Clinical trials: Cardiovascular Outcomes
Mitral Regurgitation, Mitral Valve Regurgitation
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS
The purpose of the Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation (COAPT) Trial is to confirm the safety and effectiveness of the MitraClip…
- Conditions
- Mitral Regurgitation, Mitral Valve Regurgitation, Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects, Heart Failure
- Trial name
- COAPT (NCT01626079)
- Testing
- MitraClip System
- Where
- 86 sites in United States, Canada
- Volunteers
- 776 people
- Sponsor
- Abbott Medical Devices
Myocardium; Injury, Myocardial Infarction
Effect of Colchicine in Patients With Myocardial Infarction
Over the past years, a substantial volume of evidence has accumulated identifying inflammatory processes as key mediators of the deleterious effects of ischemia/reperfusion-related phenomena in patients presenting with…
- Conditions
- Myocardium; Injury, Myocardial Infarction, Myocardial Ischemia
- Trial name
- NCT04218786
- Testing
- Colchicine
- Where
- Pakistan
- Sponsor
- Shifa Tameer-e-Millat University
InTracranial Haemorrhage
FAITH - Factor XA Inhibitor-Related InTracranial Haemorrhage
FAITH study is a multicentre retrospective analysis study that aims to understand the burden of ICH related to FXa inhibitors and the current treatment approaches in country/countries where specific reversal agents are not…
- Trial name
- FAITH (NCT06420011)
- Where
- 10 sites in Argentina, Brazil and 5 more
- Volunteers
- 123 people
- Sponsor
- AstraZeneca
Patent Foramen Ovale, Stroke, Cryptogenic
PFO tRanscatether Occlusion Long-term Outcomes National Group (PROLONG) Registry
Patent foramen ovale (PFO) has been associated with cryptogenic stroke and transient ischemic attack (TIA) in young adults. Evidence from randomized clinical trials (RCT) has shown that transcatheter PFO closure yields a 59%…
- Conditions
- Patent Foramen Ovale, Stroke, Cryptogenic, Transient Ischaemic Attack Due to Embolism, Atrial Fibrillation New Onset
- Trial name
- PROLONG (NCT06504121)
- Testing
- Septal Occluder Device
- Volunteers
- 1,360 people
- Sponsor
- IRCCS Ospedale San Raffaele
ST-Elevation Myocardial Infarction
A Safety/Efficacy Study of Intracoronary Integrilin to Improve Balloon Angioplasty Outcomes for the Treatment of Heart Attacks
The main purpose of this research study is to try to improve the results of the standard treatment for heart attacks. Normally, heart attack patients get a fast dose and a slow dose of eptifibatide in the emergency room, shortly…
- Trial name
- IC TITAN (NCT00719914)
- Testing
- eptifibatide, normal saline
- Where
- 3 sites in United States
- Volunteers
- 31 people
- Sponsor
- Brigham and Women's Hospital
Thoracoabdominal Aortic Aneurysm, Thoracoabdominal; Aortic, Aneurysm, Dissecting
Frailty and Physician Modified Fenestrated Endograft for Thoracoabdominal Aortic Pathologies
The primary objective of this single arm, prospective feasibility study, Impact of Frailty on Clinical Outcomes of Patients Treated for Thoracoabdominal and Complex Abdominal Aortic Aneurysms with Physician-Modified Fenestrated…
- Conditions
- Thoracoabdominal Aortic Aneurysm, Thoracoabdominal; Aortic, Aneurysm, Dissecting, Pararenal Aneurysm, Frailty Syndrome
- Trial name
- NCT04524247
- Testing
- Physician Modified Endografts
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Southern California
Neck Pain, Blood Pressure
Effect of Cervical Mobility on Cardiovascular And Respiratory Outcomes Among Young Adults
In some individuals, neck pain subsides within a year but reappearance is surpassing while for some patients it prevails for lifetime.
- Trial name
- NCT05257616
- Testing
- Traction Mobilization technique, Traction Mobilization technique with SNAGS
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Shifa Tameer-e-Millat University
Unstable Angina
Incidence, Clinical Characteristics and Outcomes of Unstable Angina in the contempoRary Area.
The study aims to evaluate clinical characteristics and prognostic of a contemporary population of patients with UA defined using T hs-cTn measurements The study includes all patients admitted in 2 French university centers with…
- Trial name
- ICAR (NCT06378333)
- Testing
- patients who underwent coronary angiography
- Where
- France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Montpellier
Aortic Valve Disease
Prospective Long-Term Outcomes of a Standardized Ross Procedure
This standardized prospective long-term outcome analysis will help reaffirm these findings via a multicenter patient cohort and describe the best practices/techniques for stabilization of the autograft and right ventricular…
- Trial name
- ROSS (NCT06352671)
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Baylor Research Institute
Hormone Replacement Therapy, Cardiovascular Diseases
A Prospective Multicenter Cohort Study of Contemporary Menopausal Hormone Therapy and Cardiovascular Outcomes
This prospective registry study investigates the impact of new hormone replacement therapy (HRT) delivery methods, such as creams, gels, and sprays, on cardiovascular risk in postmenopausal women.
- Conditions
- Hormone Replacement Therapy, Cardiovascular Diseases, Hormone Replacement Therapy, Post-Menopausal, Menopause
- Trial name
- CATCH-Menopaus (NCT07394049)
- Where
- 2 sites in Germany
- Volunteers
- 3,408 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Mitral Insufficiency, Mitral Stenosis
Polish Transcatheter Transfemoral Mitral Valve-in-Valve Implantation (Mitral ViV) Registry
In recent years increasing number of mitral bioprosthesis implantation, especially in elderly population, is observed. Bioprosthetic valves are associated with a lower risk of thrombotic and bleeding adverse events compared with…
- Conditions
- Mitral Insufficiency, Mitral Stenosis, Mitral Stenosis With Insufficiency, Heart Failure
- Trial name
- NCT05625607
- Testing
- Transcatheter mitral valve-in-valve implantation
- Where
- 7 sites in Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Congenital Heart Defect, Executive Function
Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study
Each year, approximately 1 child in every 100 is born with Congenital Heart Disease (CHD), making it the most common birth defect.
- Conditions
- Congenital Heart Defect, Executive Function, Children, Neurodevelopmental Disorders
- Trial name
- NCT03023644
- Testing
- Cogmed Working Memory Training
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Boston Children's Hospital
Quality of Life, Patient Reported Outcome (PRO)
Patient-Reported Outcomes in Allogeneic Stem Cell Transplantation and CAR-T Therapy
3.1. Overview Prospective, multicenter, observational cohort study comparing short-term PROs measured with the HM-PRO between two exposure groups: patients undergoing allogeneic stem cell transplantation (allo-SCT) and patients…
- Conditions
- Quality of Life, Patient Reported Outcome (PRO), Allogeneic Blood and Marrow Transplantation (BMT), CAR T Cell Therapy
- Trial name
- QOL-ONE PRO-CT (NCT07289087)
- Volunteers
- 162 people
- Sponsor
- Associazione Qol-one
Aortic Valve Stenosis, Cardiovascular Diseases
The Bicuspid Aortic Stenosis Following Transcatheter Aortic Valve Replacement Registry
The purpose of this study is to evaluate the clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid aortic valve stenosis.
- Conditions
- Aortic Valve Stenosis, Cardiovascular Diseases, Heart Valve Diseases, Bicuspid
- Trial name
- Bicuspid TAVR (NCT02394184)
- Testing
- transcatheter aortic valve replacement
- Where
- South Korea
- Volunteers
- 102 people
- Sponsor
- Seung-Jung Park
Symptomatic Hemorrhoidal Disease, Hemorrhoids Grade I and II
AI-Assisted Written Information in Symptomatic Hemorrhoidal Disease
This single-center, prospective, parallel-group, 1:1 randomized controlled trial compares standardized verbal counseling with AI-assisted written patient information in adults with symptomatic hemorrhoidal disease receiving…
- Trial name
- HD-AI (NCT07701798)
- Testing
- AI-assisted written patient information, Standardized verbal counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Sanliurfa Education and Research Hospital
Pre-Eclampsia; Complicating Pregnancy, Gestational Hypertension
Remote Postpartum Blood Pressure Monitoring and Cardiovascular Education
The goal of this clinical trial is to learn if patient education and regular text reminders are a feasible intervention to engage patients and reduce post partum hypertension.
- Trial name
- NCT06920563
- Testing
- Video, Text Reminder, Blood pressure threshold
- Where
- United States
- Volunteers
- 296 people
- Sponsor
- Ochsner Health System
Stroke
Stroke Canada Optimization of Rehabilitation by Evidence Implementation Trial SCORE-IT)
The aim of this project is to evaluate whether using an implementation intervention promotes use of best practices by rehabilitation professionals and leads to improvements in patient outcomes for individuals with stroke.
- Trial name
- NCT00359593
- Testing
- Knowledge translation intervention package
- Where
- 2 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- Toronto Rehabilitation Institute
Coronary Artery Disease
Angiography-Derived FFR And IVUS for Clinical Outcomes in Patients With Coronary Artery Disease
Comparison of Angiography-derived Fractional FLow Reserve And IntraVascular Ultrasound-guided Intervention Strategy for Clinical OUtcomes in Patients with CoRonary Artery Disease
- Trial name
- FLAVOUR II (NCT04397211)
- Testing
- Angiography-derived FFR, IVUS
- Where
- 23 sites in China, South Korea
- Volunteers
- 1,872 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
End Stage Renal Disease
Ultrafiltration Profiling and Outcomes Among Individuals on Maintenance Hemodialysis
The rate of fluid removal (ultrafiltration, UF) during hemodialysis (HD) may contribute to cardiovascular morbidity and mortality among individuals receiving maintenance HD.
- Trial name
- NCT03301740
- Testing
- UF profiling during HD, Conventional HD
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Type 2
Long-term Study of Nateglinide+Valsartan to Prevent or Delay Type II Diabetes Mellitus and Cardiovascular Complications
This study is a test of the safety and effectiveness of two drugs, one for diabetes and one for hypertension, in keeping patients with high lab values of glucose from progressing to frank diabetes and developing cardiovascular…
- Trial name
- Navigator (NCT00097786)
- Testing
- Valsartan 160 mg + nateglinide 60 mg
- Where
- 38 sites in United States, Argentina and 36 more
- Volunteers
- 9,306 people
- Sponsor
- Novartis Pharmaceuticals
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