Clinical trials: Cardiovascular Outcomes
Multiple Myeloma, Refractory Multiple Myeloma
Real World Insights During Treatment for Relapsed/Refractory Multiple Myeloma with Isatuximab
This descriptive study aims to evaluate the experience of adults with relapsed or refractory multiple myeloma receiving standard of care isatuximab-irfc through collection of quantitative, qualitative and wearable data.
- Trial name
- NCT05053607
- Testing
- Digital Health Coaching Program, Fitbit
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Pack Health
Cardiovascular Diseases, Renal Disease
OPTIMISation of Cardio-renal-metabolic-pulmonary Disease Guideline Adherence in High Risk Community Dwelling Individuals
Cardiovascular disease (CVD) causes a quarter of all deaths in the United Kingdom (UK). This is the single biggest area where the National Health Service (NHS) can save lives by detecting and treating risk factors early.
- Conditions
- Cardiovascular Diseases, Renal Disease, Metabolic Disease, Pulmonary Disease
- Trial name
- OPTIMISE (NCT06444711)
- Testing
- NICE guidance
- Where
- United Kingdom
- Volunteers
- 138 people
- Sponsor
- University of Leeds
ST Elevation Myocardial Infarction
Cardiovascular Patient Outcomes and Research Team Primary PCI Registry
The proposed study is a registry of patients treated with primary angioplasty for acute myocardial infarction. The aim of this registry is to define the outcomes of patients treated for acute, ST-segment myocardial infarction…
- Trial name
- CPORT (NCT02201264)
- Where
- 14 sites in United States
- Volunteers
- 6,726 people
- Sponsor
- Johns Hopkins University
Congenital Heart Disease, Comorbidities and Coexisting Conditions
Congenital Heart Initiative-Redefining Outcomes and Navigation to Adult Centered Care
Congenital heart defects (CHDs) are a heterogeneous group of rare diseases of varying severity, each diagnosis with its unique set of co-morbidities.
- Trial name
- CHI-RON (NCT05185232)
- Testing
- Impact of gaps in care/loss to healthcare follow-up
- Where
- 16 sites in United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Heart Failure
ODYSSEE-vCHAT Pilot Trial for Heart Failure
INTRODUCTION Psychological distress and reduced quality of life are prevalent within the heart failure (HF) population. The 1-year rehospitalization (40%) and 5-year mortality (45% for women and 60% for men) rates are high.
- Trial name
- ODYSSEE-vCHAT (NCT04966104)
- Testing
- ODYSSEE-vCHAT
- Where
- 3 sites in Canada
- Volunteers
- 61 people
- Sponsor
- University Health Network, Toronto
Atrial Fibrillation (AF)
Epicardial Adipose Tissue-Targeted DApagliflozin for Reducing Electrical Remodeling in Atrial Fibrillation
Persistent atrial fibrillation (PeAF) is associated with a high risk of recurrence following catheter ablation despite advances in ablation technology and strategies.
- Trial name
- EAT-DARE-AF (NCT07331727)
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Shanghai Chest Hospital
Heart Failure
Image Guided Mapping for Cardiac Pacing Intervention
Patients with heart failure and cardiomyopathy that have been referred for Cardiac Resynchronization Therapy (CRT) will have their CRT devices implanted using an image guided treatment plan for optimal lead delivery.
- Trial name
- MAPIT-TOO (NCT01638754)
- Testing
- Image guided Cardiac Resynchronization Therapy (CRT) device lead placement., optimizing myocardial lead placement for Cardiac Resynchronization Therapy (CRT) devices
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Diabetes Mellitus Type 2, Diabetes Mellitus Type 2 in Obese
The Effects of Nutritional Intervention on Health Parameters in Participants With Type 2 Diabetes Mellitus
The goal of this clinical trial is to evaluate the effects of nutritional intervention on anthropometric, biochemical and cardiovascular parameters in participants with type 2 diabetes mellitus.
- Conditions
- Diabetes Mellitus Type 2, Diabetes Mellitus Type 2 in Obese, Diabetes, Diabetes Mellitus Non-insulin-dependent
- Trial name
- NCT06235762
- Testing
- Nutritional Intervention
- Where
- Brazil
- Volunteers
- 84 people
- Sponsor
- Sao Jose do Rio Preto Medical School
Hypertension
Oral Cannabidiol Effect on Blood Pressure in Hypertensive Patients
The objective of this randomized, placebo-controlled and crossover study is to extend the findings from the acute studies into more chronic administration of CBD in individuals with mild or moderate hypertension who are either…
- Trial name
- HYPER-H21-4 (NCT05346562)
- Testing
- Cannabidiol
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- University of Split, School of Medicine
Acute Ischemic Stroke (AIS)
Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
Acute ischemic stroke caused by blockage of a large artery in the brain is one of the leading causes of death and long-term disability worldwide.
- Trial name
- TOPAZ (NCT07734792)
- Testing
- Tirzepatide, Standard Medical Care (SMC)
- Where
- China
- Volunteers
- 726 people
- Sponsor
- yifang zhu
Bereavement
Long-term Consequences of Bereavement in Children, Adolescents and Young Adults
The purpose of this study is to examine how the death of a parent as a child, adolescent or young adult affects health and psychosocial wellbeing in adult life and to evaluate the impact in adult life of counseling to children…
- Trial name
- NCT01453699
- Where
- Denmark
- Volunteers
- 1,225,660 people, healthy volunteers welcome
- Sponsor
- Danish Cancer Society
PCI, Drug-coated Balloon
Impact of Procedural Factors on Drug-Coated Balloon Outcomes in Coronary Artery Disease
This registry aimed to investigate drug-coated balloon procedural factors (particularly delivery time and inflation duration) to evaluate the impact on angiographic and clinical outcomes in patients undergoing percutaneous…
- Conditions
- PCI, Drug-coated Balloon, Coronary Artery Disease
- Trial name
- DT (NCT07764094)
- Where
- 7 sites in China
- Volunteers
- 500 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Chronic Disease, Mental Health
Optimizing Behavioral Health Homes for Adults With Serious Mental Illness
Adults with serious mental illness (SMI) frequently have unmet medical needs which place them at risk for adverse health outcomes.
- Conditions
- Chronic Disease, Mental Health, Behavioral Health, Cardiovascular Disease
- Trial name
- PCORI OH (NCT02318797)
- Testing
- Patient Self-Directed Care, Provider-Supported Integrated Care
- Where
- United States
- Volunteers
- 1,229 people
- Sponsor
- University of Pittsburgh
COVID-19 Respiratory Infection
Cardiovascular Disease and Outcomes Among Patients With SARS-CoV-2 Infection (COVID-19)
The coronavirus disease of 2019 (COVID-19) has affected over 2.4 million individuals worldwide and has resulted in >171,000 deaths. Cardiovascular disease (CVD) is an important contributor to death in these patients.
- Trial name
- NCT05085262
- Testing
- Bloodwork, Echocardiogram, PET/MRI, Bloodwork, Echocardiogram, MRI
- Where
- Canada
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Perioperative Complication, Stroke, Acute
Outcomes After Perioperative Stroke Following Cardiac Surgery
Perioperative stroke is a devastating complication of cardiac surgery that is currently poorly characterized but occurs in 1-5% of patients and is associated with poor outcomes including increased mortality.
- Conditions
- Perioperative Complication, Stroke, Acute, Stroke, Complication, Stroke, Cardiovascular
- Trial name
- NCT05333146
- Testing
- Cardiac Surgery
- Where
- Canada
- Volunteers
- 906 people
- Sponsor
- University of British Columbia
Aortic Valve Disease
Comparison of Two Pericardial Bioprostheses in AVR
The purpose of the study is to compare early and 1-year hemodynamic performance and clinical outcomes after aortic valve replacement using two pericardial bioprosthesis, Avalus and Carpentier Edwards Perimount Magna Ease.
- Trial name
- NCT03796442
- Testing
- AVR with AVALUS, AVR with CEPME
- Where
- 2 sites in South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul National University Hospital
Heart Valve Prosthesis
Outcomes of Pulmonary Valve Replacement With the INSPIRIS (Model 11500A) Valve
The goal of this retrospective chart review is to contribute to the literature on the mid-term durability and hemodynamics of the INSPIRS Resilia bioprosthesis when implanted in children and young adults.
- Trial name
- NCT05986396
- Testing
- INSPIRIS Resilia (model 11500A)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor College of Medicine
Incisional Hernia of Midline of Abdomen, Surgical Wound
Onlay Mesh in Abdominal Aortic Aneurysm Repair.
The aim of the study was to compare the incidence of IH after abdominal aortic aneurysm (AAA) open repair according to the abdominal wall closure technique used.
- Trial name
- NCT07416422
- Testing
- Abdominal Ultrasound or computed tomography
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Coronary Artery Disease, Atherosclerosis
Radial Artery Patency and Clinical Outcomes Trial
Coronary Artery Bypass Graft (CABG)Surgery is commonly used to treat patients with coronary artery disease (atherosclerosis) for the relief of angina (chest pain) and improve heart muscle function.
- Trial name
- RAPCO (NCT00475488)
- Testing
- Coronary artery bypass grafting
- Where
- Australia
- Volunteers
- 605 people
- Sponsor
- Austin Health
Cardiac Failure, Renal Failure
Protocolized Diuretic Strategy in Cardiorenal Failure
This research study is a randomized clinical trial to evaluate if taking diuretics (medications that increase urine production and help with fluid removal from the body) in a standardized fashion (using a guideline for adjusting…
- Conditions
- Cardiac Failure, Renal Failure, Kidney Failure
- Trial name
- ProDiuS (NCT01921829)
- Testing
- Protocolized Diuretic Strategy
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Kelly V. Liang, MD
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