Clinical trials: Cardiovascular Shock
Septic Shock, Sepsis
Effects of Paroxetine on Cardiovascular Function in Septic Patients
It is known that septic shock is characterized by arterial hypotension, decreased peripheral vascular resistance and hyporeactivity to vasoconstrictor agents, with NO being an important mediator of this organ dysfunction.
- Trial name
- NCT05725837
- Testing
- Paroxetine
- Where
- 2 sites in Brazil
- Volunteers
- 130 people
- Sponsor
- Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude
Sepsis, Septic Shock
Control Versus Liberal Cardiac Frequency in Patients in Sepse With Atrial Fibrillation of High Ventricular Response
Amiodarone is considered the medicine of choice in heart rate control in critically ill patients with atrial fibrillation with high ventricular response.
- Conditions
- Sepsis, Septic Shock, Atrial Fibrillation, Ventricular Fibrillation
- Trial name
- FAARV (NCT03715556)
- Testing
- Amiodarone, 0.9% physiological solution
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- University of Sao Paulo General Hospital
Cardiogenic Shock
An Interventional Left Ventricular Assist System for Cardiogenic Shock
Imported Impella The price is relatively expensive and difficult for ordinary patients to afford. In order to better meet the growing clinical needs in China, Anhui Tongling Bionic Technology Co., Ltd.
- Trial name
- NCT06127927
- Testing
- Interventional Left Ventricular Assist System
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Fujian Medical University
Hypotension
Use of Ultrasonography to Determine Fluid-responsiveness for Shock in a Population of Intensive Care Unit Patients
The objective of our study is to determine the correlation of transthoracic ultrasonographic indices of fluid responsiveness to changes in direct measures of cardiac output and to compare them to other established predictors of…
- Trial name
- NCT01680770
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Chicago
Cardiogenic Shock
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded.
- Trial name
- REMAP ECMO (NCT05913622)
- Testing
- Intra-aortic balloon pump
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 430 people
- Sponsor
- Erasmus Medical Center
Sepsis, Circulatory Failure
Respiratory Variations For Predicting Fluid Responsiveness 2
Objectives: To investigate whether respiratory variations of inferior vena cava diameters (cIVC) predict fluid responsiveness in spontaneously breathing patients with septic acute circulatory failure and irregular heartbeats.
- Conditions
- Sepsis, Circulatory Failure, Respiratory Physiological Phenomena
- Trial name
- ReVaPreF2 (NCT03066375)
- Testing
- Echocardiography-Doppler
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Lille
Stroke Gait Rehabilitation
The Effectiveness of Laser and Extracorporeal Shock Wave Therapy in Resolving Ankle Muscle Spasm in Stroke Patients.
Stroke is one of the leading causes of long-term disability worldwide. Spasticity (muscle spasm) is a common and disabling consequence of stroke.
- Trial name
- spasticity (NCT07364110)
- Testing
- Rehabilitation Protocol, Extracorporeal Shock Wave Therapy (ESWT), High-Intensity Laser Therapy (HILT)
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Necmettin Erbakan University
Decompensated Chronic Heart Failure, Heart Failure NYHA Class III
Epidemiology and Prognostic of the Acute Heart Failure
EPICAL 2 (Epidemiology and prognostic of the Acute Heart Failure) is an epidemiological, observational, prospective and multicenter study.
- Conditions
- Decompensated Chronic Heart Failure, Heart Failure NYHA Class III, Acute Pulmonary Edema, Cardiogenic Shock
- Trial name
- EPICAL2 (NCT02880358)
- Where
- France
- Volunteers
- 2,500 people
- Sponsor
- Central Hospital, Nancy, France
Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome
Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level
The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome, Stress Response, Cardiac Surgery Prognosis
- Trial name
- MicorSIRS (NCT03288610)
- Testing
- Preoperative copeptin level
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Circulatory Failure, Echocardiography
Diagnostic Performance of Echocardiography Performed by Emergency Physicians After a Basic Training
After a basic training to echocardiography, emergency physicians will have to answer simple clinical questions about circulatory failure mechanisms.
- Trial name
- ECHOBEDSIDE (NCT02974790)
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 89 people
- Sponsor
- University Hospital, Limoges
Coronary Artery Disease
Improvement of Cardiac Function in Patients With Ischemic Cardiomyopathy by Extracorporeal Shock Wave Therapy: a Multicenter Clinical Study
Cardiac shock wave therapy (CSWT) is a noninvasive new therapeutic option in the treatment of chronic refractory angina pectoris.
- Trial name
- NCT03398096
- Testing
- Cardiac shock wave therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai 10th People's Hospital
Fluid Responsiveness, Acute Circulatory Failure
Prediction of Fluid Responsiveness Using the Femoral Vein-to-Artery Diameter Ratio
This prospective single-center observational study aims to evaluate whether the ultrasound-measured femoral vein-to-femoral artery diameter ratio can predict fluid responsiveness in mechanically ventilated adult intensive care…
- Conditions
- Fluid Responsiveness, Acute Circulatory Failure, Shock
- Trial name
- NCT07546656
- Testing
- Ultrasound Measurement of Femoral Vein-to-Femoral Artery Diameter Ratio
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University - Cerrahpasa
ST Segment Elevation Myocardial Infarction (STEMI), Cardiogenic Shock Post Myocardial Infarction
Early Beta Blocker Administration in STEMI Patients With SCAI B Status
This study is looking at how a medication called beta-blockers (metoprolol) affects patients with a heart attack (STEMI) who are in the cardiac intensive care unit.
- Trial name
- NCT06967194
- Testing
- Metoprolol (MET), Plcacebo
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Shock, Fluid Overload
Evaluating Fluid Responsiveness in ICU Patients Using VTI and Trendelenburg Positioning
Fluid administration is a commonly performed in the ICU for critically ill patients. However, it can lead to complications such as fluid overload, pulmonary edema, and increased mortality in some patients.
- Conditions
- Shock, Fluid Overload, Cardiac Output, Low
- Trial name
- TREND-US (NCT06418022)
- Testing
- Trendelenburg positioning VTI
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Lenox Hill Hospital
Vasoplegia, Vasoplegic Shock
Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
- Trial name
- RAAS-HLM (NCT05833828)
- Testing
- on-pump surgery, off-pump surgery
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Universität Münster
Vasoplegic Syndrome of Cardiac Surgery
Inotropic Effects of Vasopressin Versus Noradrenaline In Patients With Vasoplegic Syndrome After Cardiac Surgery
This is a randomized, double-blind clinical trial designed to compare the inotropic effects of vasopressin versus norepinephrine in patients who develop vasoplegic syndrome in the immediate postoperative period following cardiac…
- Trial name
- INVASC (NCT06934798)
- Testing
- Vasopressin intravenous infusion, Norepinephrine intravenous infusion
- Where
- Brazil
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cardiogenic Shock, Frailty
Prognostic Impact of Frailty in Cardiogenic Shock
The goal of this observational study is to show prognostic impact of frailty in cardiogenic shock according to age. The main questions it aims to answer are: Can frailty successfully predict outcomes in cardiogenic shock? Whether…
- Conditions
- Cardiogenic Shock, Frailty, Age
- Trial name
- NCT07260084
- Volunteers
- 207,419 people
- Sponsor
- Samsung Medical Center
Cardiac Valve Disease, Coronary Artery Disease
The Val-CARD Trial
The Val-CARD trial aims to answer the question: "Does the drug sodium valproate reduce complications affecting the heart and kidneys in patients having heart operations?" Sodium valproate is a drug commonly used in the treatment…
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Organ Failure, Multiple
- Trial name
- Val-CARD (NCT03825250)
- Testing
- Sodium Valproate
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Leicester
Circulatory Failure
Volume Expansion With Albumin vs. Crystalloid and Expiratory Lung Impedance
Acute circulatory failure reduces oxygen delivery below cellular requirements, potentially leading to organ failure. Intravenous fluids are generally administered with the aim of increasing cardiac output and restore organ…
- Trial name
- EXHALE (NCT04037644)
- Testing
- Fluid loading with Albumin, Fluid loading with Ringer Lactate
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- University of Milan
Cardiogenic Shock
Scoring Model for Predicting Outcome in Patients With Cardiogenic Shock
This study aims to develop a predictive model for the outcomes of patients with cardiogenic shock
- Trial name
- NCT04850248
- Testing
- no intervention, this is an observational study
- Volunteers
- 999 people
- Sponsor
- National Taiwan University Hospital