Clinical trials: Cardiovascular Outcomes
Myocardial Infarction
Impact Of Eplerenone On Cardiovascular Outcomes In Patients Post Myocardial Infarction
Administration of eplerenone within 24 hours of onset of symptoms of myocardial infarction, in patients without heart failure, reduces cardiovascular mortality / morbidity.
- Trial name
- REMINDER (NCT01176968)
- Testing
- Eplerenone
- Where
- 75 sites in Canada, Czechia and 9 more
- Volunteers
- 1,012 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Coronary Artery Disease (CAD)
Investigating the Effects of Cardiac Rehabilitation eXercise Modalities on Physical and Mental Health Outcomes
Coronary revascularization improves survival for patients with coronary artery disease. However,many patients are left with poor physical and mental health.
- Trial name
- CRX-Modalities (NCT02765568)
- Testing
- High Intensity Interval Training, Moderate Intensity Continuous Exercise Training, Nordic Walking
- Where
- Canada
- Volunteers
- 135 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ischemic Stroke
Post-Stroke Sensory Reweighting on Walking and Balance Outcomes
The primary objective of this proof-of-concept study is to longitudinally track the development of post-stroke sensory reweighting (PSR), identify associated structural neuroanatomical correlates, and investigate their…
- Trial name
- PSR (NCT06727097)
- Testing
- Posturography, Walking Speed, Instrumented 7M Timed UP and GO
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Cincinnati
Coronary Artery Disease
EDUCATE: The MEDTRONIC Endeavor Drug Eluting Stenting: Understanding Care, Antiplatelet Agents and Thrombotic Events
EDUCATE is a prospective, multi-center study designed to collect real-world safety and clinical outcomes in subjects receiving one or more Endeavor Zotarolimus-Eluting Stents and either clopidogrel and aspirin or prasugrel and…
- Trial name
- EDUCATE (NCT01069003)
- Testing
- Thienopyridine Therapy, Surveillance Arm
- Where
- United States
- Volunteers
- 2,272 people
- Sponsor
- Medtronic Vascular
Aortic Valve Stenosis, Aortic Diseases
The Asian Transcatheter Aortic Valve Replacement Registry
The purpose of this study is to evaluate the clinical outcomes of transcatheter aortic valve replacement (TAVR) in the Asian Pacific population
- Trial name
- Asian TAVR (NCT02308150)
- Testing
- transcatheter aortic valve replacement
- Where
- 12 sites in China, Japan and 3 more
- Volunteers
- 1,505 people
- Sponsor
- Seung-Jung Park
Cardiovascular Diseases, Kidney Diseases
HeAlth-data Register sTudies of Risk and Outcomes in Cardiac Surgery
The overall project aim is to study risk and outcomes following cardiac surgery by cross-linking high-quality national Swedish health-data registers for population-based investigations of individual level clinically relevant…
- Conditions
- Cardiovascular Diseases, Kidney Diseases, Depression, Diabetes Mellitus
- Trial name
- HARTROCS (NCT02276950)
- Testing
- Coronary artery bypass surgery, Heart valve surgery
- Volunteers
- 150,000 people
- Sponsor
- Ulrik Sartipy, MD, PhD
Cardiovascular Diseases
SAVR: IMPACT of Pre-existing Comorbidities on Patient Outcomes and Prosthetic Valve Performance in a Real-world Setting.
The IMPACT Registry represents a non-interventional, prospective, open-label, multicenter, international registry with a follow-up of 5 years that includes data of patients undergoing aortic valve replacement with the Edwards…
- Trial name
- IMPACT (NCT04053088)
- Testing
- INSPIRIS RESILIA Aortic Valve™
- Where
- 22 sites in Austria, Germany and 2 more
- Volunteers
- 500 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Stroke, Cerebral Infarction
Assessment of Patient Reported Health Status Questions Via Four Different Methods of Administration, in Stroke Survivors.
A Patient Reported Outcome Measure (PROM) is a questionnaire that asks patients for their views on their own health or the impact of healthcare they have received on their health and quality of life (RCN, 2011).
- Conditions
- Stroke, Cerebral Infarction, Cerebral Hemorrhage, Stroke Hemorrhagic
- Trial name
- NCT03177161
- Testing
- 15 Patient Reported Health Status Questions
- Where
- 4 sites in United Kingdom
- Volunteers
- 472 people
- Sponsor
- Dr Jonathan Hewitt
Overweight, Obesity
Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity
The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease.
- Trial name
- SELECT (NCT03574597)
- Testing
- Semaglutide
- Where
- 833 sites in United States, Algeria and 40 more
- Volunteers
- 17,604 people
- Sponsor
- Novo Nordisk A/S
Heart Failure
The Effects of Self-monitoring With a Mobile Application in Heart Failure
In the United States, about 40 percent of heart failure (HF) patients are readmitted within 1-year following their first admission for HF and hospitalization accounts for approximately 70 percent of the costs of HF management.
- Trial name
- NCT03149510
- Testing
- Mobile Application
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- University of Michigan
Cardiac Arrest, Out-Of-Hospital, Ketamine
The Application of Ketamine for Sedation in Patients With Cardiac Arrest - - KetCat (KETamine in Cardiac ArresT) Study
Recent evidence suggests ketamine may attenuate harmful cellular cascades taking place after brain injury that result in permanent damage.
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Ketamine, Neurologic Manifestations
- Trial name
- KetCat (NCT04360070)
- Testing
- Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Fraser Health
Heart Failure
Image Guided Mapping for Cardiac Pacing Intervention
Patients with heart failure and cardiomyopathy that have been referred for Cardiac Resynchronization Therapy (CRT) will have their CRT devices implanted using an image guided treatment plan for optimal lead delivery.
- Trial name
- MAPIT-TOO (NCT01638754)
- Testing
- Image guided Cardiac Resynchronization Therapy (CRT) device lead placement., optimizing myocardial lead placement for Cardiac Resynchronization Therapy (CRT) devices
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Stroke
Optimal Dosing of High-Intensity Locomotor Training for Step Attainment and Locomotor Outcomes in Stroke Patients Undergoing Acute Inpatient Rehabilitation
The purpose of this study is to elucidate optimal dosing for High Intensity Gait Training (HIGT) to reduce locomotor disability for those undergoing inpatient rehabilitation (IR) in the subacute phase of stroke recovery.
- Trial name
- NCT06637839
- Testing
- Moderate-Intensity Locomotor Training Program, High-Intensity Locomotor Training Program, High-Step Count Locomotor Training Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Central Retinal Vein Occlusion
Predictive Factors of Ranibizumab Treatment in Macular Edema With CRVO
Recent studies have shown that intravitreal injection of anti-VEGF agent, Lucentis (Ranibizumab) is effective for macular edema associated with central retinal vein occlusion (CRVO).
- Trial name
- CRVO (NCT02091505)
- Testing
- Ranibizumab
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Mie University
Fitness Trackers, Sedentary Time
Fullscale_Intervention Study: Genetic Risk Communication in Coronary Heart Disease and Wearables
Background: This study aims to determine the effects of communicating genetic risk for Coronary Heart Disease (CHD) alone or in combination with goal setting and prompts from a wearable device on objectively measured sedentary…
- Conditions
- Fitness Trackers, Sedentary Time, Genetic Predisposition to Disease, Coronary Heart Disease
- Trial name
- NCT05789966
- Testing
- Genetic Risk Estimate+Health Coaching, Genetic Risk Estimate + Fitbit Functions+Health Coaching
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Heart Valve Diseases, Coronary Artery Disease
Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)
Cardiac surgery is associated with a high risk of cardiovascular and other complications. The investigators hypothesized that perioperative infusion of dexmedetomidine may reduce the incidence of complications and mortality…
- Trial name
- DOCS (NCT02237495)
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Xijing Hospital
Peripheral Vascular Disease
Pilot Study to Determine Percent Tissue Perfusion and Cellular Viability Using SPY Imaging
Little is known about chronic wound microenvironments, especially in peripheral vascular disease (PVD) and diabetic patients. At the demarcation line, the percentage of viable cells and tissue is unclear.
- Trial name
- NCT01522495
- Testing
- SPY Imaging, ICG dye (0.2 - 0.5 mg/kg), SPY Imaging
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Georgetown University
Chronic Subdural Hematoma, Registry
Registry of Chronic Subdural Hematoma
The goal of this observational study is to better understand how chronic subdural hematoma (CSDH) progresses and how patients are treated and cared for. The study focuses on three main questions: 1.
- Trial name
- CSDH Registry (NCT06759428)
- Where
- 2 sites in Netherlands
- Volunteers
- 1,500 people
- Sponsor
- Erasmus Medical Center
Diabetic Foot Ulcer
Custom Insole With Transcutaneous Electrical Nerve Stimulation on Clinical Outcomes of Diabetic Foot Ulcers
Diabetic foot ulcers (DFUs) are one of the serious complications of diabetes, typically resulting from neuropathy or peripheral arterial disease, and can often lead to amputation.
- Trial name
- NCT07109895
- Testing
- Standard Care Only, Custom Insole + Standard Care, TENS + Custom Insole + Standard Care
- Where
- Pakistan
- Volunteers
- 159 people
- Sponsor
- University of Lahore
Type 2 Diabetes, Systolic Hypertension
Blood Pressure Outcomes With Liraglutide Therapy
Purpose: The purpose of this study is to further study the mechanism by which liraglutide, a relatively new anti-hyperglycemic medication, might lower blood pressure in patients with Type 2 diabetes and high blood pressure.
- Trial name
- BOLT (NCT01755572)
- Testing
- Liraglutide
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Mount Sinai Hospital, Canada
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