Clinical trials: Carotid Artery Stenoses
Carotid Artery Stenosis
Gao's Triple Eversion Carotid Endarterectomy
Carotid endarterectomy (CEA), an important surgical approach for managing carotid plaque, has evolved over more than 70 years but still cannot be applied to all tandem carotid lesions (TCLs) because of the wide range of these…
- Trial name
- NCT06722222
- Testing
- Gao's triple eversion carotid endarterectomy
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Head and Neck Cancer, Carotid Artery Stenosis
Carotid Ultrasound to Identify Head and Neck Cancer Survivors With High Cardiovascular Risk After Radiation Therapy
The purpose of this research study is to understand how radiation therapy may affect blood vessels in the neck called the carotid arteries.
- Conditions
- Head and Neck Cancer, Carotid Artery Stenosis, Cardiovascular Complication
- Trial name
- NCT05490875
- Testing
- Carotid ultrasound, Blood draw, Survey
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Glaucoma, Retinal Vascular Disorder
Study of Human Ocular Hemodynamics by Holography Dopple
Prospective, interventional, non-randomized, open-label study, multi-center, Gehan-designed study with sequential inclusions in each subgroup, ranging from 4 subjects to a maximum 37 subjects per subgroup included
- Trial name
- HoLoEye (NCT06989996)
- Testing
- Images Acquisition
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Carotid Artery Plaque, Diagnosis
Preoperative Identification of the Histologically "Vulnerable" Plaque Using Non-invasive Imaging, Biomechanical Assessment and Baroreflex Evaluation in Patients With Severe Carotid Stenosis
Carotid artery stenosis due to atherosclerotic plaques accounts for an important cause of ischemic stroke. Current research seeks to risk stratify asymptomatic patients by characterizing rupture-prone plaques.
- Trial name
- PREDICT (NCT05566080)
- Testing
- Carotid endarterectomy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Asymptomatic Carotid Artery Stenosis
Carotid Asymptomatic Stenosis
There is debate on the natural history of asymptomatic severe carotid artery stenosis. Previous studies conducted more than 20 years ago revealed the benefit of carotid endarterectomy compared with medical therapy only on the…
- Trial name
- CARAS (NCT04825080)
- Testing
- duplex ultrasound and computed tomography angiography
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Bologna
Carotid Artery Stenoses
Pre- and Post-operative Brain MRI in Carotid Endarterectomy
Patients undergoing carotid endarterectomy in the Department of Vascular Surgery at Oslo University Hospital are consecutively included in this evaluation og pre- and postoperative brain MRI.
- Trial name
- NCT04029259
- Testing
- Brain MRI
- Volunteers
- 320 people
- Sponsor
- Oslo University Hospital
Disease Management, Diabetes Complications
Determining Rates of Cardiovascular Complications Among Patients of a Managed Diabetes Care Program
The primary objective of this study is to identify whether cardiovascular complication rates are lower in patients who participate in managed diabetes care, in comparison to provincial and national rates.
- Conditions
- Disease Management, Diabetes Complications, Diabetic Vascular Complications, Diabetic Neuropathy
- Trial name
- DECIDE (NCT00498147)
- Testing
- ADEC Program
- Where
- Canada
- Volunteers
- 1,213 people
- Sponsor
- Group Health Centre
Stroke, Carotid Stenosis
Spider Versus Emboshield Distal Protection on Cerebral Microembolization During Vulnerable Plaque in Carotid Artery Stenting
A single center, prospective, outcome-assessor-blinded, randomized controlled trial study (CASH-ES) is designed to compare the efficiency of two different distal embolism protection devices (SpiderFX and Emboshield NAV6) in…
- Conditions
- Stroke, Carotid Stenosis, Carotid Artery Stent
- Trial name
- CASH-ES (NCT04904250)
- Testing
- Emboshield, Spider
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Xuanwu Hospital, Beijing
Choroid, Carotid Stenosis
Ocular Effects of Carotid Endarterectomy
All patients undergoing carotid endarterectomy in Shaare Zedek Medical Hospital, during about 1 year, will be offered to participate. Retinal and choroidal structural changes will be assessed using swept-source OCT technology
- Conditions
- Choroid, Carotid Stenosis, Carotid Endarterectomy
- Trial name
- NCT02448355
- Testing
- OCT swept source DRI-Atlantis, Topcon
- Volunteers
- 30 people
- Sponsor
- Shaare Zedek Medical Center
Carotid Artery Stenosis
PMCF Study of Precise Pro Rx for Carotid Artery Disease
The purpose of this study is to evaluate long-term clinical safety and performance of the PRECISE PRO RX Nitinol Stent System to treat stenotic lesions of the carotid arteries.
- Trial name
- REAL-PRECISE (NCT07204678)
- Testing
- PRECISE PRO Rx Nitinol Stent System
- Where
- 4 sites in Austria, France and 1 more
- Volunteers
- 199 people
- Sponsor
- Cordis US Corp.
Carotid Stenosis
Effect on Cerebral Oxygenation by Sevoflurane or Propofol Using Near-infrared Spectroscopy in Carotid Endarterectomy
The aim of this study is comparing the effect on cerebral oxygenation by sevoflurane-remifentanil or propofol-remifentanil anesthesia in patient undergoing carotid endarterectomy.
- Trial name
- NCT02609087
- Testing
- Sevoflurane, Propofol
- Where
- South Korea
- Volunteers
- 69 people
- Sponsor
- Chonnam National University Hospital
Carotid Artery Diseases
A Single-arm, Pivotal Study to Evaluate Acute Device and Technical Success of the CGuard Prime Carotid Stent System When Used in Conjunction to the ENROUTE Transcarotid Neuroprotection System in Patients Undergoing Carotid Artery Stenting Via the Transcarotid Artery Revascularization Approach
The objective of this study is to evaluate acute device and technical success of the CGuard Prime™ Carotid Stent System (80cm) when used in conjunction with the Enroute NPS during Transcarotid Artery Revascularization procedures…
- Trial name
- NCT06653387
- Testing
- CGuard Prime 80cm stent system
- Where
- 8 sites in United States
- Volunteers
- 50 people
- Sponsor
- InspireMD
Carotid Artery Diseases
MicroNet-covered Stent System for Stroke Prevention in All Comer Carotid Revascularization
All-comer study of unselected patients suitable for carotid artery revascularization to evaluate the feasibility, efficacy and safety of first line endovascular revasculariztion using MicroNet covered stent (CGuard™) in the…
- Trial name
- PARADIGM-EXT (NCT04271033)
- Testing
- Carotid Artery Stenting
- Where
- Poland
- Volunteers
- 550 people
- Sponsor
- John Paul II Hospital, Krakow
MRI, Functional, Carotid Artery Stenosis
Cognitive Function and Brain Connectivity in CAS Patients:a Rs-fMRI Study
This is a prospective study aimed to explore the changes of cognitive function after surgery for CAS and the correlation with brain connectivity, in order to look for the clinical biomarkers to predict the carotid stent…
- Trial name
- NCT05292729
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Carotid Stenosis, Carotid Artery Disease
The MICHI NEUROPROTECTION SYSTEM: Evaluation of Performance in Carotid Artery Stent Procedures (The LOTUS Study)
The LOTUS Study is intended to demonstrate the usability of the MICHI Neuroprotection System (MICHI NPS) or MICHI Neuroprotection System with filter (MICHI NPS+f) for use in subjects who are candidates for Carotid Artery Stenting…
- Trial name
- LOTUS (NCT01958294)
- Testing
- MICHI Neuroprotection System
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Silk Road Medical
Carotid Artery Diseases, Carotid Artery Stenosis
Change of Hemodynamics and Cerebral Functions After Carotid Artery Revascularization
The majority (>80%) of strokes are of ischemic etiology, of which ≈15% to 20% are attributable to atherosclerosis of the extracranial carotid arteries.
- Conditions
- Carotid Artery Diseases, Carotid Artery Stenosis, Cerebrovascular; Disorder, Arteriosclerotic, Cardiovascular Diseases
- Trial name
- HALO (NCT05539781)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Friendship Hospital
Neurology
Assessment of Plaque Vulnerability Using a Novel Technique: Multi-spectral PhotoAcoustic Imaging.
Identification of intraplaque haemorrhage using MRI is technically demanding and sometimes uncomfortable. Photoacoustic imaging is a new non-invasive technique combining multi-wavelength infrared laser light and ultrasound…
- Trial name
- (CVENT-PAI) (NCT04763603)
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Centre Hospitalier St Anne
Revascularization, Carotid Artery Stenosis
Study on the Trans-Carotid Artery Occlusion Shunt System
The objective of the study is to evaluate the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System for Carotid Artery Revascularization during Endovascular Treatment
- Conditions
- Revascularization, Carotid Artery Stenosis, Carotid Artery Diseases
- Trial name
- NCT06924593
- Testing
- Trans-Carotid Artery Occlusion Shunt System
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Shenzhen Wecan Medical Technology Co.,Ltd
Carotid Artery Stenosis
Effect of Remote Ischemic Preconditioning on Cerebral Circulation Time in Patients With Severe Carotid Artery Stenosis (RIP-CCT)
Cerebral circulation time in patients with severe carotid artery stenosis was found to be associated with hyperperfusion syndrome. Remote ischemic preconditioning can change the ability of cerebral autoregulation.
- Trial name
- NCT05451030
- Testing
- remote ischemic preconditioning
- Where
- China
- Volunteers
- 122 people
- Sponsor
- General Hospital of Shenyang Military Region
Patients With Any Degree of Carotid Artery Stenosis and Vulnerable Features in the Carotid Artery Plaque
Prospective Carotid Artery Stenosis Trial
Researchers are collecting information and blood from subjects undergoing carotid artery interventions.
- Trial name
- NCT05724836
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic