Clinical trials: Cardioversion, open to volunteers
Atrial Fibrillation (AF)
Energy Dose and Cardioversion Outcomes in AF
This multicenter, randomized study will compare two electrical cardioversion energy strategies in adults with atrial fibrillation who are scheduled to undergo cardioversion during atrial fibrillation ablation or within 3 months…
- Trial name
- LE-HI-CV (NCT07884253)
- Testing
- Synchronized Electrical Cardioversion With Different Energy Strategies, Conventional Step-Up Energy Cardioversion
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Persistent Atrial Fibrillation, Cardiac Arrhythmia
Investigation of Cardioversion Versus Therapeutic Ablation for Persistent AF (ORBICA-AF)
The main aim of the research is to investigate whether patients undergoing pulmonary vein isolation with catheter ablation for persistent atrial fibrillation (AF) will have lower rates of AF recurrence than those treated by DC…
- Conditions
- Persistent Atrial Fibrillation, Cardiac Arrhythmia, Catheter Ablation
- Trial name
- ORBICA-AF (NCT06096246)
- Testing
- Pulmonary vein isolation, DC Cardioversion, Implantable loop recorder
- Where
- United Kingdom
- Volunteers
- 208 people
- Sponsor
- Barts & The London NHS Trust
Atrial Fibrillation (AF), Atrial Flutter
Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED)
The goal of this randomized clinical trial is to learn whether patients with symptomatic atrial fibrillation or atrial flutter (AF) who require heart imaging to rule out a blood clot before cardioversion would benefit from…
- Trial name
- LA CLOTTED (NCT07002450)
- Testing
- Cardiac computed tomography angiography, Standard of care management
- Where
- 3 sites in United States, Canada
- Volunteers
- 190 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Cardiac Death, Cardiac Arrest
Quality of Cardiopulmonary Resuscitation Pre- and Intra Hospital
The survival after intrahospital cardiac arrest has been reported to 15%. In Norway this varies between 16 and 23%.). Many factors are associated with survival after cardiac arrest, both intra- and prehospital.
- Conditions
- Cardiac Death, Cardiac Arrest, Cardiac Arrhythmia, Cardiac Disease
- Trial name
- NCT04295291
- Volunteers
- 300 people
- Sponsor
- Ostfold University College
Atrial Fibrillation (AF), Heart Failure (HF)
Diagnostic Electrical Cardioversion for Explaining Patient's AF and HF Symptoms
Rationale: The co-existence of Atrial Fibrillation (AF) and Heart Failure (HF) is associated with increased morbidity, mortality, and hospital admissions, significantly contributing to healthcare burden.
- Conditions
- Atrial Fibrillation (AF), Heart Failure (HF), Electrical Cardioversion
- Trial name
- DEEP-AF-HF (NCT07000942)
- Testing
- Electrical cardioversion (ECV)
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- M. Rienstra
Atrial Fibrillation (AF)
Optimal Shock Energy for Electrical Cardioversion of Atrial Fibrillation
Introduction For elective electrical cardioversion of atrial fibrillation, the recommended standard is the administration of a biphasic direct current shock.
- Trial name
- NCT07610980
- Testing
- Direct current biphasic electrical cardioversion, blood sampling
- Where
- Czechia
- Volunteers
- 400 people
- Sponsor
- Motol and Homolka University Hospital
Atrial Fibrillation, Electric Countershock
BIS-Guided Sedation Versus Standard Clinical Sedation During Elective Electrical Cardioversion for Atrial Fibrillation
Electrical cardioversion (ECV) is a standard procedure used to restore normal heart rhythm in patients with atrial fibrillation (AF) by delivering a brief electrical shock to the heart.
- Conditions
- Atrial Fibrillation, Electric Countershock, Deep Sedation
- Trial name
- BIS-ECV-RCT (NCT07569016)
- Testing
- BIS-guided propofol sedation, Clinical-guided propofol sedation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Cardiac Resynchronization Therapy, Left Bundle Branch Area Pacing
Feasibility and Outcomes Registry of Lumenless dEfibrillation Leads for Conduction System Pacing
The recent development and market introduction of small diameter implantable defibrillation leads able to deliver left bundle branch area pacing (LBBAP) has opened the possibility of achieving cardiac resynchronization therapy…
- Trial name
- FORGE CSP (NCT07406737)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Caen
Atrial Fibrillation, Atrial Fibrillation, Persistent
Electrical Cardioversion As a Predictor in Postoperative Preservation of Sinus Rhythm
The aim of this study is to evaluate benefits of electric cardioversion in the early and long-term postoperative period in patients after radiofrequency catheter isolation of pulmonary veins.
- Trial name
- NCT06654401
- Testing
- Transthoracic echocardiography, 24-hour ECG Monitor, Electroanatomic mapping
- Where
- Russia
- Volunteers
- 125 people
- Sponsor
- Saint Petersburg State University, Russia
Atrial Fibrillation (AF), Atrial Flutter
Electrophysiological Registry Duesseldorf
This registry at University Hospital Düsseldorf collects retrospective and prospective (from 2019 onward) data on patients undergoing electrophysiological studies (EPS), catheter ablation, and electrical cardioversion.
- Conditions
- Atrial Fibrillation (AF), Atrial Flutter, Supraventricular Tachycardias, Ventricular Tachycardia (VT)
- Trial name
- NCT07196176
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Ventricular Arrythmia, Ventricular Fibrillation
Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study
The ALARION EV Study is a prospective, multi-center, single-arm, non-randomized study without concurrent or historical controls.
- Conditions
- Ventricular Arrythmia, Ventricular Fibrillation, Ventricular Tachycardia
- Trial name
- ALARION EV (NCT07324031)
- Testing
- Atala™ lead and EV-ICD Pulse Generator
- Where
- 35 sites in United States, Netherlands
- Volunteers
- 280 people
- Sponsor
- AtaCor Medical, Inc.
Atrial Fibrillation (AF)
Exercise-induced Cardioversion in Persistent Atrial Fibrillation
This study aims to to evaluate the feasibility of conducting a larger randomized controlled trial (RCT) to assess whether an exercise stress test on an ergometer bicycle could induce sinus rhythm in patients with persistent AF…
- Trial name
- ExPAF (NCT07008066)
- Testing
- Bicycle ergometer excercise, Standard care with electrical cardioversion
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Defibrillator, Tricuspid Valve Regurgitation
Early Feasibility Study of 3930M Defibrillation Lead Implantation Via the Middle Cardiac Vein in Patients With Tricuspid Valve Regurgitation
Prospective, single center, early feasibility study designed to evaluate the initial safety and device performance of the Medtronic 3930M Lead when implanted via the Middle Cardiac Vein in patients with Tricuspid Valve…
- Trial name
- MCV3930 EFS (NCT07811609)
- Testing
- Defibrillator
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Minneapolis Heart Institute Foundation
Atrial Fibrillation
Stepwise Strategy for Treatment of Atrialfibrillation Substrate Study
Electrical/pharmacological cardioversion improves structural remodeling of left atrium. We hypothesized that radiofrequency ablation surgery for atrial fibrillation has a higher success rate and a lower recurrence rate of atrial…
- Trial name
- SAFE (NCT07129564)
- Testing
- treatment react
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Yuehui Yin
Out-of-hospital Cardiac Arrest (OHCA)
Trial of Mobile External Defibrillator for Out-of-hospital Cardiac Arrest in Singapore.
The goal of this clinical trial is to learn the feasibility of equipping the volunteer community responders (VCR) with the mobile external automated defibrillators (mAEDs) for the management of adults experiencing out-of-hospital…
- Trial name
- NCT07042061
- Testing
- Mobile external automated defibrillator
- Volunteers
- 1,000 people
- Sponsor
- Singapore General Hospital
Atrial Fibrillation Paroxysmal, Coronary Artery Disease Without Residual Ischemia
Flecainide Versus Amiodarone in the Cardioversion of Paroxysmal Atrial Fibrillation at the Emergency Department, in Patients With Coronary Artery Disease Without Residual Ischemia
Current guidelines for the cardioversion of paroxysmal Atrial Fibrillation at the Emergency Department do not prioritize between antiarrhythmic agents and do not consider the time taken for successful cardioversion.
- Trial name
- FLECA-ED (NCT05549752)
- Testing
- Flecainide Injectable Solution, Amiodarone Injectable Solution
- Where
- 3 sites in Greece
- Volunteers
- 80 people
- Sponsor
- Hippocration General Hospital
Atrial Fibrillation (AF), Atrial Flutter
Cardiologist-Administered Midazolam vs. Anaesthesiologist-Assisted Propofol Sedation For Transoesophageal Echocardiography-Guided Cardioversion of Atrial Fibrillation
Irregular heart rhythms, known as atrial fibrillation or atrial flutter, are common conditions that can increase the risk of stroke and heart failure.
- Trial name
- CARDIOZOLAM-1 (NCT07571447)
- Testing
- One-step cardiologist-only midazolam sedation, Two-step anaesthesiologist-assisted propofol sedation
- Where
- 2 sites in Denmark
- Volunteers
- 220 people
- Sponsor
- Gødstrup Hospital
Atrial Fibrillation
Shock Energy for Electrical Cardioversion of Persistent Atrial Fibrillation
The goal of this clinical trial is to compare the efficacy of a maximum output shock for cardioverting atrial fibrillation between two commonly used defibrillators in New Zealand .
- Trial name
- NCT05903170
- Testing
- 360J LifePak Monitor/Defibrillator, 200J Philips HeartStart MRx Monitor/Defibrillator
- Where
- New Zealand
- Volunteers
- 100 people
- Sponsor
- Wellington Hospital
Atrial Fibrillation (AF), Atrial Flutter
Detection of Atrial Fibrillation Through Voice Signal Processing
This study is testing a new technology that listens to a person's voice during short phone calls to help identify heart rhythm problems.
- Trial name
- NCT07212816
- Testing
- Sauti
- Volunteers
- 40 people
- Sponsor
- Vital Audio Inc
Out of Hospital Cardiac Arrest, Ventricular Fibrillation
Early Double Sequential Defibrillation in Out of Hospital Cardiac Arrest
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation.
- Conditions
- Out of Hospital Cardiac Arrest, Ventricular Fibrillation, Defibrillation, CPR
- Trial name
- DOUBLE D (NCT07174986)
- Testing
- Double sequential defibirllation, Standard defibrillation
- Where
- 14 sites in Netherlands, Spain and 1 more
- Volunteers
- 916 people
- Sponsor
- Gabriel Riva