Clinical trials: Cardiovascular System
Heart Failure, Respiratory Failure
Donor Simvastatin Treatment in Organ Transplantation
The aim of the study is to investigate the effects of donor simvastatin treatment on ischemia-reperfusion injury after heart transplantation.
- Conditions
- Heart Failure, Respiratory Failure, Liver Failure, Kidney Failure
- Trial name
- SIMVA (NCT01160978)
- Testing
- Simvastatin 80mg, Control Rx
- Where
- Finland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Congestive Heart Failure
Initial Study of Fenoterol as a Treatment for Heart Failure
Background: Fenoterol has been used to treat asthma by opening up the airways in the lungs. It also increases the heart rate without significantly increasing blood pressure.
- Trial name
- NCT01440335
- Testing
- Oral R,R'-Fenoterol, Oral Racemic Fenoterol
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Essential Hypertension, Healthy Volunteers
Phase 1 Clinical Study of MWX401 Injection in Chinese Healthy Participants and Participants With Mild Hypertension
This is a single-center, randomized, double-blind, placebo-controlled, single ascending-dose phase 1 clinical study, aimed at evaluating the safety, tolerability, PK, PD and immunogenicity of single subcutaneous administration of…
- Trial name
- NCT07803835
- Testing
- MWX401 1, MWX401 2, MWX401 3
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Hypertension
Improving Health Outcomes: Blood Pressure
This quality improvement project is focused on improving hypertension care delivery processes in ambulatory clinical practices, 5 in Illinois and 5 in Maryland for a total of 10 practice sites.The primary aim of this quality…
- Trial name
- IHO:BP (NCT02021981)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- American Medical Association
Diabetes, Coronary Artery Disease
Epicardial Fat and Clinical Outcomes After Coronary Artery Bypass Grafting in Diabetics vs. Non Diabetics
Cardiovascular disease (CVD) is a group of diseases including both the heart and blood vessels, thereby including coronary heart disease (CHD). To date, diabetics have a higher incidence and prevalence of multivessels CHD.
- Trial name
- NCT03360981
- Testing
- Incretins
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Coronary Artery Disease, Systemic Inflammatory Response Syndrome
A Comparative Study Between Dexmedetomidine Versus Methylprednisolone on Induced Inflammatory Response in Patients Undergoing On-pump CABG
A comparison between precedex versus solumedrol as anti-inflammatory stress response inhibitors in patients undergoing on-pump CABG using different inflammatroy response parameters and the outcome of the drugs on the cognitive…
- Conditions
- Coronary Artery Disease, Systemic Inflammatory Response Syndrome, Postoperative Complications
- Trial name
- NCT07101367
- Testing
- Normal saline, Dexmedetomidine, Methylprednisolone
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Aortic Stenosis
Loss of Y Chromosome in Aortic Stenosis
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body.
- Trial name
- NCT06595407
- Testing
- Blood analysis for loss-of-Y chromosome
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Heart Diseases, Lung Diseases
The Usefulness of Patients Receiving Their Own Letter After an Outpatient Attendance
As part of the NHS plan it has been proposed to extend some consultants' usual practices and to send all patients copies of the letters sent to their general practitioners (GPs) following outpatient consultations.
- Trial name
- NCT00129636
- Testing
- Additional specific letter written to patient
- Where
- United Kingdom
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity, Body Composition
Study of Macronutrients and Heart Disease Risk
The objective of this trial is to examine the long-term effects of a diet low in carbohydrates, as compared to one low in fat, on cardiovascular disease risk factors, including blood pressure (BP), body weight and composition…
- Conditions
- Obesity, Body Composition, Blood Pressure, Cardiovascular Diseases
- Trial name
- MACRO (NCT00609271)
- Testing
- low carbohydrate diet, low fat diet
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Tulane University Health Sciences Center
Cardiac Arrest, Cardiopulmonary Arrest
Lowlands Saves Lives: A Randomized Trial Comparing CPR-quality Between Face-to-face vs. Lifesaver VR Training
The objective of the Lowlands Saves Lives trial is to compare the quality of cardiopulmonary resuscitation (CPR) between face-to-face versus Lifesaver Virtual Reality smartphone application trained participants using a randomized…
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Out-Of-Hospital Cardiac Arrest
- Trial name
- NCT04013633
- Testing
- Lifesaver virtual reality training, Face-to-face training
- Where
- Netherlands
- Volunteers
- 381 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Stroke
A Mobile Brain/Body Imaging Platform for the Assessment and Optimization of Post-stroke Overground Robotic Gait Treatments
The study aims to identify neural biomarkers that can be used to monitor the recovery of locomotion and movement of post-stroke patients, both in natural settings and with enriched treatment using robotic device.
- Trial name
- COBI (NCT07510633)
- Testing
- overground wearable robotic device
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr. Franco Molteni
Cardiometabolic Disease
Metagenomics and Integrative Systems Medicine of Cardiometabolic Diseases
Supported by state-of-the-art systems medicine competences including integrative computational and functional genomics, the overarching goal of the trial is to investigate the impact of qualitative and quantitative changes in the…
- Trial name
- METACARDIS (NCT02059538)
- Testing
- Adipose tissue biopsies (omental and subcutaneous) liver, CT-scan, Stools sampling
- Where
- 3 sites in Denmark, France and 1 more
- Volunteers
- 2,350 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension
Effect of Aliskiren and Hydrochlorothiazide on Kidney Oxygenation in Patients With Hypertension
The goal of this project is to evaluate the chronic effect (8 weeks) of RASILEZ 300mg (aliskiren) on renal tissue oxygenation in patients with stage 1-2 hypertension, and to compare the chronic effect (8 weeks) of RASILEZ 300mg…
- Trial name
- NCT01519635
- Testing
- Aliskiren, Hydrochlorothiazide
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Diabetes, Hypertension
FFA Hypertension and Inflammation in Lean and Obese Subjects
Although a large number of obese patients develop high blood pressure, the cause is unknown. The purpose of this study is to look at the effect of high fatty acids (a type of fat) in the development of high blood pressure in…
- Conditions
- Diabetes, Hypertension, Obesity
- Trial name
- FFAADA (NCT00721617)
- Testing
- Intralipid 20%, Normal Saline, Oral fat load
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Behçet
Role of Femoral Vein Wall Thickness and Inflammatory Markers in Patients With Behcet Disease
Evaluation of femoral vein wall thickness and inflammatory indices in patients with Behcet disease and assessment of their relation to the disease activity and related some clinical manifestations
- Trial name
- NCT06721234
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Aneurysm, Cerebral, Endovascular Procedures
Comparison of Two Different Antiplatelet Preparations for an Unruptured Intracranial Aneurysm
Perform a randomized comparison study of dual-antiplatelet (aspirin, prasugrel) and triple-antiplatelet (aspirin, clopidogrel, and cilostazol) preparation using P2Y12 assay in patients with high on-treatment platelet reactivity…
- Trial name
- NCT03581409
- Testing
- Aspirin, Prasugrel, Clopidogrel
- Where
- South Korea
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cardiovascular Diseases
A First-in-human Study of YN001 in Healthy Volunteers
This will be a single center, randomized, double-blind, placebo-controlled, single ascending dose and multiple ascending dose study in healthy adult subjects.
- Trial name
- NCT05635084
- Testing
- YN001
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Beijing Inno Medicine Co., Ltd.
Hypertension
Bioequivalence Study of Azilsartan Medoxomil 80 mg Tablets (Gedeon Richter Plc., Hungary) and Edarbi® 80 mg Tablets (JSC Nizhpharm, Russia)
ACEis are among the most widely used classes of antihypertensive drugs. ARBs have a similar antihypertensive efficacy and protective effect as ACEis, albeit with a somewhat different mechanism for RAS inhibition and a smaller…
- Trial name
- NCT06990204
- Testing
- Azilsartan medoxomil 80 mg tablet, Edarbi® 80 mg tablets
- Where
- Russia
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Gedeon Richter Plc.
Healthy Male Subjects
Clinical Trial to Assess the Pharmacokinetic Characteristics of Lodivixx Tab. 5/160mg in Healthy Male Subjects (N=27)
To assess the pharmacokinetic characteristics of valsartan and S-amlodipine after single oral administration of Exforge tab. 10/160mg, a combination formulation of valsartan and amlodipine as reference drug and Lodivixx tab.
- Trial name
- NCT03648333
- Testing
- Exforge tab. 10/160mg, Lodivixx tab. 5/160mg
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Hanlim Pharm. Co., Ltd.
Intracranial Aneurysm
@neurIST : Intregrated Biomedical Informatics for the Management of Cerebral Aneurysms
The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA).
- Trial name
- @neurIST (NCT05526352)
- Where
- 22 sites in United States, Canada and 9 more
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
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