFS) is a genetic disease affecting the eyes, skeleton, heart and arteries. Despite MFS affecting multiple organ systems, cardiovascular manifestations are the most serious and life threatening.
- Trial name
- LIMA II (NCT04776681)
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Barts & The London NHS Trust
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Transthyretin Amyloid Cardiomyopathy (ATTR CM)
CLEOPATTRA: A Research Study to Look at the Effects of Treatment With a Medicine Called Coramitug (NNC6019-0001) in People With Heart Failure Due to Transthyretin Amyloid (ATTR) Amyloidosis
This study will find out if a new medicine called NNC6019-0001 can help reduce the risk of heart-related death and illness in participants with a condition called transthyretin amyloid cardiomyopathy (ATTR-CM), which affects the…
- Trial name
- CLEOPATTRA (NCT07207811)
- Testing
- NNC6019-0001
- Where
- 299 sites in United States, Argentina and 18 more
- Volunteers
- 1,280 people
- Sponsor
- Novo Nordisk A/S
Kidney Transplant; Complications
The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study
EFFEKTOR is a vanguard, multicenter, phase 2 randomized, double blinded, placebo controlled clinical trial to determine the feasibility, tolerability, safety, and efficacy of finerenone in kidney transplant recipients (KTRs).
- Trial name
- NCT06059664
- Testing
- Finerenone Oral Tablet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Preeclampsia
The Study of Cardiovascular Outcomes in Women With Preeclampsia Using Echocardiography: The SCOPE Study
This study will evaluate the differences in cardiovascular parameters between women with severe preterm preeclampsia and those without preeclampsia using echocardiography and maternal blood.
- Trial name
- SCOPE (NCT02357667)
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Pennsylvania
ESRD, Hemodialysis Complication
Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis
For patients with kidney failure requiring hemodialysis treatment, sometimes the blood pressure will drop too low during dialysis.
- Conditions
- ESRD, Hemodialysis Complication, Blood Pressure
- Trial name
- TAKE-HOLD (NCT03327909)
- Testing
- TAKE vs. HOLD
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Stanford University
Telehealth Services, Telehealth
Impact of Telehealth Care
Heart failure is associated with high incidence and mortality rates, limited physical activity, decreased quality of life, and increased healthcare expenses.
- Trial name
- NCT06656520
- Sponsor
- Pei-Hung Liao
Congenital Heart Disease in Children
How to Report Postoperative Outcomes After a Paediatric Cardiac Surgery ?
Congenital heart disease is a common abnormality in newborns. The marked improvement in the surgical management of congenital heart disease has led to a reduction in postoperative mortality, historically a quality criterion for…
- Trial name
- Pedia-Card (NCT05546983)
- Where
- France
- Volunteers
- 189 people
- Sponsor
- University Hospital, Strasbourg, France
Multiple Myeloma, Stem Cell Transplant Complications
The TOTOM Trial: Tai Chi to Optimize Transplant Outcomes for Multiple Myeloma
The current proposal aims to test the feasibility of immune function analysis for Tai Chi Easy (TCE) intervention in multiple myeloma (MM) patients undergoing autologous stem cell transplantation (ASCT) with concurrent…
- Trial name
- NCT04760405
- Testing
- Tai Chi Easy
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of Arizona
Obstructive Hypertrophic Cardiomyopathy
Real-world Patient Reported Outcomes Among Patients Treated With Camzyos
This real-world study will assess changes in health status among participants with symptomatic obstructive hypertrophic cardiomyopathy who are treated with mavacamten in the real world.
- Trial name
- COMPASS-HCM (NCT06551129)
- Testing
- Mavacamten
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Bristol-Myers Squibb
PTA (Percutaneous Transluminal Angioplasty ), Femoropopliteal Artery Disease
Clinical Outcomes of GENOSS PCB for Femoropopliteal Artery Disease
The GENOSS PCB study aims to evaluate the safety and efficacy of a Paclitaxel-coated PTA Balloon Catheter(GENOSS® PCB) in patients with the femoropopliteal artery disease.
- Trial name
- GENOSS PCB (NCT07399080)
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Genoss Co., Ltd.
Coronary Disease, Cardiovascular Diseases
Examining How Heart Disease Risk Factors Affect Healthy Aging (The Chicago Healthy Aging Study [CHAS])
Heart disease is the leading cause of death in the United States and is responsible for 30% of all deaths in the United States. This study will examine how risk factors for heart disease in young and middle aged people affect…
- Trial name
- CHAS (NCT00626379)
- Where
- United States
- Volunteers
- 1,395 people
- Sponsor
- Northwestern University
Coronary Artery Disease
Japan FFRangio Clinical Outcomes Study
This study aims to collect data on clinical outcomes of real world patients undergoing FFRangio guided treatment for coronary artery disease in Japan and Israel through a retrospective multicentre registry.
- Trial name
- NCT05648396
- Testing
- FFRangio
- Where
- Israel
- Volunteers
- 2,500 people
- Sponsor
- Rabin Medical Center
Wet Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Wet Age Related Macular Degeneration
Observe the Effectiveness and Safety of Ranibizumab in Real Life Setting
This study will describe the long-term safety and effectiveness, treatment patterns,and patient reported quality of life associated with ranibizumab treatment in routine clinical practice for all approved indication included in…
- Conditions
- Wet Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Wet Age Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- LUMINOUS (NCT01318941)
- Testing
- Ranibizumab
- Where
- 463 sites in Argentina, Australia and 41 more
- Volunteers
- 30,490 people
- Sponsor
- Novartis Pharmaceuticals
Charcot Joint of Foot, Osteoarthropathy
Factors Associated With an Evolution in the Quality of Life of Diabetic Patients With Chronic, Wound-free Charcot Foot
Charcot foot, characterized by progressive destructive damage to bone, soft tissue and tendons, involving joint dislocation in the ankle and foot, is a complication of diabetes that is still poorly understood by patients and…
- Trial name
- CHARQUAM (NCT05491577)
- Testing
- Filling in the SF-36, FAAM-F, PHQ-9, PHQ-2 and the simplified version of the EPICES score questionnaire
- Where
- 17 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Heart Valve Disease
D-Dimer Determined Anticoagulation INTENSITY in Patients With Mechanical Valve Replacement
The optimal intensity of oral anticoagulation in China patients undergoing mechanical valve replacements is still controversial due to the different risk profiles of thrombophilia and bleeding in Chinese patients.
- Trial name
- 3D-INTENSITY (NCT01996657)
- Testing
- Warfarin
- Where
- 2 sites in China
- Volunteers
- 772 people, healthy volunteers welcome
- Sponsor
- Wuhan Asia Heart Hospital
Transcatheter Aortic Valve Implantation (TAVI)
Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing TAVI in Europe
Non-interventional, multi-center, international registry in patients with severe aortic stenosis (sAS) undergoing transcatheter aortic valve implantation (TAVI).
- Trial name
- BENCHMARK (NCT04579445)
- Testing
- Education on tailored Quality Improvement measures
- Where
- 28 sites in Austria, Czechia and 5 more
- Volunteers
- 2,408 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Congenital Heart Defects
Outcomes in Patients and Their Closest Relatives Treated for Congenital Heart Disease With Catheter Based or Surgical Techniques
This study compares clinical, self- reported and cost outcomes in children and adolescents treated with pulmonary valve implantation, percutaneous versus open surgical technique.
- Trial name
- MEQC (NCT01421030)
- Testing
- Percutaneous pulmonary valve implantation or open heart surgery
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Coronary Artery Disease
PITT PCI Xience Registry
Stents are devices utilized to treat cholesterol blockages of the coronary (heart) arteries. The introduction of drug-eluting (coated) stents into clinical practice is regarded as a revolutionary breaktrhough, as it has reduced…
- Trial name
- NCT01299207
- Where
- United States
- Volunteers
- 2,506 people
- Sponsor
- University of Pittsburgh
Coronary Artery Disease, Atheromatosis
Prognostic Indices of Atheromatosis Severity and Coronary Artery Bypass Surgery Outcomes for Patients With Coronary Artery Disease
Coronary artery disease is a multifactorial disease. Traditional risk factors, such as obesity, diabetes, hypertension, stimulate the onset of an inflammatory process in the prone vessel and perivascular adipose tissue, which has…
- Trial name
- NCT06242171
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Onassis Cardiac Surgery Centre
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