Clinical trials: Cardiovascular System
Constipation
A Trial in Healthy Volunteers, to Evaluate the Tolerability and Cardiac Safety of Prucalopride
An escalating dose of prucalopride up to a maximum of 20 mg was given once daily to 32 healthy volunteers to determine safety at the maximum tolerable dose or at 20 mg.
- Trial name
- NCT00488215
- Testing
- prucalopride
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Movetis
CPR, Cardiac Arrest (CA)
Effect of an Educational Intervention on CPR Knowledge and Skills in Schoolchildren
This study aims to evaluate the effectiveness of a CPR intervention for children aged 7 and 8. Given the high prevalence of out-of-hospital cardiac arrests (OHCA) and the proven benefits of early CPR training, the study seeks to…
- Trial name
- NCT06929715
- Testing
- Intervention for Teaching the First Link in the Chain of Survival to 7- and 8-Year-Old Children
- Where
- Colombia
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Pregnancy Induced Hypertension, Preeclampsia and Eclampsia
Role of L-citrulline in Prevention of Pregnancy Associated Hypertension
The target population for our study is healthy nulliparous pregnant women (first pregnancy) between the 12-16 week of pregnancy. If a subject is eligible, written consent will be obtained by person to person contact.
- Conditions
- Pregnancy Induced Hypertension, Preeclampsia and Eclampsia, Gestational Hypertension
- Trial name
- NCT04979793
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Type 2 Diabetes Mellitus, Hypertension
LLM-Assisted Diabetes and Hypertension Management by Village Doctors
This is a prospective, assessor-blinded, randomized controlled study designed to evaluate whether large language model (LLM)-assisted decision support can improve village doctors' abilities in the comprehensive management of…
- Trial name
- NCT07678658
- Testing
- LLM
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu Taizhou People's Hospital
Central Retinal Artery Occlusion
Safety and Efficacy After Selective Intra-arterial Thrombolysis for Central Retinal Artery Occlusion
Central retinal artery occlusion (CRAO) is an ophthalmic emergency which leads to devastating visual function defects and poor prognosis.
- Trial name
- NCT05562284
- Testing
- intra-arterial thrombolysis, conservative treatments
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Hypertension
CKD-828 (80/5mg) Pharmacokinetic Study
A randomized, open-label, single-dose, two-period, two-way, crossover study to compare the pharmacokinetics and safety CKD-828 (Fixed Dose Combination Tablet) to coadministration telmisartan and s-amlodipine in health volunteers.
- Trial name
- NCT02250833
- Testing
- CKD-828, Telmisartan, S-amlodipine
- Where
- South Korea
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Cardiovascular Diseases Risk
Circulating Vascular Regenerative Cell Exhaustion in Individuals Without Type 2 Diabetes Who Are of South Asian or European Origins
ORIGINS-VRCE-2 is an observational study aimed to assess how blood vessel forming stem cells from individuals without diabetes or a history of cardiovascular disease differ between individuals of South Asian and European…
- Trial name
- ORIGINS-VRCE-2 (NCT06769347)
- Where
- 5 sites in Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Hypertension
Prospective Safety and Tolerability Assessment of a Cardiovascular Health Dietary Supplement
This single-arm, open-label study will assess the safety and tolerability of one daily tablet of a commercially available cardiovascular health dietary supplement by questionnaire and blood markers in adults with borderline to…
- Trial name
- NCT02452749
- Testing
- Cardiovascular health dietary supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Chronic Stable Angina
A Randomized, Open-label, Single-dose, Crossover Clinical Trial to Evaluate the Food Effect on the Pharmacokinetics of Dilatrend SR 64mg Capsule After Oral Administration in Healthy Male Volunteers
A randomized, open-label, single-dose, crossover clinical trial to evaluate the food effect on the pharmacokinetics of Dilatrend SR 64mg capsule after oral administration in healthy male volunteers.
- Trial name
- NCT01340248
- Testing
- Dilatrend 64mg capsule
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Tobacco Dependence
Effects of Yoga and Cardiovascular Exercise on Smoking Motivation
The overall purpose of this pilot study is to examine effects of Hatha yoga and cardiovascular exercise on craving, mood, cue reactivity, and smoking behavior.
- Trial name
- NCT01423578
- Testing
- Hatha Yoga (HY), Cardiovascular Exercise (CE), Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Congenital Heart Disease, Heart Failure
Gender Difference in NET Activation in Patients With Congenital Heart Disease and Heart Failure
Neutrophil hyperactivation has detrimental effects on cardiac tissue after injuries, leading to fibrosis lesions and cardiac dysfunction.
- Conditions
- Congenital Heart Disease, Heart Failure, Gender
- Trial name
- FIBRONETx (NCT05263843)
- Testing
- Biological markers of myocardial fibrosis
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Metabonomics to Investigate Effects of Healthy Diets on Blood Pressure: the OmniHeart Study
To compare the urinary metabolomes on individuals undergone three different healthy diets--a carbohydrate-rich diet, a protein-rich diet, or a diet rich in unsaturated fat.
- Trial name
- NCT03369535
- Testing
- CARB rich diet, MUFA rich diet, PROT rich diet
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Kent
Vasospastic Angina
Multidetector Coronary CT In Vasospastic Angina
The purpose of this study is to compare the extent of coronary vessel stenosis between coronary spasm-induced angina attacks (named vasospastic angina, VSA) patients and health volunteers by multi-detector computed tomography…
- Trial name
- NCT02180971
- Testing
- Positive CAG with EG test, Negative CAG with EG test
- Where
- South Korea
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dong-A University
Aging Well
Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly
Due to age-related effects, the bone and cardiovascular health are damaged. Physical exercise and in particular the strength training has been proposed as a fundamental tool to these pathologies, especially in the elderly.
- Trial name
- NCT04281264
- Testing
- Passive Hypoxia, Normoxia Circuit Training with Elastic Bands, Hypoxia Circuit Training with Elastic Bands
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Extremadura
Postprandial Hypotension, Hypoglycemia
Postprandial Hypotension and Insulin Levels
The goal of this observational study is to learn about the relationship between postprandial hypotension and insulin levels in adults.
- Trial name
- NCT06657287
- Testing
- Mixed meal test
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Stroke, Upper Extremity Paresis
Post-stroke Haptic Feedback Use Deficit: A Comparative and Reliability Study
The aim of this comparative and reliability study is to highlight a deficit in the use of vibrotactile sensory feedback (haptic effect) in the planning and execution of fine manual dexterity movements after stroke.
- Conditions
- Stroke, Upper Extremity Paresis, Manual Dexterity, Sensory Integration Dysfunction
- Trial name
- HapticS (NCT06344221)
- Testing
- Dextrain Manipulandum and haptic feedback device
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Cardiovascular Risk Factor, Sedentary Lifestyle
The Effects of Faculty/Staff Exercise Program
This study focuses on analyzing the data collected from participants in the Faculty/Staff Exercise Program to determine the success and quantifying the results of the program.
- Conditions
- Cardiovascular Risk Factor, Sedentary Lifestyle, Physical Activity
- Trial name
- NCT03385447
- Testing
- Physical Activity
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kent State University
Traumatic Shock, Hemorrhagic Shock
Prehospital Norepinephrine and Early Mortality in Traumatic Shock
The effect of early, prehospital norepinephrine use in patients with traumatic shock on mortality is unknown. Recent existing observational evidence from single system data (US, France, Japan) are conflicting.
- Conditions
- Traumatic Shock, Hemorrhagic Shock, Traumatic Brain Injury, Hypotension and Shock
- Trial name
- NCT04497155
- Testing
- Norepinephrine
- Volunteers
- 2,164 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Acute Stroke
Cerebral Blood Flow-guided Early Rehabilitation Intervention After Stroke: a Pilot Randomized Trial (STAND-OP)
The primary goal of most acute stroke interventions is to restore cerebral blood flow (CBF) in the affected region and prevent hypoperfusion during early clinical course.
- Trial name
- STAND-OP (NCT04848285)
- Testing
- Early Mobilization, Standard care
- Where
- Spain
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiac Arrest
Pediatric Resuscitation With Feedback Devices
The aim of this study was to compare four different CPR feedback devices to standard BLS in terms of the quality of single rescuer pediatric resuscitation.
- Trial name
- CPR_NURSE (NCT02294721)
- Testing
- Standard BLS, The CPREazy, TrueCPR
- Where
- Poland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- International Institute of Rescue Research and Education
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