Clinical trials: Cardiovascular Outcomes, open to volunteers
Hemianopsia, Homonymous, Brain Injury
Biofeedback for Hemianopia Vision Rehabilitation
Patients with brain injury secondary to stroke, surgery, or trauma frequently suffer from homonymous hemianopia, defined as vision loss in one hemifield secondary to retro- chiasmal lesion.
- Conditions
- Hemianopsia, Homonymous, Brain Injury, Stroke, Brain Tumor
- Trial name
- NCT05397873
- Testing
- Biofeedback training
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto
Cardiac Arrest (CA), Resuscitated Sudden Cardiac Death
Long Term Follow-up of Cardiac Arrest Survivors Exposed to Ultra-rapid Cooling
Less than 10% of patients eliciting out-of-hospital cardiac arrest (OHCA) survive, although 30% can be resuscitated by Emergency services before admission in Intensive Care Units (ICU).
- Conditions
- Cardiac Arrest (CA), Resuscitated Sudden Cardiac Death, Post Cardiac Arrest Patient Who Was Treated by Hypothermia Protocol
- Trial name
- AFTERCOOL (NCT07028372)
- Testing
- Short Form Health Survey (SF-36), Modified Rankin Score (mRS), Activity of Daily Living (ADL) questionnaire
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Clinical Response of EXTOR (Amlodipine/Valsartan) in Newly Diagnosed Hypertensive Patients.
The American College of Cardiology/American Heart Association hypertension guidelines recommend treatment initiation with dual antihypertensive therapy in adults with stage 2 hypertension (corresponding to grade 1 and 2 in the…
- Trial name
- HELP (NCT06625346)
- Testing
- Fixed-Dose Combination of Amlodipine/Valsartan
- Where
- 2 sites in Pakistan
- Volunteers
- 420 people
- Sponsor
- The Searle Company Limited Pakistan
Ventricular Tachycardia (VT), Catheter Ablation
Using Non-Invasive Mapping To Eliminate Structural Heart Disease Ventricular Tachycardia
Ventricular tachycardia (VT) is an abnormal and dangerous heart rhythm affecting the lower chambers of the heart (the ventricles).
- Trial name
- UNITE-VT (NCT07759427)
- Testing
- VIVO-assisted mapping
- Where
- 3 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- University of Warwick
Coronary Arterial Disease (CAD), Radial Artery Spasm
Impact of Preprocedural Stress Ball Use on Radial Artery Outcomes in Elective Coronary Angiography
This randomized, double-blind, controlled trial aims to evaluate the effect of preprocedural hand exercise using a stress ball on the incidence of radial artery spasm and other vascular complications in patients undergoing…
- Conditions
- Coronary Arterial Disease (CAD), Radial Artery Spasm, Radial Artery Occlusion, Transradial Angiogram
- Trial name
- SPARROW (NCT07087522)
- Testing
- Stress Ball Use
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Sakarya University
Stroke
Optimal Dosing of High-Intensity Locomotor Training for Step Attainment and Locomotor Outcomes in Stroke Patients Undergoing Acute Inpatient Rehabilitation
The purpose of this study is to elucidate optimal dosing for High Intensity Gait Training (HIGT) to reduce locomotor disability for those undergoing inpatient rehabilitation (IR) in the subacute phase of stroke recovery.
- Trial name
- NCT06637839
- Testing
- Moderate-Intensity Locomotor Training Program, High-Intensity Locomotor Training Program, High-Step Count Locomotor Training Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Severe Symptomatic Aortic Stenosis (Defined as New York Heart Association (NYHA) Class ≥ II)
PERFECT - Portuguese Evolut Registry Studying the Outcomes of Medtronic Evolut™ FX+ TAVI System by Evaluating an Optimal Care Pathway for TAVI
The goal of this registry is to learn how the Medtronic Evolut™ FX+ transcatheter aortic valve implantation (TAVI) System performs in adults with severe, symptomatic aortic stenosis who need valve replacement.
- Trial name
- PERFECT (NCT07343674)
- Where
- 12 sites in Portugal
- Volunteers
- 500 people
- Sponsor
- Portuguese Association of Interventional Cardiology
STROKE, Rehabilitation Outcome
Prospective Evaluation of Atrial Fibrillation-Related Stroke Patients in Rehabilitation Program (PEARL), an Observational Cohort Study
The goal of this observational study is to determine if rehabilitation program intensity impacts functional recovery and specific needs in adult ischemic stroke patients who require inpatient rehabilitation.
- Conditions
- STROKE, Rehabilitation Outcome, Brain Disease, Cardiovascular Disease Acute
- Trial name
- PEARL (NCT07253974)
- Testing
- Rehabilitation program based on Physiotherapy, occupational therapy and swallow and language therapy
- Where
- Spain
- Volunteers
- 213 people
- Sponsor
- Parc de Salut Mar
Stroke, Atheroscleroses
A Cohort Study on Cardiovascular and Cerebrovascular Outcomes
A standardized tool for grading carotid atherosclerotic plaques-dubbed Carotid Plaque-RADS (Reporting and Data System)-has recently been developed.
- Trial name
- NCT07178015
- Testing
- ultrasound scanning
- Where
- China
- Volunteers
- 855 people
- Sponsor
- Sun Yat-sen University
Atrial Fibrillation
MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)
The purpose of this research is to learn more about the normal care of patients with a new or pre-existing diagnosis of atrial fibrillation (AF).
- Trial name
- MANAGE-AF (NCT05978466)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- CorVita Science Foundation
Coronary Artery Bypass Grafting (CABG) Surgery, Coronary Artery Disease
Prospective Study Protocol for Multiparametric PCCT Assessment of Early Ventricular Outcomes After CABG
The goal of this observational study is to learn whether information about heart muscle tissue from preoperative photon-counting CT, a newer type of CT scan, can help predict heart recovery 3 months after coronary artery bypass…
- Trial name
- PCCT-CABG (NCT07883499)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xin Lou
Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure
Effects of a Multidisciplinary Integrated Care Model on Care Outcomes in Patients With Heart Failure With Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure cases and is associated with frequent hospitalizations, poor quality of life, and limited effective treatment options.
- Trial name
- MICM-HFpEF (NCT07798856)
- Testing
- Multidisciplinary Integrated Care Model (MICM), Usual Care
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Chimei Medical Center
Cardiogenic Shock, Mechanical Circulatory Support
OPTIMIZE 5.5 - Optimizing Impella 5.5 Outcomes Through Advanced Data Science
The main goal of this observational, study is to develop a clinical decision support tool utilizing Impella 5.5 pump parameters to predict native heart recovery and prevent adverse events, by leveraging data science and…
- Conditions
- Cardiogenic Shock, Mechanical Circulatory Support, Cardiogenic Shock Post Myocardial Infarction
- Trial name
- OPTIMIZE (NCT07619144)
- Testing
- Micro-axial flow pump support
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Heart Failure With Preserved Ejection Fraction (HFpEF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
This is a Phase III, randomized, double-blind, parallel-group, placebo-controlled, multicenter study to investigate CV outcomes with elecoglipron compared with placebo, in adults with heart failure with preserved ejection…
- Trial name
- Elevate-HF (NCT07761117)
- Testing
- Elecoglipron
- Where
- 679 sites in United States, Argentina and 30 more
- Volunteers
- 6,950 people
- Sponsor
- AstraZeneca
Aortic Diseases, Thoracic Aortic Aneurysm
Mid- and Long-term Outcomes of Custom-made Aortic Devices
This study aims to evaluate mid- and long-term outcomes after Thoracic endovascular aortic repair (TEVAR) with custom-made devices.
- Trial name
- NCT05777460
- Testing
- Thoracic endovascular aortic repair (TEVAR)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hypertensive Disorder of Pregnancy
Improving Maternal Cardiovascular Outcomes Through the Implementation of a Hypertensive Disorders of Pregnancy Bundle in Nigeria
The goal of this interventional study is to learn from patients and healthcare providers at 4 health institutions (study sites) in Abuja and Kano in Nigeria what ways to best develop the content of a Hypertensive Disorders of…
- Trial name
- IMPACT-HDP (NCT06859359)
- Testing
- Hypertension Disorders of Pregnancy (HDP) Implementation Bundle
- Where
- 4 sites in Nigeria
- Volunteers
- 1,200 people
- Sponsor
- Washington University School of Medicine
Pregnant Women
Association of Gestational Cardiovascular Health With Pregnancy Outcomes
Pregnancy is a critical period for cardiovascular health risk assessment and interventions to reduce the incidence of cardiovascular disease in both mother and child generations.
- Trial name
- NCT05776082
- Testing
- Questionnaire survey and specimen collection
- Where
- 3 sites in China, Rwanda
- Volunteers
- 5,000 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Respiration Failure, Cardio Vascular Disease
COMPARE-VENT Feasibility Pilot Study
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20%…
- Conditions
- Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness
- Trial name
- NCT07656259
- Testing
- Volume Controlled Mode, Pressure Controlled Mode
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Intracerebral Haemorrhage, Intracerebral Hemorrhage
Timing and Outcomes of Recovery After intraCerebral Hemorrhage
The TORCH registry is a prospective, observational cohort study, which will collect detailed, longitudinal data on the clinical characteristics, treatment modalities, and outcomes of patients with ICH.
- Trial name
- TORCH (NCT07166146)
- Testing
- Surgical interventions
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome
Angio-based Final Functional Effect of PCI
Fractional flow reserve (FFR) has revolutionized the diagnosis and treatment of coronary artery disease (CAD), and more recently, post percutaneous coronary intervention (post-PCI) FFR has emerged as an independent predictor of…
- Conditions
- Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome, Chronic Coronary Syndrome
- Trial name
- AFFE-PCI (NCT06255678)
- Testing
- Angiography-based vessel fractional flow reserve (vFFR) calculation
- Where
- Poland
- Volunteers
- 2,005 people
- Sponsor
- Medical University of Warsaw