Clinical trials: Cardiovascular Outcomes
Pulmonary Hypertension, Valvular Heart Disease
Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease
The purpose of this study is to evaluate the clinical efficacy of the mid-term treatment with sildenafil in patients with persistent moderate or severe pulmonary hypertension (PH) after a heart valve intervention.
- Trial name
- SIOVAC (NCT00862043)
- Testing
- Sildenafil Citrate
- Where
- 18 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Cardiac Arrest
A Comparison of CPR Outcomes Between Traditional and Endomorphic Manikins With and Without Equipment
The study's research design is a randomized experiment. 50 emergency responders (emergency medical responders, emergency medical technicians, advanced emergency medical technicians, and paramedics) will be recruited for this…
- Trial name
- NCT04283214
- Testing
- Cardiopulmonary Resuscitation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- North Dakota State University
Heart Failure
Feasibility of Implementation of Recommended Standards in Patients With Heart Failure
Longitudinal pilot study among heart failure patients from six Spanish hospitals to evaluate the feasibility of establishing and maintaining for one year the set of standards for measuring results in patients with heart failure…
- Trial name
- HFOutcomesSP (NCT04806048)
- Where
- 6 sites in Spain
- Volunteers
- 581 people
- Sponsor
- Fundación Pública Galega de Investigación Biomédica INIBIC
Heart Failure Patients
Monitoring and Self-management of Sleep Fatigue and Dyspnea
African Americans have the highest risk for developing heart failure. When African Americans are diagnosed with heart failure (AAHF) it is usually more advanced HF compared to other races.
- Trial name
- NCT04434716
- Testing
- Feasibility of wearing a Readiband to monitor Sleep and Fatigue
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Massachusetts, Amherst
Cardiovascular Diseases, Postoperative Complications
Effects of Cerebral Oxygen Saturation on Neuropsychological Outcomes
The purpose of this study is to evaluate the effects of maintaining adequate cerebral oxygen saturation (over 40%) on patients undergoing cardiac surgery.
- Trial name
- NCT00151307
- Testing
- INVOS cerebral oximeter
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Ischemic Stroke, Alteplase Adverse Reaction
Predictors of AIS Unfavorable Outcomes
The investigators evaluated whether the characteristics of ischemic stroke patients, door-to-needle time, and stroke risk factors were predictive variables for unfavourable outcomes.
- Trial name
- NCT06058884
- Testing
- Alteplase
- Where
- Egypt
- Volunteers
- 592 people
- Sponsor
- Kafrelsheikh University
Non-smoking, Healthy Adults
Effect of Short-term Portable Air Purifier Use on Occupant Health Indicators
The purpose of this research project is to examine whether short-term use of portable air pollution filtration can result in changes in indoor airborne pollutants and impact on cardiovascular and respiratory health outcomes of…
- Trial name
- NCT02736487
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Overweight, Obesity
SELECT-LIFE: A Research Study Looking at Long-term Effects of Semaglutide in People Who Took Part in the SELECT Cardiovascular Outcomes Trial
Participants are being asked to participate in SELECT-LIFE study because participants take part in the SELECT trial. SELECT-LIFE study is a survey-based study that will start when the SELECT trial ends.
- Trial name
- SELECT-LIFE (NCT04972721)
- Testing
- No treatment given
- Where
- 38 sites in United States, Algeria and 22 more
- Volunteers
- 3,439 people
- Sponsor
- Novo Nordisk A/S
Stroke
The Canadian Maraviroc Randomized Controlled Trial To Augment Rehabilitation Outcomes After Stroke
The CAMAROS trial is a randomized controlled phase II trial analyzing the effect of coupling a C-C chemokine receptor 5 (CCR5) antagonist, Maraviroc (Celsentri), and exercise to improve both upper and lower extremity recovery…
- Trial name
- CAMAROS (NCT04789616)
- Testing
- Maraviroc, Exercise Program, Activity Sensor
- Where
- 6 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University of Calgary
Coronary Heart Disease
"Nutrition Education by Nurses in Patients After Coronary Artery Bypass Grafting: Effect on Patients' Dietary Pattern, Adherence and Clinical Outcomes"
The purpose of this study is the investigation of the effect of nurse-led nutritional education of post-CABG patients on their dietary pattern, on their adherence to it, but also on their quality of life and well-being.
- Trial name
- NCT07172906
- Testing
- Patients of Group A and B both are filling out the questionnaire "Mediterranean diet questionnaire (MEDAS)", Patients of Group A and B both are filling out the "Mini Nutritional Asessment" questionnaire, Patients of Group A and B both are filling out "Nottingham Health Profile Scale" questionnaire
- Volunteers
- 160 people
- Sponsor
- Hellenic Mediterranean University
Genu Valgum or Varum, Growth; Arrested, Bone
Hinged Versus Conventional 8 Plate for Correction of Genu Valgum or Varum
To assess the therapeutic effect of hinged 8-figure plate by comparing with the traditional 8-figure plate through a randomized controlled clinical trial by assessing the differences between preoperative and postoperative data.
- Conditions
- Genu Valgum or Varum, Growth; Arrested, Bone, Epiphyseal Arrest, Lower Leg
- Trial name
- NCT03378206
- Testing
- hinged 8-figure plate, conventional 8-figure plate
- Volunteers
- 80 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Acute Myocardial Infarction
SILVER-AMI: Outcomes in Older Persons With Heart Attacks
SILVER-AMI is a research study of older persons who are admitted to the hospital with a heart attack. Patients will be interviewed in the hospital and again 6 months later.
- Trial name
- SILVER-AMI (NCT01755052)
- Where
- 81 sites in United States
- Volunteers
- 3,042 people
- Sponsor
- Yale University
Stroke
Implementation of a Registry for Patients With Stroke
Pathology registers are scientific research tools for the development of epidemiological and clinical studies and health planning, which allows access to useful elements for planning adequate health services.
- Trial name
- STRATEGY (NCT05389878)
- Testing
- rehabilitation
- Where
- 4 sites in Italy
- Volunteers
- 600 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Heart Failure, Stroke
BeyondSilos - More Personalised and Coordinated Care and Improved Outcomes for Elderly Patients
The study evaluates the impact of the new organisational models developed in the framework of the BeyondSilos pilot service in order to provide ICT supported integrated health and social care to elderly patients
- Conditions
- Heart Failure, Stroke, COPD, Diabetes
- Trial name
- BeyondSilos (NCT03111004)
- Testing
- New Care
- Volunteers
- 1,840 people
- Sponsor
- Him SA
Coronary Heart Disease (CHD)
Clinical Outcomes of Patients With Coronary Artery Disease
Coronary heart disease (CHD) stands as a foremost contributor to global mortality, characterized by complex pathogenesis that renders conventional "one-size-fits-all" preventive strategies inefficient.
- Trial name
- COCAD (NCT06216847)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Shenyang Northern Hospital
Frailty, Surgery
Telehealth Home-monitoring for Frailty in Cardiac Surgery
Cardiac surgical interventions are increasingly offered to vulnerable patients or patients living with frailty. Unfortunately, frailty has been shown to be an independent predictor of poorer outcome and increased health care…
- Conditions
- Frailty, Surgery, Cardiac Event
- Trial name
- THE-FACS (NCT05349708)
- Testing
- THE-FACS
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- New Brunswick Heart Centre
AV Block, Bundle-Branch Block
Outcomes and Safety of Various Conduction System Pacing Methods
The aim of this study is to evaluate safety and clinical outcomes after different pacing approaches of conduction system pacing in a prospective registry.
- Conditions
- AV Block, Bundle-Branch Block, Atrial Fibrillation Rapid
- Trial name
- NCT04749836
- Testing
- His bundle pacing implantation, Left bundle branch area pacing implantation, Bachmann bundle pacing
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease (CAD)
Multiple Electrode Aggregometry & Clopidogrel Resistance
Antiplatelet therapy with aspirin-clopidogrel reduces the risk of cardiovascular episodes after percutaneous coronary intervention (PCI) in patients with acute coronary syndromes.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Coronary Artery Disease (CAD), Myocardial Infraction
- Trial name
- NCT01991093
- Where
- 3 sites in Greece
- Volunteers
- 280 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Atrial Fibrillation, Stroke
Procedure RElated Outcomes With the Watchman FLX Left Atrial Appendage Closure Device
This study is a single-centre prospective post-market approval of the early experience with the Watchman FLX device for left atrial appendage closure in patients with atrial fibrillation at high risk of thromboembolic stroke and…
- Trial name
- REFLX (NCT03339193)
- Testing
- Left atrial appendage closure
- Where
- United Kingdom
- Sponsor
- Oxford University Hospitals NHS Trust
Inflammatory Rheumatism, Polymyalgia Rheumatica
PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS
To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy.
- Conditions
- Inflammatory Rheumatism, Polymyalgia Rheumatica, Giant Cell Arteritis, Idiopathic Inflammatory Myopathies
- Trial name
- PRODIGIOUS (NCT04664465)
- Where
- 12 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
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