Clinical trials: Carotenoids
Healthy
The CARO Study - Bioefficacy of Beta-Carotene in Oil and in a Mixed Diet in Healthy Subjects
A controlled dietary intervention study will be carried out based on the stable isotope method the investigators have developed to quantify both the absorption of beta-carotene and its bioconversion to retinol in oil and in a…
- Trial name
- NCT00128752
- Testing
- absorption and conversion of beta-carotene in human gastrointestinal (GI) tract
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Vitamin A Deficiency
Effect of Daily Consumption of Orange Maize on Breast Milk Retinol in Lactating Zambian Women
The purpose of the study is to determine whether daily consumption of beta-carotene biofortified maize will increase breast milk retinol concentration in lactating Zambian women.
- Trial name
- NCT01922713
- Testing
- white maize and a corn oil capsule, orange maize and a corn oil capsule, white maize and a vitamin A capsule
- Where
- Zambia
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Pediatric Population on Second Generation Antipsychotics
Beta-carotene and Oxidative Stress in Pediatric Second Generation Antipsychotic Use
Weight gain, hypertension, high cholesterol and sugar abnormalities in childhood are strongly linked and predict the risk of further complications and early death in adulthood.
- Trial name
- NCT02363816
- Sponsor
- Wayne State University
Focus of Study: Carotenoid Absorption
Comparison of Carotenoid Bioavailability From Fresh Papaya, Tomato and Carrot
The goal of this study is to determine if papaya fruits are an exceptionally good food source for carotenoids in humans, particularly when compared more common carotenoid sources like carrots and tomatoes.
- Trial name
- NCT01748916
- Testing
- Papaya, Carrot, Tomato
- Where
- 2 sites in United States, Costa Rica
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Carotenoids
Effect of the Type and Emulsification of Dietary Fat on the Carotenoids Absorption
This study is designed to assess the effects of 1) the emulsification 2) the type of dietary fat on carotenoid (CAT) absorption employing an in-vitro digestion system (Proof of Concept) and well-designed randomized controlled…
- Trial name
- NCT04323826
- Testing
- olive oil-water mixture, olive oil-water emulsion, coconut oil-water mixture
- Where
- 2 sites in Singapore
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Retinitis Pigmentosa
The Effect of Oral Administration of 9-cis Rich Powder of the Alga Dunaliella Bardawil on Visual Functions in Adolescent Patients With Retinitis Pigmentosa
The aim of this study is to determine whether 9-cis-beta Caroten rich D. Brdawiil extract is effective in the treatment of retinitis pigmentosa in adolescent patients.
- Trial name
- NCT02018692
- Testing
- Alga Dunaliella Bardawil powder
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Lifestyle Risk Reduction
Analysis of Correlation Between Skin Carotenoid Level and Basic Indicators of Health Status Related to Lifestyle in Vietnamese: An Observational Study
To clarify the relationship between vegetable intake and lifestyle-related disease in Vietnam, we measure skin carotenoid levels and basic indicators of health status related to lifestyle and analyze the correlation between them.
- Trial name
- NCT06271070
- Testing
- Non-intervention
- Where
- Vietnam
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- KAGOME CO., LTD.
Psoriasis
The Effect of Algae Dunaliella Bardawil on Psoriasis (2)
This is a Randomized, Double-Blind, , Placebo Controlled, 18 Week Study To Evaluate the Efficacy of adjuvant 9-cis-β-Carotene Rich powder of the Alga Dunaliella bardawil in Subjects With Plaque type Psoriasis treated by Narrow…
- Trial name
- NCT01121081
- Testing
- Alga Dunaliella Bardawil
- Where
- Israel
- Sponsor
- Sheba Medical Center
Macular Degenerative Disease
Effect of Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation on Skin Carotenoid Concentration: A Six-Month, Placebo-Controlled Crossover Study
To compare skin carotenoid scores over 12 weeks of individuals randomized to placebo or MacuHealth and comparing that to a 12 week crossover evaluation.
- Trial name
- NCT06965426
- Testing
- Lutein, Zeaxanthin, and Meso-Zeaxanthin Supplementation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,
Healthy
Plant Pigments for Human Health: Impact of Lycopene and Anthocyanins on Bioefficacy of Provitamin A Carotenoids From Carrots
The proposed research will help characterize the impact that simultaneous consumption of anthocyanins and carotenoids has on the bioavailability of the provitamin A carotenoids a-carotene and b-carotene and the non-provitamin A…
- Trial name
- NCT05319548
- Testing
- Purple-Red Carrot Juice, Red Carrot Juice, Purple Carrot Juice
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Retinal Drusen, Age-related Macular Degeneration
Evaluation of a New Eye-specific Multivitamin Formula in Participants at Risk of Age-related Macular Degeneration (AMD)
The aim of this study is to evaluate the clinical benefits in visual function from dietary supplementation of the Lumega-Z carotenoid liquid-supplement in participants with drusen and at risk of AMD.
- Conditions
- Retinal Drusen, Age-related Macular Degeneration, Macular Degeneration
- Trial name
- AMD (NCT03946085)
- Testing
- Lumega-Z, AREDS2
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Guardion Health Sciences, Inc.
Head Injury, Carotenoids
Carotenoids for Collision Athletes
This is a supplement study being conducted to find out if collision sport athletes who are exposed to repetitive head impacts while supplementing with carotenoids will have decreased pro-inflammatory blood biomarkers, increases…
- Trial name
- NCT06270680
- Testing
- Vision Edge Pro
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Penn State University
Cognitive Change, Achievement
Enhancing Children's Cognitive Function and Achievement Through Carotenoid Consumption
The aim of this study is to test the casual relationship between carotenoid supplementation, cognitive function, and achievement over a school-year.
- Conditions
- Cognitive Change, Achievement, Macular Pigmentation
- Trial name
- NCT05177679
- Testing
- Active supplement
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Eye Fatigue, Diet, Healthy
Lutein Supplementation in Healthy Children
This is a single site, randomized, double-blind placebo controlled parallel arm study assessing the effects of 6 months lutein supplementation on cognitive and visual outcomes in healthy children exposed to excessive digital…
- Conditions
- Eye Fatigue, Diet, Healthy, Cognitive Change
- Trial name
- NCT05314647
- Testing
- lutein
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Northcentral University
Fruit and Vegetable Consumption in Children, Fruit and Vegetable Consumption
Fruit and Vegetable Study - Pilot
Arizona State University is studying how local schools and grocery stores can work together to promote fruits and vegetables and support healthy eating among children and families.
- Conditions
- Fruit and Vegetable Consumption in Children, Fruit and Vegetable Consumption, Fruit and Vegetable Selection in the Lunchroom, Caregiver Nutrition
- Trial name
- FFVP+ Pilot (NCT07727746)
- Testing
- FFVP+, FFVP-only
- Where
- United States
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Healthy
The MULTINUTRIENT Maize Project: Results of Human Feeding Trial
The main objective of this human trial is the demonstration that β-carotene in fortified maize has good bioavailability as a plant source of vitamin A and that when humans ingest the biofortified product retinol levels are higher…
- Trial name
- MAIZE (NCT02373943)
- Testing
- β-carotene biofortified maize, β-carotene supplemented maize, Normal (non biofortified) maize without added β-carotene
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institut de Recerca Biomèdica de Lleida
Resonance Raman Spectroscopy for Dietary Carotenoid Intake
Carotenoid Response to the Intake of Vegetables and Fruits
The purpose of this study is to validate the non-invasive tool, resonance Raman spectroscopy for assessing vegetable and fruit consumption.
- Trial name
- NCT01403844
- Testing
- Carotenoid Depletion, Carotenoid Repletion, Natural Repletion
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Carotenoids
Yellow Potatoes and Carotenoids
This study will assess the effects of daily intake of yellow and white potatoes on plasma lutein and zeaxanthin concentrations. Skin carotenoid levels will be assessed using the Veggie Meter.
- Trial name
- NCT07606001
- Testing
- Yellow-flesh potatoes, White-flesh potatoes
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Vision, Eye Health
Eye and Carotenoid Augmentation Research and Evaluation (EyeCARE)
The primary study outcomes are to investigate the effects of 4-month daily carotenoid complex supplementation on carotenoid status in the macula and skin and visual fatigue among adults 20-45 years of age.
- Trial name
- EyeCARE (NCT06848101)
- Testing
- Carotenoid Group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Vitamin A Deficiency
Impact of Consumption of Orange-fleshed Sweet Potatoes on the Vitamin A Status of Bangladeshi Women of Reproductive Age
The primary purpose of this study is to determine whether daily consumption of orange-fleshed sweet potatoes increases the vitamin A status of Bangladeshi women of reproductive age.
- Trial name
- NCT00453648
- Testing
- White-fleshed sweet potatoes, Orange-fleshed sweet potatoes (boiled), Orange-fleshed sweet potatoes (fried)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of California, Davis