Clinical trials: Carotid Plaque Imaging
Carotid Artery Plaque
Carotid Plaque Assessment Using 18Fluorine (18F) -Sodium Fluoride Positron Emission Tomography (PET) /MR
Carotid plaque can lead to ischemic stroke. Treatment of asymptomatic carotid plaque, based on degree stenosis, is still controversial.
- Trial name
- CARTIS (NCT02726984)
- Testing
- 18F-sodium fluoride PET/MR
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Carotid Artery Plaque
99mTc-rhAnnexin V-128 Imaging for Carotid Atherosclerosis
This was a single-center, single-dose, study comprising a Proof of Concept (PoC) part and a subsequent Phase II part. The study was being done to assess the ability of the radiotracer 99mTc-rhAnnexin V-128 to image…
- Trial name
- NCT02667457
- Testing
- 99mTc-rhAnnexin V-128
- Where
- Canada
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Advanced Accelerator Applications
Stroke, Plaque, Atherosclerotic
ParisK: Correlation of Imaging Techniques With Histology
The possibility to identify the risk of rupture of a carotid plaque will have tremendous impact in clinical decision making. A vulnerable plaque is considered to have a large lipid rich necrotic core (LRNC), a thin fibrous cap…
- Trial name
- ParisK (NCT01709045)
- Testing
- Magnetic Resonance Imaging (MRI), Dual-Energy Computed Tomography (DECT), Ultrasound
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Plaque, Atherosclerotic
Comparison of Clopidogrel Versus Ticagrelor Therapy for Atherosclerotic Plaque Inflammation
Objectives: To compare the effects of clopidogrel versus ticagrelor on atherosclerotic plaque inflammation using serial FDG PET/CT imaging of carotid artery and ascending aorta.
- Trial name
- NCT01905566
- Testing
- Clopidogrel, Ticagrelor
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Atherosclerotic Carotid Disease, Atheroma
Effects Of Atorvastatin On Macrophage Activity And Plaque Inflammation Using Magnetic Resonance Imaging
A new way of scanning narrowing in the arteries (main blood vessels) caused by fatty deposits known as plaques has been developed. Heart attacks and strokes occur when plaques become inflamed, depending on the artery affected.
- Conditions
- Atherosclerotic Carotid Disease, Atheroma, Atherosclerosis
- Trial name
- NCT00368589
- Testing
- atorvastatin
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Carotid Stenosis
Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control
Cerebrovascular accident (CVA) constitutes a major health public problem. This represents the second cardiovascular death cause. CVA is ischemic in 80% of cases.
- Trial name
- ACABII (NCT02748941)
- Testing
- HITS quantification, Ultrasound examinations, High Resolution MRI
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Hospices Civils de Lyon
Atherosclerosis, Atherosclerotic Plaque
Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
This will be a pilot study of 9 patients undergoing standard-of-care clinically indicated carotid endarterectomy. The nine patients will receive an injection of Indocyanine green (ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as…
- Conditions
- Atherosclerosis, Atherosclerotic Plaque, Carotid Stenosis
- Trial name
- BRIGHT-CEA (NCT01873716)
- Testing
- Indocyanine green
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Carotid Plaque, Ischemic Stroke
Evaluation of Vulnerability of Carotid Plaques and Prediction of Cardio-Cerebrovascular Event Using Ultrasonic Imaging
This study included patients with carotid artery atherosclerotic plaques to conduct multimodal ultrasound examinations, aiming to establish a plaque vulnerability assessment model based on ultrasonic imaging indicators, clinical…
- Conditions
- Carotid Plaque, Ischemic Stroke, Cardiovascular Events
- Trial name
- NCT06473272
- Testing
- Cardiovascular and cerebrovascular diseases
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Inflammation, Atheromatous Plaques
Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque
The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of…
- Conditions
- Inflammation, Atheromatous Plaques, Carotid Artery Diseases
- Trial name
- NCT01608516
- Testing
- 68Ga-NODAGA-RGD PET/CT
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Lausanne Hospitals
Carotid Artery Diseases, Carotid Artery Plaque
The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study
Carotid artery disease is a main cause of ischemic stroke and vascular dementia, and a highly prevalent disease. There is uncertainty about the optimal management of patients with serendipitously or systematically detected…
- Conditions
- Carotid Artery Diseases, Carotid Artery Plaque, Carotid Atherosclerosis
- Trial name
- NCT04679727
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Carotid Artery Plaque
Ultrasound Elastography for Individual Carotid Plaque Stratification
Ischemic strokes are a leading cause of death and disability worldwide. In 20% of cases they are caused by the rupture of atherosclerotic plaques in carotid arteries. Risk estimation of plaque rupture is currently suboptimal.
- Trial name
- Ultra-COMPASS (NCT05029661)
- Testing
- Carotid ultrasound
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Stroke, Atheroscleroses
A Cohort Study on Cardiovascular and Cerebrovascular Outcomes
A standardized tool for grading carotid atherosclerotic plaques-dubbed Carotid Plaque-RADS (Reporting and Data System)-has recently been developed.
- Trial name
- NCT07178015
- Testing
- ultrasound scanning
- Where
- China
- Volunteers
- 855 people
- Sponsor
- Sun Yat-sen University
Ischemic Stroke, Transient Ischemic Attack
Chinese Atherosclerosis Risk Evaluation- Phase II
Stroke is the first and the fourth leading cause of death in the United States and China, respectively. Disruption of cerebrovascular vulnerable atherosclerotic plaque is the major etiology of ischemic stroke.
- Conditions
- Ischemic Stroke, Transient Ischemic Attack, Carotid Atherosclerotic Disease
- Trial name
- CARE-II (NCT02017756)
- Where
- 14 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Tsinghua University
Arteriosclerosis, Diabetes Mellitus
A High-Resolution Magnetic Resonance Imaging Study to Evaluate the Effect of Rosuvastatin on Carotid Atherosclerotic Plaques
The aim of this study is to assess whether high intensive statin therapy could regress carotid atherosclerotic plaques as determined by High-Resolution Contrast Enhanced Magnetic Resonance imaging (CE-MRI).
- Conditions
- Arteriosclerosis, Diabetes Mellitus, Lipid Disorder
- Trial name
- NCT02305862
- Testing
- Rosuvastatin 5mg, Rosuvastatin 20mg
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Capital Medical University
Atherosclerosis
Ultrasound and Other Images of Artery Blockages
Background: Treatments for partly blocked carotid arteries are determined by a person s symptoms and by tests that show how severe the blockage is.
- Trial name
- NCT01419574
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Carotid Artery Stenosis
Imaging of Unstable Carotid Plaque in Patient Referred to Endarterectomy
This study will assess unstable plaque imaging features by using high resolution MR imaging and Sodium Fluoride F-18 PET. This is a comparative study between symptomatic and asymptomatic patient referred to carotid…
- Trial name
- CAROTEP (NCT03353103)
- Testing
- Sodium fluoride F-18 PET imaging
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Caen
Hypercholesterolemia, Hypercholesterolemia, Familial
PET Imaging of Inflammation and Lipid Lowering Study
While 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging has been used as an early marker of drug efficacy in numerous clinical cardiovascular drug trials, as a glucose analog, its signal in the vasculature…
- Conditions
- Hypercholesterolemia, Hypercholesterolemia, Familial, Atherosclerosis, Carotid Artery Plaque
- Trial name
- PIILL (NCT04073797)
- Testing
- Inclisiran, 68Ga-DOTATATE PET-MRI, Colchicine
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- University of Cambridge
Carotid Stenosis
Evaluation of the Carotid Plaque Stability by Ultrafast-ultrasound Imaging (UF)
Unstable plaques are characterized by lower segmental stiffness and intimal neovascularization compared to stable plaques. Our objective is to determine the capacity of the elastographic parameters obtained by the UF to…
- Trial name
- UF-Plaques (NCT03234257)
- Testing
- UF-ultrasound
- Where
- France
- Volunteers
- 69 people
- Sponsor
- French Cardiology Society
Carotid Stenosis
Histological Validation Of Carotid Plaque Composition In Preoperative Imaging
Patients scheduled for carotid endarterectomy undergo preoperative imaging to assess vulnerable plaque. The imaging modalities include (in various combinations at different study sites) 3-dimensional ultrasound, PET/CT imaging…
- Trial name
- NCT01456403
- Testing
- Histological validation
- Where
- 3 sites in Canada
- Volunteers
- 95 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Artery Disease, Carotid Artery Diseases
Carotid Plaque Characteristics by MRI in AIM-HIGH (Carotid MRI Substudy)
Heart attacks and strokes caused by the unstable atherosclerotic plaques remain the leading cause of death in the United States. Unstable plaques often have more fat than stable plaques.
- Conditions
- Coronary Artery Disease, Carotid Artery Diseases, Atherosclerosis
- Trial name
- NCT01178320
- Testing
- Simvastatin, simvastatin plus extended-release niacin
- Where
- 19 sites in United States, Canada
- Volunteers
- 230 people
- Sponsor
- University of Washington