Clinical trials: Cartilage, Articular
Osteoarthritis, Knee
Evaluation of the Evolution of Imaging Markers of Cartilage Degradation in Patients With Knee Osteoarthritis Receiving DROGLICAN
A previous multicenter trial led by Bioiberica S.A. has confirmed the efficacy and safety of DROGLICAN for the treatment of osteoarthritis (OA) in patients with severe pain.
- Trial name
- DRIP (NCT02821468)
- Testing
- Droglican, Paracetamol or oral NSAIDs excluding COX2 inhibitors
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Bioiberica
Defect of Articular Cartilage
Mesenchymal Stem Cells in a Clinical Trial to Heal Articular Cartilage Defects
The purpose of this study is to: Compare the treatment efficacy of autologous mesenchymal stem cells (Mesenchymal Stem Cells) versus chondrocytes implanted in a commercial available scaffold in a human clinical trial.
- Trial name
- NCT00885729
- Testing
- stem cells, Chondrocytes, Rehabilitation program
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Articular Cartilage Damage
NeoCart Phase 2 Clinical Trial
The objective of this study is to gather additional information regarding the performance of NeoCart to fill articular cartilage defects in the knee.
- Trial name
- NCT00548119
- Testing
- NeoCart, microfracture
- Where
- 6 sites in United States
- Volunteers
- 30 people
- Sponsor
- Histogenics Corporation
Defect of Articular Cartilage, Knee Injuries
DeNovo NT Natural Tissue Graft Stratified Knee Study
The purpose of this study is to evaluate the long-term relief of pain and return to function for patients receiving DeNovo NT for cartilage lesions in the knee.
- Trial name
- NCT01670617
- Testing
- Particulated Juvenile Articular Cartilage
- Where
- 18 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Volar Plate Injury, Thumb, Metacarpophalangeal Joint
Metacarpophalangeal Joint Reconstruction Using a Vascularized Cartilage and Bone Graft
Traumatic cartilage loss of the joint is central to the development of joint failure in arthritis. The study on the use of a bone graft for reconstruction of metacarpophalangeal joint defects.
- Trial name
- MJRUVCBG (NCT01467752)
- Testing
- MCP joint
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Second Hospital of Qinhuangdao
Knee Osteoarthritis
A Safety and Efficacy Study of Anti-inflammatory (Canakinumab) and Cartilage Stimulating (LNA043) Drugs Injected Into the Knee Joint of Participants With Knee Osteoarthritis (OA)
The study was established to show safety and efficacy of canakinumab and LNA043 in patients with knee osteoarthritis (OA).
- Trial name
- NCT04814368
- Testing
- canakinumab, LNA043
- Where
- 11 sites in United States, Czechia and 4 more
- Volunteers
- 23 people
- Sponsor
- Novartis Pharmaceuticals
Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis
Gait Rehabilitation to Treat FastOA
The purpose of this study is to determine the effects of real-time gait biofeedback delivered over a 6-week period on early markers of FastOA and conduct 6-week and 6-month follow-up assessments in anterior cruciate ligament…
- Conditions
- Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, Knee Osteoarthritis, Osteo Arthritis Knee
- Trial name
- NCT05848622
- Testing
- Real-time gait biofeedback
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of North Carolina, Chapel Hill
Degenerative Osteoarthritis, Defect of Articular Cartilage
Follow-Up Study of CARTISTEM® Versus Microfracture for the Treatment of Knee Articular Cartilage Injury or Defect
This is a long term follow-up study to investigate the safety and efficacy of CARTISTEM®, human umbilical cord blood-derived mesenchymal stem cells, in repair of cartilage injury or defects, compared with microfracture.
- Trial name
- NCT01626677
- Testing
- CARTISTEM, Microfracture
- Where
- 10 sites in South Korea
- Volunteers
- 103 people
- Sponsor
- Medipost Co Ltd.
Osteoarthritis, Exercise
Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading
In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise.
- Trial name
- NCT01090375
- Testing
- Exercise, Non Exercise
- Sponsor
- Bispebjerg Hospital
Osteoarthritis, Knee
Effects of Intra-articular Stromal Vascular Fraction Injection on Clinical Symptoms and Cartilage Health in Osteoarthritic Knees
Background: Osteoarthritis (OA) is a prevalent form of arthritis worldwide. Intra-articular stromal vascular fraction (SVF) injections are a potential therapeutic option for patients with OA.
- Trial name
- NCT06562101
- Testing
- Intra-articular Stromal Vascular Fraction Injection
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Shu-Hao Chang, MD
Defect of Articular Cartilage, Knee Osteoarthritis
Clinical Trial to Compare ReJoinTM to Sodium Hyaluronate Injection for Knee Osteoarthritis Cartilage Defects
The purpose of this study is to evaluate the effectiveness of ReJoinTM for the Knee Osteoarthritis patients with Cartilage Defects comparing to Sodium Hyaluronate Injection.
- Trial name
- NCT02855073
- Testing
- ReJoinTM, Sodium Hyaluronate
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Shanghai AbelZeta Ltd.
Knee Osteoarthritis, Cartilage Damage
Clinical Study of Pain Reduction by Peri-arthroscopic PRP Application in Knee Degeneration
The purpose of this study is to investigate reduction of pain, gain of function and improvement of life quality by intraoperative applied platelet- rich- plasma ( PRP ) during knee arthroscopy for degeneration and osteoarthritis…
- Conditions
- Knee Osteoarthritis, Cartilage Damage, Meniscal Tear
- Trial name
- PRP-Bochum (NCT02189408)
- Testing
- Platelet rich plasma
- Where
- Germany
- Volunteers
- 58 people
- Sponsor
- Ruhr University of Bochum
Tendonitis, Bursitis
Efficacy and Safety of Ketoprofen Topical Patch 20% in the Treatment of Pain Associated With Shoulder, Elbow or Knee Tendonitis or Bursitis
The purpose of this study is to evaluate the effect of a ketoprofen topical patch on the pain associated with tendonitis or bursitis of the shoulder, elbow or knee
- Trial name
- NCT00426985
- Testing
- Ketoprofen Topical Patch 20%
- Where
- United States
- Volunteers
- 381 people
- Sponsor
- Alkemira SA
Articular Cartilage Defects of Knee
Observation of the Result After Chondron (Autologous Chondrocytes) Treatment
This investigator-sponsored trial attempts to evaluate the effectiveness of Chondron transplantation by tracking subjects who had the Chondron implantation to observe effectiveness.
- Trial name
- NCT01056900
- Testing
- Autologous Chondrocyte Implantation
- Where
- South Korea
- Volunteers
- 127 people
- Sponsor
- Cellontech Co., Ltd.
Obesity, Osteoarthritis
Reducing Obesity and Cartilage Compression in Knees
OA is a degenerative joint disease that involves the degradation of articular cartilage and underlying subchondral bone. Obesity is identified as a critical and potentially modifiable risk factor for the development and…
- Conditions
- Obesity, Osteoarthritis, Knee Osteoarthritis
- Trial name
- ROCCK (NCT04730557)
- Testing
- Weight Loss
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Duke University
Cartilage Destruction
Оptical Spectroscopy in the Diagnosis of Intra-articular Injuries
Intra-articular joint injuries are the most common and prognostically unfavorable in case of untimely or erroneous diagnosis, which leads to a significant violation of the quality of life and activity of patients.
- Trial name
- NCT05454605
- Where
- Russia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Articular Cartilage Disorder
Investigation of a Customized Femoral Resurfacing Implant
The purpose is to assess the safety profile and performance of a femoral resurfacing implant for localized chondral lesions.
- Trial name
- Knee100 (NCT01690689)
- Testing
- Implant surgery
- Where
- 3 sites in Sweden
- Volunteers
- 10 people
- Sponsor
- Episurf Medical Inc.
Chondral Lesion Plus Partial Medial Meniscectomy
Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage Lesions
The purpose of this study is to evaluate changes in clinical and imaging outcomes following arthroscopic treatment of a single medial femoral chondral lesion plus partial medial meniscectomy by Radiofrequency-Based debridement or…
- Trial name
- ACT (NCT01803880)
- Testing
- Mechanical Debridement, RF-Based Debridement
- Where
- 7 sites in United States
- Volunteers
- 148 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis
The Effect of Corrective Osteotomy on in Vivo Cartilage Mechanobiology in Patients With Knee Osteoarthritis
Our overall hypothesis is that a sudden ambulatory load reduction (caused by corrective osteotomy) leads to changes in cartilage biology that delay or reverse osteoarthritic processes determining the clinical outcome and…
- Trial name
- Osteotomy (NCT02622204)
- Testing
- Corrective osteotomy
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Articular Cartilage Lesion of the Femoral Condyle
Autologous Mesenchymal Stem Cells vs. Chondrocytes for the Repair of Chondral Knee Defects
The objective of our study is to compare the safety and effectiveness of the use of autologous cultured adipose tissue-derived stem cells versus cultured autologous chondrocytes for the treatment of chondral knee lesions.
- Trial name
- ASCROD (NCT01399749)
- Testing
- Implantation of autologous cells
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz