Clinical trials: Carnosine
Dietary Modification
Creatine, Carnitine and Carnosine in Vegetarians
Balanced vegetarian diets are popular and contain health-promoting characteristics. A balanced lacto-ovo-vegetarian diet differs in nutrient intake from an omnivorous diet, e.g.
- Trial name
- NCT03194334
- Testing
- Vegetarian diet, creatine, Beta-alanine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Ghent
Spinal Cord Injuries
Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury
Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines.
- Trial name
- NCT02604927
- Testing
- Beta-alanine, Dextrose
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Nutrition
Impact of Food Process and Mastication on Nutrient Bioavailability
This project aims at assessing the impact of heat treatment on the bioavailability of meat carnosine and amino acids, the interaction between masticatory efficiency and heat treatment of meat on the bioavailability of carnosine…
- Trial name
- DREAM (NCT02709837)
- Testing
- Nutritional
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Oxidative Stress
Pharmacokinetics of Carnosine
The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.
- Trial name
- NCT00721708
- Testing
- pure carnosine, Beef, Chicken
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Tufts University
Gulf War Illness, Persian Gulf War Syndrome
Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans
Determine if: genetic differences of CNDP1 gene the previously defined GWI/Chronic Fatigue Syndrome (GWI/CFS) cerebrospinal fluid proteome contents psychometric other variables can differentiate between veterans of the 1990-1991…
- Trial name
- NCT00810225
- Where
- United States
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Muscle Weakness, Muscle; Fatigue, Heart
The Impact of Beef on Muscle Fatigue in Older Adults
The goal of this controlled-feeding cross-over diet intervention is to compare a beef diet to a vegetarian diet on muscle fatigue in older adults.
- Conditions
- Muscle Weakness, Muscle; Fatigue, Heart, Older Adults
- Trial name
- NCT05860088
- Testing
- Beef Diet, Vegetarian Diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Muscle Function
β-alanine Supplementation on Knee Extensor Contractile and Force Properties
Carnosine (made by bonding β-alanine and histidine) has been suggested to contribute to the extension of physical exercise, counteracting the decline in muscle performance due to fatigue.
- Trial name
- NCT02819505
- Testing
- beta-alanine
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Subjective Cognitive Impairment, Mild Cognitive Impairment
Molecular Mediators of Physical Exercise and Carnosine Induced Effects in Patients With Preclinical and Early Stage Neurodegenerative Disease
The purpose of this study is to investigate the beneficial effects of regular exercise and the impact of food supplement carnosine on cognitive, motoric and metabolic functions as well as on specific biologically active…
- Conditions
- Subjective Cognitive Impairment, Mild Cognitive Impairment, Parkinson Disease, Healthy Volunteers
- Trial name
- NCT03330470
- Testing
- exercise, carnosine supplementation, stretching
- Where
- 3 sites in Slovakia, Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Visceral Obesity, Non-alcoholic Fatty Liver
Effect of Multi-ingredient on Visceral Adiposity & Non-alcoholic Fatty Liver Disease in Postmenopausal Women With Abdominal Obesity
This study aims to evaluate the effect of daily intake of a specific combination of different natural histidine-related amino acids in combination with dietary recommendations, in the reduction of visceral fat, as well as their…
- Conditions
- Visceral Obesity, Non-alcoholic Fatty Liver, Postmenopausal
- Trial name
- FATHIS+ (NCT06377631)
- Testing
- Multi-ingredient of L-histidine, L-serine, L-carnosine and N-Acetylcysteine
- Where
- 2 sites in Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Exercise Training, Carnosine
The Influence of Exercise on Tissue Beta-alanine Uptake and Carnosine Synthesis Rates
B-alanine supplementation is highly efficient in increasing intramuscular carnosine content, leading to improved physical performance, especially in high-intensity exercises (HIIE).
- Conditions
- Exercise Training, Carnosine, Dietary Supplements
- Trial name
- NCT04936737
- Testing
- Beta-alanine supplementation, High intensity interval exercise
- Where
- Brazil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy
Effect of β-alanine Supplementation on Muscle Carnosine
Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.
- Trial name
- LitmusMagnet (NCT00813553)
- Testing
- beta-alanine
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Carnosine
Carnosine Supplementation and Cardiovascular Function
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high…
- Trial name
- NCT05723939
- Testing
- Carnosine supplementation, Controls
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Insulin Sensitivity
The Potential of Carnosine Supplementation in Reducing the Cardiometabolic Risk
The aim of this study is to determine whether carnosine supplementation in overweight/obese individuals can improve insulin secretion and/or insulin resistance by decreasing sub clinical inflammation.
- Trial name
- NCT02686996
- Testing
- carnosine
- Where
- Australia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Monash University
Muscle Function
The Effects of 4 Week β-alanine Supplementation on Knee Extensor Contractile and Force Properties in the Over 60s
The older population is the fastest growing age group worldwide, but it is also the most susceptible to chronic diseases and disabilities.
- Trial name
- NCT03111979
- Testing
- beta-alanine
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Oral Diseases
Carnosine Supplementation on Quantity/Quality of Oral Salivae.
The aim of this study is to elucidate the mutual relationship between salivae characteristics and oral microbiome and to compare them with common oral disease; furthermore, by using specific bioinformatic tools to analyse the…
- Trial name
- PHoral (NCT04295525)
- Testing
- 400 mg mucoadhesive oral tablet
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Milan
Poor Glycemic Control, Cardiovascular Risk Factors
The Potential of Carnosine Supplementation in Optimising Cardiometabolic Health
The investigators hypothesise that carnosine supplementation will improve: 1. glycaemic control 2. cardiovascular risk factors 3.
- Conditions
- Poor Glycemic Control, Cardiovascular Risk Factors, Cognitive Function 1, Social
- Trial name
- NCT02917928
- Testing
- carnosine
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Monash University
Multiple Sclerosis, Exercise Therapy
Carnosine Loading and Periodized Training in MS and HC
Increasing evidence favours exercise therapy as an efficient tool to counteract inactivity related secondary symptoms in MS. Furthermore, exercise therapy may affect MS-associated muscle contractile and energy supply…
- Conditions
- Multiple Sclerosis, Exercise Therapy, Dietary Supplement
- Trial name
- NCT03418376
- Testing
- Beta-alanine supplementation, Exercise intervention
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Visceral Obesity, Non-Alcoholic Fatty Liver Disease
Effect of a Multi-ingredient on Visceral Adiposity and Non-alcoholic Fatty Liver Disease in Individuals With Abdominal Obesity
The aim of this study is to validate the efficacy of specific combination of different natural histidine-related amino acids in the reduction of visceral fat and liver steatosis, as well their associated comorbidities, in…
- Trial name
- FATHIS (NCT05807204)
- Testing
- Multi-ingredient of L-histidine, L-serine, L-carnosine and N-Acetylcysteine
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Periodontal Index, Pain
Efficacy of Zinc L-Carnosine Mouth Rinse
A clinical trial to assess the effect of a Zinc-L-Carnosine-based mouth rinse on periodontal tissues and pain after scaling and root planing
- Trial name
- NCT04430998
- Testing
- Zinc L-Carnosine, Chlorhexidine, Water
- Where
- Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Milan
Exercise, Fatigue
Effect of Beta-Alanine on Heart Rate Response
Beta-alanine, as a method to increase muscle carnosine, has been shown to enhance muscle buffering capacity and delay fatigue. Various fatigue tests have been utilized to examine the effectiveness of beta-alanine supplementation.
- Trial name
- NCT01745016
- Testing
- Beta-alanine
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill